Ketonal duo for osteochondrosis reviews

Ketonal Duo - instructions for use

For muscle and joint pain, Ketonal Duo tablets are used, which are classified as non-steroidal anti-inflammatory drugs (NSAIDs). The duration of their use depends on the severity of the disease, stage of progression, age and individual characteristics of the patient. The maximum daily dose is 200 mg of ketoprofen. Due to the possible negative effect of the substance on the mucous membranes, it is allowed to combine Duo Ketonal with antacids to prevent gastrointestinal diseases.

The dosage regimen depends on the format of the medicine and the course of symptoms. Approximate dosages will be:

• Ketonal Forte tablets – 100-200 mg per day (1 tablet 1-2 times per day), can be combined with suppositories according to the scheme: a tablet in the morning and a suppository in the evening;
• Duo Ketonal capsules - for patients over 15 years of age, 1 capsule (150 mg) per day, washed down with water or 100 ml of milk;
• parenteral (“past the intestines”) administration - intramuscular, 100 mg of ketoprofen twice a day, infusions are done only in a hospital, the procedure lasts up to an hour, with intravenous administration - no longer than two days, a maximum of 200 mg can be consumed per day;
• suppositories - rectal administration, one suppository into the rectum 1-2 times a day.

Compound

The composition of the drug differs in the form of release. Tablets contain 50 mg of the active ingredient ketoprofen and lactose, suppositories - 100 mg, solution for infusion - 50 mg/ml, propylene glycol, benzyl alcohol, sodium hydroxide and purified water. Duo Ketonal hard capsules have the following composition :

Release form

The active substance ketoprofen contains all formats of the drug: rectal suppositories, solution for infusion, film-coated tablets and prolonged action. Ketonal modified-release capsules have a transparent tablet body and a blue cap, inside there are white and yellow pellets.

Pharmacodynamics and pharmacokinetics

The active substance ketoprofen is a NSAID and has an analgesic, anti-inflammatory and antipyretic effect. During inflammation, it increases the synthesis of prostaglandins, inhibits the activity of enzymes, and stabilizes the permeability of the cell membrane. Ketoprofen reduces the severity of pain in primary dysmenorrhea, has a universal analgesic effect, and relieves the symptoms of the inflammatory process in the musculoskeletal system.

The substance is quickly absorbed by the gastrointestinal tract; ketoprofen reaches its maximum concentration after oral administration after 1.5 hours. Bioavailability is 90%. The medicine acts by releasing the active substance and has a prolonged effect. Eating food, especially fatty foods, slows down the rate of absorption of ketoprofen. With rectal administration, the concentration of methotrexate becomes maximum after an hour, with parenteral administration - five minutes. Plasma clearance of ketoprofen is 0.08 l/kg/h.

The substance penetrates the synovial fluid, relieves joint pain, and eliminates stiffness. Ketoprofen does not accumulate within tissues. Metabolism is carried out by the liver, the drug is excreted in urine and feces. In patients suffering from liver failure, ketoprofen can be found in the form of accumulations in tissues, and in old age it can slow down in metabolism and excretion.

Indications for use

Ketonal Duo is actively used for toothache, joint diseases, algodismenorrhea (pain during menstruation). Other indications for taking the drug are:

• rheumatoid, psoriatic, reactive arthritis;
• ankylosing spondylitis;
• gout, pseudogout;
• osteoarthritis;
• extra-articular rheumatism;
• pain syndromes;
• lumbago;
• post-traumatic pain in articular cartilage and muscles, postoperative pain syndromes;
• cancer pain due to the development of metastases in the bones.

Release form and composition

The drug is produced in the form of modified-release capsules: with a transparent body and a blue cap, size No. 1;
inside the capsules the contents are in the form of yellow and white pellets (10 pieces in blisters, 1, 2 or 3 blisters in a cardboard package and instructions for use of Ketonal DUO). Composition per 1 capsule:

• active ingredient: ketoprofen – 150 mg;
• auxiliary components of the capsule contents: lactose monohydrate, croscarmellose sodium, microcrystalline cellulose, polysorbate 80, povidone;
• pellet shell (only 40% of the pellets in each capsule are coated): Eudragit RL 30D, Eudragit RS 30D, polysorbate 80, talc, triethyl citrate, colloidal silicon dioxide, yellow iron oxide;
• capsule body and cap: titanium dioxide, indigo carmine, gelatin.

1 capsule of ketoprofen contains 150 mg. MCC, lactose monohydrate, croscarmellose sodium, polysorbate, povidone - as excipients.

Capsules 150 mg No. 30.

For external use, Ketonal comes in two dosage forms: gel and cream.

Cream Gel
Ketonal in gel form:

1. Ketonal gel contains 2.5% of the main active ingredient. 1 g of external product contains ketoprofen in the amount of 25 mg.
2. As auxiliary components, the composition includes components in the form of carbamer, trolamine, ethanol, essential lavender oil, and prepared water.
3. Physical characteristics: homogeneous, transparent, colorless gel-like structure with a faint odor.
4. Release form: tubes of 50, 100 g, packed in cardboard boxes.
5. For external use.

Ketonal in cream form:

1. Ketonal cream contains 5% of the main active ingredient. 1 g of external product contains 50 mg (twice as much as in the gel) of ketoprofen.
2. As auxiliary components, the composition includes components in the form of methylhydroxybenzoate, propylene glycol, petroleum jelly, fatty acid esters, magnesium sulfate, and prepared water.
3. Physical characteristics: white or almost white creamy texture.
4. Cream release form: 30.50 g aluminum tubes, packed in cardboard boxes.
5. For external use.

special instructions

Instructions for use of Duo Ketonal contain a special instructions section that provides information about the drug:

• is contraindicated in the third trimester of pregnancy, in the first two it is allowed to take capsules if the benefit to the mother exceeds the risk to the fetus; according to reviews, it does not affect the child;
• blood pressure more often when treating patients with cardiovascular diseases that occur with fluid retention in the body;
• according to reviews, ketoprofen reduces the inhibition of prostaglandins and is able to hide the signs of infectious diseases;
• there is no data on the negative impact of Duo Ketonal on the ability to drive, but it is better to avoid hazardous activities with increased concentration that require rapid psychomotor reactions.

Release form of the drug

Ketonal is available without a prescription in several forms:

• Ketonal suppositories 0.1 g;
• Solution for intravenous injection in ampoules of 1 m;
• Ketonal ointment, cream or gel for external use;
• Ketonal tablets;
• Capsules, the dose of which is 0.05 g.

Instructions for use of capsules

Capsules are taken orally with a small amount of water (about 100 ml):

1. For severe inflammation: 50 mg (1 capsule) 3 times a day. The maximum daily dose is 300 mg (6 capsules).
2. For arthritis and osteoarthritis: 50 mg (1 capsule) 4 times a day.
3. For algodismenorrhea: 50 mg (1 capsule) 3 times a day.
4. To prevent the development of NSAID gastropathy in patients, the doctor sometimes prescribes in parallel with
5. Taking antacids with Ketonal.
6. Duo Ketonal capsules are taken with meals, with plenty of water, at a dosage of 1 capsule/day. In rare cases, it is prescribed to take two capsules per day with an interval of 12 hours.

Instructions for use of ampoules

Ketonal is also available in the form of injections and a solution for intramuscular injection, so it is important to know how to inject the drug. The drug is prescribed 3 times a day in the amount of 0.1 g (1 ampoule). For more effective treatment, in especially severe cases, it is recommended to take pills and use suppositories along with injections.

Administration of Ketonal intravenously is possible only during hospital treatment. The solution is injected intermittently or continuously to numb the specific area where severe pain occurs.

Intermittent administration is carried out using two ampoules of Ketonal, which contain approximately 200 mg of the active substance. The ampoules are diluted into 100 ml of solution, and then the medicine is injected into the patient’s vein. The whole procedure takes no more than an hour. This administration of the drug is repeated after 8 hours.

With a continuous process of administration, 2 ampoules of Ketonal, diluted in 500 ml of solution, will be required. For these purposes, hospitals use a special glucose solution. The effect of the injection lasts about 8 hours. The procedure is repeated after 9 hours. For severe excruciating pain, the patient is prescribed Ketonal injections together with a narcotic analgesic.

Instructions for use of Ketonal tablets

To relieve severe pain, Ketonal painkillers are taken once a day. The maximum daily dose, which is allowed only as a last resort, is 2 tablets. This drug is taken during meals or immediately after meals with plenty of water.

Taking the medicine together with antacids will help prevent the development of NSAID gastropathy. The effect of the drug begins no later than 30 minutes after use.

Instructions for use of rectal suppositories

Rectal suppositories Ketonal are indispensable in complex therapy. They are administered 2 times a day. In parallel with the use of suppositories, you can take Ketonal tablets or capsules, maintaining a sufficient interval between the use of different forms of the drug - take the tablet in the morning, and insert the suppository at night.

Interaction with other drugs

Duo Ketonal has the following effects on the body when taken simultaneously with other medications:

• with other NSAIDs – binds plasma proteins, reduces the bioavailability of drugs;
• Dose adjustment is required if therapy is carried out with anticoagulants, sulfonamides, hydantoins;
• increases the risk of ulcers forming inside the stomach and intestines when taken with glucocorticosteroids;
• enhances the effects of anticoagulants, acids, increases the risk of bleeding when using antithrombotic agents;
• reduces the effect of Mifepristone, antihypertensive drugs, diuretics, increases the risk of nephrotoxicity, renal disorders when taking antirheumatic drugs;
• parallel intake of cardiac glycosides causes exacerbation of heart failure, reduces the excretion of lithium salts with the use of lithium preparations;
• increases the risk of nephrotoxicity of cyclosporine, fatal toxicity of methotrexate, requires discontinuation of mifepristone because it reduces the effectiveness of mifepristone.

Side effects

The side effects of Ketonal are transient in nature. These include the following effects:

• anemia;
• nosebleeds, hematomas;
• bronchospasm, shortness of breath, angioedema, anaphylaxis;
• depression, nervousness, nightmares during sleep, drowsiness, disorientation, speech impairment;
• headache, asthenia, discomfort, dizziness, paresthesia;
• blurred vision, conjunctivitis, tinnitus;
• swelling of the larynx, pharyngitis, rhinitis;
• nausea, diarrhea, vomiting, stomatitis, gastritis, colitis;
• jaundice, hepatitis, skin rash, eczema, urticaria, dermatitis, photosensitivity;
• nephritis, acute pyelonephritis, menometrorrhagia.

Indications for use

It is used in the treatment of diseases of the musculoskeletal system that are inflammatory and degenerative in nature. These include:

1. rheumatoid arthritis;
2. Bekhterev's disease;
3. Reiter's syndrome;
4. inflammation of the joints in patients with psoriasis;
5. gout, incl. pseudogout;
6. osteoarthritis.

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Used to reduce and eliminate pain, such as:

• headache;
• for inflammation of the joint capsule;
• with inflammation of the tendons;
• muscle pain;
• neuralgia;
• radiculitis;
• pain after injuries and operations;
• algosmenorrhea (pain during menstruation);
• in oncology.

Contraindications

According to the instructions for use of Duo Ketonal, the following contraindications are identified for which it is prohibited to prescribe ketoprofen:

• hypersensitivity to the components of the product, salicylates;
• heart failure, blood diseases;
• treatment of pain after aortic bypass surgery;
• chronic dyspepsia;
• peptic ulcer of the stomach;
• gastrointestinal bleeding, diabetes mellitus;
• tendency to hemorrhages;
• liver and kidney diseases;
• bronchial asthma;
• third trimester of pregnancy, breastfeeding;
• age up to 15 years.

Adverse reactions and overdose

Ketonal Duo, if the dosage is not followed, can cause negative consequences in the form of an overdose. This may result in:

• nausea and vomiting reactions;
• pain in the abdominal area;
• vomiting reactions with bleeding, melena;
• disorder of consciousness;
• respiratory depression;
• convulsive reactions;
• impaired renal function, incl. renal failure.

In case of overdose, you should consult a specialist. As first aid, you should rinse your stomach and drink activated charcoal.

The medication can provoke adverse reactions, including negative reactions from the digestive organs, central nervous system, sensory organs, heart, hematopoietic system, genitourinary organs, allergic reactions and some others may also occur.

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Price for Ketonal Duo

You can buy the drug in an online pharmacy or order it in your usual department. The cost will depend on the format of the medicine and the markup level of the retailer. Approximate prices are shown in the table:

Reviews

Yana, 18 years old

After knee surgery, my leg hurt very badly. The doctor prescribed a new medicine, Ketonal, in capsules, and prescribed me to take one every day. I liked the product - it quickly relieved pain, it acted quickly. After a week I could do without it, but I remembered it for the future as an effective pain reliever.

Maxim, 33 years old

The membrane inside my tooth became inflamed, my gums hurt terribly and ached. I went to the dentist and received a referral for an autopsy. To prevent pain from causing discomfort, the doctor prescribed Duo Ketonal. I came to the pharmacy and wanted to buy, but the pharmacist dissuaded me and gave me an over-the-counter equivalent. I gave in, but I didn’t regret it, it costs less, but the effect is the same.

Mila, 27 years old

Due to constant work on the computer, my thumb joint became inflamed, it hurt very much, and caused inconvenience. The doctor prescribed injections and Ketonal capsules to relieve pain. I liked that they instantly calmed the inflammation; I didn’t even immediately understand why I felt so comfortable. Excellent product, works quickly, lasts a long time, I recommend it!