What kind of drug
Veroshpiron capsules are a diuretic and belong to the pharmacological group of potassium-sparing diuretics.
Removes excess fluid from the body, saving potassium ions. Used to relieve swelling of various origins.
Release form: opaque gelatin capsules with white powder inside.
Manufacturer: Gedeon Richter, Hungary.
Veroshpiron is available by prescription.
Description of Veroshpiron tablets
Veroshpiron is a diuretic that exhibits a potassium-sparing effect. It is the property of not washing away, but replenishing the level of potassium in the body that distinguishes Veroshpiron from a number of diuretic drugs. The effective chemical formula of the drug was developed by the Hungarian pharmaceutical company - GEDEON RICHTER.
However, it should be noted that at the moment the drug is produced in the Russian Federation by a division of Gedeon Richter JSC.
That is why this drug has not only high quality, but also an affordable price.
Veroshpiron is produced only in tablet and capsule forms. The manufacturer produces tablets No. 20, 25 mg. and capsules No. 30, 50 mg. and 100 mg.
Note! Veroshpiron tablets have a specific odor and are labeled “VEROSPIRON”. Protect yourself from counterfeit!
Pharmacological properties
Potassium-sparing diuretic, suppresses aldosterone activity, increases urine volume. Has an anti-edematous effect, improves blood circulation.
Pharmacodynamics and pharmacokinetics
The active ingredient of the drug, spironolactone, prevents the retention of sodium ions and fluid in the renal tubules. Prolongs the effect of the drug, reduces the excretion of potassium, and reduces the acidity of urine.
Increased urination helps lower blood pressure.
The drug is quickly absorbed from the gastrointestinal tract, entering the systemic circulation. The effect after administration is observed after 5 hours. 80% of the drug is excreted from the body by the kidneys. The elimination period is up to 12 hours.
Pharmacokinetics
Suction
After oral administration, it is quickly and completely absorbed from the gastrointestinal tract; bioavailability is 100%. After taking 100 mg of spironolactone daily for 15 days, Cmax is 80 ng/ml; the time to reach Cmax after the next morning dose is 2-6 hours.
Distribution
Binds to plasma proteins by 98%.
Spironolactone penetrates poorly into organs and tissues, while spironolactone itself and its metabolites penetrate the placental barrier, and canrenone passes into breast milk. Vd - 0.05 l/kg.
Metabolism
During the biotransformation process in the liver, active sulfur-containing metabolites 7-alpha-thiomethylspironolactone and canrenone are formed. Canrenone reaches its Cmax after 2-4 hours, its binding to plasma proteins is 90%.
Removal
T1/2 - 13-24 hours. Excreted mainly in urine (50% in the form of metabolites, 10% unchanged) and partially in feces. Canrenone excretion (mainly in the urine) is biphasic, T1/2 in the first phase is 2-3 hours, in the second - 12-96 hours.
Pharmacokinetics in special clinical situations
In liver cirrhosis and heart failure, the duration of T1/2 increases without signs of cumulation, the likelihood of which is higher in chronic renal failure and hyperkalemia.
Indications for use
What does Veroshpiron help with? The drug is prescribed for:
- prolonged elevated a/d;
- chronic heart failure;
- paroxysmal paralysis;
- treatment and prevention of hypokalemia;
- severe burns;
- myasthenia gravis.
An additional indication for the use of Veroshpiron is cirrhosis of the liver, accompanied by edema.
Directions for use and dosage
Instructions for use of Veroshpiron are advisory in nature. Capsules are taken before or after meals with water.
The dosage of Veroshpiron depends on the diagnosis and clinical picture of the disease.
For persistent high blood pressure, the daily dose is 50-100 mg in one dose. It is increased once every 2 weeks, bringing it to 200 mg. The course of therapy is 2-3 weeks.
Nephrotic syndrome - if other drugs are ineffective, 100-200 mg per day is prescribed.
Edema caused by heart failure - 100 mg three times a day.
Treatment of edema in liver cirrhosis - 200-400 mg per day. The maintenance dose is selected individually.
Edema in children - 30-90 mg per day in three doses. If necessary, the dose is adjusted after 5 days.
Video on the topic
In the complex treatment of hypertension, the drugs Veroshpiron and Indapamide are often prescribed. What's better? This video will help you get acquainted with the pharmacological characteristics of the latter:
The information on the MyMedNews.ru website is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment.
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In childhood, during pregnancy and breastfeeding
For children, the medication is prescribed upon reaching 5 years of age.
The drug should not be used during pregnancy.
Spironolactone is converted into metabolites that cross the placenta, which can lead to the threat of congenital pathologies of the fetus.
The active ingredient is absorbed into breast milk. If treatment is necessary during lactation, the patient should switch to artificial feeding.
Showing
- Persistent heart failure in patients with seizures, if the patient does not respond to treatment with other diuretics or there is a need to potentiate their effects.
- Essential arterial hypertension, mainly due to episodes of hypokalemia, occurs in combination with other antihypertensive drugs.
- In cases of liver cirrhosis, it is accompanied by swelling and/or ascites.
- To treat primary hyperaldosteronism.
- With swelling, swelling and nephrotic syndrome.
- To treat hypokalemia in episodes of inability, other therapy is discontinued.
- For the prevention of hypokalemia in patients who need to remove cardiac glycosides, in cases of seizures, when other approaches are considered to be ineffective or inappropriate.
Side effects
Against the background of individual intolerance to the components in the medication, negative reactions of the body occur, leading to side effects of Veroshpiron:
- from the gastrointestinal tract - nausea, vomiting, abdominal pain;
- from the central nervous system - headache, dizziness, confusion;
- skin – itching, urticaria, rash;
- endocrine system – menstrual irregularities, dysmenorrhea;
- disturbances in liver function.
If the above symptoms and those not described in the instructions occur, you must stop taking the drug and consult a doctor.
special instructions
During drug treatment, drinking alcoholic beverages is contraindicated.
Do not combine the medicine with other diuretics.
In case of liver and kidney diseases, it is necessary to regularly monitor electrolytes in the blood.
Use with caution in patients with diabetes.
During therapy, avoid eating foods high in potassium.
At the beginning of treatment, it is not recommended to drive vehicles or operate complex machinery. Restrictions are assigned individually.
Contraindications
For certain pathologies, the use of spironolactone is either prohibited or carried out with great caution. Veroshpiron is absolutely contraindicated for:
- hypersensitivity to any component of the drug;
- Addison's disease;
- renal failure in an advanced stage;
- hyponatremia;
- lack of lactase;
- lactose intolerance;
- anuria;
- problems with the absorption of galactose or glucose.
The drug is not prescribed to women during pregnancy and lactation, as well as to children under 3 years of age.
In other cases, only a doctor can decide on the advisability of prescribing Veroshpiron. This medicine is prescribed with extreme caution for:
- liver cirrhosis;
- metabolic acidosis;
- hypercalcemia;
- pathological enlargement of the mammary glands;
- diabetic nephropathy;
- diabetes mellitus;
- liver diseases;
- AV block;
- menstrual irregularities.
Also, Veroshpiron is not always prescribed for the treatment of elderly patients.
The drug Veroshpiron is contraindicated in the following situations:
- The presence of individual intolerance or hypersensitivity to substances included in the structure of the product.
- Chronic adrenal insufficiency, or hypocortisolism (Addison's disease).
- Elevated levels of potassium in the patient’s blood.
- Reduced sodium levels in the blood.
- Functional renal pathologies with creatinine clearance less than 10 ml/min.
- Pathological conditions in which the flow of fluid into the bladder stops (anuria).
- The period of gestation and subsequent breastfeeding.
- Age indicator up to three years from birth.
- Galactosemia, glucose-galactose malabsorption, and lactose intolerance.
Therapy with the drug Veroshpiron is possible with extreme caution in case of a history of pathologies:
- Increased calcium levels in the blood.
- Disturbances in the acid-base balance, causing a decrease in blood pH and low bicarbonate levels (metabolic acidosis).
- Atrioventricular block.
- Diabetic diseases with specified or suspected functional pathologies of the kidneys.
- Diabetic nephropathy.
- Use of medications that cause the development of gynecomastia.
- Surgical interventions using general and local anesthesia.
- Pathologies of menstrual cyclicity.
- Enlargement of the mammary glands.
- Liver pathologies, expressed in insufficiency of functional action.
- Cirrhotic liver diseases.
- Elderly patients.
Contraindications for Veroshpiron are: hypersensitivity to the components of the drug, hyperkalemia, hyponatremia, Addison's disease, anuria, severe renal failure (creatinine clearance less than 10 ml/min), pregnancy and lactation. The drug is prescribed with extreme caution for metabolic acidosis, hypercalcemia, AV blockade, diabetes mellitus, diabetic nephropathy, menstrual irregularities, general and local anesthesia, liver and kidney diseases, as well as in the elderly.
Overdose
A drug overdose occurs very rarely and occurs when the frequency of use and the prescribed dose are violated.
A sign of intoxication is an exacerbation of side effects.
If a situation arises, the patient's stomach is washed, vomiting is induced, and caffeine is given to raise A/D. Pathogenic therapy is prescribed.
Drug interactions
In combination treatment, Veroshpiron neutralizes the effect of direct and indirect anticoagulants.
Increases the effects of adrenaline and herbal medicines.
Hormonal drugs and diuretics, when used together, enhance the effect of the medication.
Nonsteroidal anti-inflammatory drugs reduce the activity of the active substances of the drug.
Interaction with other medications
Based on the composition of the drug Veroshpiron, we can conclude that this drug enhances the diuretic effect of any diuretics (Indapamide, Thiazide, Indap). However, spironolactone is not recommended to be taken concomitantly with lithium and digoxin.
If the patient is taking anticoagulants, then you should know that the action of Veroshpiron slows down the blood thinning process. There is also a pronounced increase in the diuretic effect during the interaction of hormonal drugs (GCS) and spironolactone.
Attention! It is strictly forbidden to take potassium preparations simultaneously with the drug Veroshpiron.
Features of the interaction between Asparkam and Veroshpiron
Many patients suffering from arterial hypertension take the drug Asparkam. After a doctor prescribes Veroshpiron, Asparkam should be discontinued, as there is a risk of developing hyperkalemia.
Attention! Asparkam is a potassium and magnesium preparation. This drug should not be combined with Veroshpiron. If you are taking Asparkam, be sure to inform your doctor about this.
Excessive levels of potassium and magnesium in the body can provoke coma and, subsequently, death.
