Codelac NEO For Dry Cough (Description and Indications)

pharmachologic effect

Codelac Neo is an antitussive, expectorant, bronchodilator, anti-inflammatory.

Pharmacodynamics

A non-opioid antitussive agent that has a direct effect on the cough center. Butamirate citrate is neither chemically nor pharmacologically related to opium alkaloids. It has an antitussive, expectorant, moderate bronchodilator and anti-inflammatory effect, improves spirometry (reduces airway resistance) and blood oxygenation.

Pharmacokinetics

Oral drops, syrup

Suction. After oral administration, the drug is quickly and completely absorbed from the gastrointestinal tract. After taking 150 mg of butamirate, the Cmax of the main metabolite (2-phenylbutyric acid) in the blood plasma is reached after approximately 1.5 hours and is 6.4 mcg/ml.

Distribution and metabolism. Hydrolysis of butamirate, initially to 2-phenylbutyric acid and diethylaminoethoxyethanol, begins in the blood. These metabolites also have antitussive activity, and, like butamirate, are largely (about 95%) bound to plasma proteins, which determines their long half-life. 2-phenylbutyric acid is partially metabolized by hydroxylation.

When taking the drug again, cumulation is not observed.

Excretion. T1/2 is 6 hours. All three metabolites are excreted mainly in the urine. Moreover, 2-phenylbutyric acid is mainly excreted in the form associated with glucuronic acid.

Modified-release film-coated tablets

Absorption is high. After oral administration of a modified-release tablet, the plasma Cmax of the main metabolite (2-phenylbutyric acid) is observed after 9 hours and is 1.4 mcg/ml.

Hydrolysis of butamirate, initially to 2-phenylbutyric acid and diethylaminoethoxyethanol, begins in the blood. These metabolites also have antitussive activity, and, like butamirate, are largely (about 95%) bound to plasma proteins, which determines their long half-life. 2-phenylbutyric acid is partially metabolized by hydroxylation. When taking the drug again, cumulation is not observed.

T1/2 of butamirate is 13 hours. Metabolites are excreted mainly by the kidneys. Moreover, 2-phenylbutyric acid is mainly excreted in the form associated with glucuronic acid.

Description of Codelac NEO

The problem with a dry cough is that this symptom does not bring out mucus. That is, all bacteria and microbes settle in the throat, lungs, bronchi and trachea, irritate the mucous membrane and cause discomfort in the patient. Codelac NEO for cough blocks the cough reflex in the brain, thanks to the active substance butamirate citrate, and also reduces irritability of the respiratory tract and helps remove phlegm from the body. Also, its gentle formula is indicated for both children and adults.

The drug is available in three forms (in the form of drops, in the form of syrup and in the form of tablets), which allows it to be used for different ages.

The syrup form is especially preferred not only by children, but also by some adults and old people because it is easy to swallow, as well as for its pleasant taste.

Therefore, the line has its advantages:

• the formula does not affect the respiratory system;
• does not contain components to which addiction occurs (for example, codeine);
• a type of drug in the form of drops is indicated for children from 2 months;
• from the first day of treatment, the cough intensity decreases;
• substances act for 6 hours (liquid forms) and up to 12 hours (tablets);
• the antitussive effect lasts for a long time.

Contraindications

• hypersensitivity to the components of the drug;
• pregnancy (first trimester);
• breastfeeding period;
• fructose intolerance (oral drops, syrup);
• lactose intolerance, lactase deficiency, glucose-galactose malabsorption (modified-release film-coated tablets)
• children up to 2 months (oral drops), up to 3 years (syrup), up to 18 years (modified-release film-coated tablets).

How to use the product

And here is what the instructions for use say about the dosage of the drug. Drops are taken as follows. A child from 2 months to a year is prescribed 10 drops 4 times a day. For a child from 1 to 3 years old, 15 drops four times a day. For a child over three years old, 25 drops, also four times a day.

When using syrup, the dosage is as follows: for a child from 3 to 6 years old, 5 ml 3 times a day, for a child from 6 to 12 years old, 10 ml three times a day, for children over 12 years old, 15 ml also three times a day. When using the syrup by adults, the dosage is the same - 15 ml, but 4 times a day. As has already been said here, the instructions for use indicate that the tablets are used only by adult patients. The dosage is as follows: 1 tablet every 8-12 hours. The tablets are taken without chewing 0.5 hours before meals.

Drops, syrup, and tablets should not be taken for more than five days. If the drug does not give the desired effect, and the dry cough does not stop, then you should consult a doctor, who will most likely prescribe you another remedy.

special instructions

There is a danger when using the drug in patients with a tendency to develop drug dependence, with liver diseases, alcoholism, epilepsy, and brain diseases.

Drops for oral administration, syrup.

The drug can be used by patients with diabetes mellitus, because No sucrose or glucose is used as a sweetener.

Modified-release film-coated tablets.

Each tablet contains 241 mg of lactose. The drug is contraindicated in patients with lactose intolerance, lactase deficiency, and glucose-galactose malabsorption.

Impact on the ability to drive vehicles and operate machinery.

It is recommended to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions, because the drug may cause drowsiness and dizziness.

Codelac NEO for children

Codelac neo for dry cough for children is used only in two forms. As syrup, or in the form of drops. However, the tablets can only be taken by adults. And syrup is prescribed only from 3 years of age.

Considering that this is a safe drug, and it does not contain components to which the child will become addicted, doctors have been confidently prescribing it for a long time.

Although the syrup is used not only by children, but also by adults who find it difficult to swallow or who prefer the liquid form of the medicine. That’s why old people also drink syrup instead of pills.

But, although this is a relatively safe medicine for a child, safety precautions should be observed. And first, parents should read the instructions to find out what problems may arise after taking this dosage form. Although at an early age, parents may not even know about the existence of certain forms of allergies in their child.

Therefore, if your baby has even the slightest hint of intolerance to any component, you should not hesitate and immediately consult a doctor. Therefore, no matter how wonderful the medicine is, if you have a dry cough, you should first consult with your pediatrician.

Pharmacology and composition

Codelac for children - modern types of the drug:

• Neo – at the initial stage of cough (dry);
• Broncho - to get rid of phlegm;
• Gel Codelac Pulmo;

The complex of the drug Codelac Neo includes the active substance – butamirate.

Acts as a soothing agent for inflamed bronchial mucosa and trachea, activates expectoration, does not affect respiratory processes, and is not addictive. It begins to act almost immediately and has a long-lasting effect. During use, patients experience increased oxygen exchange in the blood. Due to the rapid absorption of the active components into the mucous membrane of the digestive tract, the effect of the medicine is accelerated, which brings a positive result closer. Residual elements are eliminated naturally, using the renal system.

• Tablets – for teenagers over 12 years old;
• Sweet suspension – for children from three years old;
• Drops – from two months.

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Analogs

All analogues of Codelac Neo tablets can be divided into two groups:

• medicines based on butamirate;
• drugs with other active ingredients.

The first group includes:

• Omnitus;
• Sinecode;
• Stoptussin;
• Panatus Forte.

In case of individual intolerance to butamirate, medications with a similar antitussive effect from the second group are selected. For example:

• Libexin;
• Bronchicum S;
• Bronchitusen Vramed;
• Bronholitin;
• Glycodin;
• Bronchocin;
• Bronchoton;
• Rengalin.

Important! Only a doctor can correctly select a replacement medication in accordance with the characteristics of the patient’s body and disease. Doing this yourself is prohibited!

Indications for use

for adults

The main indication for use of Codelac Neo is dry cough. The drug effectively eliminates this symptom in standard respiratory diseases, including whooping cough and influenza. In addition, Codelac can be prescribed to relieve cough in the pre- and postoperative period.

Doctors also often prescribe this medicine when bronchoscopy is necessary.

Considering the stages of cough formation during respiratory diseases, Codelac Neo has two periods as indications:

• The onset of the disease when the cough is still dry;
• Residual effects after recovery.

The period of the height of the disease is usually accompanied by a productive cough, during which Codelac Neo cannot be used.

for children

Codelac Neo can be used from two months of age. The indication for use is the same as for adult patients – dry cough. In childhood, drugs based on opioid components are strictly prohibited, so butamirate becomes a good alternative to relieve symptoms in a child.

for pregnant women and during lactation

According to the official instructions, Codelac Neo is contraindicated in the first trimester of pregnancy and during breastfeeding. Starting from the second trimester, the drug can be prescribed if the potential benefit to the mother outweighs the possible risk to the child. Despite being available over-the-counter from pharmacies, this medicine should not be used for self-medication. The final decision in this category of patients is made by the doctor.

Mode of application

Take Codelac Neo orally before meals. If no improvement is observed within five days, you need to contact your local physician or pediatrician.

Drops inside:

1. Infants from two months to one year are given ten drops four times a day.
2. For young children from one year to three years - fifteen drops four times a day.
3. Children over three years old - twenty-five drops four times a day.

Syrup inside:

1. Young children from three to six years old are given five milliliters three times a day.
2. Older children (up to twelve years old) – ten milliliters three times a day.
3. Adolescents over twelve years of age are prescribed fifteen milliliters in the morning, afternoon and evening.
4. For adults and elderly people, the doctor prescribes the same dosage.

Pills:

The tablets are swallowed without chewing and washed down with plenty of warm water. Reception course: every twelve hours.

Children under two years of age are given the drug according to an individual regimen prescribed by the attending physician.

Side effects

In this section we will talk about what side effects are listed in the instructions for use of Codelac Neo. Reviews from users of this medicine and warnings from the manufacturer state that in rare cases the following may occur:

• exanthema;
• diarrhea;
• nausea;
• vomit;
• dizziness;
• drowsiness;
• skin rashes;

Dizziness caused by taking the medicine can be eliminated by lowering the dose or stopping it completely.

Composition and release forms

This article will discuss a fairly popular and effective non-opioid antitussive drug with central action. The active ingredient in it is butamirate. It is also worth paying attention to the fact that the product is of domestic origin.

The drug has several forms, which has additionally gained popularity among other cough medications.

The following can be found in the tablets:

• butamirate citrate (fifty milligrams);
• magnesium stearate;
• hypromellose;
• low molecular weight povidone;
• talc;
• milk sugar (lactose monohydrate);
• colloidal silicon dioxide.

Five milliliters of syrup contains:

• butamirate citrate (7.5 milligrams);
• sodium saccharinate;
• 30% sodium hydroxide solution;
• glycerol;
• water;
• benzoic acid;
• 95% ethyl alcohol;
• vanillin;
• sorbitol syrup.

One milliliter of drops contains:

• 5 milligrams of butamirate citrate;
• sodium saccharinate;
• 30% sodium hydroxide solution;
• glycerol;
• water;
• benzoic acid;
• 95% ethyl alcohol;
• vanillin;
• sorbitol syrup.

Codelac Neo: instructions for use for children of syrup, drops, tablets Broncho

In pediatric practice, the drug Codelac is widely used to treat cough in children. It is available in various forms, so every mother can choose the most convenient product for her child.

In addition to the fact that this medicine effectively and quickly eliminates the symptoms of respiratory tract diseases, it is safe for the sensitive child’s body.

In order to understand what type of drug is suitable for a child, it is recommended to carefully study the information about each form of the drug.

Description and release forms of Codelac series drugs

The drug is produced by a pharmaceutical company - the leader in sales of drugs that are sold without a prescription on the Russian market. The Codelac brand includes the following antitussive drugs:

• Codelac Neo drops and syrup;
• elixir and tablets Codelac Broncho with thyme;
• Codelac Pulmo gel.

Codelac Neo

Codelac Neo for young patients is available in the form of drops and syrup. Drops are used to treat children from 2 months, syrup - from 3 years.

Such dosage forms are easy to use even for the youngest children. Children like the mild sweet taste and pleasant unobtrusive vanilla smell, and they drink the medicine with great pleasure.

Detailed information on the release forms of Codelac Neo is presented in the table.

There are also Codelac Neo tablets, but this dosage form is approved for use in patients over 18 years of age.

Codelac Broncho

Codelac Broncho with thyme for babies is available in the form of an elixir and tablets. The first dosage form is used to treat children from 2 years old, the second - from 12 years old. Due to the absence of alcohol, sugar and artificial colors, the elixir is absolutely safe for sensitive children's health. Information on the release forms of Codelac Broncho with thyme is presented in the table.

Codelac Pulmo

Codelac Pulmo is available in the form of a cosmetic massage gel. It includes the following auxiliary components:

• gum turpentine;
• glycerol;
• racemic camphor;
• vegetable and fir oil;
• vinylin;
• aristoflex;
• germaben;
• polyethylene glycol;
• red pepper extract.

The gel is a white cream with a light and non-greasy consistency. The medicine, 50 ml, is packaged in a soft plastic tube with a screw cap. Codelac Pulmo is approved for use in children over 3 years of age.

Indications for use and contraindications

Before giving your child drops or syrup, you must make sure that he has no restrictions on the use of the medicine. If a child has a predisposition to developing drug dependence, liver and brain diseases, epilepsy, drugs that contain ethyl alcohol should be used with great caution.

For clarity, information about the indications and contraindications of Codelac is presented in the table.

Instructions for use: methods and dosages

If the cough persists for more than 5 days after starting to use the drug, the child should be taken to the pediatrician. The maximum duration of use of syrup and elixir without consulting a doctor is 5 days.

Side effects and overdose

The drug may cause the following side effects:

• drowsiness;
• dizziness (stops when you stop taking the medicine or reduce the dose);
• nausea and vomiting;
• diarrhea or constipation;
• allergies in the form of hives, itching and skin rashes;
• exanthema;
• dry mouth;
• copious mucus discharge from the nose;
• pain in the stomach area.

An overdose may be accompanied by nausea, vomiting, drowsiness, diarrhea, dizziness, low blood pressure, impaired coordination of movements and indigestion.

If symptoms of overdose appear, you need to induce artificial vomiting or rinse the stomach within 2 hours after taking the medicine, take activated charcoal and a drug with a laxative effect.

Prices and analogues

The cost of the drug depends on the form of release, dosage and region of sale. The price can also be influenced by the form of ownership the pharmacy belongs to - public or private. It is not recommended to buy medicines online, as such a purchase does not guarantee their authenticity and quality. Information on the cost of the drug and names of analogues is presented in the table.

Source: https://RosMedPlus.ru/aptechka/preparaty/kodelak-neo-kapli-dlya-detej-instrukciya.html

Indications and contraindications

As mentioned earlier, Codelac Neo is intended to combat cough, and cough can be of absolutely any etiology. The product can cope with dry cough that occurs with whooping cough, flu or a common cold. In addition, indications include the preoperative and postoperative periods, as it is used for bronchoscopy and surgical interventions.

General contraindications include:

• pregnancy, especially the first trimester;
• lactation period;
• intolerance to any component of the drug.

Taking tablets is contraindicated for people who suffer from lactose deficiency or lactose intolerance, and for children under the age of 18, that is, 18 years. The medicine in syrup form can be taken by children aged three years and older; the drug is contraindicated for persons suffering from fructose intolerance. "Codelac Neo" in the form of drops is contraindicated for children under two months of age and for babies with fructose intolerance. For epilepsy, kidney problems, brain diseases and alcoholism, the drug should be taken with great caution and under the supervision of a doctor.

What kind of cough does it help with - dry or wet?

According to the instructions, Codelac Neo tablets have an antitussive effect, and therefore are prescribed for any dry cough. Clinical trials have proven the positive results of tablets in the treatment of:

• ARVI and acute respiratory infections;
• flu;
• whooping cough, etc.

According to the instructions, Codelac Neo series can also be used to relieve cough before and after surgery and during bronchoscopy.

The use of tablets for wet cough due to the lack of components that have a mucolytic effect will be useless and ineffective.

Which is better - tablets or syrup?

Doctors often have to answer the question, which is better - Codelac Neo syrup or tablets?

The choice of form primarily depends on the age of the patient. After all, according to the instructions, Codelac Neo tablets for children cannot be used until the age of 18. While the use of syrup is allowed from 3 years of age. That’s why pediatricians most often use syrup.

The concentration of the main component is also significantly different:

• in 5 ml of syrup – 7.5 mg of butamirate;
• in 1 tablet – 50 mg.

In addition, the syrup contains ethyl alcohol, so it cannot be used by people with liver diseases, alcoholism, epilepsy and brain pathologies.

Otherwise, the pharmacological action, diseases for which the medication is prescribed, and adverse reactions from use are almost identical.

Before choosing one of the forms of the drug, you should consult your doctor and carefully study the instructions for use.

Codelac Neo drops: instructions for use and reviews

› Drops ›

Codelac is a line of antitussive drugs that are produced in the form of tablets, syrup, and drops. Codelac Neo are drops produced specifically for children from 2 months. With their use, a dry, irritating cough subsides. The drug is not an opioid antitussive; therefore, it is not addictive.

Composition, release form of the antitussive agent

The cough suppressant is a colorless, slightly opalescent liquid with a pleasant vanilla odor. A yellowish tint of the solution is allowed. Thanks to the vanilla smell and pleasant taste, young children do not refuse to take the drug. The antitussive effect is provided by the main active ingredient – ​​butamirate citrate. The composition additionally includes the following components:

• sodium saccharinate;
• vanillin;
• sorbitol;
• sodium hydroxide solution;
• purified water;
• ethanol;
• benzoic acid.

The drug is poured into darkened dropper bottles. The volume of one bottle is 20 ml. Sealed in cardboard packaging with instructions inside. The drug is produced by OAO Pharmstandard-Leksredstva in Russia.

Pharmacodynamics, pharmacokinetics

The active component does not belong to opium alkaloids either in terms of pharmacological action or chemical structure, and therefore, dependence does not develop with its use. Its main effect is cough suppression, which is achieved through a direct effect on the cough center. Butamirate has a moderate anti-inflammatory, bronchodilator, and expectorant effect.

Due to the expansion of the bronchi, breathing becomes easier, spirometry indicators improve, and the blood is saturated with oxygen. After ingestion, the active substance quickly penetrates through the mucous membrane of the gastrointestinal tract into the blood.

The main active metabolites of butamirate are diethylaminethoxyethanol and 2-phenylbutyric acid. They have the same effect as the main active substance. Metabolites are approximately 95% bound to plasma proteins.

The maximum concentration of 2-phenylbutyric acid is detected 9 hours after taking the drug.

Metabolites bind tightly to proteins, due to which they are eliminated from the body for a long time. Their half-life can take up to 6 hours. Partial metabolism of 2-phenylbutyric acid occurs through hydroxylation. When Codelac Neo is used repeatedly, it does not accumulate in the body. The components are excreted mainly through the kidneys with urine.

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Indications and contraindications for the use of Codelac Neo drops

Drops are taken to get rid of dry cough of any origin, including whooping cough, cough associated with colds, and flu.

Codelac Neo is prescribed to suppress cough before and after surgery, during bronchoscopy.

The medication is contraindicated in case of hypersensitivity to the substances included in the composition, fructose intolerance, 1st trimester of pregnancy, during breastfeeding. Age limit – up to 2 months.

Antitussive drops are used with caution in the 2nd and 3rd trimester of pregnancy. Since the composition contains ethyl alcohol, caution is necessary in case of brain pathology, liver diseases, epilepsy, a high risk of developing drug addiction, alcohol addiction, including the period of treatment for addiction.

Instructions for use of Codelac Neo drops for children

1 ml of antitussive contains 22 drops - 5 mg of active substance. The solution is taken before meals. The dosage is calculated depending on age:

• infants from 2 months to 1 year are given 10 drops 4 times a day;
• for children from 1 year to 3 years, 15 drops 4 times a day;
• Children over 3 years old are prescribed 25 drops also 4 times a day.

Drops should only be given to children under 2 years of age after consulting a doctor. The duration of use is on average 5 days; if there is no effect from the drug, the cough persists or worsens, or side effects occur, you should consult a doctor.

Cough drops for children for inhalation.

Side effects, overdose of Codelac Neo drops

Negative manifestations rarely occur. Possible side effects include the following symptoms:

• drowsiness;
• dizziness;
• nausea;
• bowel dysfunction (usually diarrhea);
• hives;
• an allergic reaction in the form of skin rashes and itching.

An overdose can occur if you accidentally drink a bottle of the drug (more often this applies to children) or exceed the dosage specified in the instructions. It may appear:

• impaired coordination of movements;
• irritability;
• nausea;
• vomiting;
• severe drowsiness;
• dizziness;
• diarrhea;
• decreased blood pressure;
• discomfort or pain in the abdomen.

First aid when taking large doses of drops: induce vomiting, take sorbents (activated carbon, Polysorb or other agents), saline laxatives. Further treatment depends on the symptoms that appear.

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special instructions

There is no data on the absorption of the components of the drops into breast milk, so if the drug is prescribed to nursing mothers, it is better to transfer the baby to artificial feeding for the period of treatment.

To prevent milk from disappearing during this period, it must be expressed to maintain lactation. The composition does not contain sucrose or glucose, and therefore it is allowed to take the drug for diabetes mellitus.

While taking it, drowsiness and dizziness are possible, so driving, operating machinery, or working at heights during the treatment period is not recommended.

It is also recommended to perform work that requires a quick psychophysical reaction and concentration.

The instructions do not indicate that Codelac Neo cannot be combined with any other drugs.

But you should still refrain from the parallel use of antipsychotics, sleeping pills, tranquilizers, and alcohol consumption, since they may have a depressing effect on the central nervous system.

Expiration date, conditions of sale, storage

From the date of release indicated on the packaging, the drug retains its medicinal properties for 2 years. It is stored away from children and sunlight at a temperature of no more than 25°C. The pharmacy sells the drug without a doctor's prescription.

The average cost of Codelac Neo drops for children in Russia is 210 rubles.

Analogs

Codelac Neo can be replaced with similar drugs containing the same active ingredient: Omnitus, Sinekod, Grypocitron-broncho. If you are intolerant to the active component of the drugs - butamirate citrate, Codelac Neo can be replaced with products with a different composition, but similar indications:

1. Rapitus is a peripherally acting drug for the treatment of dry cough without sputum production. The active ingredient is levodopropizine, which is not addictive. There are no contraindications based on age.
2. Paxeladin syrup - indicated for dry cough due to its direct effect on the cough center. It is not an opioid or antihistamine, so it is not addictive.
3. Herbion syrup of Icelandic moss - suppresses cough. Additionally, the drug has antibacterial, anti-inflammatory, and immunostimulating effects. Used for dry cough caused by diseases, as well as cough that occurs when staying in rooms with dry air, heavy load on the ligaments.
4. Stoptussin is a combined remedy for treating cough and accelerating the removal of sputum. Contains 2 chemicals: butamirate dihydrogen citrate, guaifenesin. Used for diseases of the upper respiratory tract accompanied by a dry irritating cough.

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These drugs are used after consulting a doctor.

Reviews

Diana, 28 years old, Astrakhan, gave Codelac Neo to a 4-year-old child as prescribed by a pediatrician when he had whooping cough. The cough was very strong, the daughter could not even sleep, as the cough became stronger at night. Gave 25 drops 4 times a day. The drops have a very pleasant smell, my daughter did not refuse to take them.

The cough began to subside on the second day in the evening. We treated the cough for 6 days and got rid of it. I was satisfied with the drug. Natalya, 26 years old, Moscow. I have two kids, and if one gets a cold, the other immediately catches it. Therefore, I select medications to treat cold symptoms so that I can give them to both babies at once.

When they cough, I give them Codelac Neo; the pediatrician recommended it a long time ago. They are allowed to be used from 2 months, my children are 11 months and 2.5 years old. They are not bitter and have a pleasant taste, so there is no need to think about how to get your child to drink them. The cough usually goes away in 4-5 days, there have never been any side effects. Alexandra, 33 years old,

Perm I am familiar with Codelac Neo drops, but I was not very pleased. My son caught a bad cold and developed a cough. The doctor prescribed this drug for 5 days. On the second day of use, my son became drowsy, wanted to sleep all the time and could not concentrate at school.

The drug helped us, the cough went away quickly and this is a plus, but because of drowsiness I will not buy it again. According to reviews from parents who treated coughs in children with Codelac Neo drops, the drug is very effective. The results after its use are noticeable within a day after application.

In rare cases, drowsiness and other side effects are observed, which is most often associated with hypersensitivity to the active substance in the composition or non-compliance with the dosage.

Codelac Neo drops: instructions for use and reviews Link to main publication

Source: https://infofarma.ru/kapli/kodelak-neo