Comparison of drugs for the treatment of the gastrointestinal tract: which is better Novobismol or De-Nol?

For pathologies of the digestive system, patients often take De-Nol. Since this drug is expensive, many patients are looking for a replacement, choosing, for example, Novobismol.

For pathologies of the digestive system, patients often take De-Nol or the cheaper Novobismol.

Pharmacology of the drug

What are Novobismol tablets? Instructions for use indicate that this is an antiulcer drug with bactericidal activity against Helicobacter pylori. It has an astringent and anti-inflammatory effect.

In the acidic environment of the stomach, the medication forms insoluble bismuth citrate and oxychloride, as well as chelate compounds in the form of a protective film on the surface of erosions and ulcers.

By increasing the formation of mucus, the synthesis of prostaglandin E and the secretion of bicarbonate, the drug in question activates cytoprotective mechanisms, increases the resistance of the gastrointestinal mucosa to the effects of hydrochloric acid, pepsin, enzymes and bile acids. It also accumulates epidermal growth factor in the defect area and reduces the activity of pepsinogen and pepsin.

How to take Novobismol?

The use of Novobismol should be monitored by the attending physician; only he can prescribe an individual dose for each patient.

But most often Novobismol is taken in the following variations:

• Children from 4 to 8 years old are prescribed 8 mg per kilogram of the child’s weight. This dose is divided into two doses and drunk half an hour before meals;
• Children from 8 to 12 years old are usually prescribed 1 tablet of Novobismol twice a day, also before meals;
• People over 12 years of age are prescribed one tablet three times a day before meals, and another one before bed. Another option allows you to take Novobismol two tablets in the morning and evening before meals.

Novobismol should not be taken with milk, yogurt, juice and other antacid-containing products, as they reduce the amount of action of the drug and reduce its activity in the body. Therefore, it is recommended to take the drug with clean, non-carbonated water.

It is recommended to use Novobismol for one or two months. Further increase in the course may contribute to the development of overdose.

Pharmacokinetics

What kinetic properties are inherent in Novobismol tablets? Instructions for use (the price of the medicine is indicated below) states that bismuth tripotassium dicitrate is almost not absorbed from the gastrointestinal tract. Although in some cases a small amount of this substance can still enter the systemic circulation.

The medication is excreted mainly through feces. A small part of the bismuth that enters the plasma is excreted through the kidneys.

Release form and composition

For 1 tablet 120 mg:

• Active ingredients: bismuth tripotassium dicitrate - 304.6 mg (in terms of bismuth oxide Bi2O3 - 120.0 mg);
• Excipients: corn starch - 70.6 mg, povidone K 30 - 17.7 mg, potassium polyacrylate - 23.6 mg, macrogol 6000 - 6.0 mg, magnesium stearate - 2.0 mg;
• Shell: opadry OY-S-7366 (hypromellose 5 mPa•s - 3.2 mg, macrogol 6000 - 1.1 mg).

8, 10, 16 or 20 tablets in a blister pack. 1, 2, 3, 4, 5, 6, 7, 14, 28 blister packs (8 tablets each) or 1, 2, 3, 4, 5, 6, 7, 12, 24 (10 tablets each) , or 1, 2, 3, 4, 5, 6, 7, 14 (16 tablets each), or 1, 2, 3, 4, 5, 6, 7, 12 (20 tablets each) along with instructions for for use, place in a cardboard box.

Novobismol is produced in the form of biconvex film-coated tablets. The color of the tablets is white-cream, there is no odor (or a slight odor of ammonia is allowed).

1 tablet contains 304.6 mg of bismuth tripotassium dicitrate, 120 mg in terms of bismuth oxide.

8 pcs. – contour cell packaging (1, 2, 3, 4, 5, 6, 7, 14, 28), cardboard packs.

10 pieces. – contour cell packaging (1, 2, 3, 4, 5, 6, 7, 12, 24), cardboard packs.

16 pcs. – contour cell packaging (1, 2, 3, 4, 5, 6, 7, 14), cardboard packs.

20 pcs. – contour cell packaging (1, 2, 3, 4, 5, 6, 7, 12), cardboard packs.

Dosage and method of administration

How should I use Novobismol? The instructions for use indicate that this drug is prescribed not only to adults, but also to young patients, starting from 4 years old.

The tablets are taken orally 2-4 times a day exactly 30 minutes before eating. The dosage of the medicine is selected individually. As a rule, it depends on the age of the patient.

The course of treatment with the drug in question is 4-8 weeks. In the next 8 weeks, it is strictly forbidden to take medications that also contain bismuth.

To eliminate Helicobacter Pylori, Novobismol tablets should be used in combination with antibacterial drugs that have anti-Helicobacter activity.

Analogs

There are structural analogues for Novobismol tablets.

A bismuth preparation, which is available in the dosage form of a tablet for oral administration. Used for adults and children for the comprehensive treatment of ulcerative pathology, as well as irritable bowel syndrome. Contraindicated for pregnant and breastfeeding women.

The drug contains bismuth salts and is produced in the dosage form of film-coated tablets. The package contains 28, 56 or 112 tablets. Suitable for children from 4 years of age and adults. Contraindicated in case of individual intolerance to the components, as well as for pregnant and breastfeeding women.

The drug contains bismuth in the form of a salt and is available in tablets of 40 or 112 pieces per package. Indicated for the treatment of ulcerative pathology in adults and children over 4 years of age in appropriate dosages. Do not use by pregnant or breastfeeding women, or with severe renal failure.

Side effects

Does the drug "Novobismol" have side effects? Reviews from patients say that after taking these tablets they often experience adverse events. From the digestive tract, the patient develops transient effects such as nausea, increased bowel movements, vomiting or constipation. Dermatological reactions in the form of skin rash and itching may also occur.

With prolonged use, especially in high dosages, the patient may develop encephalopathy from the central nervous system, which is associated with the accumulation of bismuth in the central nervous system.

Indications for use

Novobismol is prescribed for the treatment of:

• acute chronic gastritis and gastroduodenitis;
• irritable bowel syndrome accompanied by diarrhea;
• ulcers of the stomach and duodenum in the acute phase;
• symptoms of dyspepsia not associated with gastrointestinal pathologies.

The drug is effective in the treatment of the diseases listed above caused by various reasons, including infection of the digestive tract by bacteria of the Helicobacter pylori species.

Special Recommendations

It is strictly forbidden to take the Novobismol medication for more than 2 months in a row.

During therapy, it is highly recommended not to exceed the recommended daily dosage for adults and small children.

At the end of the course of treatment, the concentration of the active component in the blood plasma usually does not exceed 5-60 mcg/l, and intoxication is observed only at 100 mcg/l or more.

Against the background of the use of the drug in question, stool may become dark in color. In rare cases, slight darkening of the tongue is noted.

Contraindications

You cannot be treated with Novobismol for the following pathologies/conditions:

• severe renal dysfunction,
• pregnancy,
• lactation period,
• children up to 4 years old,
• individual intolerance to the drug.

It is unknown how the drug affects the intrauterine development of the fetus, so it is not prescribed to pregnant women. The main component tends to pass into breast milk, so nursing mothers taking tablets must suspend lactation during treatment. It can be resumed 24–48 hours after taking the last dose of the drug. Novobismol is not given to patients under 4 years of age, since the safety and effectiveness of its use in young children have not been proven.

The drug "Novobismol": analogues and cost

Structural analogues of this product are: “De Nol” and “Ventrisol”. Similar medications according to the pharmacological group include: “Ankrusal”, “Alsukral”, “Venter”, “Kaopectate”, “Rebamipide McLeodz”, etc.

How much does the drug "Novobismol" cost? The price of this medicine varies between 550-600 rubles for 112 tablets.

De-Nol, composition

The main substance of the medicine is bismuth. Once in the stomach, it settles without dissolving and forms a protective film, covering ulcers and erosions. Helps produce prostaglandin “E”, activates mucus production. After a ten-day course, relief and healing of the mucous membrane in the damaged areas occurs.

De-Nol

Indications

In accordance with the instructions, prescribing the medication is advisable for the following diagnoses:

• ulcers in the stomach, intestines - damage to the mucous membrane is formed under the influence of bacteria, exposure to bile or gastric juice;
• acute or chronic gastritis, duodenitis;
• irritable bowel syndrome;
• dyspeptic symptoms.

Contraindications

Bismuth-based medications are contraindicated for:

• kidney disorders;
• pregnancy;
• hypersensitivity to the components of the composition;
• childhood;
• lactation.

Note! A common side effect of the drug is darkening the stool. This is not at all dangerous; after completing the course of treatment, this symptom goes away spontaneously.

Mode of application

The medicine should not be taken for more than two months. The tablet is taken half an hour before meals. The drug is prescribed in combination with other medications for adults and children over 14 years of age. The standard dose is 4 tablets in 2-4 doses. Course 1-2 months. If you need to continue using the drug, take a break of at least two months.

Analogs

2-3 reviews

I think De-Nol is a good remedy; it helped me cope with incipient gastritis. It really works and has a small list of side effects. It is advisable to take it in combination with other medications. With monotherapy, the effect is noticeably reduced.

Dmitry, 26 years old

“De-Nol” helped me quickly relieve a bad feeling, the doctor prescribed it. I am very pleased with the medicine.

Irina, 32 years old

Price

The cost of the medicine is on average 520 rubles. for 56 tablets.