Instructions for use of suspension for children Amoxiclav

• July 30, 2020
• Infectious
• Olga Simchenko

Amoxiclav 125 mg suspension is an antibiotic intended for systemic use. The medicine is available in the form of a white or yellowish powder. The drug is prescribed for the treatment of diseases caused by bacterial infections. The medicine can be taken by children from an early age, but it must be remembered that it has certain indications and contraindications that are important to consider.

Feature of the drug

Amoxiclav suspension is a powerful broad-spectrum antibiotic that is produced by the pharmaceutical industry in several dosage forms. In pediatrics, the drug is used mainly in the form of a suspension. The widespread and widespread use of this drug is due to its high effectiveness and treatment of a wide range of diseases.

This drug stops the growth and development of many pathogens. The components of the drug act on bacterial cells, promoting their destruction. As a result, the microbes can no longer develop and die.

pharmachologic effect

Amoxiclav has a broad spectrum antibacterial effect. Amoxicillin is a beta-lactam antibiotic (we recommend reading: Amoxicillin antibiotic for children).

In the literature, the action of the antibiotic is explained in a complex scientific form that is incomprehensible to people without medical education. Simply put, amoxicillin acts at the cellular level. It violates the integrity of bacterial cell walls and leads to their complete destruction. As a result, pathogenic microorganisms die.

Some pathogens independently produce beta-lactamases, which destroy the active substance of the drug. This means that the antibiotic is not able to kill such bacteria, as it loses its healing properties.

Clavulanic acid itself does not affect bacteria and does not have bactericidal properties. It is a beta-lactam related to penicillins. Clavulanic acid prevents the destruction of amoxicillin in a pathogenic environment. With its help, the drug is able to influence a larger number of microorganisms, which makes it almost universal. This is the key role of the substance.

Amoxiclav has a detrimental effect on the following groups of microorganisms:

• staphylococci;
• streptococci;
• Echinococcus;
• bordetella;
• Brucella;
• salmonella;
• Proteus;
• clostridium, etc.

According to medical practice, Amoxiclav is active even against some bacteria that are resistant to it. Doctors have found that treatment with the drug gives positive results, but there is no single scientific basis for this.

Composition and release form

The active components of the Amoxiclav 125 mg suspension provide a good antibacterial effect. The drug contains components such as clavulanic acid and amoxicillin. These components lead to suppression of the growth and reproduction of pathogenic microorganisms.

In addition, the drug contains a complex of excipients that promote much better absorption of the drug by the human body. These should include the following:

• lemon acid;
• silica;
• sodium citrate;
• sodium saccharinate;
• xanthan gum;
• silica;
• flavorings.

The drug is a powder mass used to prepare a suspension. The color of the substance can vary from white to yellowish-white. The prepared suspension is intended for oral use. It has a yellowish tint. Available in bottles of different sizes. The kit includes dosing spoons and pipettes.

Features of use and indications for use of Amoxiclav 500 mg

Indications for prescribing Amoxiclav 125 mg for children are bacterial infections that are afraid of amoxicillin:

• for severe infectious diseases of the ears and throat (otitis media, tonsillitis, pharyngitis, etc.);
• to cure respiratory diseases (bronchitis, sinusitis, etc.);
• for the treatment of mild and moderate urinary and biliary tract infections.
• to eliminate other negative effects and damage to bones, joints and soft tissues (bacterial infections of the skin, including after surgery);
• in the treatment of sexually transmitted diseases (gonorrhea, etc.).

Interesting! Amoxicillin is designed to destroy the cell walls of bacteria inside the body. If the dose of the substance is exceeded, the drug will have a negative effect.

When using Amoxiclav 125, you must remember that there are contraindications for use, which can make this treatment with the drug meaningless. Basically, such contraindications will be personal intolerance to the components of the drug or diseases of the urinary and hematopoietic organs.

Amoxiclav 500 mg per 125 mg is prescribed primarily to adults for infections caused by bacteria such as staphylococcus, enterococcus, brucella and many others.

The most common prescriptions are for respiratory diseases and otolaryngeal diseases.

Amoxiclav 500 powder for injection is prescribed for sexually transmitted infections and infections that appear after surgery.

For children, Amoxiclav 125 mg or 250 mg is recommended. Prescribing Amoxiclav 500 is possible in severe cases, but a specialist must weigh the pros and cons of such a prescription.

Indications for use

When a pediatrician diagnoses a child with a cold, he often prescribes the drug Amoxiclav. This is a combination product with an antibacterial effect. Many parents are interested in what Amoxiclav is prescribed for and what effect it has. This antibiotic is prescribed for diseases of the respiratory system and urinary tract.

The instructions indicate that the medicine can eliminate germs and bacteria. For the treatment of infectious diseases that occur in children of any age, this particular drug is often prescribed. Babies from 3 months of age can take it.

In pediatrics, the drug is used quite often, due to its wide spectrum of action. The advantage of the drug is that this drug has no side effects or complications during therapy.

Therefore, if you strictly follow the dosage and follow all the doctor’s recommendations, then treatment of infectious diseases with this medicine can be considered safe.

Indications for use

The drug Amoxiclav is used in the treatment of diseases of the genitourinary, respiratory, digestive systems, and skin. The manufacturer emphasizes its effectiveness against the following diseases:

Pneumonia

• pneumonia;
• pyelonephritis;
• cystitis;
• gonorrhea;
• pneumonia;
• tracheitis;
• abscess;
• otitis;
• sepsis;
• bronchitis;
• meningitis;
• salmonellosis;
• osteomyelitis;
• vaginitis.

The medication is recommended for the treatment of infections that appear after surgery and abortion.

Since cough is one of the signs of an infectious disease, the patient may be prescribed Amoxiclav when this symptom appears. It allows you to quickly get rid of it and significantly improves the patient’s condition. Before taking the pills, you need to make sure that this condition is caused by a bacterial infection. This is indicated by a prolonged cough that lasts about 5–7 days and is accompanied by sputum production. It is advisable to use the product when the initial signs of respiratory tract diseases appear, when the patient is bothered by a dry or wet cough.

In a situation where the cough is caused by a virus infection, Amoxiclav does not help.

The drug can be taken even by newborn babies, but only in powder form. The medicine is well tolerated and exhibits, in comparison with other antibiotics, the fewest adverse reactions.

Features of application

To achieve a quick positive result and minimize side effects, you need to correctly calculate the dosage of the drug. This takes into account:

• child's age;
• his weight;
• pathology;
• degree of severity of the disease.

On average, the course of taking the drug is 5-14 days. The duration of treatment is determined by the attending physician, taking into account the severity of the disease.

An important feature is that you cannot stop the prescribed course of taking the drug. You need to drink it completely, strictly observing the intervals between doses, even if there is a noticeable improvement in your well-being. Otherwise, symptoms may return and the antibiotic will not have the required effect.

Amoxiclav powder must be properly diluted to prepare the suspension. To do this, the substance in the bottle is poured to a special mark, which is present on its glass surface. Water must be boiled and cooled. After this, shake the mixture well so that it is evenly mixed. The prepared suspension can be stored in the refrigerator for no more than a week.

Using a syringe or measuring spoon, measure the required dosage of the Amoxiclav suspension. When prescribing an antibiotic, the doctor must indicate the amount of the drug for the child.

Many parents are interested in how to take Amoxiclav suspension - before meals or after? Doctors recommend taking the medicine while eating, as this significantly reduces the risk of side effects from the gastrointestinal tract.

Amoxiclav suspension for bronchitis reviews

Active substance:

Amoxicillin* + Clavulanic acid* (Amoxicillin* + Clavulanic acid*)

Dosage form and composition: Film-coated tablets 1 tablet active substances (core): amoxicillin (in the form of trihydrate) 250 mg clavulanic acid (in the form of potassium salt) 125 mg excipients: colloidal silicon dioxide - 5.4 mg; crospovidone - 27.4 mg; croscarmellose sodium - 27.4 mg; magnesium stearate - 12 mg; talc - 13.4 mg; MCC - up to 650 mg film shell: hypromellose - 14.378 mg; ethylcellulose 0.702 mg; polysorbate 80 - 0.78 mg; triethyl citrate - 0.793 mg; titanium dioxide - 7.605 mg; talc 1.742 mg Film-coated tablets 1 tablet active substances (core): amoxicillin (in the form of trihydrate) 500 mg clavulanic acid (in the form of potassium salt) 125 mg excipients: colloidal silicon dioxide - 9 mg, crospovidone - 45 mg, croscarmellose sodium - 35 mg, magnesium stearate - 20 mg, MCC - up to 1060 mg film shell: hypromellose - 17.696 mg, ethylcellulose - 0.864 mg, polysorbate 80 - 0.96 mg, triethyl citrate - 0.976 mg, titanium dioxide - 9.36 mg, talc - 2.144 mg Film-coated tablets 1 table active substances (core): amoxicillin (in the form of trihydrate) 875 mg clavulanic acid (in the form of potassium salt) 125 mg excipients: colloidal silicon dioxide - 12 mg; crospovidone - 61 mg; croscarmellose sodium - 47 mg; magnesium stearate - 17.22 mg; MCC - up to 1435 mg film shell: hypromellose - 23.226 mg; ethylcellulose - 1.134 mg; polysorbate 80 - 1.26 mg; triethyl citrate - 1.28 mg; titanium dioxide - 12.286 mg; talc 2.814 mg Powder for the preparation of a suspension for oral administration 5 ml of suspension active substances: amoxicillin (in the form of trihydrate) 125 mg clavulanic acid (in the form of potassium salt) 31.25 mg ratio - 4: 1 excipients: citric acid (anhydrous) - 2.167 mg; sodium citrate (anhydrous) - 8.335 mg; sodium benzoate - 2.085 mg; MCC and carmellose sodium - 28.1 mg; xanthan gum - 10 mg; colloidal silicon dioxide - 16.667 mg; silicon dioxide - 0.217 g; sodium saccharinate - 5.5 mg; mannitol - 1250 mg; strawberry flavoring - 15 mg Powder for preparing a suspension for oral administration 5 ml of suspension active ingredients: amoxicillin (in the form of trihydrate) 250 mg clavulanic acid (in the form of potassium salt) 62.5 mg ratio - 4: 1 excipients: citric acid (anhydrous) - 2.167 mg ; sodium citrate (anhydrous) - 8.335 mg; sodium benzoate - 2.085 mg; MCC and carmellose sodium - 28.1 mg; xanthan gum - 10 mg; colloidal silicon dioxide - 16.667 mg; silicon dioxide - 0.217 g; sodium saccharinate - 5.5 mg; mannitol - 1250 mg; wild cherry flavor - 4 mg Powder for preparing a suspension for oral administration 5 ml of suspension active ingredients: amoxicillin (in the form of trihydrate) 400 mg clavulanic acid (in the form of potassium salt) 57 mg ratio - 7: 1 excipients: citric acid (anhydrous) - 2.694 mg; sodium citrate (anhydrous) ;— 8.335 mg; MCC and carmellose sodium - 28.1 mg; xanthan gum - 10 mg; colloidal silicon dioxide - 16.667 mg; silicon dioxide - 0.217 g; sodium saccharinate - 5.5 mg; mannitol - 1250 mg; wild cherry flavor - 4 mg; lemon flavor - 4 mg Indications:

Infections caused by sensitive strains of microorganisms:

• upper respiratory tract and ENT organs (including acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsillitis, pharyngitis);
• lower respiratory tract (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia);
• urinary tract;
• in gynecology;
• skin and soft tissues, including human and animal bites;
• bone and connective tissue;
• biliary tract (cholecystitis, cholangitis);
• odontogenic.

Contraindications:

• hypersensitivity to the components of the drug;
• history of hypersensitivity to penicillins, cephalosporins and other beta-lactam antibiotics;
• cholestatic jaundice and/or other liver dysfunction caused by a history of taking amoxicillin/clavulanic acid;
• infectious mononucleosis and lymphocytic leukemia.

With caution: history of pseudomembranous colitis, gastrointestinal diseases, liver failure, severe renal impairment, pregnancy, lactation, simultaneous use with anticoagulants.

Use during pregnancy and breastfeeding:

During pregnancy and lactation, Amoxiclav® is used only if the expected benefit to the mother outweighs the potential risk to the fetus and child.

Side effects:

From the digestive system: loss of appetite, nausea, vomiting, diarrhea, abdominal pain, gastritis, stomatitis, glossitis, black “hairy” tongue, darkening of tooth enamel, hemorrhagic colitis (can also develop after therapy), enterocolitis, pseudomembranous colitis, disorder liver function, increased activity of ALT, AST, alkaline phosphatase and/or bilirubin levels in the blood plasma, liver failure (more often in the elderly, men, with long-term therapy), cholestatic jaundice, hepatitis.

Allergic reactions: itching, urticaria, erythematous rashes, erythema multiforme exudative, angioedema, anaphylactic shock, allergic vasculitis, exfoliative dermatitis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, a syndrome similar to serum sickness, toxic epidermal necrolysis.

From the hematopoietic system and lymphatic system: reversible leukopenia (including neutropenia), thrombocytopenia, hemolytic anemia, reversible increase in PT (when used together with anticoagulants), reversible increase in bleeding time, eosinophilia, pancytopenia, thrombocytosis, agranulocytosis.

From the central nervous system: dizziness, headache, convulsions (may occur in patients with impaired renal function when taking high doses of the drug), hyperactivity. Feelings of anxiety, insomnia, behavior changes, agitation.

From the urinary system: interstitial nephritis, crystalluria, hematuria.

Other: candidiasis and other types of superinfection.

Overdose:

There are no reports of death or life-threatening side effects due to drug overdose.

Symptoms: in most cases - gastrointestinal disorders (abdominal pain, diarrhea, vomiting), anxiety, insomnia, dizziness are also possible, and in isolated cases - seizures.

Treatment: in case of overdose, the patient should be under medical supervision, treatment should be symptomatic.

In case of recent use (less than 4 hours) of the drug, it is necessary to perform gastric lavage and prescribe activated charcoal to reduce absorption. Amoxicillin/potassium clavulanate is removed by hemodialysis.

Directions for use and dosage:

Film-coated tablets

Inside. The dosage regimen is set individually, depending on the age, body weight, kidney function of the patient, as well as the severity of the infection.

Amoxiclav® is recommended to be taken at the beginning of a meal for optimal absorption and to reduce possible side effects from the digestive system.

The course of treatment is 5–14 days. The duration of treatment is determined by the attending physician. Treatment should not continue for more than 14 days without repeated medical examination.

Dosage of the drug

According to the instructions, Amoxiclav 125 mg suspension for children can be prescribed from 3 months of age. When calculating a safe and effective amount, they are guided by the baby’s weight. The dosage of the Amoxiclav suspension is selected individually by the attending physician. However, it is worth remembering that per 1 kg of child’s body weight there should be 30 mg of the drug per day.

In order not to make a mistake with the dosage, when measuring the suspension, you need to use the measuring spoon that comes in the package with the medicine. For children over 3 months of age, when treating infectious diseases that occur in a complex form, the drug is prescribed at the rate of 40 mg per 1 kg of the child’s weight 2 times a day, observing an interval between doses of the medicine of 12 hours.

One teaspoon of Amoxiclav 250 mg suspension contains 62.5 mg of potassium clavulanate. For very young patients, a drug is available that contains 125 mg of antibiotic. The child takes this medicine without problems, as it has a pleasant fruity aroma.

It is very important to know how to calculate the dose of Amoxiclav suspension so that there is no overdose of the drug. In order not to make a mistake with the amount of medicine, you need a 5 ml measuring spoon, which is contained in the package with the medicine. Before carrying out therapy, you need to visit a pediatric doctor and consult.

The dosage of Amoxiclav suspension for children aged 3 months to 1 year when treating bronchitis, rhinitis and pneumonia is 0.5 tsp. The frequency of taking the drug is 3 times a day.

Amoxiclav suspension is prescribed to a child per year in a dosage of 1 tsp. You need to take the medicine 3 times during the day. The same dosage is prescribed for children under 7 years of age.

For children under 14 years of age, the optimal amount of the drug is 2 tsp. suspensions that need to be taken 3 times a day. Children over 14 years old can take tablets.

When administering a 125 mg suspension intravenously, the optimal dosage is calculated in the same way as when taking the drug orally.

When carrying out a course of therapy with Amoxiclav, already on the third day after taking the medicine, you can notice a change in the child’s condition for the better. To prevent the subsequent development of pathogens that provoked the disease, as well as the development of immunity to the drug, the course of therapy must be completed in full.

The doctor decides what the duration of treatment will be. Usually it is no more than 2 weeks. In some cases, the doctor may change the amount of the drug taken. Often, a one-time increased dosage has a positive result. For example, for children suffering from infectious diseases, in severe cases of the disease, a pediatrician may prescribe the drug at a dosage of 1.2 grams 3 times a day.

Before you start Amoxiclav therapy, you need to do a test for an allergic reaction. If the body does not react to taking the drug in any way, then this drug can be given throughout the entire process of treating the disease.

If the child has an allergy, then treatment with this drug should be abandoned. You need to consult a doctor so that he can select the safest analogue for the child.

Use of tablets

"Amoxiclav" in the form of film-coated tablets is prescribed to children over 6 years of age.

• Take the drug at the beginning of a meal, without chewing, with water.

• Children from 6 to 12 years old take 40 mg/kg body weight in three doses.
• Children over 12 years old weighing more than 40 kilograms: 250 mg + 125 mg tablets three times a day every 8 hours with an average course of the disease.
• In severe cases of the disease, 500 mg + 125 mg is prescribed every 12 hours, twice a day.
• The duration of use of the product is 5 – 14 days.

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Contraindications for use

According to the instructions, the Amoxiclav 125 suspension for children has certain contraindications for use, which must be taken into account when carrying out therapy. This drug is not prescribed:

• with hypersensitivity to the components of the drug;
• individual intolerance to penicillin or severe susceptibility to substances of this group;
• the child has kidney or liver failure.

Also, Amoxiclav suspension is not prescribed if the child has digestive diseases.

Amoxiclav tablets

The tablets are best taken before or during meals. The course of treatment should not exceed two weeks, otherwise dysbiosis will develop. Different release forms have different dosages of active substances. So, 675 mg tablets contain 500 mg of amoxicillin and 125 mg of clavulanic acid, and 375 mg tablets contain 250 mg of amoxicillin and 125 mg of clavulanic acid. Therefore, the doctor should select the necessary dosages.

According to the instructions, a child under 7 years old is not prescribed pills. To prescribe tablets, the child's weight must be more than 40 kg.

Article verified by Anna Moschovis - family doctor.

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Side effects

According to the instructions for use, Amoxiclav children's suspension may cause side effects. These should include the following:

• nausea;
• diarrhea;
• pain in the stomach;
• allergic skin rashes.

If you strictly follow the dosage of the drug, the side effects will be short-term and will pass quickly enough.

To determine whether a sick child is allergic to the components of the drug used during therapy, you need to do a standard test. To do this, take a drop of the suspension and apply it to the child’s wrist. If a reaction occurs, then you should refuse to use the Amoxiclav 125 mg suspension and choose a safer option.

If a child experiences adverse reactions while taking this drug, you should immediately stop treatment and consult a doctor.

Side effects

Taking Amoxiclav is sometimes accompanied by dizziness, nausea, and diarrhea. Doctors have recorded cases of allergies, seizures, and interstitial nephritis. These symptoms are more pronounced in patients with kidney problems. There were also complaints from patients about insomnia and increased anxiety.

The use of amoxicillin affects the liver and can cause jaundice or hepatitis. Patients undergoing Amoxiclav therapy need to monitor the amount of liver enzymes in the blood.

Laboratory tests of the blood of a patient taking Amoxiclav show a decrease in the number of platelets and leukocytes in the blood. Cases of hemolytic anemia and pancytopenia have been reported. Some patients were diagnosed with candidiasis during drug treatment.

special instructions

Like any other antibiotic, Amoxiclav 125 mg suspension for children has a number of individual properties that must be taken into account not only by the doctor, but also by the patient. During course therapy with the drug, the condition of all organs and hematopoietic systems, kidneys and liver of the patient is monitored.

In order to reduce the likelihood of undesirable manifestations from the gastrointestinal tract, it is recommended to take Amoxiclav suspension while consuming food. For patients with severe kidney pathologies, dosage regimen adjustments will be required.

Adverse reactions

Most adverse reactions are mild and transitory.

1. From the digestive system:

• diarrhea;

• nausea;
• dyspepsia;
• vomit;
• gastritis;
• flatulence;
• glossitis;
• stomatitis.
• From the hematopoietic system:
• anemia;
• leukopenia;
• thrombocytopenia;
• eosinophilia.
• From the nervous system:
• headache;
• dizziness;
• convulsions;
• insomnia;
• sense of anxiety;
• hyperactivity.
• From the skin:
• erythematous rash;
• itching;
• hives;
• Stephen–Jones syndrome;
• anaphylactic shock;
• angioedema.
• Other adverse reactions:

• hematuria;
• fever;
• candidiasis.

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Analogues of the drug

If for some reason it is impossible to take Amoxiclav suspension for children, the antibiotic is replaced with another drug. Among the most popular analogues, the following should be highlighted:

• "Augmentin".
• "Flemoxin Solutab".
• "Ampisid."
• "Tazocin."

The drug "Augmentin" is a complete analogue of the drug "Amoxiclav". It is produced in the form of a powder for preparing a suspension for children. The differences between these two drugs are minimal. In a suitable dosage form, the antibiotic can be used from birth.

The drug "Flemoxin Solutab" contains amoxicillin as an active component. The drug is available in the form of soluble tablets. Doctors prescribe antibiotics to patients of any age.

"Ampiside" is a combination drug that contains ampicillin and sulbactam as an active component. The drug is produced in the form of a powder for the preparation of a solution for intramuscular and intravenous administration, as well as in the form of a powder for the preparation of a suspension, tablets. The drug is used to treat children, including premature babies.

The drug "Tazocin" is considered a good substitute for "Amoxiclav" in the clinical and pharmacological group. Its active ingredients are tazobactam and piperacillin. The medicine has a wide spectrum of antibacterial activity. Patients over two years of age are allowed to take it.

However, all of these analogues of Amoxiclav suspension can be purchased and used only after a doctor’s prescription.

Forms of release of the drug with the concentration of active substances

The universal qualities of the medicine allow it to be used to treat many ailments. Doctors often prescribe it to children and adults.

That is why it is available in two forms - tablets and powder for preparing a suspension. In addition, each of them has several types of active substance concentrations. Thanks to this, the drug can be easily selected for people of different ages, weights, physical conditions, and also depending on the severity of the infection.

Reviews

The powder for preparing the Amoxiclav suspension has earned mostly positive reviews. The suspension is quite easy to take. Allergies to this drug are quite rare. As a rule, treatment takes place without serious health consequences.

The effectiveness of this antibiotic is beyond any doubt. It quickly copes with infection due to the presence of clavulanic acid. It gives a particularly good result for sore throat, as it helps to quickly cope with the disease.

Despite the fact that the antibiotic Amoxiclav has received mostly positive reviews, there are also negative points. Parents whose children took this medicine noted damage to the child's tooth enamel. Doctors say that the drug often causes intestinal dysbiosis, so it is important to take it together with powders that normalize the microflora of the mucous membranes.

The drug "Amoxiclav" is a safe and effective remedy for the child's body. This medicine can be used to treat babies starting from 3 months of age. For therapy to be most effective, you must strictly follow the rules of administration. The dosage, as well as the duration of the course of therapy, is determined only by the attending doctor. Self-medication is not recommended so as not to cause serious harm to the child’s health.

Amoxiclav: instructions for use for children

No matter how you play it safe, no matter how much you watch your child, he will still get sick. This is a normal process of adaptation to the environment in general and to the microorganisms inhabiting it in particular. This is the most effective way to develop immunity. But diseases are different. There are serious cases and their dangerous consequences. In such cases, antibiotic therapy cannot be avoided.

One of the most popular antibiotics with a wide spectrum of action (that is, against everything at once) is Amoxiclav. This is a penicillin drug enhanced with clavulanic acid.

Like any drug, it has its side effects and contraindications, but at the same time it is highly effective , for which it has earned a number of positive reviews among mothers.

Release form and composition of the drug

The drug Amoxiclav has three main forms of release:

The drug contains amoxicillin (hereinafter abbreviated as Am) and clavulanate (also known as clavulanic acid, hereinafter abbreviated as C). Their proportions vary depending on the form of release:

1. Powder for the preparation of syrups (suspensions) 125 or 250 mg plus 31.25 or 62.5 mg per 5 milliliters. Consists of 125 or 250 mg Am and 31.25 or 62.5 mg Cl per 5 ml of syrup, respectively. The bottle holds 100 ml of syrup.
2. Powder for suspensions 400 mg plus 57 mg per 5 milliliters. Consists of 400 mg Am and 57 mg Cl in 5 ml of solution. There are bottles designed for 35 and 70 ml of syrup.
3. Tablets 500 or 878 plus 125 mg . The composition includes 500 or 875 mg Am, respectively, and 125 mg Cl. Sold in packs of 14 pieces.
4. KVIKTAB tablets 500 plus 125 mg and 875 plus 125 mg . They consist of 500 and 875 mg Am and 125 mg Cl, respectively. Sold in blisters of 10 pieces.
5. Powder for injection solution 500 plus 100 milligrams and 1000 plus 200 milligrams. Consists of 500 and 1000 mg Am and 100 and 200 mg Cl acid, respectively. Available in bottles, 5 per pack.

In addition to the active ingredients, the different forms of the drug contain additional substances that are designed to keep the dosage form the way it should be, also providing the color, taste and smell of the medicine.

Operating principle

To understand how the drug works, let’s break it down into its components:

1. Amoxicillin is a semi-synthetic substance of the penicillin series and with a wide spectrum of action.
2. Clavulanic acid is an irreversible β-lactamase inhibitor that forms inactive compounds with enzymes, thereby preventing the destruction of the previous component of the drug.

The complex of these substances has antibacterial activity against:

When using oral forms, the therapeutic concentration of the drug in the blood is achieved literally a couple of hours after taking the medicine. The components of Amoxiclav are well distributed in fluids and tissues (with the exception of the brain and cerebrospinal fluid), having a destructive effect on pathogenic microflora.

The bulk of the drug is excreted from the body with the assistance of the urinary system, a small part of it is eliminated through the intestines and lungs.

Indications for prescribing the medication

The medicine is prescribed for the following pathologies:

At what age is the drug approved for use?

The drug is prescribed to children from the age of two months. Doctors recommend having this medicine on hand in the following cases:

With any pathological phenomenon during pregnancy or during childbirth, there is a risk that the baby may get sick at such a young age. Of course, you should use the drug only after consulting a doctor, but pediatricians and neonatologists often prefer Amoxiclav to other penicillin medications.

Contraindications in children

Just like any drug, Amoxiclav has a number of categorical contraindications:

Side effects when taken

Adverse reactions to the drug, if the dosage and doctor’s recommendations are followed, are mild and pass quickly enough. Most often they manifest themselves in disorders of the digestive system and to relieve them it is enough to take the medicine during meals. But other reactions are also observed clinically.

Often:

Infrequently:

Rarely:

Very rarely:

Amoxiclav: instructions for use of tablets and suspension (syrup) for children

This is one of those drugs that is dosed not so much according to the patient’s age, but rather according to the patient’s weight. For children under 6-8 years old, it is preferable to use a suspension, for children under 10-12 years old - KVIKTAB, and regular tablets for older children.

Suspension

First of all, it needs to be prepared. To do this, use a bottle of suspension powder and well-boiled and cooled water. There is a mark on the bottle of powder.

First, shake the powder in the bottle (it should come off the bottom and sides). Then pour water into the bottle about halfway, close the lid and shake it well - the powder should dissolve.

After this, add water to the control mark, the amount depends on the size of the bottle.

Before each use of the medicine, the bottle must be shaken thoroughly, since over time the powder will still precipitate.

The dosage of the finished Amoxiclav suspension 125, 250 and 400 milligrams for children is calculated according to the weight and table in the instructions. In general, the drug is given in the following quantities:

Before taking any concentration of the medicine, you should definitely consult with your doctor; only he will be able to calculate the correct dosage based on the age, weight and characteristics of the course of the disease in the baby.

Pills

Ordinary pills are no different in their action from KVIKTAB, it’s just that the latter have a pleasant smell and taste, children “eat” them more willingly. To make it easier, we will also format the dosage in the case of tablets in a table:

The duration of use of the medicine is at least 5 days, but it is determined only by the attending physician. However, like the dose of medicine. I recommend taking the drug during meals.

Signs of overdose

The first signs of this phenomenon are pathological reactions of the digestive system (vomiting, diarrhea, pain in the abdominal area). These signs are treated symptomatically.

In rare cases, patients experience a skin rash, hypersensitization reactions, drowsiness, loss of consciousness for a short period of time, clonic convulsions, renal failure, acidosis and hemolytic reactions.

In such cases, the first thing to do is stop taking the drug. After this, you should immediately consult the doctor who prescribed it and who is observing the child.

Interaction with other drugs

The medicine should not be used in combination with the following drugs:

Terms of sale and storage

All forms of Amoxiclav must be dispensed strictly according to a doctor's prescription, but many pharmacies neglect this rule. The medicine must be stored in a place with low humidity at a temperature not exceeding room temperature (20-25°C) until the expiration date (it is indicated on the package). The prepared suspension should be stored in the refrigerator for no more than seven days.

Amoxiclav for children - reviews

Ekaterina Onisina, gastroenterologist

The drug is good, unlike other antibiotics it causes dysbiosis only in very severe cases, when maximum doses are prescribed.

Oleg Nikolaev, ENT

He copes very well with “my” diseases. Moreover, it helps against otitis media, sinusitis, sinusitis, and tonsillitis. But urticaria-type reactions often occur, so the dosage should be prescribed carefully.

Irina Petrushenko, mother

It helped us very well with a sore throat, the child didn’t even have any reactions. Of all the antibiotics for sore throat in children, I liked it the most. But it doesn’t work on ears, so I had to use another product.

Tatyana Vasnetsova, mother

The doctor prescribed it to us, the effect was noticeable within a day. I highly recommend it. But at the same time, take something anti-allergic, my son had a rash all over his body.

Characteristics of the drug Amoxiclav - video

In this video, an experienced doctor answers many questions related to the drug. Starting from the composition and release forms and ending with contraindications and possible side effects.

Amoxiclav is an excellent antibiotic with a wide spectrum of antimicrobial action. The advantage of the drug is that it is prescribed even to the youngest patients (literally from 2 months). In addition, it is a fairly affordable medicine.

It is important to remember that no matter how good the medicine is, it can only be used with the permission of a doctor, strictly following the instructions given by him. Only a doctor can calculate the correct dosage of Amoxiclav, which will show the effect and will not cause adverse reactions, remember this.

Source: https://fok-zdorovie.ru/deti/antibiotik-amoksiklav-instrukcziya-po-primeneniyu-dlya-detej

Use in children

The use of Amoxiclav 125 mg 31.25 mg in children is possible according to indications in compliance with the dosage regimen.

How to take Amoxiclav suspension for children should first of all be explained by the doctor, since the course of treatment is determined by the attending physician based on the patient’s condition and can be purely individual.

The method of using Amoxiclav suspension is simple for small patients, since its liquid form is easy to swallow and is somewhat reminiscent of syrup for children, and therefore less likely to cause a gag reflex in children. Reviews from parents about analogues often indicate a problem with taking the drugs.

You can measure the required dose using the pipette included in the kit. The antibiotic begins to act in children within an hour, and is eliminated in 1-1.5 hours.

The absorption of the antibiotic does not depend in any way on food intake, but pediatricians often recommend feeding the child immediately after taking the drug.

Attention! In case of severe infection, treatment is prescribed in tablets or other types of antibiotics are used.

Conditions of release and storage

After opening the bottle, it must be stored in the refrigerator. The shelf life after opening in diluted form can be no more than 7 days.

If the bottle is not opened, it can be used for two years.

The medicine is prescribed by the attending physician, after which a prescription must be written in Latin.

Attention! Amoxiclav suspension for children is not sold without a prescription.

The drug is dispensed as prescribed by the attending physician. Amoxiclav 125 mg 31.25 mg can be purchased with a prescription.

How to take it correctly

We can say that Amoxiclav 500 mg is an effective drug of combined action, since when taken correctly, the antibiotic has an effect on different types of microbes.

You can drink Amoxiclav 500 only after a prescription has been issued, in which the specialist must indicate how to take it for an adult and individually calculated dosages. Also, Amoxiclav 500 will not be sold in pharmacies without a prescription.

Important! It is recommended to use Amoxiclav 500 before meals, as the drug is well absorbed and better absorbed.

The method of administration of the drug is mainly oral, not counting the use of injections. Basically, the drug is prescribed for one week, taking the medication 2 times a day.

Attention! The action of Amoxiclav 500 begins within an hour.

For children, the rules of administration will be similar, but it is worth remembering that the child’s body is more susceptible to the action of the components, which may lead to a greater likelihood of unwanted effects.

Dosage

When calculating the drug, the doctor takes into account the following factors:

• age;
• body mass;
• functioning of the urinary system;
• infection level.

After an examination, the specialist determines what dosage is needed for an adult. On average, for adults with mild and moderate infections, 1 tablet is prescribed every 12 hours, for severe forms, 1 tablet every 8 hours.

Use for children over 12 years of age and with a body weight of more than forty kilograms, the dosage is fully consistent with that of an adult, and when setting doses for young children, they are guided by the figure of 40 ml of the drug for every 10 kg of weight, taking into account the dosage of amoxicillin per 5 milligrams.

Example: if a child weighs 8 kg and is under one year of age, the daily dose of Amoxiclav 500 will be as follows – 40 mg * 8 kg * 5 ml/500 = 3.2 ml. This dosage should be divided into 2 - 3 doses per day. If necessary, the tablet can be divided in half.

The course of taking this medication lasts no more than 14 days, at least 7 days. On average, Amoxiclav 500 is taken two or three times a day.

Since this drug has a very wide spectrum of action, it is necessary to ensure that there are no restrictions on its use.

It is possible to prescribe Amoxiclav 500 for more than two weeks, but this can only happen after an examination by a specialist.

Amoxiclav 500, like any other antibiotic of the penicillin group, affects the body of a pregnant or lactating woman, so it can only be prescribed if there is a vital need.

Amoxicillin passes into breast milk along with the blood and is excreted only during feeding or pumping. And clavulanic acid can even penetrate the placental walls, which also has a negative effect on the fetus.

Pharmacokinetics

After oral administration, both components are quickly absorbed into the gastrointestinal tract. Concomitant food intake does not affect absorption. TCmax - 45 min. After oral administration at a dose of 250/125 mg every 8 hours, Cmax of amoxicillin is 2.18–4.5 mcg/ml, clavulanic acid is 0.8–2.2 mcg/ml, at a dose of 500/125 mg every 12 hours Cmax amoxicillin - 5.09-7.91 mcg/ml, clavulanic acid - 1.19-2.41 mcg/ml, at a dose of 500/125 mg every 8 hours Cmax of amoxicillin - 4.94-9.46 mcg/ml, clavulanic acid - 1.57–3.23 μg/ml, at a dose of 875/125 mg Cmax of amoxicillin — 8.82–14.38 μg/ml, clavulanic acid — 1.21–3.19 μg/ml. After intravenous administration in doses of 1000/200 and 500/100 mg, the Cmax of amoxicillin was 105.4 and 32.2 μg/ml, respectively, and clavulanic acid was 28.5 and 10.5 μg/ml. The time to reach a maximum inhibitory concentration of 1 mcg/ml for amoxicillin is similar when used after 12 hours and 8 hours in both adults and children. Bonding with plasma proteins: amoxicillin - 17–20%, clavulanic acid - 22–30%. Both components are metabolized in the liver: amoxicillin - by 10% of the administered dose, clavulanic acid - by 50%. T1/2 after administration at a dose of 375 and 625 mg is 1 and 1.3 hours for amoxicillin, 1.2 and 0.8 hours for clavulanic acid, respectively. T1/2 after intravenous administration at a dose of 1200 and 600 mg is 0.9 and 1.07 hours for amoxicillin, 0.9 and 1.12 hours for clavulanic acid, respectively. Excreted mainly by the kidneys (glomerular filtration and tubular secretion): 50–78 and 25–40% of the administered dose of amoxicillin and clavulanic acid are excreted unchanged, respectively, during the first 6 hours after administration.

Interactions with other drugs

Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce absorption; ascorbic acid increases absorption. Bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) have an antagonistic effect. Increases the effectiveness of indirect anticoagulants (by suppressing intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index). When taking anticoagulants simultaneously, it is necessary to monitor blood clotting indicators. Reduces the effectiveness of oral contraceptives, drugs, during the metabolism of which PABA is formed, ethinyl estradiol - the risk of developing breakthrough bleeding. Diuretics, allopurinol, phenylbutazone, NSAIDs and other drugs that block tubular secretion, increase the concentration of amoxicillin (clavulanic acid is excreted mainly by glomerular filtration). Allopurinol increases the risk of developing skin rash.

Directions for use and doses

In order to correctly calculate the dosage of Amoxiclav 125, the attending physician or pharmacist must take into account the patient’s age and weight, but also, after a medical examination and tests, understand whether the body will withstand it.

Basically, the dosage for children is 40 mg per 10 kg. For treatment of infants with Amoxiclav, it is better to check with a pediatrician. The daily dosage of the drug can be calculated using the formulas:

• Child’s weight*40 mg (example: the child’s weight is 12 kg, the required amount of amoxicillin per day will be 12*40=480 mg);
• 5 ml*Daily dosage of the drug/125 mg (example: 5 ml*480/125=19.2 ml) is the volume per day, it is divided into doses - 2 or 3 per day.

For adults, the dosage of Amoxiclav syrup 125 mg is determined by the doctor. More often they correspond to the maximum dosage for children.

To determine how to give Amoxiclav 125 mg to children, and most importantly what dose can be given, you must consult a doctor and be aware of the possible consequences.

Important! To ensure that pregnancy and childbirth occur in safe conditions for the child and mother, antibiotics are used only in life-threatening conditions.

How to divorce

In order to find out how to take it for children, and most importantly how to dilute amoxiclav correctly, you should refer to the instructions for use:

1. Shake the powder bottle to loosen the powder.
2. First add purified water to the bottle to the middle of the bottle and shake, then add more water to the bottle, but up to the mark on the bottle. After this, shake the Amoxiclav suspension again.

The drug is diluted with 86 milliliters of water, and the finished suspension for children is left open for a week.

Interesting! The method of preparing Amoxiclav 125 mg suspension for a two-year-old child will be no different from diluting the drug for a 12-year-old child. It is important to correctly calculate the dosage so that the syrup has its effect.

How much to take

According to the instructions, Amoxiclav should be taken for 5 to 7 days, but if prescribed by a doctor, you can take the medicine for up to two weeks. It will not be advisable to take Amoxiclav 125 for more than 14 days, due to the likelihood of addiction to the drug.

The main thing to remember when taking Amoxiclav 125 mg is that how many days to use the drug should be determined by the attending physician. Violations of the pediatrician's instructions can lead to unpleasant side effects.

General description of the drug

"Amoxilav" is a drug of semi-synthetic origin , an antibiotic that falls into the category of the penicillin series. The substance is supplemented with clavulanic acid, which enhances the antimicrobial effects of the drug and prolongs the therapeutic effect. The drug begins its effect an hour after administration. It is distinguished by its uniform distribution across tissues in the body.

The drug is excreted through the kidneys. On average, during normal operation, primary excretion is recorded 1.5 hours after administration. If there is a disturbance in the functioning of the renal system, the elimination process can be within 8 hours .