Lazolvan, instructions for use, dosage for children and adults

The white or yellowish tablets have a round, flattened shape, beveled at the edges, with carved company symbols on one side and a demarcation strip and engraving on the other. Lazolvan contains the substance ambroxol hydrochloride - 30 mg in one tablet, which is aimed at producing and liquefying mucus in the lungs. In addition to ambroxol, each tablet contains lactose monohydrate 171 mg, corn starch 36 mg, colloidal silicon dioxide 1.8 mg and magnesium stearate 1.2 mg. By stimulating ciliary activity and increasing secretion, the medicine facilitates coughing, increases the amount of mucus inside the respiratory tract, which promotes more active sputum discharge. People with chronic lung disease noticed an improvement in their condition and a reduction in repeated attacks of the disease after 2 months of using Lazolvan.

Lazolvan for inhalation - instructions

This medication is equally recommended for adults and children. The active components have an astringent effect, so they quickly dry out mucus and promote its rapid separation and removal from the bronchopulmonary system. The active ingredient is ambroxol hydrochloride. Additionally, it demonstrates anti-inflammatory, restorative and tonic properties, a mild analgesic effect, and is characterized by the absence of side effects. Before talking about daily doses, it is necessary to decide on the form of release of the chosen medicine.

The medical drug Lazolvan (solution for oral administration and inhalation) is especially effective for wet coughs. The instructions say that the medicine is produced in liquid form, has a brown tint and a barely perceptible odor. Designed for internal use, the package also includes a measuring cup and a dropper. It is recommended to use this solution internally as follows:

1. For patients under 6 years of age, take 1 home inhalation per day, and use only 2 ml of the medicine to prepare the medicinal composition.
2. For patients aged 6 years and older, two home procedures with a solution volume of 2-3 ml per session are recommended.
3. In order for the treatment to be as productive as possible, it is necessary to combine Lazolvan and saline solution in equal proportions, and then warm the resulting composition to room temperature.
4. To perform home inhalations, use a purchased or home-made device available, or specially purchase an inhaler from a pharmacy (necessarily a non-steam type).
5. The duration of treatment is discussed in advance with the attending physician; daily doses may be adjusted.

Cross-drug interactions

When using Lazolvan in any form, several features should be taken into account:

• Concomitant use with other mucolytics can provoke abundant accumulation of mucus, weakening its output due to suppression of the cough reflex. Therefore, the use of any antitussive drugs must be agreed with your doctor.
• When combined with antibiotics (penicillin and tetracycline groups, Erythromycin), ambroxol enhances the penetration of their components into the bronchial mucus.
• Can be combined with drugs that inhibit labor.
• Patients with asthma should take into account that using Lazolvan for inhalation may result in bronchospasm, since the drug contains an allergenic preservative.

Lazolvan syrup

In childhood, parents select medications that act effectively and do not cause problems with taking a single dose. Young patients can safely be given Lazolvan (syrup for children) to combat cough and its consequences. The instructions say that this medical product is bottled in 100 ml bottles, and has no color, but tastes very good. So infants and older children are not upset by such treatment, and soon the little patient will definitely get better.

The abstract for Lazolvan states that this syrup is allowed to be drunk by adults, the main thing is to correctly select and observe single servings. At the initial stage of the disease, this is 10 ml of Lazolvan at a time; after three days of intensive therapy, the prescribed portion is shown to be reduced to 5 ml. The number of daily doses of medication is 2-3, which depends on the diagnosis and age characteristics. Take the syrup only during meals, with a sufficient amount of liquid.

Lazolvan composition and release forms

There are such forms of release of this drug: tablets, Lazolvan syrup, for inhalation and oral administration in the form of a solution.

Lazolvan in tablets. One tablet contains 30 mg of the key active substance – ambroxol hydrochloride. And also the following auxiliary elements are included in the tablets:

• Magnesium stearate.
• Silicon colloidal.
• Dried cornstarch.
• Lactose.

The tablets are round in shape and may be white or yellowish in color. The shape is flat on both sides and beveled edges. One blister includes 10 tablets; one package may contain 2 blisters or 5, respectively.

Lazolvan tablets

This form of release is more suitable for adult patients, and the therapeutic effect is noticeable within 2-3 days from the moment you start taking the tablets orally. Those suffering from bronchitis or other diseases of the bronchopulmonary system should take 1 capsule per day with a moderate amount of water. Such treatment should not be combined with main meals; in case of complicated clinical pictures, the daily dose should be increased. If the choice fell on Lazolvan (tablets), the instructions say that this is a productive and safe treatment for patients 6-12 years old.

Characteristics of the drug

Lazolvan belongs to the category of expectorants and mucolytics. Its main effect is to liquefy mucus and stimulate its release from the respiratory system.

The painful symptoms begin to be suppressed within 30 minutes after entering the body. The therapeutic effect lasts for 8-12 hours. The active component is completely concentrated in the lungs. The medication does not affect the condition of other body systems. It does not accumulate in internal organs and is easily broken down under the influence of liver enzymes.

Compound

The main active ingredient is ambroxol, an expectorant that is widely used in the treatment of productive cough.

Impact on the body

What cough does Lazolvan help get rid of? This is a combination medicine. It is effective for both wet and dry coughs:

1. For a non-productive cough, the active component stimulates the process of sputum production. This ensures the transformation of a dry cough into a wet one.
2. Penetrating into the body, the active substance affects mucus at the cellular level and changes its consistency. This way the mucus becomes less viscous and leaves the body much better.
3. The layer of bronchi is covered with cilia, which ensure the removal of sputum. Under the influence of thick mucus, their function is significantly reduced. Reducing viscosity ensures restoration of eyelash function.
4. Lazolvan activates the production of a special surfactant substance, which protects lung tissue from a variety of pathological processes.
5. When Lazolvan is combined with antibiotics, it improves the penetration of the latter into lung tissue. This ensures the highest concentration of medicinal components at the site of inflammation.

Release forms

1. The syrup is perfect for babies; it is even prescribed for infants. It has a pleasant taste of forest berries and does not contain alcohol. The syrup is allowed to be consumed by patients suffering from diabetes.
2. Nasal spray Lazolvan Rino is a new drug that effectively relieves nasal congestion and provides a long-term therapeutic effect. The active ingredient tramazolin has a double effect. It perfectly constricts blood vessels and reduces swelling. Thanks to these properties, nasal breathing is restored quickly (in about 5 minutes) and for a long time. These nasal drops can only be used from 6 years of age.
3. Lozenges are based on ambroxol. Excellent for soothing the throat and eliminating cough. Often used for laryngitis. The lozenges contain natural eucalyptus and mint oils. They provide a reduction in swelling and hyperemia of the larynx. There is no sugar in the lozenges. At what age can you use the medication? From 6 years old.
4. The solution is intended for oral administration and inhalation. Able to reduce mucus viscosity. In addition, it ensures the dissolution of sputum stagnant in the bronchi. The solution can be used for inhalation on any equipment, with the exception of a steam inhaler.

Lazolvan Rino

This medication is presented in the form of a nasal spray. Lazolvan Rino is available in special bottles with a spray, has a yellow color and a rich eucalyptus aroma. The spray can be used to restore the bronchopulmonary system in childhood, the main thing is to determine the daily dose in advance. To get rid of alarming symptoms for a long time, perform 1-2 emissions into each nasal passage, the number of approaches per day is 3-4 times.

If you are interested in the mucolytic drug Lazolvan Rino, the instructions for use for children inform that for this category of patients the treatment is safe, there are no side effects, and cases of overdose are excluded. When the drug begins to act, its use calms the patient and provides a long-awaited period of remission.

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Compound

To quickly get rid of a cough and prevent the development of bronchitis and pneumonia, this is the best medicine at all times. The instructions for Lazolvan determine the pharmacological action of the medication and the characteristics of its chemical composition. The active component is ambroxol hydrochloride, which provides productive relief from dry and wet cough, guarantees the prevention of bronchitis and other lesions of the bronchopulmonary system.

If you take Lazolvan against cough, the composition of the drug will additionally help get rid of other symptoms that arose after the appearance of an unpleasant and even obsessive cough reflex. During intensive therapy, the drug activates surfactant, which maintains the functionality of the bronchopulmonary system at an acceptable level.

What side effects may occur?

Lazolvan is a fairly safe drug that has a minimal number of possible side effects, as well as a low frequency of their development.

However, like any other drug, Lazolvan still has undesirable effects that can cause significant discomfort:

• The most common manifestations are from the gastrointestinal tract, such as diarrhea or, conversely, constipation. With long-term use of high doses of Lazolvan, nausea, vomiting, abdominal pain or heartburn may occur.
• Allergic reactions are also possible. The highest likelihood of developing a relatively harmless skin rash or urticaria, however, more serious options such as anaphylactic shock are also possible.
• You may also be concerned about a feeling of weakness, urinary disorders, and dryness of the mucous membranes of the oral cavity.
• When administered by injection, the speed at which the drug enters the bloodstream is also important. If it is injected into a vein too quickly, an unpleasant feeling of numbness, a drop in blood pressure, shortness of breath, and an increase in body temperature may occur.

Indications for use

The medication can be purchased at an affordable price, but first find out whether such treatment will harm the patient. The instructions indicate that this specific medication can be used at any age, and young children are no exception. In addition, it is necessary to select the most suitable form of release of the drug in order to speed up the approach of the therapeutic effect as much as possible. The dosage is selected individually, and general information about drug therapy is presented below:

1. Tablets: take 1 pill orally once a day.
2. Medicine: give in children 5 ml up to 2-3 times a day.
3. Solution for inhalation: clean the bronchopulmonary system once a day; use Lazolvan preferably before bedtime.
4. If it is Lazolvan nasal spray, the indications for use indicate that it is necessary to perform 2 emissions into each nasal passage at a time, a total of 3 daily procedures is enough.
5. The solution for adults should also be taken orally, always as part of the main meal up to 2-3 times a day.

For children

If a child begins to cough, the doctor prescribes Lazolvan syrup (for children) - the instructions provide a detailed description of this medication. At such a young age, it is better not to violate daily doses; take into account the age of the young patient. The recommendations are:

1. If this is a child under 2 years old, a single serving is half a teaspoon twice a day.
2. Children from 2 to 6 years old are supposed to drink the same dose, but three times a day.
3. Patients over 6 years of age should take 5 ml at a time three times a day.

During pregnancy

Since a woman in an “interesting position” is especially susceptible to pathogenic attacks, she also needs to be treated, and in a timely manner. Inhalations with Lazolvan during pregnancy are an approved remedy, since they provide a high therapeutic effect in the absence of negative effects on the fetus. As for the pills, pregnant women are prohibited from taking them in the 1st trimester. For the rest of the period, treatment should proceed under strict medical supervision. It has been clinically proven that ambroxol penetrates the placental barrier, but does not harm intrauterine development.

Pharmacological properties

Pharmacodynamics.

It has been preclinically proven that the active ingredient of Lazolvan ® tablets, ambroxol hydrochloride, increases the formation of the serous component of bronchial secretions. Ambroxol enhances the secretion of pulmonary surfactant by direct action on type II pneumocytes in the alveoli and Clara cells in the bronchioles, and also stimulates ciliary activity, resulting in a decrease in sputum viscosity and improved excretion (mucociliary clearance). Improved mucociliary clearance has been proven during clinical and pharmacological studies.

Increased production of serous secretion and increased mucociliary clearance facilitate expectoration and reduce cough.

Patients with COPD who received ambroxol hydrochloride extended-release capsules 75 mg for 6 months had a significant reduction in the number of exacerbations compared with placebo at the end of 2 months of treatment. Patients treated with ambroxol hydrochloride had significantly fewer days of illness and required fewer days of antibiotic therapy. They also experienced statistically significant reductions in symptoms such as difficulty clearing, cough, shortness of breath and auscultatory sounds compared to placebo.

The local anesthetic effect of ambroxol hydrochloride was observed in a rabbit eye model, which may be explained by the sodium channel blocking properties. In vitro studies have shown that ambroxol hydrochloride blocks neuronal sodium channels; binding was reversible and concentration dependent.

Ambroxol hydrochloride has demonstrated anti-inflammatory effects in vitro. Thus, ambroxol hydrochloride significantly reduces the release of cytokines from mononuclear and polymorphonuclear cells of blood and tissues.

As a result of clinical trials involving patients with pharyngitis, a significant reduction in pain and redness in the throat when using the drug was proven.

Thanks to the pharmacological properties of ambroxol, pain was quickly relieved in the treatment of diseases of the upper respiratory tract, which was observed during studies of the clinical effectiveness of inhaled forms of ambroxol.

The use of ambroxol hydrochloride increases the concentration of antibiotics (amoxicillin, cefuroxime, erythromycin and doxycycline) in bronchopulmonary secretions and sputum. To date, no clinical significance has been found for this finding.

Pharmacokinetics.

Absorption. Absorption of ambroxol hydrochloride from immediate-release oral forms is rapid and complete, with a linear dose response over the therapeutic range. The maximum plasma level is achieved after 1-2.5 hours when taking oral immediate release dosage forms and on average after 6.5 hours when using slow release dosage forms.

Bioavailability after taking a 30 mg tablet is 79%.

Distribution. When taken orally, the distribution of ambroxol hydrochloride from the blood to the tissues is rapid and pronounced, with a high concentration of the active substance in the lungs. The expected volume of distribution after oral administration is 552 L. In blood plasma in the therapeutic dose range, approximately 90% of the drug is protein bound.

Metabolism and excretion. Approximately 30% of the dose after oral administration is eliminated as a result of first-pass metabolism. Ambroxol hydrochloride is metabolized in the liver by glucuronidation and breakdown to dibromanthranilic acid (approximately 10% of the dose). Studies in human liver microsomes have shown that CYP3A4 is responsible for the metabolism of ambroxol hydrochloride to dibromoantranilic acid.

After 3 days of oral administration, about 6% of the dose is excreted in the urine unchanged, about 26% of the dose is excreted in conjugated form.

The plasma half-life is approximately 10 hours. The total clearance is approximately 660 ml/min. Renal clearance is approximately 8% of the total. After 5 days, approximately 83% of the total dose is excreted in the urine.

Pharmacokinetics in special groups of patients. In patients with impaired liver function, the excretion of ambroxol hydrochloride is reduced, which provokes a 1.3-2 times higher level in the blood plasma. Since the therapeutic range of ambroxol hydrochloride is quite wide, there is no need to change the dosage.

Age and gender do not have a clinically significant effect on the pharmacokinetics of ambroxol hydrochloride, so any dose adjustment is not required.

Food intake does not affect the bioavailability of ambroxol hydrochloride.

Contraindications

If a doctor prescribes Lazolvan for the effective treatment of dry or wet cough, the instructions for use inform that this medication is not allowed to be used by all patients with characteristic symptoms. There are contraindications, the violation of which can only complicate the course of the prevailing clinical picture. So, the medical restrictions are:

• newborn age;
• incompatibility with individual components of the chemical composition;
• liver and kidney diseases (chronic diagnoses).

Interaction with other drugs

It is important to note the main limitation in the use of Lazolvan syrup - it should never be used together with drugs that are designed to suppress cough. The main purpose of the syrup is to increase the production of sputum, make it more liquid and facilitate its discharge as much as possible, but if other substances suppress the motor function of the villi, then a large amount of mucus will accumulate in the respiratory tract, creating conditions for the development of inflammatory processes and a significant aggravation of the situation.

It is also worth considering that ambroxol increases the effectiveness of certain groups of antibiotic drugs, in particular erythromycin and amoxicillin.

Side effects

Ambroxol adapts imperceptibly in the body and acts gently. According to patient reviews and descriptions from the instructions, side effects should not be excluded either. More often they are associated with intolerance to ambroxol, and are represented by allergic and local reactions. In this case, treatment should be stopped immediately, and the prescribed regimen should be reviewed with the attending physician and use more gentle analogues at an affordable price. In general, if it is Lazolvan, side effects rarely bother a weakened body at any age.