AnviMax, 24 pcs., 5 g, powder for oral solution, raspberry

Compound

Contraindications for use

Before you start taking Anvimax

, it is necessary to study the contraindications that are indicated in the instructions.

The medicine is prohibited for use in the following cases:

• intolerance to the components of the drug;
• gastrointestinal diseases, period of exacerbation of ailments;
• hemorrhagic diathesis;
• lack of fat-soluble vitamin K;
• hemophilia;
• thyroid diseases;
• lack of platelets in the blood;
• liver and kidney diseases during exacerbation;
• chronic alcoholism;
• lactose intolerance;
• pregnancy and breastfeeding;
• hypercalcemia;
• sarcoidosis

In addition, it should be noted that patients should be treated with Anvimax

capsules only under the supervision of doctors.
This category includes people with epilepsy, diabetes mellitus, and atherosclerosis of the cerebral vessels. Due to the fact that Anvimax
can worsen the patient’s condition, the advisability of using this drug can only be determined by a doctor.

Before purchasing the drug at the pharmacy, consult a doctor who will advise you on the use of this drug.

Anvimax

capsules indicate that it is unacceptable to use the drug in the presence of metastatic tumors.
In addition, the drug is prohibited for patients who drink alcohol. This is due to the fact that paracetamol has a detrimental effect on damaged liver cells. The need to use Anvimax
can only be determined by the attending physician.

Patients who drive a vehicle during treatment should be careful, as the drug slows down psychomotor reactions.

To find out about the compatibility of tablets with other medications, consult your doctor.

Description of the dosage form

Contents of the bag

- a mixture of powder and granules from almost white to yellow with a greenish tint with a characteristic smell (cranberry or lemon, or lemon with honey, or raspberries, or black currants). The presence of single pink granules is allowed.

Solution after dissolving the powder

- colorless or with a yellowish tint, slightly cloudy, with a characteristic odor (lemon, lemon with honey, raspberries, black currants). The presence of undissolved yellow particles is allowed.

Capsules P

hard gelatin No. 0, blue. The contents of the capsules are a mixture of powder and granules of white or white with a creamy or pinkish tint, the presence of lumps is allowed.

Capsules P

hard gelatin No. 0, red. The contents of the capsules are a mixture of powder and granules from yellow to yellow with a greenish tint and white, the presence of lumps is allowed.

Analogs

Interestingly, there are no structural analogues with the same active ingredient in the pharmacy. As for the pharmacological group, this may include Aspirin, Fervex, Colds, Paracetamol. Reviews from doctors claim that one of the most similar analogues is Antigrippin-Maximum.

Anvimax or Theraflu which is better?

These two drugs have different components in their composition. Similarities are observed only for paracetamol and ascorbic acid. The advantage of Anvimax is that it is an etiotropic drug that primarily affects the viruses that cause the disease. Moreover, Anvimax is sold not only in powder form, but also in capsule form.

Anvimax and alcohol compatibility

As for alcohol, chronic alcoholism is indicated as a contraindication for use. So if you abuse these substances, it is better to abstain before taking treatment, consult with your doctor and ask when it can be used and in what doses.

"AnvimMax" is a combined drug that has antiviral, antipyretic, analgesic, antihistamine and angioprotective effects. It copes well with viral diseases - ARVI, colds, muscle pain and chills.

Pharmacodynamics

The combined drug has antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effects.

Paracetamol

has analgesic and antipyretic effects.

Ascorbic acid

participates in the regulation of redox processes, promotes proper capillary permeability, blood clotting, tissue regeneration, plays a positive role in the development of the body’s immune reactions, and replenishes vitamin C deficiency.

Calcium gluconate,

as a source of calcium ions, it prevents the development of increased permeability and fragility of blood vessels, causing hemorrhagic processes in influenza and ARVI, and has an antiallergic effect (the mechanism is unclear).

Rimantadine

has antiviral activity against the influenza A virus. By blocking the M2 channels of the influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication. Induces the production of alpha and gamma interferons. For influenza caused by virus B, rimantadine has an antitoxic effect.

Rutoside

considered an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. Inhibits aggregation and increases the degree of deformability of red blood cells.

Loratadine

- H1-histamine receptor blocker - prevents the development of tissue edema associated with the release of histamine.

Anvimax indications

Anvimax belongs to a group of essential pharmaceutical drugs that provide effective antiviral treatment. Effective against influenza (type A). It also works well in the symptomatic treatment of conditions such as:

• Cold;
• ORV infections;
• Conditions in which body temperature rises, chills appear, as well as headaches and muscle pain.

Anvimax contraindications

Before deciding to take the drug, you must familiarize yourself with the list of its contraindications, information about which is contained in the instructions included with the drug. So, the use of Anvimax is not advisable in the following cases:

• The presence of hypersensitivity, both acquired and hereditary intolerance to the components of the drug;
• Pathology of the gastrointestinal tract, especially during exacerbations;
• With hemorrhagic diathesis;
• With a deficiency of fat-soluble vitamin K;
• If you have hemophilia;
• With portal hypertension;
• For problems with the thyroid gland;
• If an insufficient number of platelets is detected;
• For acute diseases of the kidneys and liver, as well as their chronic pathologies during the period of exacerbation;
• In severe conditions of hypercalcemia and hypercalciuria;
• For chronic alcoholism;
• For sarcoidosis;
• For phenylketonuria;
• During pregnancy and during breastfeeding;
• If the patient is lactose intolerant.

In addition, there may be such health conditions of patients when certain diseases require treatment under medical supervision

For example, when the use of a drug is extremely necessary for successful treatment at a given moment in the current condition, however, the patient suffers from a disease in which the use of the said drug should be carried out with great caution. There is only one way out of this situation - to carry out treatment procedures only in a hospital setting

Here is a list of pathologies for which it is impossible to do without the supervision of medical personnel:

• For epilepsy;
• With atherosclerosis of cerebral vessels;
• For diabetes mellitus;
• With sideroblastic anemia;
• With an increased content of oxalates in the blood plasma;
• With malabsorption syndrome;
• With glucose-6-phosphate dehydrogenase deficiency;
• For dehydration and exicosis;
• For thalassemia;
• When there are disturbances in the electrolyte composition of the blood;
• In old age, especially in the presence of pathologies of the cardiovascular system, which are accompanied by arterial hypertension.

Pharmacokinetics

Paracetamol.

Absorption is high. Communication with plasma proteins - 15%. Penetrates through the BBB. Metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine ​​and mercapturic acid. The main cytochrome P450 isoenzymes for this metabolic pathway are CYP2E1 (usually), CYP1A2 and CYP3A4 (minor role). With glutathione deficiency, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways include hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates. In adults, glucuronidation predominates. Conjugated metabolites of paracetamol (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity. Excreted by the kidneys in the form of metabolites, usually conjugates, only 3% unchanged. In elderly patients, drug clearance decreases and T1/2 increases.

Based on the results of clinical studies, the following pharmacokinetic parameters of paracetamol were established: Cmax in blood plasma is achieved when using the powder after (0.7±0.39) hours and is (4.79±1.81) mcg/ml, T1/2 is equal to ( 2.73±0.76) h; Cmax in blood plasma is achieved when using capsules after (1.2±0.72) hours and is (5.01±1.7) mcg/ml, T1/2 is (3.04±1.01) hours.

Ascorbic acid

absorbed in the gastrointestinal tract (usually in the jejunum). Communication with plasma proteins - 25%. Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinks reduce the absorption of ascorbic acid in the intestine. The normal plasma ascorbic acid concentration is approximately 10–20 µg/ml. Tmax in blood plasma after oral administration is 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations. It is usually metabolized in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate. It is excreted by the kidneys, through the intestines, with sweat, unchanged and in the form of metabolites. Smoking and ethanol consumption accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body. Excreted during hemodialysis.

Calcium gluconate.

Approximately 1/5–1/3 of orally administered calcium gluconate is absorbed in the small intestine; this process depends on the presence of ergocalciferol, pH, diet and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with calcium deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) by the intestines.

Rimantadine.

After oral administration, it is almost completely absorbed from the intestines. Absorption is slow. Communication with plasma proteins is about 40%. Vd - 17–25 l/kg. The concentration in nasal secretions is 50% higher than the plasma concentration. Metabolized in the liver. More than 90% is excreted by the kidneys within 72 hours, usually in the form of metabolites, 15% unchanged. With chronic renal failure, T1/2 increases 2 times. In persons with renal failure and advanced age, toxic concentrations may accumulate if the dosage is not adjusted in proportion to the decrease in creatinine Cl. Hemodialysis has little effect on the clearance of rimantadine.

Based on the results of clinical studies, the following pharmacokinetic parameters of rimantadine were established: Cmax in blood plasma is achieved when using the powder after (5.28 ± 2.54) hours and is (69 ± 19.7) ng/ml, T1/2 - (33. 26±12.76) h; Cmax in blood plasma is achieved when using capsules after (4.53±2.52) hours and is (68.2±26.6) ng/ml, T1/2 - (30.51±9.83) hours.

Rutoside.

Tmax in blood plasma after oral administration is 1–9 hours. It is usually excreted in the bile and, to a lesser extent, in the kidneys. T1/2 - 10–25 hours.

Loratadine.

Quickly and completely absorbed into the gastrointestinal tract. Cmax in older people increases by 50%. Communication with plasma proteins - 97%. Metabolized in the liver to form an active metabolite (descarboethoxyloratadine) with the participation of cytochrome isoenzymes CYP3A4 and, to a lesser extent, CYP2D6. Does not penetrate the BBB. Excreted by the kidneys and bile. In patients with chronic renal failure and during hemodialysis, the pharmacokinetics remain virtually unchanged.

Based on the results of clinical studies, the following pharmacokinetic parameters of loratadine were established: Cmax in blood plasma when taking the powder is achieved after (3.28±1.25) hours and is (1.85±0.95) ng/ml, T1/2 is ( 11.29±5.52) h; Cmax in blood plasma when taking capsules is achieved after (2.92±1.31) hours and is (2.36±1.53) ng/ml, T1/2 is equal to (12.36±6.84) hours.

ANVIMAX

Effervescent tablets
from light pink to dark pink, with lighter and darker inclusions, round, flat-cylindrical, with a rough surface, chamfered, with a characteristic odor; inclusions of greenish-yellow color are allowed; hygroscopic.

Excipients: citric acid – 716 mg, sodium bicarbonate – 584 mg, sorbitol – 97.85 mg, macrogol (polyethylene glycol 6000) – 75 mg, isoleucine – 75 mg, cranberry flavor (food powder flavor “Cranberry 924”) – 75 mg, acesulfame K – 20 mg, aspartame – 20 mg, povidone K30 – 3.75 mg, beet red dye (E162) – 0.4 mg.

10 pieces. – tubes (1) – cardboard packs.

pharmachologic effect

A combined drug with antiviral, interferonogenic, antipyretic, anti-inflammatory, analgesic, antiallergic and angioprotective effects.

Ascorbic acid

participates in the regulation of redox processes, normalizes capillary permeability, blood clotting, tissue regeneration, activates the immune system, and replenishes vitamin C deficiency.

Calcium gluconate

prevents the development of increased permeability and fragility of blood vessels, which cause hemorrhagic processes in influenza and ARVI, and also restores capillary circulation and has an antiallergic effect (the mechanism is unclear).

Loratadine

– a blocker of histamine H1 receptors, prevents the development of tissue edema associated with the release of histamine.

Paracetamol

has antipyretic, analgesic and anti-inflammatory effects.

Rimantadine

– an antiviral agent, active against influenza A virus. By blocking the M2 channels of the influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication. Induces the production of alpha and gamma interferons. For influenza caused by virus B, rimantadine has an antitoxic effect.

Rutoside

– angioprotector. Reduces increased capillary permeability, swelling and inflammation, strengthens the vascular wall. It has an antiplatelet effect and increases the degree of red blood cell deformation.

Pharmacokinetics

Ascorbic acid

Ascorbic acid is absorbed from the gastrointestinal tract (mainly in the jejunum).

Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestine.

The normal concentration of ascorbic acid in plasma is approximately 10-20 μg/ml. The time to reach Cmax in blood plasma after oral administration is 4 hours.

Plasma protein binding – 25%.

Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye. Penetrates through the placental barrier.

In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.

Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate. It is excreted by the kidneys, through the intestines, with sweat, unchanged and in the form of metabolites.

Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body. Excreted during hemodialysis.

Calcium gluconate

Approximately 1/5-1/3 of orally administered calcium gluconate is absorbed in the small intestine; this process depends on the presence of ergocalciferol, pH, dietary characteristics and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with calcium deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) through the intestines.

Loratadine

Source: https://health.mail.ru/drug/anvimaks-2/

Side effects

In accordance with the components included.

From the side of the central nervous system:

increased excitability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing of the face.

From the digestive system:

damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mouth, lack of appetite, bloating (flatulence), diarrhea (diarrhea).

From the urinary system:

moderate pollakiuria.

From the hematopoietic organs:

changes in blood parameters (monitoring needed).

Other:

inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).

Allergic reactions:

skin rash, itching, urticaria.

If any of these side effects worsen or other side effects not listed in the instructions appear, you should immediately inform your doctor.

Side effects

Anvimax for the flu allows you to quickly get rid of the unpleasant symptoms characteristic of a viral infection. However, some categories of people who are highly sensitive to the components contained in the drug, or who take this medication for a long time, may suffer from the development of negative manifestations.

Adverse reactions:

• Central nervous system: trembling of the limbs, dizziness and pain in the head, increased excitability or, conversely, drowsiness;
• Gastrointestinal organs: disorders that disrupt the normal digestive process, ulcerative lesions of the mucous membranes, dry mouth;
• bladder and urinary tract: moderate pollakiuria;
• circulatory system: dysfunction of the pancreas;
• skin reactions: the appearance of urticaria, itching, rash.

Anvimax, like other medications, should be taken without exceeding the dosage regimen indicated in the instructions. If you do not follow this rule, there is a high probability of overdose, including the appearance of unpleasant symptoms such as nausea, epigastric pain, tachycardia, and exacerbation of chronic pathologies.

Symptoms of overdose that appear require immediate adoption of measures such as:

• stopping the use of Anvimax;
• gastric lavage;
• acceptance of sorbents;
• contacting a medical institution where the patient will be given antidotes (methionine, acetylcysteine).

In addition, it is important to consider the principles of drug interactions between this medication and other drugs:

1. The combined use of drugs with a pronounced hepatoxic effect can provoke the development of severe intoxication of the body.
2. The effectiveness of paracetamol will be lower if you simultaneously take uricosuric substances or drink barbiturates for a long time.
3. Caffeine will invigorate you more if you take Anvimax (it contains rimantadine, which gives this effect).
4. Ascorbic acid contained in the medication will reduce the rate of iron absorption and reduce the effectiveness of antipsychotic drugs.

Special instructions:

• the drug is prohibited for use in people with malignant tumors that have metastases;
• paracetamol has the ability to damage the liver; people who have problems with this organ should first obtain medical advice;
• During treatment with Anvimax, the reaction rate may decrease, so you should not drive vehicles or operate complex machinery.

Interaction

Paracetamol

reduces the effectiveness of uricosuric drugs. Concomitant use of paracetamol in high doses will increase the effect of anticoagulant drugs. Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites of paracetamol, which determines the ability to develop severe intoxications even with a small overdose. When used simultaneously with metoclopramide, an increase in the rate of absorption of paracetamol is likely. Long-term use of barbiturates reduces the effectiveness of paracetamol. Inhibitors of microsomal oxidation reduce the risk of hepatotoxicity.

Rimantadine

enhances the stimulating effect of caffeine. Cimetidine reduces the clearance of rimantadine by 18%.

Ascorbic acid

will increase the concentration of benzylpenicillin in the blood. Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine. Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids). Reduces the blood concentration of oral contraceptives. It will increase the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body. When used simultaneously, it reduces the chronotropic effects of isoprenaline.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Loratadine.

Inhibitors of CYP3A4 and CYP2D6 increase the concentration of loratadine in the blood.

AnviMax

Non-narcotic analgesics and non-steroidal anti-inflammatory drugs.

Composition of AnviMax

Paracetamol 360 mg, ascorbic acid 300 mg, calcium gluconate monohydrate 100 mg, rimantadine hydrochloride 50 mg, rutoside trihydrate 20 mg, loratadine 3 mg.

Manufacturers

PharmVilar NPO (Russia), Pharmproject (Russia)

Side effects of AnviMax

In accordance with the components included.

https://www.youtube.com/watch?v=_ZGXA-NZ6iw

From the central nervous system.

Increased excitability, drowsiness, tremor, hyperkinesia, dizziness, headache, “flushes” of blood to the face.

From the digestive system.

Damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membrane in the mouth, lack of appetite, bloating (flatulence), diarrhea (diarrhea).

From the urinary system.

Moderate pollakiuria.

From the hematopoietic organs.

Changes in blood parameters.

Control is needed.

Other.

Inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).

Allergic reactions.

If any of the side effects indicated in the instructions worsen, you should immediately inform your doctor.

Indications for use

Etiotropic treatment of influenza type A, symptomatic treatment of “colds”, influenza and ARVI, accompanied by fever, muscle pain, headache, chills in adults.

Contraindications AnviMax

Hypersensitivity to one or more components included in the drug; erosive and ulcerative lesions of the gastrointestinal tract in the acute phase; gastrointestinal bleeding; hemophilia; hemorrhagic diathesis; hypoprothrombinemia; portal hypertension; vitamin deficiency K; renal failure; pregnancy, breastfeeding period; diseases of the thyroid gland, acute diseases of the kidneys, liver (acute glomerulonephritis, acute pyelonephritis, acute hepatitis, or exacerbation of chronic diseases of these organs); chronic alcoholism; hypercalcemia, severe hypercalciuria, nephrourolithiasis, sarcoidosis, simultaneous use of cardiac glycosides (risk of arrhythmias); lactose intolerance, lactase deficiency, glucose-galactose malabsorption; phenylketonuria.

Children under 18 years of age.

Carefully:

• restriction of use for epilepsy,
• cerebral atherosclerosis,
• diabetes mellitus,
• deficiency of glucose-6-phosphate dehydrogenases,
• hemochromatosis,
• sideroblastic anemia,
• thalassemi,
• hyperoxaluri,
• kidney stone disease,
• dehydration,
• electrolyte disturbances (risk of developing hypercalcemia,
• diarrhea,
• malabsorption syndrome,
• calcium nephrourolithiasis (history,
• hypercalciuria.

Elderly patients with arterial hypertension (the risk of hemorrhagic stroke increases due to rimantadine, which is part of the drug).

Use during pregnancy and breastfeeding is contraindicated.

Directions for use and dosage

Inside.

Dissolve the contents of one sachet in half a glass of boiled warm water.

Use immediately after dissolution.

Stir the solution before use.

For adults:

• take 1 sachet 2-3 times a day after meals for 3-5 days (no more than 5 days) until the symptoms of the disease disappear.

If you do not feel better, you should stop taking the drug and consult a doctor.

Overdose

Symptoms:

• during the first 24 hours after administration - pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region;
• impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases.

Symptoms of liver dysfunction may appear 12-48 hours after an overdose.

In case of severe overdose – liver failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage).

Treatment:

• administration of SH-group donors and precursors for the synthesis of glutathione - methionine within 8-9 hours after an overdose and acetylcysteine ​​- within 8 hours.

Gastric lavage, symptomatic therapy.

The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Interaction

Paracetamol reduces the effectiveness of uricosuric drugs.

Concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs.

Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with a small overdose.

When used simultaneously with metoclopramide, it is possible to increase the rate of absorption of paracetamol.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

Microsomal oxidation inhibitors reduce the risk of hepatotoxicity.

Rimantadine enhances the stimulating effect of caffeine.

Cimetidine reduces the clearance of rimantadine by 18%.

Ascorbic acid increases the concentration of benzylpenicillin in the blood.

Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine.

Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, and increases the excretion of drugs that have an alkaline reaction (including alkaloids).

Reduces the blood concentration of oral contraceptives.

Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

When used simultaneously, it reduces the chronotropic effect of isoprenaline.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Loratadine.

Inhibitors of CYP3A4 and CYP2D6 increase the concentration of loratadine in the blood.

special instructions

Duration of use – no more than 5 days.

Do not use in the presence of metastatic tumors.

Persons prone to drinking ethanol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.

Impact on the ability to drive vehicles and other mechanisms that require increased concentration. During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Storage conditions

Store in a dry place, out of reach of children, at a temperature not exceeding 25 C.

Leave procedure

Available without a prescription.

Source: https://elixir.farm/lekarstva/anvimaks/

Directions for use and doses

Inside.

Powder for solution for oral administration

Dissolve the contents of 1 pack. in half a glass of boiled warm water. Use immediately after dissolution. Stir the solution before use.

Adults take 1 pack. 2-3 times a day after meals for 3-5 days (no more than 5 days) until the symptoms of the disease disappear.

Capsules

For adults. 1 caps. P blue and 1 caps. P red (single dosage) 2-3 times a day after meals, washed down with water, for 3-5 days, until the symptoms of the disease disappear.

If you do not feel better, you should stop taking the medicine and consult a doctor.

AnviMax powder summary (instructions for use) in photographs

Photo of instructions for use of AnviMax powder, part 1

Photo of instructions for use of AnviMax powder, part 2

Photo of instructions for use of AnviMax powder, part 3

Photo of instructions for use of AnviMax powder, part 4

Photo of instructions for use of AnviMax powder, part 5

Photo of instructions for use of AnviMax powder, part 6

Photo of instructions for use of AnviMax powder, part 7

Photo of instructions for use of AnviMax powder, part 8

Overdose

Symptoms:

during the first 24 hours after administration - pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region; impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases. Symptoms of liver dysfunction may appear 12–48 hours after overdose. In case of severe overdose - liver failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage).

Treatment:

administration of SH-group donors and precursors for the synthesis of glutathione - methionine - within 8-9 hours after an overdose and acetylcysteine ​​- within 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Contraindications

There are a number of diseases and conditions for which Anvimax is contraindicated. The drug is not prescribed for:

• tendency to bleeding in the digestive organs;
• acute gastrointestinal ulcer;
• hemorrhagic diathesis (increased susceptibility to bleeding);
• hypovitaminosis K;
• hemophilia (hereditary disease associated with blood incoagulation);
• portal hypertension (increased pressure in the portal vein system);
• pathologies of the thyroid gland;
• decreased platelet count;
• acute diseases of the liver (hepatitis) and kidneys (glomerulonephritis, pyelonephritis, renal failure), chronic pathologies of these organs in the acute stage;
• hypercalcemia;
• hypercalciuria;
• alcoholism in the chronic stage;
• phenylketonuria (hereditary disease associated with impaired metabolism of amino acids, especially phenylalanine);
• malignant neoplasms;
• intolerance to the components of the drug;
• insufficient absorption of glucose and galactose.

The drug should be taken with caution in case of epilepsy, cerebral atherosclerosis, sideroblastic anemia, hemochromatosis, diabetes mellitus, arterial hypertension, urolithiasis and other chronic diseases. In these cases, the dosage of the drug is adjusted, and treatment is carried out under the supervision of a doctor in a hospital setting.

special instructions

Duration of use - no more than 5 days. Do not use in the presence of metastatic tumors. Persons prone to drinking ethanol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.

Impact on the ability to drive vehicles and other mechanisms that require increased concentration.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Indications and contraindications

Anvimax is a drug approved for the treatment of conditions of this kind:

• influenza type A;
• ARVI;
• eliminating unpleasant catarrhal symptoms: elevated body temperature, pain in the head, joints, muscles, chills, nasal congestion.

Anvimax cannot be used by all people, without exception. The instructions for the drug contain a clear list of conditions in which its use is prohibited.

Contraindications that do not allow the use of Anvimax:

• prolonged liver pathologies;
• acute glomerulonephritis;
• acute pyelonephritis;
• bleeding of the gastrointestinal tract;
• exacerbation of existing erosive changes or ulcers of the gastrointestinal tract;
• diathesis of hemorrhagic type;
• hemophilic pathology;
• hypertension;
• kidney failure;
• thyroid diseases;
• hypoprothrombinemia;
• vitamin K deficiency;
• the presence of tumors accompanied by the formation of metastases;
• any liver damage;
• chronic alcoholism;
• hypercalcemia;
• sarcoidosis;
• lactose intolerance by the body;
• hypercalciuria;
• simultaneous use of cardiac glycosides;
• pregnancy status;
• nephrourolithiasis;
• phenylketonuria;
• children's age up to 18 years;
• lactation period;
• individual sensitivity to any component of the product.

Indications for use Anvimax

The list of indications for use of the drug Anvimax in the instructions is not very large, but its effectiveness does not decrease because of this. It helps for the etiotropic treatment of influenza, which is type A. Also, the effect of the drug with this form of release will appear in the symptomatic treatment of colds, ARVI and influenza, which are accompanied by high fever, headache and chills.

Contraindications for taking Anvimax

Instructions for use consist not only of indications, but also of contraindications. For example, it is completely prohibited for children, and this powder is contraindicated for adults with hemophilia, bleeding in the stomach or intestines, portal hypertension, thyroid diseases, chronic alcoholism, sarcoidosis, nephrourolithiasis, pregnancy, lactation, renal failure and hypersensitivity to components.

Anvimax application

The use of the drug is carried out regardless of its release form only for internal use.

Anvimax powder should be diluted with warm water that has been boiled. Half a glass is enough for one single sachet. Pour the contents of the sachet into a glass of water and, after thoroughly mixing it, take it orally.

Take 1 sachet - two or three times a day. It is advisable to take the drug after meals. The recommended course of treatment with the drug is five days. It is strictly forbidden to prolong treatment on your own.

The drug should be taken in capsules no more than two or three times a day, one capsule. As well as capsule powder, it is also recommended to drink after meals. They should be washed down with plenty of water. The course of treatment consists of five days and, as in the case of powders, cannot be extended. If relief does not occur and your health does not improve, treatment should not be continued, but you should see a doctor.

Anvimax for children

The drug is intended exclusively for adults and is not allowed for use by children under the age of eighteen.

Anvimax special instructions

Since the effect of paracetamol on the liver can be damaging, those patients who have liver failure or any chronic pathology in this area should consult a doctor before starting treatment with Anvimax. The same must be done for those who are prone to drinking alcohol.

Although the use of the drug Anvimax has not been noted to have an effect on concentration and other types of psychomotor response, when treating with this drug it is advisable to exercise caution for those who drive vehicles and work with complex mechanisms

Anvimax instructions

Being a fairly popular drug during viral epidemics, the drug naturally arouses considerable interest. In order to obtain complete information about the drug, you must carefully read the instructions that come with it. It describes in detail what this drug is, what its composition is and for what diseases its use is indicated. In addition, there is information about contraindications and side effects that occur with its use. Therefore, before deciding to purchase a medicine, you can read its instructions directly at the pharmacy.

Anvimax composition

The drug Anvimax is quite popular today, and on pharmacy shelves it can be found in two forms: Anvimax powder and capsules of the same name.

Anvimax capsules

The drug in the form of capsules goes on sale in cardboard packs, which contain two plates with capsules of 10 pieces each. There are two types of capsules differing in their composition and labeling.

Capsule P is a hard gelatin blue container for the drug itself, which consists of a white powder mixed with granules.

Active ingredients that make up this type of capsule: Paracetamol, gelatinized starch, colloidal silicon dioxide, lactose monohydrate, magnesium stearate

Capsule P also contains: Gelatin, titanium dioxide, patented blue dye.

Capsule P is a hard gelatin red container for a mixture of granules and powder having a yellow-green color.

Capsule R contains: Ascorbic acid, calcium gluconate monohydrate, rimantadine hydrochloride, rutoside trihydrate, magnesium stearate, loratadine, potato starch.

It also contains: Gelatin, iron oxide in the form of a yellow dye, crimson dye, iron oxide in the form of a red dye, titanium dioxide.

Anvimax powder

Powder for oral administration is the dosage of biologically active substances, which is calculated per sachet for one-time use. The powder consists of: Paracetamol, ascorbic acid, calcium gluconate monohydrate, rimantodine hydrochloride, rutoside trihydrate, loratadine.

Auxiliary components: Lactose monohydrate, aspartame, colloidal silicon dioxide, hypromellose, food flavoring with a variety of tastes.

Pharmacology

Being a combined drug and containing a number of biologically active substances, Anvimax is capable of providing a complex therapeutic effect on the body. It has a fairly wide range of pharmacological effects:

• Reducing high body temperature;
• Analgesic effect;
• Elimination of irritation of the nasal mucosa;
• Inhibition of virus development;
• Strengthening immunity;
• Strengthening the vascular system and eliminating edema.