Protargol 200 mg powder for solution for topical use with solvent

Composition per 1 ml:

Pharmacological properties

Pharmacodynamics

Oxymetazoline belongs to the group of alpha-agonists for topical use. Has a vasoconstrictor effect. When administered intranasally, it reduces swelling of the mucous membrane of the upper respiratory tract and nasal discharge. Restores nasal breathing. Elimination of swelling of the nasal mucosa helps restore aeration of the paranasal sinuses and middle ear cavity, which reduces the likelihood of bacterial complications (sinusitis, sinusitis, otitis media). When used locally intranasally in therapeutic concentrations, it does not irritate or cause hyperemia of the nasal mucosa. The drug begins to act quickly, within a few minutes. The duration of action of the drug is up to 12 hours.

Pharmacokinetics

When administered locally intranasally, oxymetazoline does not have a systemic effect. The half-life of oxymetazoline when administered intranasally is 35 hours. 2.1% of oxymetazoline is excreted in the urine and about 1.1% in the feces.

Composition, mechanism of action, indications and contraindications for use

Currently, the market for medicines is abundant.
Dozens of new drugs are released every year. Medicines for topical use are of particular importance. One of their representatives is “Protargol”. This medicine contains silver ions. This drug is available in the form of a solution for topical use. Many people know that silver has been used as a bactericidal substance for many decades. How to Simply Recommend

Why the medicine does not work The key to successful treatment is, of course, following all the doctor’s recommendations and informing him of all significant changes during therapy. However, a specialist can talk as much as he wants about the regimen and duration of taking the drug, but most patients will still violate these rules. Read more

“Protargol” is able to suppress the growth and reproduction of pathogenic microorganisms, and at significant concentrations it kills them.

The mechanism of the therapeutic action of this drug is based on its ability to relieve inflammation as a result of the formation of a special film on the skin and mucous membranes. It helps reduce skin sensitivity.

The silver contained in it suppresses bacteria, fungi and viruses. Indications for use are: pharyngitis, otitis, sinusitis, sinusitis, cystitis, ethmoiditis, urethritis and other inflammatory processes. Very often, Protargol is prescribed in pediatrics to prevent blepharitis in newborns.

The main area of ​​application is the treatment of runny nose and conjunctivitis. It should only be used topically. If consumed orally, it can cause poisoning, especially in children. Contraindications are individual intolerance, pregnancy and breastfeeding.

Carefully

In patients with increased intraocular pressure, suffering from diseases of the cardiovascular system (arterial hypertension, coronary heart disease, chronic heart failure, tachycardia, arrhythmias), impaired carbohydrate metabolism (diabetes mellitus), impaired thyroid function (hyperthyroidism), pheochromocytoma, chronic renal insufficiency, prostatic hyperplasia (urinary retention), severe atherosclerosis, porphyria, pregnancy, breastfeeding, as well as patients taking tricyclic antidepressants and bromocriptine.

Side effect

Burning or dryness of the mucous membranes of the nasal cavity, dryness of the mucous membranes of the mouth and throat; sneezing; an increase in the volume of secretions released from the nose, nosebleeds; after the effect of using the drug wears off, a strong feeling of “stuffiness” in the nose (reactive hyperemia).

Side effects caused by the systemic effect of the drug: increased blood pressure, headache, dizziness, palpitations, tachycardia, anxiety, restlessness, fatigue, drowsiness, sedation, irritability, sleep disturbances (in children), nausea, insomnia, exanthema, disturbance vision (if it gets into the eyes), hallucinations, Quincke's edema, itching, convulsions, respiratory arrest (in infants). With long-term use - tachyphylaxis, reactive hyperemia of the mucous membrane and atrophy of the nasal mucosa.

The preservative benzalkonium chloride, which is part of the drug, may cause swelling of the nasal mucosa. If this happens, it is necessary to change the drug to another one that does not contain preservatives.

If you experience side effects listed in the instructions or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

How to treat with Protargol?

Protargol for bacterial rhinitis should be instilled into the nasal cavity.
If nasal breathing is impaired and a lot of secretions have accumulated in the nasal cavity, you should rinse your nose before using the silver proteinate solution. For this purpose, it is better to use an isotonic or hypertonic sodium chloride solution (for example, Humer, AquaMaris, Dolphin and other saline solutions). Hypertonic solutions, due to the difference in osmotic pressure, will better remove purulent and thick discharge. Sometimes, before instilling Protargol, it is recommended to use vasoconstrictor nasal drops, for example, Xylometazoline, Oxymetazoline and others. After these procedures, you should take 3-4 drops of silver proteinate into a pipette and drop them into each nasal passage. The frequency of use of the drug is 2-3 times a day, and the course of treatment, as a rule, should not exceed two weeks. Protargol should be used with extreme caution to treat children, especially young children.

We advise you to study: Rinomaris - a nasal spray that is not like others

Overdose

If the drug is accidentally ingested or overdose, the following symptoms may appear: anxiety, restlessness, hallucinations, convulsions, decreased body temperature, lethargy, drowsiness, coma, constriction or dilation of the pupils, fever, sweating, pallor, cyanosis, palpitations, bradycardia, arrhythmia, cardiac arrest, increased blood pressure, decreased blood pressure, nausea, vomiting, respiratory depression, respiratory arrest.

Treatment: symptomatic. In case of accidental ingestion, gastric lavage and administration of activated charcoal. Vasopressor drugs are contraindicated.

Interaction with other drugs

When used concomitantly with monoamine oxidase inhibitors (including a period of 14 days after their discontinuation), tricyclic antidepressants or other drugs that increase blood pressure, an increase in blood pressure may occur. The drug slows down the absorption of local anesthetic drugs and prolongs their effect.

Co-administration of other vasoconstrictor drugs increases the risk of side effects.

If you are using the above or other medications (including over-the-counter medications), consult your doctor before using Sialor®rino.

Protargol 200 mg powder for solution for topical use with solvent

pharmachologic effect

Antiseptic.

Composition and release form Protargol 200 mg powder for the preparation of a solution for topical use with a solvent

1 fl.

• Active ingredient: Silver proteinate (protargol) - 200.0 mg;
• Solvent: water for injection - 10 ml.

Powder for preparing a solution for topical use.

Powder for preparing a solution for topical use: 200 mg of powder in dark glass bottles of 10, 15, 25 ml, sealed with stoppers or dropper stoppers, with screw-on caps or screw-on caps with control of the first opening, the use of screw-on caps or screw-on caps is also allowed with first opening control without stoppers or dropper plugs.

Labels made of label or writing paper or a self-adhesive label are glued onto the bottles.

Solvent: water for injection (RU No. LP-002529 dated 07/08/2014) 10.0 ml in polypropylene or polyethylene ampoules or water for injection (RU No. LP-000711 dated 09/29/2011) 10.0 ml in polymer ampoules.

Each bottle of 10, 15, 25 ml with a solvent (water for injection) in a polypropylene, polyethylene or polymer ampoule of 10 ml and a cap with a pipette is placed in a polyethylene terephthalate cradle and, together with instructions for medical use, is placed in a cardboard pack.

It is allowed to pack a bottle, an ampoule with a solvent and a cap with a pipette in a cardboard pack without a holder.

Description of the dosage form

Powder for preparing a solution for topical use, yellow-brown to brown in color, light, amorphous, odorless; slightly hygroscopic; appearance changes when exposed to light.

Directions for use and doses

Locally in the form of a 2% solution.

To prepare a 2% solution, add 10 ml of solvent (water for injection) to the powder (200 mg).

Method for preparing the drug solution before use (see figure):

Before using the drug, it is recommended to rinse and clean the nasal passages.

Adults and children over 6 years old: 2-3 drops in each nasal passage 3 times a day.

Children from 3 to 6 years old: 1-2 drops in each nasal passage 3 times a day.

The course of treatment is 5-7 days.

If there is no improvement after 7 days, you should consult a doctor.

If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor. Use the drug only according to the method of use and in the doses indicated in the instructions.

Pharmacodynamics

Silver preparation.

Has an astringent, antiseptic and anti-inflammatory effect.

Dissociates with the formation of silver ions, which bind to bacterial DNA and prevent their reproduction on mucous membranes under local application.

Pharmacokinetics

When applied topically, it is practically not absorbed.

Indications for use Protargol 200 mg powder for the preparation of a solution for topical use with a solvent

Symptomatic treatment of acute nasopharyngitis (runny nose), sinusitis.

Contraindications

Hypersensitivity to the drug, atrophic rhinitis, pregnancy, breastfeeding, children under 3 years of age (for this dosage).

Application of Protargol 200 mg powder for the preparation of a solution for topical use with a solvent during pregnancy and breastfeeding

The use of the drug during pregnancy is contraindicated.

The drug is not recommended for use by nursing mothers; If it is necessary to use the drug, breastfeeding should be stopped.

special instructions

Nasal discharge may turn gray or blue.

Impact on the ability to drive vehicles and operate machinery

Does not affect.

Overdose

Symptoms

With the recommended method of use, an overdose is unlikely. Possible increased side effects. If a large amount of the drug is accidentally swallowed, irritation of the gastrointestinal tract may occur. With prolonged uncontrolled use of the drug, it is theoretically possible for a very rare disease to appear - argyrosis (gray or bluish discoloration of the skin and mucous membranes). If the recommended dosage regimen is followed, the risk of argyrosis is unlikely.

Treatment

In case of severe irritation, burning, itching of the eyes, skin, mucous membranes, rinse with plenty of water for 15 minutes. Treatment is symptomatic.

Side effects Protargol 200 mg powder for the preparation of a solution for topical use with a solvent

Mild irritation of the mucous membrane, burning, itching, allergic reactions (urticaria, atopic dermatitis, Quincke's edema, anaphylactic shock).

If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Drug interactions

Pharmacodynamic, pharmacokinetic interaction: not studied.

Pharmaceutical interaction: salts of zinc, copper, lead, silver, mercury, iron, aluminum form insoluble precipitates with a solution of silver proteinate; silver proteinate solution is inactivated by alkaloid salts and organic bases (epinephrine).

If you are using the above or other medications (including over-the-counter medications), consult your doctor before using Protargol.

special instructions

Use the recommended dose for no more than 7 days without consulting a doctor. If symptoms worsen or improvement does not occur within 3 days, you should consult your doctor. Avoid getting the drug into your eyes.

To avoid the spread of infection, it is necessary to use the drug individually. After opening, use within 14 days.

With prolonged use and overdose of oxymetazoline, the therapeutic effect may weaken, and the risk of reactive hyperemia (rhinitis medicamentosa) and atrophy of the nasal mucosa may increase.

Release form

Nasal drops 0.01%, 0.025% and 0.05%.

1 ml in a dropper tube with a valve (for a concentration of 0.01%) or 2 ml in a dropper tube with a valve (for a concentration of 0.025%) or 10 ml in polymer ampoules (for a concentration of 0.05%).

Labels are placed on dropper tubes, ampoules, and bottles.

2.5 dropper tubes of 1 ml (for a concentration of 0.01%) or 2.5 dropper tubes of 2 ml (for a concentration of 0.025%) with instructions for use are placed in a cardboard pack.

1 polymer ampoule of 10 ml (for a concentration of 0.05%) complete with a dark glass bottle with a screw neck, sealed with a spray nozzle, with instructions for use, is placed in a cardboard pack.

How does the drug work?

Protargol nasal drops for children are an antiseptic and antibacterial agent that has pronounced anti-inflammatory characteristics. The composition of protargol includes silver ions – 2-8%. The product is made to order in pharmacies. Today you can find drugs in the form of tablets that must be dissolved in water. For example, nasal drops with protargol sialor are an analogue. Collargol nasal drops for children have a similar effect.

In appearance, the drug resembles a dark brown liquid, which has a bitter taste and does not have any odor. The more silver it contains, the higher the effect of using the product. The shelf life of protargol after opening is 28 days. After this, the product loses its effectiveness. The price of protargol nasal drops is approximately 250 rubles.

As the disease progresses, lesions appear on the surface of the skin. Thanks to the use of protargol, a kind of film is formed in this place. This can be achieved due to the fact that proteins are precipitated by silver ions. Protargol for green snot reduces the sensitivity of the epithelium and has a vasoconstrictor effect, which helps suppress inflammatory processes. Through the use of silver ions, it is possible to cope with the activity of bacterial microorganisms.

Protargol drops are often prescribed for sinusitis. However, the drug is prescribed not only by otolaryngologists. The instructions for use state that it is allowed to be used in urology and for the treatment of eye diseases. However, nasal drops based on protargol are most often prescribed. With the help of the drug it is possible to cope with rhinitis.

The medicine does not provoke dysbiotic disorders and does not lead to addiction. It is allowed to be dripped for various types of bacterial rhinitis. This substance is especially useful for purulent rhinitis and sinusitis.

Drops with silver in the nose for children are prescribed if pathological processes are accompanied by pharyngitis or eustachitis. Good results can be obtained in the treatment of otitis media, blepharitis, and adenoiditis.

So, the properties of protargol allow the drug to be used for the following disorders:

1. Conjunctivitis.
2. Rhinitis.
3. Otitis.
4. Pharyngitis.
5. Adenoids.
6. Urethritis.
7. Cystitis.

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Protargol

Protargol is not used for a runny nose in a baby, but the drug is an excellent prophylactic for preventing blepharitis in newborns. For treatment to bring results, it is important to choose the right dosage. A qualified doctor can do this.

After active silver ions enter the nose, they quickly enter the microbial structure, disrupt the integrity of the membrane and interfere with their normal functioning. Protargol copes not only with bacteria, but also with fungal microorganisms, which helps prevent the development of dysbiosis in a child.

The protargolan solution is not effective against viruses, therefore it is not used for exacerbation of viral infections. With the help of the drug, a film is formed that becomes a barrier to new microorganisms. This accelerates the healing of damaged mucous membranes.

The drug helps to constrict blood vessels, which reduces swelling and nasal congestion. After the first use, inflammation slows down. By the end of therapy it is possible to completely stop the inflammation.