RINZASIP POWDER FOR PRIGING SOLUTION INSIDE SACHE 5G N10 LEMON

Instructions for use

The use of this pharmaceutical product usually does not cause difficulties.
You need to pour the contents of one dose of the drug into a glass of pre-boiled hot water and stir the liquid thoroughly. You need to drink the medicine immediately after preparing it. The prepared solution cannot be stored. https://youtube.com/watch?v=MiwFCVoppc4

If such a desire arises, you can add a little honey or sugar to the contents of the sachet in the water.

Dosing Features:

• children over 15 years of age and adult patients can drink from 3 to 4 sachets per day with a time interval of 6 hours;
• the course of therapy can last from three to five days.

It is very important to read the instructions, in particular the conditions that reflect the specifics of using the medication. https://www.youtube.com/embed/fVzjpeuauDQ

https://youtube.com/watch?v=fVzjpeuauDQ

Special conditions:

• while using Rinzasip, you should not drink alcohol, take antidepressants or other drugs that have a hypnotic effect;
• It is prohibited to take other products containing paracetamol;
• if it is necessary to use other pharmaceutical drugs simultaneously, you should obtain specialist advice about their interactions in advance;
• if the patient’s condition does not improve within 3-5 days from the start of drug therapy, you should consult a doctor;
• the drug has a slight effect on the reaction rate, so you should avoid working with complex mechanisms, as well as driving vehicles.

Despite the fact that you can purchase the product without presenting a medical prescription, if you have any doubts about the possibility of using this medicine, you should consult your doctor.

It is very important to strictly follow the dosage regimen indicated in the instructions, otherwise the likelihood of an overdose increases, which is especially dangerous due to the presence of paracetamol in Rinzasip. Overdose symptom:

Overdose symptom:

• nausea;
• dyspeptic disorders;
• epigastric pain;
• loss of appetite;
• liver dysfunction;
• paleness of the skin.

To alleviate the patient’s condition, you should immediately rinse his stomach, give him sorbents to drink, and seek medical help. In a hospital setting, a person can be given paracetamol antidotes - acetylcysteine, methionine. In addition, to improve his well-being, symptomatic therapy is indicated.

Rinzasip - a remedy for flu and colds

Rinzasip is a complex medicine containing several active substances. The drug is used to eliminate negative symptoms that develop during an acute respiratory viral infection that affects the respiratory organs.

Release forms and composition of the drug

The composition of the drug includes several components, each of which performs the functions assigned to it, eliminating one or another symptom.

Rinzasip with vitamin C is a powder packaged in packets for single doses. The powder is granules of two colors: orange and white. The medicine may have different tastes, depending on what flavor was added (blackcurrant, orange, lemon).

The pharmacological action, pharmacodynamics of Rinzasip, is provided by the following active ingredients:

• phenylephrine hydrochloride (10 mg);
• paracetamol (750 mg);
• pheniramine maleate (20 mg);
• caffeine (30 mg);
• sodium citrate (500 mg);
• for preparations with different tastes: citric acid (200 mg);
• sucrose;
• carmoisin dye.

There is only a powder form of release; the packaging is a cardboard box containing from 5 to 100 sachets of powder.

The therapeutic effectiveness of the drug is achieved due to the action of its main components:

1. Paracetamol : a substance belonging to the group of non-steroidal and anti-inflammatory drugs. Responsible for blocking cyclooxygenase, which prevents it from stimulating the production of prostaglandins (mediators of inflammation and pain) by the hypothalamus.
2. Caffeine : a brain stimulant that increases productivity and improves mood.
3. Phenylephrine hydrochloride: a vascular alpha receptor stimulant that causes vasoconstriction, resulting in decreased tissue swelling, decreased nasal mucus, and easier breathing.
4. Pheniramine maleate : a histamine receptor blocker that helps reduce allergic manifestations that necessarily develop against the background of every acute respiratory viral infection.

Each of these substances is actively absorbed by the walls of the digestive tract, penetrating into the bloodstream. Metabolic processes of all active substances pass through the liver, after which active metabolites are released. They leave the body along with urine.

Some people believe that Rinzasip is a drug. This to me is completely erroneous; the drug does not contain substances that can have such a negative effect on the human body. Compliance with the rules of dosing of a pharmaceutical product does not in any way affect a person’s consciousness, only removing the catarrhal symptoms of a cold.

Indications and contraindications

The use of Rinzasip is indicated for people suffering from influenza, ARVI, febrile conditions caused by the development of other infectious pathologies, as well as after orthopedic operations.

The medicine is used to eliminate the following cold symptoms:

• headaches, muscle, joint pain;
• nasal congestion;
• sneezing;
• cough;
• increased body temperature;
• general weakness;
• discharge from the nasal cavity.

Despite the high effectiveness of the drug, not all patients can use it.

Contraindications to the use of Rinzasip:

• pregnancy period;
• breastfeeding time;
• child's age under 15 years;
• simultaneous use of other medications related to monoamine oxidase inhibitors, tricyclic antidepressants, beta-blockers;
• personal intolerance to the components of the drug.

In addition, there is a list of indications when you can take the powder, but only after receiving doctor’s approval:

• atherosclerosis;
• increased blood pressure readings;
• diabetes;
• thyrotoxicosis;
• insufficiency of production of a number of enzymes;
• bronchial asthma;
• systemic blood pathologies;
• chronic pulmonary obstruction;
• liver diseases.

Before starting treatment with Rinzasip, you should make sure that the person does not have conditions where its use is prohibited.

Instructions for use

The use of this pharmaceutical product usually does not cause difficulties. You need to pour the contents of one dose of the drug into a glass of pre-boiled hot water and stir the liquid thoroughly. You need to drink the medicine immediately after preparing it. The prepared solution cannot be stored.

If such a desire arises, you can add a little honey or sugar to the contents of the sachet in the water.

Dosing Features:

• children over 15 years of age and adult patients can drink from 3 to 4 sachets per day with a time interval of 6 hours;
• the course of therapy can last from three to five days.

It is very important to read the instructions, in particular the conditions that reflect the specifics of using the medication.

Special conditions:

• while using Rinzasip, you should not drink alcohol, take antidepressants or other drugs that have a hypnotic effect;
• It is prohibited to take other products containing paracetamol;
• if it is necessary to use other pharmaceutical drugs simultaneously, you should obtain specialist advice about their interactions in advance;
• if the patient’s condition does not improve within 3-5 days from the start of drug therapy, you should consult a doctor;
• the drug has a slight effect on the reaction rate, so you should avoid working with complex mechanisms, as well as driving vehicles.

Despite the fact that you can purchase the product without presenting a medical prescription, if you have any doubts about the possibility of using this medicine, you should consult your doctor.

It is very important to strictly follow the dosage regimen indicated in the instructions, otherwise the likelihood of an overdose increases, which is especially dangerous due to the presence of paracetamol in Rinzasip.

Overdose symptom:

• nausea;
• dyspeptic disorders;
• epigastric pain;
• loss of appetite;
• liver dysfunction;
• paleness of the skin.

To alleviate the patient’s condition, you should immediately rinse his stomach, give him sorbents to drink, and seek medical help. In a hospital setting, a person can be given paracetamol antidotes - acetylcysteine, methionine. In addition, to improve his well-being, symptomatic therapy is indicated.

Rinzasip for children

Children's dosages of the drug are not sold. Rinzasip is not used for children until they reach 15 years of age.

Rinzasip during pregnancy and lactation

During pregnancy, Rinzasip powder is not allowed to be used. The drug easily overcomes the blood-brain and placental barriers, penetrating the fetus and disrupting the normal development of its internal organs and systems.

Rinzasip may pass into breast milk during breastfeeding.

Pregnancy, lactation, children under 15 years of age are contraindications to the use of pharmaceuticals.

Side effects

Using the drug for a long time can provoke the development of negative manifestations from various body systems.

Side effects:

• Gastrointestinal organs: pain in the abdomen, dryness of the oral mucosa, nausea, changes in liver functionality;
• heart and blood vessels: increased blood pressure, increased heart rate;
• Central nervous system: dizziness, headaches, sleep disturbances, increased nervous excitability;
• sense organs: dilated pupils, increased intraocular pressure;
• circulatory system: development of thrombocytopenia, pancytopenia, occurrence of agranulocytosis, anemia;
• organs of the urinary system: delay in the normal rhythm of urination, toxic damage to the kidneys;
• allergic manifestations: the appearance of redness and rashes on the skin, accompanied by severe itching. development of Quincke's edema, bronchospasm, anaphylactic shock.

Any, even minor, adverse reactions are a reason to discontinue the drug and seek medical help.

Before using the medicine, it is very important to study the instructions for the compatibility of other pharmaceuticals with Rinzasip.

Drug interactions:

• enhancing the effect of ethanol, sedatives, monoamine oxidase inhibitors;
• increased risk of developing adverse reactions when using drugs against Parkinson's disease, antipsychotic compounds, antidepressants, phenothiazine derivatives;
• combination with glucocorticosteroids increases the risk of glaucoma;
• the use of Rinzasip and diuretics reduces the effectiveness of the latter;
• the hepatotoxic effect of paracetamol increases if a person simultaneously takes carbamazepine, rifampicin, barbiturates, diphenin;
• the antihypertensive effect of Guanethidine will be reduced;
• Guanethidine may increase the stimulant effect produced by phenylephrine hydrochloride;
• combined use of Halothane may provoke the development of ventricular arrhythmia;
• tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine hydrochloride.

Analogues of the drug

Rinzasip has several analogues with similar composition and pharmaceutical effects.

Rinzasip analogues:

1. Rinicold Hotmix (made in India): costs a little less than Rinzasip, has the same composition of active ingredients. Not allowed for pregnant women, nursing mothers and children under 6 years of age.
2. Rinza (made in India): refers to analgesic drugs. Used to eliminate the symptoms of acute respiratory viral infections and influenza, through exposure to the same active substances.
3. Maxicold (made in Russia): a combined product, in the dosage form of a powder for dissolution in water. Contains ascorbic acid and paracetamol.
4. Theraflu (made in Canada): a drug used to get rid of the symptoms of infectious and inflammatory diseases. It is in powder form and contains paracetamol, phenylephrine and pheniramine maleate.
5. Grippoflu (made in Russia): powder used in children over 12 years of age, but prohibited for pregnant women, lactating women and those suffering from diabetes. Indicated to reduce negative cold symptoms.

Any combination drug aimed at reducing the manifestations of ARVI should be selected strictly after reading the instructions or consulting with a doctor. Such medications contain a whole complex of constituent substances that have different effects on the human body.

Source: https://bezgrippa.com/preparaty/rinzasip/

"Rinza": instructions for use - tablets for children

In tablet form, the treatment is indicated for children over 15 years of age. The dosage in this case is the same as for adults. For young children, a special children's form has been developed - “Rinzasip for Children”, which is a powder in a sachet for making a hot drink.

The child's treatment regimen is as follows:

• 1 sachet of medicine is poured into a glass and poured with heated boiled water (not boiling water), mixed thoroughly;
• single dosage of sachets - 1 pc.;
• highest daily dosage: 6–10 years – 2 doses; 10-12 years - 3 doses, 12-15 years - 4 doses;
• the recommended interval between doses is 4–6 hours;
• the total duration of therapy is no more than 5 days.

The drug is not prescribed to children under 6 years of age.

The medicine contains the following components:

• paracetamol (280 mg);
• pheniramine (10 mg);
• vitamin C (100 mg);
• auxiliary ingredients: sweeteners - sucrose, sugar substitute aspartame, sunet; source of magnesium vitamin - magnesium citrate; raspberry flavoring and coloring.

Thanks to the presence of vitamin C, the drink allows you to restore the child’s natural immunity. The effect of this vitamin on the body is determined by the acceleration of metabolic processes as a result of the formation of the necessary enzymes; antioxidant effect on body cells; participation in carbohydrate metabolism, the synthesis of hemoglobin and collagen, necessary for normal growth of teeth, bones and tissue regeneration.

Ascorbic acid does not accumulate in the body, so it is necessary to replenish it daily with food or medications, especially during illness.

"Rinza": instructions for use - tablets

Before using medications to combat cold symptoms, even if they are available over-the-counter, you must carefully read the accompanying documentation, study the drug dosage regimen, possible side effects, contraindications and other data. The drug “Rinza-tablets” is no exception; the medication instructions provide precise information about the recommended dosage, which should not be exceeded.

In the modern rhythm of life, a long cold or flu is an unaffordable “luxury”. Although viral and bacterial diseases of this group of diseases are not dangerous, everyone would like to quickly get rid of unpleasant and painful symptoms. But do not forget that the abuse of drugs in order to speed up recovery can cause harm to the body.

Side effects and overdose

Side effects are similar for Rinzasip and Rinza-tablets; The instructions contain the following information about this:

1. Taking medications may be accompanied by allergic manifestations: skin rashes, itching, swelling and, in rare cases, anaphylactic shock.
2. Side effects when exposed to the central nervous system manifest themselves in the form of dizziness, lethargy, headache, drowsiness or sleep disturbances, and excitability.
3. A negative effect on the cardiovascular system can be expressed by increased blood pressure, tachycardia, and palpitations.
4. Digestive system disorders are possible: nausea, diarrhea, vomiting, abdominal pain.
5. Disturbances in the hematopoietic system: anemia, agranulocytosis, thrombocytopenia, leukopenia, methemoglobinemia, pancytopenia.
6. In the genitourinary system, renal colic, dysuria, and glucosuria may occur.
7. Pathologies of other organs and systems: increased intraocular pressure, bronchospasm, blurred vision, dilated pupils, acute pustulosis, extensive erythema, Lyell's syndrome.

In case of overdose, gastrointestinal disorders, tachycardia, headache, increased blood pressure, impaired liver and kidney function, insomnia, agitation, tremor, delirium, hallucinations, anemia, convulsions, anticholinergic syndrome, dysuria, hepatic encephalopathy and, in severe cases, may occur. coma.

Side effects

Using the drug for a long time can provoke the development of negative manifestations from various body systems.

Side effects:

Before using the medicine, it is very important to study the instructions for the compatibility of other pharmaceuticals with Rinzasip. Drug interactions:

Drug interactions:

• enhancing the effect of ethanol, sedatives, monoamine oxidase inhibitors;
• increased risk of developing adverse reactions when using drugs against Parkinson's disease, antipsychotic compounds, antidepressants, phenothiazine derivatives;
• combination with glucocorticosteroids increases the risk of glaucoma;
• the use of Rinzasip and diuretics reduces the effectiveness of the latter;
• the hepatotoxic effect of paracetamol increases if a person simultaneously takes carbamazepine, rifampicin, barbiturates, diphenin;
• the antihypertensive effect of Guanethidine will be reduced;
• Guanethidine may increase the stimulant effect produced by phenylephrine hydrochloride;
• combined use of Halothane may provoke the development of ventricular arrhythmia;
• tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine hydrochloride.

Release form, composition and packaging

Powder for the preparation of a solution for oral administration is light orange to orange in color, with white and orange inclusions, with orange flavor.

Excipients: anhydrous citric acid, sodium saccharin, sodium citrate, sucrose, sunset yellow FCF dye, orange flavor.

5 g - sachet (5) - cardboard packs.5 g - sachet (10) - cardboard packs.5 g - sachet (25) - cardboard packs.5 g - sachet (50) - cardboard packs.5 g - sachet (100 ) - cardboard packs.

Powder for preparing a solution for oral administration is light yellow to yellow in color, with white and yellow specks, with a lemon flavor.

Excipients: anhydrous citric acid, sodium saccharin, sodium citrate, sucrose, quinoline yellow dye, lemon flavor.

5 g - sachet (5) - cardboard packs.5 g - sachet (10) - cardboard packs.5 g - sachet (25) - cardboard packs.5 g - sachet (50) - cardboard packs.5 g - sachet (100 ) - cardboard packs.

Powder for preparing a solution for oral administration is pink to pinkish-red in color, with white and red specks, with a blackcurrant flavor.

Excipients: anhydrous citric acid, sodium saccharin, sodium citrate, sucrose, carmoisin dye, fruit flavor, raspberry flavor, blackcurrant flavor.

5 g - sachet (5) - cardboard packs.5 g - sachet (10) - cardboard packs.5 g - sachet (25) - cardboard packs.5 g - sachet (50) - cardboard packs.5 g - sachet (100 ) - cardboard packs.

Release forms and composition of the drug

The composition of the drug includes several components, each of which performs the functions assigned to it, eliminating one or another symptom.

Rinzasip with vitamin C is a powder packaged in packets for single doses. The powder is granules of two colors: orange and white. The medicine may have different tastes, depending on what flavor was added (blackcurrant, orange, lemon).

The pharmacological action, pharmacodynamics of Rinzasip, is provided by the following active ingredients:

• phenylephrine hydrochloride (10 mg);
• paracetamol (750 mg);
• pheniramine maleate (20 mg);
• caffeine (30 mg);
• sodium citrate (500 mg);
• for preparations with different tastes: citric acid (200 mg);
• sucrose;
• carmoisin dye.

There is only a powder form of release; the packaging is a cardboard box containing from 5 to 100 sachets of powder.

The therapeutic effectiveness of the drug is achieved due to the action of its main components:

1. Paracetamol : a substance belonging to the group of non-steroidal and anti-inflammatory drugs. Responsible for blocking cyclooxygenase, which prevents it from stimulating the production of prostaglandins (mediators of inflammation and pain) by the hypothalamus.
2. Caffeine : a brain stimulant that increases productivity and improves mood.
3. Phenylephrine hydrochloride: a vascular alpha receptor stimulant that causes vasoconstriction, resulting in decreased tissue swelling, decreased nasal mucus, and easier breathing.
4. Pheniramine maleate : a histamine receptor blocker that helps reduce allergic manifestations that necessarily develop against the background of every acute respiratory viral infection.

Each of these substances is actively absorbed by the walls of the digestive tract, penetrating into the bloodstream. Metabolic processes of all active substances pass through the liver, after which active metabolites are released. They leave the body along with urine.

Some people believe that Rinzasip is a drug. This to me is completely erroneous; the drug does not contain substances that can have such a negative effect on the human body. Compliance with the rules of dosing of a pharmaceutical product does not in any way affect a person’s consciousness, only removing the catarrhal symptoms of a cold.

Pharmacological properties

Pharmacodynamics

Paracetamol is part of the anilides group and is an analgesic and antipyretic. It has antipyretic and analgesic (eliminates headache, joint and muscle pain, as well as sore throat) effects, and is also characterized by slight anti-inflammatory activity. The substance exhibits virtually no toxic properties compared to other drugs in this group.

Paracetamol is an inhibitor of prostaglandin synthesis. This process is carried out by blocking both forms of the cyclooxygenase enzyme. The compound also selectively blocks COX3 (central nervous system) without affecting COX1 and COX2, which are localized in the periphery.

Paracetamol does not negatively affect the functioning of the gastrointestinal tract and does not lead to disturbances in water-electrolyte balance and retention of sodium ions in the body.

Pheniramine is a potent antihistamine and histamine H1 receptor blocker. It reduces the degree of capillary permeability, eliminates bronchial spasm and is characterized by anti-edematous activity, eliminates itching of the throat, nose and eyes, hyperemia and swelling of the paranasal sinuses and mucous membranes of the nose and nasopharynx. The substance also exhibits weak sedative properties, reduces exudative manifestations and can reduce the intensity of mucus production in the bronchi and nasopharynx.

Caffeine stimulates the central nervous system and improves both mental and physical performance. In combination with paracetamol, it increases effectiveness and accelerates the absorption of the latter in the body.

Phenylephrine is an alpha-adrenergic agonist that helps to constrict blood vessels, reduce pressure in the paranasal sinuses and middle ear, eliminate swelling of the mucous membranes, and also increases blood pressure. If a substance is used frequently and over a long period of time, the body may develop tolerance to it, which will require increasing the dosage.

Pharmacokinetics

Paracetamol crosses the blood-brain and placental barriers and is absorbed in the small intestine. The degree of binding to blood plasma proteins is quite high. The maximum concentration of the substance in the body is determined 30–60 minutes after administration. The pharmacokinetics of the remaining active components of Rinzasip have not been sufficiently studied.

pharmachologic effect

Rinzasip is a combination drug. The caffeine in its composition is necessary in order to have an effect on the central nervous system. This will help you get rid of increased drowsiness and fatigue.

This component can also increase physical and mental performance. Paracetamol has analytical and antipyretic properties. It will help reduce the intensity of symptoms such as joint, headache or muscle pain. In addition, this component allows you to get rid of high temperatures.

Phenylephrine reduces the overflow of blood vessels in the respiratory mucosa, as well as swelling of the paranasal sinuses. Another component is pheniramine. It is necessary to relieve the patient from itching in the throat, eyes and nose.

Side effects

When taking Rinzasip for children, the following adverse reactions may develop:

In very rare cases, the following serious skin reactions occur while taking Rinzasip for children:

• Stevens-Johnson syndrome (erythema malignant exudative): a severe form of erythema multiforme, accompanied by the appearance of blisters on the skin and mucous membranes, including the eyes, mouth, throat and genitals;
• acute generalized exanthematous pustulosis: an acute condition manifested by fever, the appearance of a pustular rash, diffuse erythema with burning and itching, sometimes accompanied by swelling of the mucous membranes, face and hands;
• toxic epidermal necrolysis (Lyell's syndrome): severe allergic bullous dermatitis, resulting from extensive death of epithelial tissue cells (keratinocytes) and leading to detachment of large areas of skin at the dermoepidermal junction (externally, the skin looks like it has been scalded with boiling water).

Composition, release forms, instructions for use

This drug is available in the form:

• tablets;
• powder for preparing a solution for oral administration - rinzasip with vitamin C ( for adults
  ) and rinzasip for children;
• lozenges - rinza lorcept.

Rinz tablets

500 mg 30 mg 10 mg 2 mg Additional components of Rinza tablets are:

• silicon dioxide;
• corn starch;
• magnesium stearate;
• povidone;
• sodium methyl parahydroxybenzoate;
• talc;
• crimson dye;
• sodium carboxymethyl starch.

10 or 20 tablets

Drink (powder for dissolution) rinzasip

200 mg 30 mg 750 mg 10 mg 20 mg ascorbic acid sachets of 5 g each
Excipients are:

• lemon acid;
• sodium saccharinate;
• sodium citrate;
• sucrose;
• sunset yellow dye;
• quinoline yellow dye;
• Azorubine dye;
• orange flavor;
• lemon flavor;
• fruit flavor;
• raspberry flavor;
• blackcurrant flavouring.

Rinzasip for children

sachet 100 mg 280 mg 10 mg Additional components of the drug for children are:

• aspartame;
• potassium acesulfate;
• magnesium citrate;
• sucrose;
• raspberry flavor;
• Azorubine dye.

Analogues of the drug Rinza

If necessary, Rinza tablets can be replaced with the following drugs:

• Gripgo
  is a drug that contains the same components as Rinza. It provides symptomatic treatment - reduces fever, headache, nasal congestion, sore throat, pain in the eyes, muscles and joints.
• Rinicold
  is a combination drug that treats colds accompanied by runny nose, headache, fever, nasal congestion, and chills.
• Combiflu
  is a drug that is available in tablet form and is also used for the symptomatic treatment of acute viral diseases of the respiratory tract.

If necessary, Rinzasip with vitamin C can be replaced:

• anti-influenza;
• Fervex;
• Theraflu;
• coldact flu plus and others.

RINZASIP: instructions, reviews, analogues, price in pharmacies

The drug Rinzasip is a combination drug that has antipyretic, analgesic, alpha-adrenergic, vasoconstrictor and antihistamine effects, and eliminates the symptoms of “colds”.
Paracetamol is a non-narcotic analgesic; blocks cyclooxygenase (COX), mainly in the central nervous system, affecting the centers of pain and thermoregulation; has an analgesic and antipyretic effect. Phenylephrine is an alpha-adrenergic agonist with a moderate vasoconstrictor effect.

Reduces swelling and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses. Pheniramine is a blocker of H1-histamine receptors. Has an antiallergic effect: eliminates itching of the eyes, nose and throat, swelling and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and paranasal sinuses, reduces exudative manifestations.

Caffeine has a stimulating effect on the central nervous system, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance, reduces fatigue and drowsiness.

Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and in the synthesis of steroid hormones; reduces vascular permeability and increases the body's resistance to various adverse environmental factors

Mode of application

Pour the contents of 1 sachet (sachet) of Rinzasip into a glass, add hot water, stir until completely dissolved and drink (you can add sugar or honey if desired).

Adults and children over 15 years of age: take one sachet 3-4 times a day with intervals between doses of 4-6 hours. The maximum daily dose is 4 sachets.

The course of treatment without consulting a doctor is no more than 5 days.

Pregnancy

The drug Rinzasip is contraindicated during pregnancy and lactation.

Interaction with other drugs

Rinzasip enhances the effects of monoamine oxidase inhibitors, sedative drugs, ethanol. Antidepressants, antiparkinsonian drugs, antipsychotics, phenothiazine derivatives increase the risk of developing urinary retention, dry oral mucosa, and constipation.

Glucocorticosteroids increase the risk of developing glaucoma. Paracetamol reduces the effectiveness of uricosuric drugs. Pheniramine simultaneously with monoamine oxidase inhibitors and furazolidone can lead to hypertensive crisis, agitation, and hyperpyrexia.

Tricyclic antidepressants enhance the alpha-adrenomimetic effect of phenylephrine; simultaneous administration of halothane increases the risk of developing ventricular arrhythmia. When administered simultaneously with barbiturates, phenytoin, carbamazepine, rifampicin, etc.

inducers of microsomal liver enzymes increases the risk of developing the hepatotoxic effect of paracetamol.

Storage conditions

Store in a dry place at a temperature not exceeding 25 ° C. Indication of the need to store the medicinal product in places inaccessible to children. Store in places inaccessible to children.

Release form:

Rinzasip – powder for preparing a solution for oral administration (orange, lemon, blackcurrant). Packaging: 10 sachets.

Compound

1 sachet (5 g) Rinzasip contains active ingredients: ascorbic acid (Vitamin C) – 200 mg, caffeine – 30 mg, paracetamol – 750 mg, phenylephrine hydrochloride – 10 mg, pheniramine maleate – 20 mg.

Excipients: orange: citric acid 200.0 mg, sodium saccharinate 40.0 mg, sodium citrate 500.0 mg, sucrose 3062.5 mg, sunset yellow dye (E110) 7.5 mg, orange flavor 150.0 mg ;- citric: citric acid 200.0 mg, sodium saccharinate 40.0 mg, sodium citrate 500.0 mg, sucrose 3136.0 mg, quinoline yellow dye (E104) 1.0 mg, lemon flavor 83.0 mg;- blackcurrant: citric acid 200.0 mg, sodium saccharinate 40.0 mg, sodium citrate 500.0 mg, sucrose 2915.0 mg, azorubine dye (E122) 4.0 mg, fruit flavor (Tutti Frutti) 166.7 mg, raspberry flavor 66.7 mg, blackcurrant flavor 66.7 mg.

Overdose

An overdose of Rinzasip is usually caused by paracetamol, and its symptoms appear after taking 10–15 g of the latter. It is usually expressed by symptoms such as nausea, vomiting, anorexia, increased activity of liver transaminases, hepatonecrosis, increased prothrombin time, and pale skin. If they occur, you should immediately consult a doctor.

As treatment, gastric lavage is recommended, followed by the intake of activated carbon, symptomatic therapy and the administration of methionine 8–9 hours after an overdose and acetylcysteine ​​– after 12 hours.

RINZASIP

Drug for symptomatic treatment of acute respiratory diseases

Active ingredients

– caffeine (caffeine) – paracetamol (paracetamol) – phenylephrine hydrochloride (phenylephrine)

– pheniramine maleate (pheniramine)

Release form, composition and packaging

◊ Powder for solution for oral administration

from light orange to orange in color, with white and orange inclusions, with an orange flavor.

Excipients: anhydrous citric acid, sodium saccharin, sodium citrate, sucrose, sunset yellow FCF, orange flavor.

5 g – sachet (5) – cardboard packs. 5 g – sachet (10) – cardboard packs. 5 g – sachet (25) – cardboard packs. 5 g – sachet (50) – cardboard packs.

5 g – sachet (100) – cardboard packs.

◊ Powder for solution for oral administration

from light yellow to yellow, with white and yellow splashes, with a lemon flavor.

Excipients: anhydrous citric acid, sodium saccharin, sodium citrate, sucrose, quinoline yellow dye, lemon flavor.

5 g – sachet (5) – cardboard packs. 5 g – sachet (10) – cardboard packs. 5 g – sachet (25) – cardboard packs. 5 g – sachet (50) – cardboard packs.

5 g – sachet (100) – cardboard packs.

◊ Powder for solution for oral administration

pink to pinkish-red in color, with white and red flecks, with a blackcurrant flavor.

Excipients: anhydrous citric acid, sodium saccharin, sodium citrate, sucrose, carmoisin dye, fruit flavor, raspberry flavor, blackcurrant flavor.

5 g – sachet (5) – cardboard packs. 5 g – sachet (10) – cardboard packs. 5 g – sachet (25) – cardboard packs. 5 g – sachet (50) – cardboard packs.

5 g – sachet (100) – cardboard packs.

pharmachologic effect

A combined drug used for colds.

Paracetamol is an analgesic-antipyretic, reduces the pain syndrome observed during colds - sore throat, headache, muscle and joint pain, reduces high body temperature.

Phenylephrine is a sympathomimetic, has a vasoconstrictor effect on peripheral vessels, reduces swelling and hyperemia of the mucous membrane of the upper respiratory tract and sinuses.

Pheniramine is a blocker of histamine H1 receptors, has an antiallergic effect: eliminates itching (including eyes, nose), swelling and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and sinuses, reduces exudation phenomena.

Caffeine has a stimulating effect on the central nervous system, which leads to a decrease in fatigue and drowsiness and an increase in mental and physical performance.

Pharmacokinetics

Data on the pharmacokinetics of the drug Rinzasip are not provided.

Indications

Symptomatic therapy (to reduce pain, fever and rhinorrhea):

- flu;

— ARVI and other colds.

Dosage

Adults and children over 15 years old

Prescribe 1 sachet 3-4 times a day with intervals between doses of at least 4-6 hours. The maximum daily dose is 4 sachets. The course of treatment should not exceed 5 days.

The drug is taken 1-2 hours after meals with plenty of liquid.

The contents of 1 sachet are dissolved in 1 glass of hot water (stir until completely dissolved). You can add sugar or honey.

From the side of the central nervous system:

dizziness, difficulty falling asleep, increased excitability, mydriasis, increased intraocular pressure, accommodation paresis.

From the cardiovascular system:

increased blood pressure, tachycardia.

From the digestive system:

nausea, epigastric pain, dry mouth, hepatotoxic effect.

From the hematopoietic system:

anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia.

From the urinary system:

urinary retention, nephrotoxic effect (papillary necrosis).

Allergic reactions:

skin rash, itching, urticaria, angioedema.

Other:

broncho-obstructive syndrome.

Overdose

Symptoms of overdose due to the effects of paracetamol appear when taking the drug in a dose corresponding to 10-15 g of paracetamol.

Symptoms:

pallor of the skin, anorexia, nausea, vomiting, increased activity of liver transaminases, hepatonecrosis, liver failure (increased prothrombin time).

Treatment:

gastric lavage, activated carbon orally; carrying out symptomatic therapy, administering methionine 8-9 hours after an overdose and N-acetylcysteine ​​after 12 hours.

Pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

For impaired renal function

Carefully _

the drug is prescribed for renal failure.

For liver dysfunction

Carefully _

The drug is prescribed to patients with hereditary hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndrome) and liver failure.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

The drug should be stored in a dry place, out of reach of children, at a temperature not exceeding 25°C. Shelf life – 3 years.

The description of the drug RINZASIP is based on officially approved instructions for use and approved by the manufacturer.

Found an error? Select it and press Ctrl+Enter.

Source: https://health.mail.ru/drug/rinzasip/

Basic pharmacological properties of the drug

This drug is a combination drug that immediately affects several main mechanisms of the development of colds. Paracetamol is a non-steroidal pain reliever with a mild anti-inflammatory effect. It is also worth noting that this component only reduces the “feverish” temperature. Paracetamol is quickly absorbed by the tissues of the digestive system; at normal doses, it does not affect the mucous membrane of the stomach and intestines, and does not affect the water-salt balance.

Phenylephrine hydrochloride causes constriction of small vessels, thereby reducing swelling of the mucous membrane of the nasal passages, facilitating breathing and reducing the severity of exudative phenomena.

Pheniramine maleate, in turn, relieves spasm of smooth muscles (including bronchospasm), reduces swelling, and has mild sedative properties.

Caffeine stimulates the activity of the central nervous system, eliminates drowsiness, increases performance, and also enhances the analgesic effect of paracetamol.

RINZASIP FOR CHILDREN contraindications for use

Hypersensitivity to paracetamol and other components included in the drug; taking other medications containing substances included in RINZASIP FOR CHILDREN; severe dysfunction of the liver and kidneys; blood diseases deficiency of the enzyme glucose-6-phosphate dehydrogenase, phenylketonuria; children under 6 years of age.

Precautions for use

Diabetes mellitus, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes).

The drug should not be taken together with other medicines containing paracetamol. During the treatment period, monitoring of the functional state of the liver, kidneys and peripheral blood picture is necessary. Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.

If there is no therapeutic effect (hyperthermia for more than 3 days and pain for more than 5 days), you should consult a doctor.

The drug contains sucrose, which must be taken into account for children suffering from diabetes mellitus, as well as children on a hypocaloric diet. 1 single dose of the drug contains 2361.7 mg of sucrose, which corresponds to 0.20 XE.

Contraindications

Contraindications to the use of Rinzasip are:

• Pregnancy and lactation (breastfeeding);
• Children under 15 years of age;
• Simultaneous use of medications that contain the active components of Rinzasip, MAO inhibitors, tricyclic antidepressants, beta-blockers;
• Hypersensitivity to paracetamol and other substances of the drug.

Rinzasip should be taken with caution in case of diseases such as:

• Arterial hypertension;
• Severe atherosclerosis of the coronary arteries;
• Pheochromocytoma;
• Thyrotoxicosis;
• Bronchial asthma;
• Diabetes;
• Glucose-6-phosphate dehydrogenase deficiency;
• Chronic obstructive disease;
• Hereditary hyperbilirubinemia, including Gilbert, Dubin-Johnson and Rotor syndromes;
• Blood diseases;
• Angle-closure glaucoma;
• Liver and/or renal failure;
• Prostatic hyperplasia.

Indications and contraindications

It is important to use Rinzasip when symptoms of acute respiratory diseases occur. They are mainly accompanied by symptoms such as high fever, headaches, runny nose, and body aches.

Experts have identified several conditions in which taking this drug would be detrimental to the patient’s health. The medicine cannot be used for treatment in the following cases:

1. The period of breastfeeding and pregnancy.
2. Allergy to active or excipients.
3. Simultaneous use with drugs that have the same active ingredients as Rinzasip.
4. The medicine is not taken by people under 15 years of age.

This drug is used with extreme caution for treatment if the patient has atherosclerosis of the coronary arteries or high blood pressure. The remedy is also not recommended for people with diabetes mellitus, chronic lung pathologies, bronchial asthma and systemic blood diseases.

In this regard, before purchasing Rinzasip, you should definitely consult a doctor.

Indications and contraindications

The use of Rinzasip is indicated for people suffering from influenza, ARVI, febrile conditions caused by the development of other infectious pathologies, as well as after orthopedic operations.

The medicine is used to eliminate the following cold symptoms:

• headaches, muscle, joint pain;
• nasal congestion;
• sneezing;
• cough;
• increased body temperature;
• general weakness;
• discharge from the nasal cavity.

Despite the high effectiveness of the drug, not all patients can use it.

Contraindications to the use of Rinzasip:

• pregnancy period;
• breastfeeding time;
• child's age under 15 years;
• simultaneous use of other medications related to monoamine oxidase inhibitors, tricyclic antidepressants, beta-blockers;
• personal intolerance to the components of the drug.

In addition, there is a list of indications when you can take the powder, but only after receiving doctor’s approval:

• atherosclerosis;
• increased blood pressure readings;
• diabetes;
• thyrotoxicosis;
• insufficiency of production of a number of enzymes;
• bronchial asthma;
• systemic blood pathologies;
• chronic pulmonary obstruction;
• liver diseases.

Side effects after using the drug Rinza

Using a rhinza can be complicated:

• Changes in the nervous system.
  This is accompanied by headache, dizziness, increased excitability, and drowsiness.
• Disorders of the cardiovascular system.
  In this case, there is an increase in blood pressure, tachycardia, and a feeling of palpitations.
• Disorders of the digestive system.
  These disorders are manifested by nausea, vomiting, pain in the epigastric region, diarrhea (
  diarrhea
  ), dryness of the oral mucosa.
• Damage to the blood system.
  Rinza can negatively affect the process of hematopoiesis, as a result of which anemia (
  low hemoglobin in the blood
  ), thrombocytopenia (
  low platelet count in the blood
  ), leukopenia (
  low white blood cells - leukocytes
  ), and methemoglobinemia (
  increased methemoglobin
  ) can occur.
• Changes in the urinary system.
  The use of Rinza can be complicated by renal colic, glucosuria (
  the presence of glucose in the urine
  ), and difficulty urinating.
• Serious skin reactions, which are extremely rare.
  These reactions can be acute generalized exanthematous pustulosis (
  a disease characterized by the development of purulent rashes on the skin, accompanied by burning and itching, fever
  ), Steven-Johnson syndrome (
  a condition in which blisters appear on the mucous membrane of the mouth, throat, eyes, and genitals
  ). Toxic epidermal necrolysis, which is characterized by the detachment of large areas of skin, may also occur. As a result, the affected skin has the appearance of skin scalded by boiling water.

Interaction of Rinza with other drugs

Interaction of Rinza with other medications

Interaction

When combined with the drug, the effect of ethanol, sedatives and MAO inhibitors is enhanced.

The likelihood of adverse reactions from the drug increases when combined with antidepressants, neuroleptics, phenothiazine derivatives, corticosteroids, and antiparkinsonian drugs.

The effectiveness of diuretics taken simultaneously with paracetamol is significantly reduced.

When combined with guanethidine, the hypotensive effect of the drug is reduced, and the alpha-adrenergic stimulating effect of Rinzasip is enhanced.

It is not recommended to combine the drug with barbiturates, carbamazepine, inducers of microsomal liver enzymes, and diphenin due to increased load on the liver.