ACC Long tablets are a mucolytic drug. It is used for diseases of the respiratory system in which difficult to separate viscous sputum is formed in: acute and chronic bronchitis, obstructive bronchitis, pneumonia, laryngitis, tracheitis, bronchial asthma.
Registration number:
P N008857
Trade name of the drug:
ACC® Long
International nonproprietary name:
acetylcysteine
Dosage form:
effervescent tablets
ACC Long composition
1 effervescent tablet contains: active ingredient:
- acetylcysteine - 600.00 mg;
Excipients:
- anhydrous citric acid - 625.00 mg;
- sodium bicarbonate - 327.00 mg;
- sodium carbonate - 104.00 mg;
- mannitol - 72.80 mg; lactose - 70.00 mg;
- ascorbic acid - 75.00 mg;
- sodium cyclamate - 30.75 mg;
- sodium saccharinate dihydrate - 5.00 mg;
- sodium citrate dihydrate - 0.45 mg;
- blackberry flavor “B” - 40.00 mg.
Photo of the packaging of ACC Long tablets, which shows the composition of the drug
Description round flat-cylindrical tablets of white color, with a bevel and a score on one side, with the smell of blackberry. There may be a faint sulfuric odor.
Reconstituted solution: colorless, transparent solution with a blackberry odor, possibly containing a weak
Pharmacotherapeutic group: mucolytic agent.
ATX code: R05CB01
Pharmacological properties Pharmacodynamics Acetylcysteine is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates the expectoration of sputum due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum. It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH-groups) to bind to oxidative radicals and thus neutralize them. In addition, acetylcysteine promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.
With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.
Pharmacokinetics Absorption is high. They are quickly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetyl cysteine, cystine and mixed disulfides. Bioavailability after oral administration is 10% (due to the presence of a pronounced “first pass” effect through the liver). The time to reach maximum concentration in blood plasma is 1-3 hours. Communication with blood plasma proteins is 50%. Excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). The half-life (T1/2) is about 1 hour, impaired liver function leads to an extension of T1/2 to 8 hours. Penetrates the placental barrier. There are no data on the ability of acetylcysteine to penetrate the blood-brain barrier and be excreted in breast milk.
PROCEDURE FOR OPERATING THE DEVICE
3.1. Moisten the electrodes with saline solution or water. 3.2. Using the diagrams included in the instructions below, find on the body the recommended reflex zone or pain point for treatment. 3.3. Lightly press all three electrodes against the skin, placing the active electrode (5a) on the reflex zone or pain point. 3.4. By moving the electrodes over the skin in the reflex zone, determine the desired point by more pronounced twitching or vibration sensations. If a burning sensation occurs, it is necessary to reduce the force of the regulator (3). 3.5. The total duration of one procedure should be on average 15-20 minutes, the duration of exposure to one reflex zone or pain point from 3 to 10 minutes. After completing the procedure, you should rest in a calm, relaxed state for 30-40 minutes.
ACC Long contraindications
- Hypersensitivity to acetylcysteine or other components of the drug;
- peptic ulcer of the stomach and duodenum in the acute stage;
- hemoptysis, pulmonary hemorrhage;
- pregnancy;
- lactation period;
- children under 14 years of age (for this dosage form);
- lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
With caution: a history of gastric and duodenal ulcers, bronchial asthma, obstructive bronchitis, liver and/or renal failure, histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine affects the metabolism of histamine and can lead to signs of intolerance , such as headache, vasomotor rhinitis, itching), varicose veins of the esophagus, adrenal diseases, arterial hypertension.
Use during pregnancy and breastfeeding Data on the use of acetylcysteine during pregnancy and breastfeeding are limited, therefore the use of the drug during pregnancy is contraindicated.
If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.
Reviews
As a rule, patients leave positive opinions about this medicine.
People really like the low cost of the medicine, a large list of analogues, a convenient form of administration, the ability to take the drug during breastfeeding/pregnancy , as well as a minimal set of contraindications.
Among the negative aspects, patients note the absence of Caleflon in the pharmacy, which causes discomfort to patients, because they are forced to order the product through friends or third-party sites.
All gastroenterology clinics and medical centers in your city. Tests and ultrasound. Consultation with a gastroenterologist. Diseases of the digestive system. Find out more: - In Kiev (Hertz, Ilaya, Euromed) - In St. Petersburg (SM-Clinic, Longevity, Allergomed, Doctor +, BaltZdrav, Professor) - In Moscow (SM-Clinic, Medlux, Onmed) - In Kharkov ( TsMEI, Olympic, Victoria, Fortis, Ecomed) - In Minsk (Belgirudo, Art-Med-Company, Sinlab, Mikosha, GrandMedica, MedClinic) - in Odessa (Medea, On Clinic, Into Sano, Venus) - In Razyan (Trust + , Polyclinic-Pesochnya, Evrikas +) - in Nizhny Novgorod (Only Clinic, Alpha Center, EuroClinic, SOLO, Altea) - gastroenterological clinics of Tyumen (Doctor A+, Clinic "Vera", Avicenna, Medis, Sibirina, Your Doctor)
ACC Long tablets dosage and method of administration
Inside, after eating. Effervescent tablets should be dissolved in one glass of water.
The tablets should be taken immediately after dissolution; in exceptional cases, the ready-to-use solution can be left for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug. For short-term colds, the duration of use is 5-7 days. For chronic bronchitis and cystic fibrosis, the drug should be taken for a longer period of time to achieve a preventive effect. In the absence of other prescriptions, it is recommended to adhere to the following dosages:
Mucolytic therapy: Adults and children over 14 years of age: 1 effervescent tablet once a day (600 mg).
Photo of the packaging of ACC Long tablets, which indicates the method of use of the drug
ACC Long side effects
According to the World Health Organization (WHO), adverse effects are classified according to their frequency as follows: very common (≥1/10), common (≥1/100, <1/10), uncommon (≥1/1000, < 1/100), rare (>1/10000, <1/1000) and very rare (<1/10000); frequency unknown (the frequency of events cannot be determined from the available data).
Allergic reactions : uncommon: skin itching, rash, exanthema, urticaria; angioedema, decreased blood pressure, tachycardia! very rare: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).
From the respiratory system : rarely: shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).
From the senses : uncommon: tinnitus.
From the gastrointestinal tract Uncommon: stomatitis, abdominal pain, nausea, vomiting, diarrhea, dyspepsia.
Other very rare: headache, fever, isolated reports of bleeding due to a hypersensitivity reaction, decreased platelet aggregation.
Overdose Symptoms: in case of erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.
Treatment: symptomatic.
Interaction with other drugs When acetylcysteine and antitussives are used simultaneously, sputum stagnation may occur due to suppression of the cough reflex.
When used simultaneously with oral antibiotics (penicillins, tetracyclines, cephalosporins, etc.), they may interact with the thiol group of acetylcysteine, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine should be at least 2 hours (except for cefixime and loracarbef).
Concomitant use with vasodilating agents and nitroglycerin may lead to increased vasodilatory effects.
Special instructions for patients with diabetes mellitus: 1 effervescent tablet corresponds to 0.001 Xt.
When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.
When using acetylcysteine, cases of severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been very rarely reported. If changes occur in the skin and mucous membranes, you should immediately consult a doctor and stop taking the drug.
In patients with bronchial asthma and obstructive bronchitis, acetylcysteine should be prescribed with caution under systemic monitoring of bronchial patency.
You should not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).
Effect on the ability to drive vehicles and machinery There is no data on the negative effect of the drug ACC Long in recommended doses on the ability to drive vehicles or machinery.
Special precautions when destroying unused medicinal product There is no need for special precautions when destroying unused ACC® Long.
Close the tube tightly after taking the tablet!
Release form Effervescent tablets 600 mg
Primary packaging 6, 10 or 20 effervescent tablets in a polypropylene tube.
Secondary packaging 1 tube in a cardboard box along with instructions for use.
Photo of a tube with ACC Long tablets
Photo of the packaging of ACC Long tablets, which shows the price of the drug
Storage conditions: In a dry place, protected from light, at a temperature not exceeding 30°C. Keep out of the reach of children.
Photo of the packaging of ACC Long tablets, which indicates storage conditions and the manufacturer of the drug
Shelf life: 3 years. Do not use after expiration date.
A photograph of the packaging of ACC Long tablets, which indicates the series, release date and until what year the drug is valid
Dispensing conditions Without a prescription.
Manufacturer holder of RU: Sandoz d.d., Verovshkova 57, 1000 Ljubljana, Slovenia; Manufactured by: Hermes Arzneimittel GmbH, Germany. Consumer complaints should be sent to Sandoz CJSC: 123317, Moscow, Presnenskaya embankment, 8, building 1; phone: (495) 060-75-09; Fax.
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Tablets ACC Long summary (instructions for use) of the drug in photographs
Photo of instructions for use of ACC Long tablets, part 1
Photo of instructions for use of ACC Long tablets, part 2
ACC Long tablets: reviews of the drug
Victoria Ponomareva, Novokuibyshevsk The ACC Long tablets were prescribed to us by our pediatrician for severe nasal congestion. It was necessary to dissolve 1/2 tablet in 2 ml of water and drop 1 drop into each nasal passage. After two days of this treatment, the nasal congestion went away, and then we treated the runny nose with drops. And when I got sick and had a dry cough, I also took these pills. They help remove phlegm well, but they struggle with the cough itself for a long time, and after a week of treatment with this drug, I still bought cough syrup and continued treatment with it. The drug helps, of course, but not as effectively as we would like, especially since it is not cheap. Elizaveta Zlobina, Novoshakhtinsk I had a cough, and I decided to treat it with ACC Long tablets, well advertised on TV. I dissolved this effervescent tablet in a glass of water and drank it once a day, as written in the instructions. I was treated with them for three days and kept waiting for the effect, which never came. It seems to me that my cough, on the contrary, has become even worse. The remedy turned out to be ineffective for me, maybe it helps someone. But I was treated with a different syrup. Anatoly Moiseenko, Stavropol I was very sick, I had a cough and terrible phlegm, which, it seems to me, became a lump in my throat, and I could not cough it out. My wife brought me ACC Long effervescent tablets. I took 2 tablets a day according to the instructions, dissolving one in half a glass of water. On the second day I started coughing a lot and finally this lump in my throat disappeared. I was satisfied with the effect of this medicine. This drug, although expensive, is very effective. Nina Mikhailova, Naberezhnye Chelny Before the New Year, I became very ill; I had a terrible cough that accompanied me day and night. I simply didn’t have time to be treated with folk remedies, since the holiday was in 4 days, and I had to have time to recover. At the pharmacy, on the advice of a young specialist, I purchased the drug ACC Long in the form of effervescent tablets. They turned out to be at a normal and affordable price. I took 1 tablet once a day. By the evening, after taking the first tablet, I noticed that it became easier for me to cough, and the phlegm began to come out. After three days of treatment with these tablets, my cough has practically disappeared. I was simply happy with this result of treatment. An effective product that helped me very quickly. Lyudmila Platonova, Vladimir I started coughing a lot, and the cough was very dry, I even started to have a sore throat from the cough. I bought Ambroxol cough syrup at the pharmacy, but after 4 days of taking it I didn’t notice any effect. And my friend advised me to also take ACC Long tablets, which help cope with phlegm and relieve cough. I took these effervescent tablets according to the written instructions. Sputum began to come out, and the cough became milder, but it did not go away completely, so I decided to take cough syrup again to completely heal. Alexander Mirchenko, Rostov-on-Don ACC Long tablets are a good drug, they help remove phlegm well, but they do not cure cough, in my opinion, they should be taken only in complex treatment. Then you can get rid of both phlegm and cough. These tablets do not cause side effects or allergic reactions. But for the price they cost, you can buy a more potent drug.
