The inability to provide oneself with regular nutritious food, poor quality of drinking water, constant stress associated with professional activities or personal life - all this has an extremely negative impact on a person’s physical condition. As a rule, the organs of the gastrointestinal tract are affected first. And if the problem is not solved for a long time, then it can develop into a much more serious condition - peptic ulcer disease. It is much more difficult to deal with it, and it must be done extremely delicately. That is why such patients strive to find the best possible remedy that will help them overcome the disease. Many people opt for the antiulcer drug “Hairabezol”. The instructions for use define it as an incredibly effective remedy in this regard. However, is this really so? Who is the drug in question indicated for? In what cases should it not be taken? What do doctors, as well as those patients who have already completed their course of treatment with this drug, say about the drug “Hairabezol”? Answers to these, as well as many other questions, will be given below in this article.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Antiulcer drug, a representative of proton pump inhibitors. Blocks the secretion of hydrochloric acid (the final stage), reducing stimulated and basal secretion. Penetrates well into the cells of the stomach, providing a cytoprotective effect.
The antisecretory effect occurs within an hour, and the total duration of action is 48 hours. Restoration of secretory activity is observed 3 days after the end of treatment. The drug has no effect on the cardiovascular system and central nervous system .
Pharmacokinetics
Absorbed in the small intestine, the degree of absorption is high. Cmax in the blood is determined after 3.5 hours. Bioavailability is about 52%, and it does not increase with repeated use. 97% bound to blood proteins. Metabolized in the liver with the participation of the cytochrome system . Excreted by the kidneys. T1/2 is 1.5 hours.
pharmachologic effect
The drug "Hairabezol" reviews and instructions for use are defined as an effective antiulcer agent that actively reduces the secretion of gastric juice. The active substances of the drug penetrate the cells of the stomach tissue, thus exerting a cytoprotective effect on them.
The active substances of the drug are absorbed in the intestines. The main effect of the medicine begins within an hour after taking it. In general, its components remain active for forty-eight hours. The maximum concentration of the drug in the blood is observed three and a half hours after application of the drug. And secretory activity is fully normalized within three days after the last dose of the medicine. The half-life of the drug is only one and a half hours (the drug is eliminated by the kidneys).
It is important to note that the drug in question does not have any effect on the central nervous system or cardiovascular system.
Khairabezol, instructions for use (Method and dosage)
Khairabezol tablets are taken orally, in the morning before meals, swallowed without chewing.
Peptic ulcer during exacerbation - 20 mg 1 time in the morning for up to 6 weeks. The dose for children 12 years old is 20 mg once a day.
GERD - once a day for up to 8 weeks. Maintenance treatment is carried out at a dose of 10 mg 1 time per day. For GERD without esophagitis , take 10 mg per day, month.
Helicobacter pylori eradication regimens in combination with clarithromycin and amoxicillin .
If renal or liver function is impaired, the dose is not reduced. Withdrawal of the drug does not result in rebound syndrome. Secretion is restored in 2-3 days.
Side effects
There is one more important nuance that you need to familiarize yourself with before you start using the drug “Hyrabezol”. The side effects that most often bother patients are headache, as well as gastrointestinal upset (nausea, diarrhea).
Other adverse reactions occur much less frequently, but you should also be aware of them: dizziness, constipation, vomiting, flatulence, abdominal pain, weight gain, rash, sweating, itching, nervousness, insomnia, arthralgia, depression, convulsions, myalgia, leukocytosis , thrombocytopenia, sinusitis, cough, leukopenia.
Reviews about Khairabesol
According to studies in which the drug was prescribed for the treatment of erosive and ulcerative defects of the stomach, on the 2nd day of therapy in 75% of patients the pain syndrome decreased, and after a week of use no one had any complaints. In 91% of patients, by the end of the 2nd week of treatment, according to the results of FGDS, healing of erosive and ulcerative defects . The drug has a persistent antisecretory effect; when taken, the number of refluxes . All this is confirmed by patient reviews.
- “...The medicine Khairabezol was prescribed for an exacerbation of an ulcer. Feeling better within a day. I was treated for a month and the discomfort and pain in the stomach went away.”
- “... The pills worked for me, I’m happy with the result of the treatment. They're inexpensive."
- “...I liked the drug!!! The pain and heartburn disappeared. I used to take Pariet, but it is very expensive. I didn’t see any difference in the effectiveness of those and other tablets.”
- “... I take it for exacerbations of ulcers. It helps me personally. Conveniently, you only need to take it once a day and the package lasts for 15 days. Satisfied with the price and efficiency. I didn’t feel any side effects.”
- “...Only Pariet helps me. I only take this drug.”
Side effects included minor headache and constipation .
HAIRABESOL
I already wrote that during my last gastrointestinal examination, erosions were discovered in my esophagus. The gastroenterologist prescribed me a whole treatment regimen, and in the first line there were two drugs, of which I had to choose one. This is Pariet, already familiar to me, and a completely unfamiliar drug called Khairabezol. Both drugs contained the active substance rabeprazole and were proton pump inhibitors. Well, to put it simply, they reduced the increased acidity of the stomach, which mainly leads to erosions and then ulcers of the mucous membrane. I will say right away that I have nothing against Pariet and am even very grateful to this drug, it saved me from a stomach ulcer and helped cure erosive gastritis. The reason why I chose a different drug this year is a financial issue. I'm not quite …
Hayrabezol price, where to buy
You can buy Khairabezol in all pharmacies. Tablets of 20 mg are offered at a price of 590-711 rubles, the cost of tablets of 10 mg is 415-484 rubles.
- Online pharmacies in RussiaRussia
WER.RU
- Khairabezol tablets 20 mg 30 pcs.
- Khairabezol tablets 20 mg 15 pcs.
- Khairabezol tablets 10 mg 15 pcs.
Pharmacy 36.6
- Khairabezol tablet p.o. 20mg N30HIGLANCE LABORATORIES
- Khairabezol tablet p.o. 20mg N15HIGLANCE LABORATORIES
- Khairabezol tablet p.o. 10mg N15HIGLANCE LABORATORIES
Pharmacokinetics
Absorption
Rabeprazole is rapidly absorbed from the intestine and peak plasma concentrations (Cmax) are achieved approximately 3.5 hours after a 20 mg dose. Changes in peak plasma concentrations and area under the pharmacokinetic concentration-time curve (AUC) of rabeprazole are linear in the dose range from 10 to 40 mg. Absolute bioavailability after oral administration of 20 mg (compared to intravenous administration) is approximately 52%. In addition, bioavailability does not change with repeated dosing of rabeprazole. Neither the time of taking the drug during the day nor antacids affect the absorption of rabeprazole. Taking the drug with fatty foods slows down the absorption of rabeprazole by 4 hours or more, but neither Cmax nor the degree of absorption changes.
Distribution
In humans, the degree of binding of rabeprazole to plasma proteins is about 97%. Metabolism
Rabeprazole is metabolized in the body in two ways. A significant part of it is metabolized systemically by a non-enzymatic route with the formation of thioester derivatives. Rabeprazole is also metabolized in the liver via cytochrome P450 to form sulfonic and desmethyl derivatives.
In healthy volunteers, the plasma half-life is approximately 1 hour (varies from 0.7 to 1.5 hours), and the total clearance is 3.8 ml/min/kg.
Removal
After a single oral dose of 20 mg of 14C-labeled rabeprazole, about 90% of the drug is excreted in the urine, mainly in the form of carboxylic acid thioester, its glucuronide and in the form of mercapturic acid derivatives. No unchanged drug is detected in the urine. The remainder of the rabeprazole taken is excreted through the intestines. The total elimination is 99.8%.
End stage renal failure
In patients with stable end-stage renal disease who require maintenance hemodialysis (creatinine clearance <5 ml/min/1.73 m2), the elimination of rabeprazole is similar to that of healthy volunteers. AUC and Cmax in these patients were approximately 35% lower than in healthy volunteers. On average, T1/2 of rabeprazole was 0.82 hours in healthy volunteers, 0.95 hours in patients during hemodialysis and 3.6 hours after hemodialysis. Clearance of the drug in patients with kidney disease requiring hemodialysis was approximately twice as high as in healthy volunteers.
Chronic compensated cirrhosis
Patients with chronic compensated liver cirrhosis tolerate rabeprazole 20 mg once daily, although AUC is doubled and Cmax is increased by 50% compared to healthy volunteers.
Elderly patients
In elderly patients, the elimination of rabeprazole is somewhat slower. After 7 days of taking rabeprazole at a dose of 20 mg 1 time per day in elderly individuals, AUC was approximately twice as high and Cmax was increased by 60% compared to young healthy volunteers; There were no signs of drug accumulation.
СYР2С19 polymorphism
In patients with slow metabolism via the CYP2C19 isoenzyme, after 7 days of taking rabeprazole at a dose of 20 mg per day, the AUC increases by 1.9 times and the half-life by 1.6 times compared with the same parameters in “rapid metabolizers”, while how Cmax increases by 40%.
Indications for use
- Gastric ulcer in the acute stage and anastomotic ulcer;
- Duodenal ulcer in the acute stage;
- Erosive and ulcerative gastroesophageal reflux disease or reflux esophagitis;
- Maintenance therapy for gastroesophageal reflux disease;
- Non-erosive gastroesophageal reflux disease;
- Zollinger-Ellison syndrome and other conditions characterized by pathological hypersecretion;
- In combination with appropriate antibacterial therapy for the eradication of Helicobacter pylori in patients with gastric and duodenal ulcers or chronic gastritis.
Instructions for use of Khairabezol, tablet dosages
The tablets are intended for oral use. The drug is taken orally in the morning before meals, the tablet is swallowed immediately with a sufficient amount of liquid.
The initial dosage is 1 tablet of Hairabezol 10 mg once a day for 4-8 weeks. If the therapeutic effect is weak, the instructions for use recommend increasing the dosage of Hairabezol tablets to 20 mg per day.
For the symptomatic treatment of reflux esophagitis, 10 mg is prescribed once a day for 1-2 months.
For the treatment of Zollinger-Ellison syndrome and other conditions characterized by pathological hypersecretion of gastric juice, the attending physician selects the dose individually.
Treatment of chronic gastritis resulting from Helicobacter pylori infection or duodenal/gastric peptic ulcer is recommended to be carried out over a course of 1 week using one of the following combinations:
- I – 2 times a day: 20 mg Khairabezol + 500 mg clarithromycin + 1000 mg amoxicillin;
- II – 2 times a day: 20 mg Khairabezol + 500 mg clarithromycin + 400 mg metronidazole.
For gastroesophageal reflux disease (GERD), 1 tablet of Hairabezol 20 mg is prescribed once a day for 4-8 weeks. For maintenance therapy for GERD - at a dose of 10 or 20 mg 1 time per day, depending on the patient’s response.
For the symptomatic treatment of GERD in patients without esophagitis - at a dose of 10 mg once a day for 4 weeks.
Side effects
The instructions warn about the possibility of developing the following side effects when prescribing Khairabezol:
- From the digestive system: often – diarrhea, nausea; uncommon – vomiting, abdominal pain, flatulence, constipation; rarely – dry mouth, belching, dyspepsia; very rarely - disturbance of taste, anorexia, stomatitis, gastritis, increased transaminase activity.
- From the nervous system and sensory organs: often – headache; rarely – dizziness, asthenia, insomnia; very rarely - nervousness, drowsiness, depression, visual disturbances, taste disturbances.
- From the musculoskeletal system: rarely – myalgia; very rarely - arthralgia, cramps of the calf muscles.
- From the respiratory system: rarely - inflammation or infection of the upper respiratory tract, severe cough; very rarely – sinusitis, bronchitis.
- From the hematopoietic organs and hemostasis system: rarely – thrombocytopenia, leukopenia; very rarely - leukocytosis.
- Allergic reactions: rarely - rash, itching.
Contraindications
It is contraindicated to prescribe Hayrabezol tablets in the following cases:
- hypersensitivity to the drug or components;
- age under 18 years;
- pregnancy and breastfeeding;
Caution should be used in severe liver failure and severe renal failure.
Treatment cannot be carried out without examination and confirmed peptic ulcer (or other disease), since the drug can mask the symptoms of cancer of the stomach and intestines, thereby delaying the correct diagnosis.
Overdose
There are no known cases of overdose. There is no specific antidote. Rabeprazole is poorly excreted by dialysis. Symptomatic therapy is carried out.
