Indovazin - instructions for use, composition, analogues, indications

"Indovazin" is a medicine for external use with a pronounced anti-inflammatory and angioprotective effect.

The drug is produced in the form of an ointment and gel for external application in aluminum tubes of 45 grams. The medicine has a denser mass, unlike the gel, and is prescribed to people with dry skin. What does Indovazin ointment help with?

The main active components of the drug are indomethacin and troxerutin. Ethyl alcohol acts as an additional substance.

Medicinal properties

The drug is a combination medicine for external use. Indomethacin has a pronounced anti-inflammatory, as well as analgesic and decongestant effect.

When the medication is applied to the patient’s skin, pain is reduced, swelling subsides, and recovery processes are accelerated. What does Indovazin ointment help with?

Troxerutin, which is part of the structure of the drug Indovazin, belongs to bioflavonoids. This component belongs to the group of angioprotectors, reduces the permeability of the vascular wall, improves the elasticity of capillaries, and has a pronounced venotonic effect.

Under the influence of the drug, the fragility of blood vessels decreases and the outflow of blood from the legs improves. In case of severe microcirculation disorders, the trophism of damaged tissues improves. What is Indovazin ointment used for?

When Indovazin is applied to the surface of the epidermis, the active substances enter its deep layers, reaching the capillaries. The active components of the drug lower local body temperature and improve the general condition of the source of the lesion.

Indovazin is a drug based on indomethacin and troxerutin. Doctor's recommendations

External medications are used as anti-inflammatory and painkillers.

They are used to restore blood circulation, improve regeneration of the skin and deeper tissues, and improve the functioning of blood vessels.

External medications, which are applied several times during the day, are easily absorbed and penetrate deep into the skin.

Problems with veins occur in every third woman and every fifth man.

Varicose veins are a serious vascular pathology, which is accompanied by impaired venous circulation in the extremities. Pathology causes pain, swelling, heaviness.

To alleviate the condition, patients use external medications. Indovazin is often used .

The drug not only alleviates the general condition of varicose veins, it can eliminate pain after bruises, soft tissue injuries, and stretched muscle fibers.

Instructions for use

Indovazin is a combination drug that is presented as an ointment (gel substance) . The medicine is intended to relieve inflammation and swelling of soft tissues.

pharmachologic effect

The therapeutic effect of Indovazin is provided by two active elements: indomethacin and troxerutin.

Indomethacin has a pronounced anti-inflammatory effect, and also has an anti-edematous and analgesic effect. Under the influence of indomethacin, healing and restoration of damaged tissue occurs faster due to the suppression of the synthesis of active prostaglandins. Blocking the synthesis of prostaglandins occurs by stopping the action of two forms of cyclooxygenases.

Troxerutin belongs to the group of bioflavonoids. Trihydroxyethylrutinoside belongs to the category of angioprotectors. Thanks to the action of troxerutin, capillary permeability decreases, which helps to activate the venotonic effect. In addition, swelling of the integument and fragility of capillary plexuses are reduced.

External use of Indovazin reduces pain at the site of tissue damage, sprains and muscles, and helps lower the temperature of tissue at the site of injury..

The drug has good absorbing and penetrating ability, which ensures a positive effect on blood vessels. The combined composition has a protective and venotonic effect on tissues and helps stimulate regenerative processes.

Release form, composition

The drug Indovazin is presented as a gel substance of white or white with a yellowish tint. The drug is available in aluminum tubes of 45 g. The tubes are packaged together with instructions for use in cardboard boxes.

The active ingredients of the drug are indomethacin, troxerutin . 1 gram of the drug contains 30 and 20 mg of active substances, respectively.

Additional substances - carbomer, ethanol, sodium benzoate, marcrogol, propylene glycol.

Indications for use

Indovazin gel is indicated for use in the following cases:

for chronic venous insufficiency of the lower extremities (varicose veins) to relieve swelling and heaviness in the legs;
inflammatory processes of venous vessels;

periarthritis;
inflammatory process occurring in the periarticular bursa;

thrombophlebitis, resulting complications;
swelling of soft tissues after surgical operations, as well as resulting from dislocations, sprains, injuries, bruises.

In addition, Indovazin is recommended for use for radiculitis, neuralgia, psoriasis with joint damage.

Important! Indovazin is most effective as part of complex treatment. Treatment methods should be selected by the doctor taking into account the complexity of the lesion.

Directions for use, dosage

It is recommended to apply a thin layer of Indovazin gel viscous substance to the affected area at least three or four times during the day . One use of the drug involves squeezing it 2-3 centimeters out of the tube. It is not recommended to use more than 20 centimeters of the drug per day. The gel should not be used for more than ten days.

The gel is well absorbed. To improve the effect, it is recommended to lightly rub the product with stroking movements with your fingertips or palm.

Interaction with other drugs

Concomitant use of Indovazin with Heparin ointment may cause bleeding.

When Indovazin interacts with drugs that cause photosensitivity, the effect of the latter may be enhanced.

The gel should not be used with corticosteroids due to their potentiation of ulcerogenic effects.

Indovazin should be used with caution with oral medications belonging to the group of non-steroidal anti-inflammatory drugs, as well as with acetylsalicylic acid.

Important! When treated with other medications, the patient should consult a doctor about the use of Indovazin. Undescribed drug interactions may negatively affect the patient's health.

Overdose

An applied dose in excess of the recommended one may cause a burning sensation, in some cases a slight burn of the surface layer of the skin is possible . If the product is accidentally swallowed, signs of poisoning may occur: nausea, vomiting, as well as a burning sensation in the mouth, salivation, and sore throat. In this case, it is recommended to lavage the stomach, mouth area, and also take enterosorbents.

During pregnancy and lactation

Indovazin should not be used during feeding. Use with caution in the first stages of pregnancy; contraindicated in the third trimester .

Impact on the ability to drive vehicles and operate machinery

Indovazin does not affect the functioning of the nervous system , and also has no effect on the psychomotor reaction. The drug can be used by people driving, as well as by those whose work involves attention and concentration.

Use in childhood

The gel is not recommended for use by children due to the tenderness of the skin. Indovazin is not used in practice in pediatrics.

For liver and kidney dysfunction

No negative effects of Indovazine on health have been described in cases of impaired liver or kidney function.

Storage conditions and periods

It is recommended to store the tube with Indovazin in a dark and cool place, out of reach of children. The shelf life of the gel is no more than a year from the date of manufacture (indicated on the tube or cardboard packaging).

Price

Average price in Russia

The cost of a tube of Indovazin is from 200 rubles .

Average price in Ukraine

The cost of a tube of Indovazin is from 50 hryvnia .

Analogs

In terms of composition, Indovazin has a unique combination.

In terms of therapeutic effect, the gel analogues are:

Venoruton . The product is recommended for heaviness in the legs, varicose veins, vascular nutritional disorders;
Troxgel . The drug relieves swelling, pain, promotes the healing of hematomas;
Panthevenol . Used for swelling, pain arising from venous insufficiency;
Troxevasin . The drug is a venoprotector, has an anti-edematous effect, and belongs to the group of painkillers.

Independently replacing a drug recommended by a doctor requires his approval.

: “The drug Troxevasin: where is it used?”

Reviews

In general, reviews from patients who have used Indovazin are positive.

People note a positive effect with monotherapy, when the gel was used after minor injuries and bruises. Patients note a rapid reduction in swelling after a day of using the gel.

Some people note a burning sensation after application , which goes away after a few minutes.

With varicose veins, patients note pain relief: systematic use of the gel helps to feel lightness in the legs, the feeling of heaviness disappears.

Some patients did not like the smell of the drug; in isolated cases, a local allergic reaction was noted.

If you have used Indovazin, please describe your feeling after using it. Perhaps your experience will help others.

Conclusion

Thus, Indovazin is a gel for external use, which is used to relieve pain, swelling, inflammation after injuries, bruises, as well as in the presence of diseases of the veins or blood vessels.

The gel is easy to apply and should be used no more than four times during the day. Rub the product onto the affected area of the body with light massaging movements.

Indovazin should not be applied to mucous membranes, damaged skin, or wounds.

The gel does not affect concentration. The drug has no contraindications in the presence of diseases associated with the functioning of the liver or kidneys. However, Indovazin should not be used by children, as well as pregnant and lactating women.

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What does Indovazin help with?

The ointment is prescribed to people to eliminate the following pathological conditions:

Venous insufficiency.
Varicose veins (pathological changes in the veins, accompanied by their saccular expansion, increase in length, formation of convolutions and knot-like tangles, which leads to valve incompetence and impaired blood flow).
Edema.
Bursitis (inflammation of the mucous bursae, mainly in the joint area).
Stagnant phenomena.
Sensation of fullness in the calf muscles.
Fibrositis (a disorder characterized by pain and stiffness of the trunk and limbs, as well as the presence of a number of specific painful areas).

Does Indovazin ointment help with bruises? The drug is recommended for use for the following problems:

Inflammatory processes along the vein.
Thrombophlebitis (inflammatory process in the internal venous wall with the formation of a blood clot).
Complications due to thrombophlebitis.
Tenosynovitis (a complex inflammatory process that affects the muscle tendon and its vagina).
Inflammation of the periarticular bursa.
Periarthritis (a disease characterized by an inflammatory process in the periarticular tissues of large joints: the joint capsule, its ligaments, surrounding tendons and muscles).
Swelling of soft tissues.
Stretches.
Dislocations.
Bruises.

Indovazin gel

Price from 263 rub.

Non-hormonal anti-inflammatory vascular strengthening drug.

Application – venous insufficiency, thrombophlebitis, phlebitis.

Analogues - Indomethacin Plus, Detragel, Troxevasin. You can find out more about analogues, their prices, and whether they are substitutes at the end of this article.

Today we’ll talk about Indovazin gel. What is this product and how does it affect the body? What are the indications and contraindications? How and in what doses is it used? What can be replaced?

What kind of gel

In the treatment of inflammatory diseases of the joints and some other diseases, the drug Indovasin gel is used as a local remedy.

Instructions for use describe the product as a local anti-inflammatory, analgesic and vascular strengthener.

Eliminates swelling in case of injuries, varicose veins and venous insufficiency, in the postoperative period or during recovery after a fracture. The list of indications includes various positions - from damage to trophism to bruises.

For bruises, it prevents inflammation, eliminates swelling, and helps normalize trophism.

The drug is presented in the form of a thick liniment, the color can vary from light yellow to brown.

Active ingredient and composition

This is a combined drug to solve a whole range of problems. It contains 2 active substances - indomethacin and troxevasin.

Indomethacin is a non-steroidal anti-inflammatory drug.

Troxevasin is a rutin derivative, a flavonoid.

10 grams contain 0.3 grams of indomethacin and 0.2 grams of troxerutin.

Auxiliary components:

polyethylene glycol;
sodium benzoate;
dimethyl sulfoxide;
disodium edetate;
carbomers;
flavoring;
ethanol

Pharmacodynamics and pharmacokinetics

The drug is combined in such a way that the medicinal properties of indomethacin are enhanced by troxerutin. Indomethacin is a derivative of indoleacetic acid.

Its anti-inflammatory, analgesic and antipyretic effect is based on the mechanism of inhibition of COX enzymes with subsequent inhibition of the synthesis of prostaglandins from arachidonic acid.

Prevents platelet aggregation. When used externally, it relieves pain, swelling, and redness.

Troxerutin tones the veins, strengthens and gives elasticity to the vessels, and prevents their fragility. Shows anti-edematous, anti-inflammatory and antioxidant effects. Due to the participation of the substance in redox reactions, hyaluronidase is inhibited.

The content of hyaluronic acid in cell membranes is normalized, as a result of which the permeability and fragility of capillaries decreases, and the density of vascular walls increases.

Reduces the secretion and accumulation of lymphatic fluid in tissues. The substance prevents the migration of cells through the walls of blood vessels (diapedesis).

If necessary, increase the density of blood vessels is prescribed in combination with ascorbic acid to enhance the pharmacological effect. The substance is non-toxic.

The absorption of indomethacin and troxerutin from the skin surface is facilitated due to the gel structure of the drug.

Medicinal concentrations of substances are found in subcutaneous tissue, periarticular tissues and fluid. In the general bloodstream, the concentration of substances is insignificant and does not have a pronounced effect on the body.

Indications

Prescribed for the treatment of diseases of muscles, joints and venous blood flow disorders:

bursitis;
synovitis;
tenosynovitis;
fibrositis;
periarthritis;
chronic and acute polyarthritis;
plexitis;
radiculitis;
arthropathic psoriasis (affecting the joints);
thrombophlebitis;
chronic venous insufficiency;
phlebitis;
swelling after dislocations, bruises, sprains, contusions.

Helps get rid of bruises, resolves small scars and cicatrices, smoothes skin texture.

Directions for use and dosage

A single dose is 4-5 centimeters of gel squeezed out of the tube.

3-4 applications per day are indicated.

The maximum duration of a single dose should not exceed 20 centimeters, the treatment course should not exceed 10 days.

Side effects

The most common side effects from using the gel are allergic reactions. There are urticaria-type rashes, contact dermatitis, redness, itching, burning sensation, numbness, tingling at the site of application.

Systemic reactions occur extremely rarely and are possible with long-term treatment with excess dosage.

Manifested by abdominal pain, nausea, vomiting, increased levels of liver transaminases.

On the part of the immune system, an asthmatic attack, angioedema, and suffocation may develop.

In childhood, during pregnancy and pregnancy

Prohibited for use in children under 14 years of age due to lack of sufficient data on its safety.

Prohibited for use during pregnancy.

If necessary, it is prescribed to nursing mothers, but feeding is interrupted during treatment.

Restrictions

Before treatment with Indovazin, the patient is advised to carefully read the instructions for use, since the medication has a number of the following contraindications:

Open wounds.
Last trimester of pregnancy.
Breast-feeding.
Age up to 14 years.
Individual intolerance to components.
Disorders of the blood coagulation system.

The drug is recommended with extreme caution to patients with the following ailments:

Bronchial asthma (a chronic inflammatory disease of the respiratory tract, characterized by asthma attacks of varying duration and frequency).
Allergic rhinitis (allergic inflammation of the nasal mucosa).
Polyps of the nasal cavity (outgrowths of hypertrophied mucous membrane of the nasal cavity or paranasal sinuses).

The drug is recommended with caution when combined with oral medications from the group of non-steroidal anti-inflammatory drugs.

Action of main components

The original medicine, like many of its analogs (especially structural substitutes), has a number of restrictions on use.

The gel is contraindicated for use:

in case of individual sensitivity to the composition of the drug or to NSAIDs;
pregnant women in the 3rd trimester;
patients who have a coagulation disorder of unknown nature;
persons with diagnosed exacerbation of peptic ulcers;
children under 14 years of age;
women breastfeeding;
in case of violations of the integrity of the skin in the areas where the product is applied.

Indovazin gel is prescribed very carefully to people suffering from bronchial asthma and allergic rhinitis. Only a doctor can recommend treatment with this drug to such patients. People who have nasal polyps should not use the gel without consulting a doctor.

In addition, it should be remembered that this product contains a strong non-steroidal anti-inflammatory component. Therefore, it is not recommended to combine this drug with other NSAIDs.

The key directions of action of the active components of the drug are the elimination of edema, relief of pain symptoms and the fight against inflammatory processes, and therefore damaged tissues are restored much faster.

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The mechanism of action is based on blocking the production of prostaglandins due to the reversible blockade of COX-2 and COX-1. The effectiveness of Indovazin is due to the activity of the main components.

Troxerutin is presented in the form of a bioflavonoid, which belongs to the category of angioprotectors. The component produces a venotonic effect and helps reduce capillary permeability, and also blocks the spread of the inflammatory process to perivenous tissue.

There is an improvement in trophism in venous insufficiency, relief of edema, an antiplatelet effect, and a decrease in capillary fragility. The component is also characterized by blocking the vasodilating effect of acetylcholine, bradykinin and histamine.

Applying the gel to the skin helps penetrate the affected blood vessels and block the edematous reaction, reduce the temperature and relieve pain symptoms in the area of inflammation, which can be localized both deep in the tissue and on the surface.

The effect of the drug is capillary protective and venotonic.

What is Indovazin ointment used for?

The drug is intended for external use only. The medicine is applied to the affected skin in a thin layer and rubbed in with massaging movements. The ointment is applied only to clean, dry epidermis 3-4 times a day.

The duration of treatment with the medication according to the annotation is 10 days. If there is no expected pharmacological effect or if the pathology progresses, the sick person should contact a medical specialist.

How to use

The chemical and pharmacological properties of the active components of Indovazin allow it to be used only externally. Rules of application:

A small amount of gel (cream) is carefully rubbed in a circular motion into clean, dry skin of the affected area.
The frequency of use during the day is up to 4 times, continuous therapy should last no more than 10 days.
To prescribe a second course of treatment, if there is no improvement or worsening of the condition, you should consult a specialist again.

Can the drug be used during pregnancy?

Indovazin ointment for sprains and other problems with the musculoskeletal system is not recommended for use by women in the first trimester of an “interesting position”, since at this time all the internal organs of the unborn baby are formed, and the active components of the medicine can disrupt this process.

The use of a medication in the second trimester is possible only in a situation where the likely benefit to the mother is slightly higher than the risk to the fetus.

According to reviews and instructions for use, Indovazin ointment is not recommended for use by expectant mothers in the last trimester of pregnancy. Using the medicine at this time can lead to bleeding and premature birth, since the active components, although in small quantities, are still absorbed into the blood.

The use of the medication during lactation is prohibited, since the components of Indovazin partially pass into breast milk and then into the baby’s body. If it is necessary to use medication for nursing mothers, it is important to think about stopping lactation.

Composition and release form

Indovazin is available in the form of a gel with a slight opalescence, yellow or yellow-brown color. The gel is packaged in special aluminum tubes of 45 grams.

1 gram of gel contains 20 mg of troxerutin and 30 mg of indomethacin.

Clinical and pharmacological group: drug with anti-inflammatory and angioprotective effects

Available in the form of a gel or ointment, it is yellow in color, with the possibility of a brown tint. Sold in tubes, the capacity of which can be 20 and 45 mg. Additionally, it is packaged in cardboard boxes, each of which contains instructions for use. We allow vacation without a doctor's prescription.

1 g of Indovazin gel combines two active ingredients:

30 mg indomethacin;
20 mg troxerutin.

The product is a gel of uniform consistency, which is characterized by a yellow or pale brown color with slight opalescence.

Indovazin gel is produced in a volume of 45 g. The pharmacy chain offers one packaging - 1 membrane aluminum tube in a cardboard package.

gel. In tubes of 20 and 45 g.

The medical drug Indovazin is produced in aluminum tubes of 20 and 45 grams, packaged in a cardboard box and contains instructions. You can purchase it without a doctor's prescription. Unlike gel, the cream has a thick consistency and is suitable for people with dry skin.

The main active ingredients of the drug are indomethacin and troxerutin. Thanks to the action of these components, the ointment quickly penetrates the skin, effectively eliminating symptoms. The product also contains some additional substances:

Carbomer.
Sodium benzoate.
Macrogol 400.
Ethyl alcohol 96%.
Propylene glycol.

The shelf life of Indovazin is 24 months; after this period, it is strictly not recommended to use the cream.

Side effects

As a rule, the medication is well tolerated by patients. In rare situations with increased sensitivity, certain negative reactions are likely to occur:

Burning.
Itching.
Rashes.
Hyperemia (overflow of blood vessels of the circulatory system of any organ or area of the body).
Local increase in temperature.
Nettle rash (a disease whose main symptom is the appearance of blisters on the skin).

These signs are not dangerous and in most cases do not require stopping treatment.

Pharmacological properties of the drug

Indovazin is considered a complex two-component agent that has the following effects:

reduces inflammatory processes in blood vessels;
relieves swelling in perivenous tissues;
acts as an antispasmodic;
restores affected joints, tissues, capillaries;
blocks the biosynthesis of prostaglandins, which activate the development of inflammatory processes, pain, and fevers;
reduces the vulnerability and permeability of blood vessels;
prevents platelet clogging;
activates microcirculation, has a beneficial effect on damaged cells;
tones and strengthens venous walls;
reduces hyperthermia in the area of inflammation.

The medicinal properties of the drug combine the healing qualities of the main active elements, which act individually.

Indomethacin is considered a non-steroidal substance that actively relieves swelling, pain, fever, blocks the production of prostaglandins, and inhibits the union of platelets.
Troxerutin normalizes microcirculation in blood vessels, improves lymphatic drainage, and increases capillary elasticity.

After application, the ointment is quickly absorbed, the intensity of redness, inflammation, swelling is weakened, and hyperthermia in the area of the pathological process is reduced.

Penetrates deep into the tissue, reaching maximum concentration in the affected areas after 60-120 minutes. It is evacuated by the kidneys, also with feces and bile per day.

Recommendations

"Indovazin" is not applied to open wounds, as this can lead to severe bleeding. To avoid the occurrence of adverse reactions, it is not recommended to apply the drug to a gauze bandage and leave it on the skin for a long time.

After using Indovazin on the epidermis, you should wash your hands well so that the ointment does not get on the mucous membranes of the eye. If the medication accidentally gets into the visual organs or mucous cavities, the area should be rinsed well with water.

The medication has no effect on the central nervous system and does not suppress the speed of psychomotor reactions. People with increased sensitivity may experience a burning sensation and a local increase in body temperature when applying the drug Indovazin. After 10-15 minutes, these phenomena disappear and do not require cessation of therapy.

Since there is no information regarding the safety of the drug on the child’s body, Indovazin should not be used by people under 14 years of age.

Special instructions for use

Strict adherence to the doctor’s recommendations and instructions for use guarantees the most effective treatment without causing harmful side effects to the body.

When using the ointment, be very careful not to get it in your eyes or mouth.
Do not apply the gel to open wounds and mucous membranes; if this happens, immediately wash off the ointment with clean water and soap to avoid redness and pain.
If you have an allergic reaction to certain substances, be very careful when using the ointment as it contains sodium benzoate, which can cause skin irritation and other dermatological reactions.

The use of this drug does not have any effect on concentration and, accordingly, does not exclude driving a vehicle while undergoing a course of therapy.

Analogs

Medicines that have similar effects to Indovazin are:

"Hepatrombin."
"Ginkor".
"Venoruton".
"Troxerutin."
"Venolife".
"Troxevasin".
"Venorutinol".

Before changing a drug to a substitute, it is important to consult a doctor.

Instructions

The use of Indovazin in the form of ointments and gels is practically no different from the use of other similar products.

Indovazin's instructions consist of some rules for its use:

First, the skin in the right place is cleaned and wiped dry.
With clean hands, take a small amount of medicinal substance and rub it into the sore spot.
Perform such manipulations 2 times a day.
The therapeutic course should not last longer than 10 days; as a rule, it is 5-7 days.

The medicine has a slight odor, but it does not disappear from the skin for a long time, therefore, it is better to smear the joints with Indovazine once before going to bed, and carry out another manipulation either early in the morning or during the day. Reducing the number of manipulations is prohibited, as this will reduce the therapeutic effect.

Opinions

With the help of its complex composition, Indovazin ointment has a combined effect, which helps to use the drug in several areas of medicine at once: surgery, traumatology, phlebology, for a variety of pathological processes:

Bruises.
Injuries.
Varicose lesions.
Bursitis (acute, subacute or chronic inflammation of the synovial bursa, which is accompanied by abundant formation and accumulation of exudate in its cavity).

The ointment is easy to apply and absorbs well into the skin, without requiring the use of bandages. The medicine is produced in tubes that are convenient to take with you. Feedback about the drug is mostly positive, since the medication helps to quickly eliminate pain - this is what all patients with bruises and traumatic disorders of the musculoskeletal system expect. What does Indovazin ointment help with?

With varicose veins of the legs, swelling is quickly eliminated. Among the adverse reactions, patients note the development of mild itching, sometimes hyperemia in the area of application, which go away on their own after stopping treatment and do not require medical intervention.

As a rule, Indovazin ointment is recommended to reduce pain and eliminate the inflammatory process. The effectiveness of treatment using this drug is confirmed by the responses of real patients who got rid of unpleasant symptoms and restored a person’s ability to work and their usual way of life.

Indovazin (ointment, gel): instructions for use, price, what it is used for, reviews, analogues

For vein diseases that are accompanied by an inflammatory process, complex therapy is recommended.

Treatment costs can be minimized by selecting a multicomponent composition that provides diverse effects.

One of these is Indovazin .

Composition and release forms

Pharmacological companies produce the product in the form of ointment and gel .

Their active substances are the same, as are the indications for use.

Ointment

The composition is based on the following components: troxerutin and indomethacin.

1 g of medicine contains 20 and 30 mg, respectively.

For convenient use and better penetration of substances into the deep layers of the epidermis, the following is also used in production:

propylene glycol;
macrogol;
ethanol;
carbomer;
sodium benzoate.

Gel

The active substances in the gel are included in a similar dosage.

As an addition to the manufacture of medicine, use:

disodium edetate;
dimethyl sulfoxide;
carbomer;
macrogol 400;
sodium benzoate;
flavor (Fresco BM&GD R.08.0932.1);
isopropanol;
distilled water.

External signs: viscous substance, color from yellow to yellow-brown, slight opalescence is noted.

Pharmacology

One of the active substances, indomethacin, belongs to the group of non-steroidal anti-inflammatory drugs.

Among the valuable properties of the chemical compound: rapid relief of the inflammatory process, elimination of swelling and redness.

Indomethacin also reduces local temperature, which increases with tissue damage.

Another active compound, troxerutin, has a beneficial effect on the walls of blood vessels, promotes blood thinning, which ensures rapid relief of the inflammatory process.

After application to the skin, indovazin acts instantly, providing a venotonic and capillary-protective effect.

Price

You can buy a pharmacological drug at any pharmacy or online store.

The medicine is available without a prescription . But this does not mean that it can be used uncontrollably.

Before starting treatment, you need to consult a doctor about the advisability of using the composition for the treatment of a specific pathology.

The price of a tube with a capacity of 45 g is 296 rubles .

What is Indovazin used for?

A two-component composition is recommended to eliminate the following pathological processes:

phlebitis, superficial thrombophlebitis, post-phlebitis conditions;
complex therapy of chronic venous insufficiency of the lower extremities;
tendovaginitis, fibrositis, periarthritis, bursitis and other rheumatic lesions of soft tissues;
swelling after surgery, with dislocations, sprains, contusions.

Indovazin during pregnancy and lactation

Clinical trials have not been conducted for this category of patients.

According to theoretical data, the active components do not have a negative effect on the development of the fetus when used in the first and second trimester of pregnancy.

Regardless of the severity of the disease, Indovazin can be used for medicinal purposes during pregnancy for no more than 5 days in minimal doses.

In the third trimester, the drug is contraindicated .

The ointment is not suitable for treating large affected areas, since a single portion of the composition should not exceed 7-8 cm.

If there is a need for medication during lactation , breastfeeding is artificially interrupted, or a safer substitute is selected.

Adolescents over 14 years of age can be prescribed Indovazin.

The treatment regimen involves applying the medicine to the skin to form a thin layer.
The regularity of treatments is determined by the doctor, taking into account the severity of the pathology (from 1 to 3 times a day).
You need to rub the ointment lightly, without waiting for it to be completely absorbed. This precaution is due to the risk of increasing the concentration of active substances in healthy tissues.

The duration of therapy is usually 5-7 days. But in some cases, the attending physician recommends continuing treatment for up to 10 days.

Changing the treatment regimen on your own is strictly prohibited.

Adverse reactions

The drug is usually easily tolerated. Negative reactions are extremely rare.

Possible manifestations include: burning on the treated area of skin, rash, itching, redness. These symptoms are the result of an allergy to the pathogen present in the drug.

There is also a risk of developing contact dermatitis.

To eliminate unwanted reactions, symptomatic therapy is carried out using antihistamines.

Restrictions on use

The manufacturer warns in the annotation about restrictions on the use of Indovazin.

The drug is contraindicated in the presence of the following risk factors:

age up to 14 years;
third trimester of pregnancy;
breastfeeding period;
the presence of dermatological problems or other skin damage in the area where the medication is applied;
allergy to one or more components of the composition.

When Indovazin is combined with NSAIDs, it becomes necessary to consult a doctor.

A doctor's opinion regarding the use of ointment is required in the presence of diagnosed pathologies:

polyps of the nasal mucosa;
bronchial asthma;
allergic rhinitis.

Precautionary measures

When using pharmaceutical products, it is recommended to adhere to the following precautions:

Do not apply ointment to open wounds and damaged areas of skin;
if the composition gets into your eyes, you must immediately rinse (it is recommended to use saline solution or distilled water);
for medicinal purposes, it is allowed to use an ointment with an appropriate shelf life;
expired product must be disposed of;
the composition contains substances that can cause irritation (propylene glycol and benzoate), so you should test the medicine on the back of your hand before the procedure;
the period of therapy can be combined with work activity; the active components do not affect psychomotor skills and reaction speed.

Pharmacodynamics and pharmacokinetics

The ointment base used for the preparation of the medication ensures maximum solubility and release of the active components troxerutin and indomethacin. The dosage form in the form of a gel provides the best therapeutic effect due to the good absorption of active substances from the surface of the skin. Application to the skin allows you to create therapeutic concentrations of active substances in the periarticular tissues and subcutaneous fat. A small amount of active substances enters the systemic circulation.

Contraindications

Indovazin is not used in pediatric practice (age limit is 14 years due to lack of experience in clinical practice).

Absolute contraindications:

breast-feeding;
individual hypersensitivity to NSAIDs;
damaged skin, violation of their integrity at the site of application of the ointment;
third trimester of pregnancy .

Relative contraindications:

allergic rhinitis;
taking other medications containing NSAID components;
polyps in the mucous membranes of the nasal cavity;
bronchial asthma.

pharmachologic effect

Indovazin gel contains 2 active substances, the complex action of which provides a pronounced therapeutic effect of the drug.

Indomethacin has several effects:

anesthetic;
anti-inflammatory;
decongestant.

The active substance allows you to quickly reduce the severity of pain , relieve swelling, and shorten the recovery period of affected and damaged tissues. The main principle of action is based on suppressing the processes of synthesizing active substances of prostaglandins by reversibly blocking cyclooxygenases of the first and second types.

Troxerutin is a bioflavonoid . Trihydroxyethylrutinoside is an angioprotector . The venotonic effect is manifested due to the ability of the active substance to reduce capillary permeability . Troxerutin is able to block the venodilating effect of bradykinin , histamine and acetylcholine . An anti-inflammatory effect is manifested in relation to perivenous tissue . The component has an antiplatelet (inhibiting aggregation) effect , reduces the severity of swelling, reduces capillary fragility, and has a positive effect on trophism in pathology.

Indovazin gel, when applied externally, suppresses the severity of pain, reduces the temperature in the inflammatory focus, and reduces inflammatory swelling. The drug is characterized by capillary protective (protective) and venotonic effects.

Action of the constituent components

The active ingredients of Indovazin gel are indomethacin and troxerutin. Both components act on the cause of the disease, eliminating it and restoring damaged tissues and natural processes.

Indomethacin is a substance with analgesic, anti-edematous and anti-inflammatory properties. When indomethacin enters the body, symptoms such as swelling and pain decrease.
Troxerutin is a bioflavonoid component that belongs to the group of angioprotectors. As a result of the action of troxerutin, vascular permeability decreases and venous tone increases. The overall effect helps relieve inflammation, reduce vascular fragility and activate regenerative processes.

The composition of the Indovazin gel, enhanced with additional components, prevents the development of the disease and completely eliminates the symptoms of the pathology, due to deep penetration into the blood vessels.

Cheap analogues of Indovazin

If the patient has contraindications to the use of Indovazin, or the drug does not give the desired results, a replacement is prescribed. Indovazin analogues have the same effects, but differ in the components included in the composition, cost, contraindications and side effects.

Troxerutin and Indovazin - what to choose?

Troxerutin is presented in the form of yellowish capsules of 300 mg each. Produced in Russia, the main component is Troxerutin.

A brief description of.

Troxerutin is more suitable for the treatment of advanced phase venous insufficiency and hemorrhoids. The main component is considered a derivative of rutin and has a powerful anti-edematous effect. Indovazin has a broader effect and is more suitable for combating joint diseases.
The analogue has much fewer side effects and contraindications; as a rule, they consist of allergic reactions. Indovazin, on the other hand, cannot boast of good tolerability and availability.
The cost of Troxerutin is 52 rubles, almost the same as that of the opponent.

If you choose between Troxerutin and Indovazin for the treatment of diseases of the musculoskeletal system, it is better to give preference to the second remedy.

Indovazin or Troxevasin - which is better?

Troxevasin and Indovazin are considered analogues, but their mechanism of action differs.

Comparative characteristics.

Troxevasin contains 2 active substances, one of them is troxerutin. Indovazin additionally contains indomethacin, which has a strong anti-edematous, antispasmodic and anti-inflammatory effect.
After applying Troxevasin, the active components practically do not penetrate into the bloodstream, which cannot be said about Indovazin.
The analogue is not used in pediatrics; it is approved for use in children over 18 years of age. Indovazin can be prescribed to adolescents over 14 years of age, this is considered its advantage.
The cost of Troxevasin is on average 200 rubles, which is more expensive than Indovazin.

For venous diseases, Troxevasin is more effective and has a complex effect in comparison with its opponent. For joint pathologies, it is better to give preference to Indovazin.

Venoruton or Indovazin - what is the difference?

Venoruton and Indovazin differ in their mechanism of action and active substance. The first drug includes rutozoid in its composition and has a powerful angioprotective and venotonic effect.

Which drug is better to choose?

Venoruton is considered a combined drug with complex action, used for the treatment of varicose pathologies of the legs and other similar ailments. It is also prescribed for the prevention of vascular diseases.
Venoruton is available in the form of cream, gel, capsules, and effervescent tablets. There are more varieties of the drug than Indovazin.
Venoruton helps reduce swelling, prevents thrombosis - it has almost the same effects as the opponent, but more effectively fights trophic ulcers caused by disruptions in the blood flow of soft tissues.
The cost of the analogue is much higher - about 700 rubles. This is considered its disadvantage.
Venoruton has a smaller list of contraindications.

Which of these remedies is better depends on the purpose of its use. For venous pathologies, Venoruton is much more effective and accessible in terms of contraindications, the drug is endowed with more powerful properties. Indovazin “specializes” more in the fight against joint diseases and provides symptomatic treatment for pathologies of the musculoskeletal system.

Indovazin or Venorutinol - which is cheaper?

Venorutinol and Indovazin have the same effect, the differences between them are insignificant, but it is better to know about them in order to make the right choice.

The analogue of Indovazin is produced in the form of gel and capsules. The active substance is rutin.
The opponent is prohibited for use in children under 14 years of age; Indovazin also has the same contraindication. Venorutinol is also not prescribed to people with gastrointestinal pathologies.
The price for analog capsules is on average 600 rubles, and a tube of gel costs 300 rubles. The cost of Indovazin is cheaper.

There are no more differences between the drugs; if there are contraindications to Indovazin, you can safely replace it with Venorutinol.

Gepatrombin and Indovazin - what is the difference?

Indovazin and Gepatrombin are considered not complete analogues; their principles of action and composition differ significantly.

Differences between medications.

Hepatrombin is produced in the form of a gel and ointment, like Opposite.
The active substance is sodium heparin, allantoin, dexpanthenol. Indovazin contains indomethacin and troxerutin.
Hepatrombin has a more powerful venosclerotic effect, unlike Indovasin.
The number of indications for both drugs is almost identical, but there are much fewer contraindications - these include individual intolerance to the components of the drug and the presence of open wounds.
The analogue contains essential oils that have an additional calming and bactericidal effect.
The cost of Gepatrombin is 150-200 rubles per tube, Indovazin costs about the same.

Hepatrombin has a more powerful and faster effect than Indovazin, since it contains 3 active components, and the list of contraindications is significantly lower.

Indovazin price, where to buy

The average cost of a medicine in Russia is 250 rubles. The price of Indovazin gel depends on the region and pharmacy. The price of Indovazin ointment in Ukraine is 45 UAH.