Cavinton - indications for use, contraindications, method of application

To normalize blood circulation in the brain area, the doctor may prescribe the drug Cavinton. In addition, the drug has a vasodilator and antimicrobial effect.

It can also be prescribed for:

• neurological diseases;
• mental disorders;
• often used in gynecological practice (in the treatment of menopause);
• ENT practice for hearing treatment;
• Oculists prescribe the drug to normalize vision.

Active ingredient : Vinpocetine . Available in tablets with active ingredient 5 mg and forte 10 mg, as well as in ampoule form.

The price of the drug, depending on the form, can range from 220 to 260 rubles . Produced in Hungary, Gedeon Richter company.

Compound

1 tablet contains 10 m of vinpocetine - the active drug.

Additional ingredients: talc, magnesium stearate, colloidal silicon dioxide, lactose monohydrate, corn starch.

Release form

Tablets, 5 mg. In a PVC/aluminum blister of 25 pcs. 2 blisters in a cardboard box.

Concentrate for solution for infusion, 5 mg/ml. In brown glass ampoules of hydrolytic class I with a white breaking point, 2, 5 or 10 ml. 5 amps in a plastic tray. 2 and 5 ml - 2 plastic trays in a cardboard box. 10 ml - 1 plastic tray in a cardboard box.

The Gedeon Richter company produces Cavinton Forte in the form of tablets of 30 or 90 pieces per pack.

Pharmacological group

Indications for use

Used for neurological and mental disorders associated with cerebral circulatory disorders (after a stroke, post-traumatic, atherosclerotic origin); for memory disorders, dizziness, aphasia (speech impairment), etc.; for hypertension (persistent increase in blood pressure), vasovegetative symptoms (impaired vascular tone) during menopause, etc. In ophthalmological practice, Cavinton is prescribed for atherosclerotic and angiospastic (associated with a sharp narrowing of the lumen of blood vessels) changes in the retina and choroid of the eye, degenerative changes ( with a violation of the tissue structure) of the macula (the most sensitive area of ​​the retina), secondary glaucoma (increased intraocular pressure) associated with partial thrombosis (blockage) of blood vessels, etc. It is also effective in cases of decreased hearing of vascular or toxic (drug) origin and labyrinthine dizziness origin (associated with a disorder of the vestibular apparatus).

Pharmacodynamics and pharmacokinetics

Cavinton Forte is a drug whose action is aimed at improving brain metabolism, as well as increasing the consumption of oxygen and glucose by brain tissue. Vinpocetine enhances the resistance of neurons to hypoxia, increases the delivery of glucose to brain tissue through the BBB, converts glycolysis into a more energy-efficient process of aerobic glucose breakdown, and selectively blocks calcium-dependent PDE.

It increases the concentration of cGMP and AMP in the brain, the ATP content and the relative ATP/AMP ratio, increases the tissue metabolism of serotonin and norepinephrine, activates the formation of cells of the ascending noradrenergic system, and has antioxidant effectiveness. Reduces the ability of platelets to aggregate and thins the blood, enhances the deforming properties of red blood cells and prevents their utilization of adenosine, and helps to increase the release of oxygen from red blood cells.

Expands the neuroprotective effects of adenosine. Increases cerebral blood flow and reduces vascular resistance of the brain, without significantly affecting systemic circulation (including blood pressure, heart rate, minute volume, general peripheral resistance). It is not characterized by a steal effect, but even increases blood supply, especially in ischemic areas of the brain with insufficient perfusion.

When taken orally, vinpocetine is absorbed mostly in the proximal gastrointestinal tract. The average Tmax is 60 minutes. It does not undergo metabolic transformations when passing through the intestinal walls. Tissue Cmax is observed after 2-4 hours. Connection with plasma proteins is 66%, bioavailability is about 7%.

Metabolized outside the liver, as evidenced by its clearance - 66.7 l/h, exceeding the hepatic plasma volume (50 l/h). With further oral administration in the dose range of 5-10 mg, linear kinetics of the drug is observed. Excreted by the intestines and kidneys in a ratio of 2:3. T1/2 fluctuates between 4-6 hours.

Cavinton and alcohol

As for interaction with alcohol, the drug is completely incompatible. The fact is that Cavinton promotes vasodilation and increases blood circulation in the brain. Accordingly, alcohol will be absorbed into the blood at a faster rate, and its cells will enter the brain, which can cause adverse consequences. Severe intoxication is possible, which may pose a health risk. At critical doses, the body may not be able to withstand it, even in a healthy person.

Interesting fact: Viagra was invented by accident during the development of a drug to treat heart disease.

Interesting fact: The most common infectious disease in the world is dental caries.

Interesting fact: Diabetes ceased to be a deadly disease only in 1922, when insulin was discovered by two Canadian scientists.

Interesting fact: The human brain is as active during sleep as it is during wakefulness. At night, the brain processes and integrates the experiences of the day, decides what to remember and what to forget.

Interesting fact: The liver breaks down alcohol most effectively between 6 and 8 p.m.

Interesting fact: Only humans and dogs can get prostatitis.

Interesting fact: The human nose is a personal air conditioning system. It heats cold air, cools hot air, and traps dust and foreign bodies.

Interesting fact: The highest body temperature was recorded in 1980 for Willie Jones from Atlanta, USA; upon admission to the hospital it was 46.5C.

Interesting fact: According to Californian scientists, people who eat at least 5 walnuts a week live 7 years longer on average.

Interesting fact: The Egyptian pharaohs used leeches; in ancient Egypt, researchers found images of leeches carved on stones, as well as scenes of their treatment.

Fun fact: Babies are born with 300 bones, but this number drops to 206 by adulthood.

Interesting fact: Three quarters of the bacterial species living in the human intestine have not yet been discovered.

Interesting fact: The total distance that blood travels in the body per day is 97,000 km.

Interesting fact: Until the 19th century, teeth were removed not by dentists, but by general practitioners and even hairdressers.

Interesting fact: There are approximately one hundred trillion cells in the human body, but only a tenth of them are human cells, the rest are microbes.

Cavinton is a drug that helps improve cerebral circulation and metabolism in the brain.

Contraindications

Indications for the use of the drug include conditions of cerebral circulatory insufficiency, where Cavinton Forte is used to reduce the symptoms of mental and neurological disorders. These conditions include: the rehabilitation period after an ischemic stroke, the recovery stage after a hemorrhagic stroke, post-stroke complications, cerebral vascular atherosclerosis, vascular dementia, transient ischemic attack, vertebrobasilar insufficiency, hypertensive/post-traumatic encephalopathy.

In otorhinolaryngology, the use of drugs is indicated for the treatment of idiopathic tinnitus, Meniere's disease and conditions associated with decreased perceptual hearing.

The drug is also used for chronic vascular pathologies of the organs of vision, including lesions of the retina and their choroid.

Side effects of Cavinton

• frequent or recurrent headache;
• tachycardia (rapid heartbeat);
• increased drowsiness;
• general weakness;
• dizziness;
• dry mouth;
• heartburn;
• allergic skin rash (urticaria);
• increased sweating;
• frequent changes in blood pressure.

If any side effects develop after using this drug, it is recommended to consult with your doctor!

In this article, we found out what Cavinton helps with, as well as how to drink it correctly.

Directions for use and doses

Pills

Inside, after eating. Typically the daily dose is 5–10 mg 3 times a day (15–30 mg per day). The initial daily dose is 15 mg. The maximum daily dose is 30 mg. The therapeutic effect develops approximately a week from the start of taking the drug. The course of treatment is 1–3 months.

For kidney and liver diseases, the drug is prescribed in the usual dose; the absence of accumulation allows for long courses of treatment.

Concentrate for the preparation of solution for infusion

IV, drip, slowly (maximum infusion rate - 80 drops/min).

It is prohibited to administer intramuscularly or intravenously without dilution.

To prepare the infusion, you can use saline solution or solutions containing dextrose (Ringer, Salsol, Rindeks, Reomacrodex).

The usual initial daily dose is 20 mg (2 amps) in 500 ml of infusion solution. Depending on tolerability, the dose can be increased to no more than 1 mg/kg/day over 2–3 days. The average duration of treatment is 10–14 days.

The average daily dose for a body weight of 70 kg is 50 mg (5 amps in 500 ml of infusion solution).

For liver and kidney diseases, no dose adjustment is required.

At the end of the course of IV therapy, it is recommended to continue treatment with Cavinton® forte tablets (1 tablet 3 times a day) or Cavinton® (2 tablets 3 times a day).

The infusion solution with Cavinton® should be used within the first 3 hours after preparation.

Description of the drug

Cavinton is a drug that regulates blood circulation in the brain and improves metabolic processes in brain tissue. The drug Cavinton can be used to treat people of different age groups, including children. Unlike other vasodilator drugs, Cavinton is well tolerated by the body and has a minimal list of contraindications and side effects.

The basis of Cavinton is vinpocetine, which has the ability to have a positive effect on oxygen metabolism and have an antithrombotic and vasodilator effect. The high therapeutic effect of the drug is present in vascular diseases of the brain, which are accompanied by decreased memory, hearing, and impaired concentration. Cavinton can be used in the complex treatment of vegetative-vascular therapy and ischemic disorders.

Cavinton is available in tablets and solution for injection. Cavinton tablets contain 5 mg of the active ingredient - vinpocetine, as well as excipients. The package contains 2 blisters containing 25 tablets. The pharmacological industry offers its customers Cavinton Forte, but unlike the usual drug, it is much stronger and contains 10 mg of vinpocytine.

The injection solution contains 10 mg of vinpocytine. Available in ampoules of 2 ml in packaging No. 10 ampoules for intravenous administration. It is strictly forbidden to administer the drug subcutaneously.

Cavinton injections are mainly performed in a hospital setting, and tablets are prescribed for outpatient treatment. Only the attending physician can prescribe a dose of medication or a therapeutic course.

For adult patients, specialists usually recommend 1-2 tablets of Cavinton three times a day. The maintenance dose is halved. A significant improvement in well-being is observed by the end of the first week of therapy.

Cavinton Forte tablets, which this type of drug helps with for similar indications, are recommended to be taken one at a time with water three times a day. On average, the course is 3.5–4 months, according to individual indications – up to six months. If the medication must be stopped, gradual withdrawal is carried out over at least 2-3 days.

Intravenous administration of con is carried out at a dosage of 10–20 mg, with mandatory dilution in 500 ml of saline solution. For special indications, even drip administration of a pharmacological agent is permissible, followed by transferring the patient to taking tablets.

Cavinton tablets in Minsk cost 9-17, infusion solution - 5-28 Belarusian rubles. In Moscow, the price of the drug starts at 225 rubles. You can buy the medicine in Kyiv and Kazakhstan for 148 hryvnia and 2200 tenge (Cavinton Forte 10 mg (vinpocetine) No. 30 tablets GEDEON RICHTER, Plc. (Hungary))

Numerous positive reviews about the drug "Cavinton" indicate that this drug really has a pronounced positive effect if used in the doses and course duration recommended by a specialist.

In pediatric practice, neurologists practically do not use it for fear of complications. However, there is positive experience of use for the prevention of childhood convulsive syndrome after brain injury. When using the medication, undesirable effects still occur, such as sleep disturbance in children and increased irritability.

Cavinton Forte, instructions for use

Instructions for use Cavinton Forte recommends internal (oral) administration of drug tablets after meals.

The duration of treatment and sufficient dosages of the drug are prescribed by the doctor based on the individual situation.

As a rule, tablets are taken three times every 24 hours at a dose of 5-10 mg. Therapy should be started with a daily dose of 15 mg, with its increase, if necessary, to the maximum permissible daily dose of 30 mg. The therapeutic effectiveness of treatment is observed after 7 days, and the full effect of therapy requires taking the drug for 3 months.

Liver/kidney pathologies do not require dosage adjustment.

special instructions

Cavinton ampoules contain sorbitol, so if a person suffers from diabetes, he needs to constantly monitor his blood glucose levels. During the period of taking the drug, it is necessary to avoid drinking alcoholic beverages, and also strictly adhere to the recommended doses of the medication.

In general, people who have taken Cavinton for therapeutic or prophylactic purposes note the high effectiveness of the drug, as well as a persistent therapeutic effect after the course of treatment.

Cavinton and Cavinton Forte tablets contain lactose. If the patient has hypersensitivity to lactose, it should be taken into account that one tablet contains 41.5 mg of lactose monohydrate.

Cavinton infusion solution contains sorbitol, therefore, in case of diabetes mellitus, blood sugar concentrations should be periodically monitored.

If you have fructose intolerance or fructose 1,6-biphosphatase deficiency, it is not recommended to use vinpocetine in concentrate form when using Cavinton.

Manufacturer

Concentrate for the preparation of solution for infusion.

JSC "Gedeon Richter", Hungary. 1103, Budapest, st. Demrei, 19-21.

Pills

1. JSC "Gedeon Richter", Hungary.

2. JSC "Gedeon Richter-RUS". 140342, Russia, Moscow region, Egoryevsky district, Shuvoe village, st. Lesnaya, 40.

Consumer complaints should be sent to the following address: Moscow Representative Office of JSC Gedeon Richter. 119049, Moscow, 4th Dobryninsky lane, 8.

Tel.; Fax.

Interaction

Combined use with Methyldopa sometimes led to a slight increase in the hypotensive effect, and therefore, with such a combination, constant monitoring of blood pressure is required.

When used in parallel with Imipramine, Clopamide, Pindolol, Glibenclamide, Acenocoumarol, Digoxin and Hydrochlorothiazide, no significant interactions were observed.

Judging by the effects of vinpocetine, its co-administration with antiarrhythmic, central and anticoagulant drugs should be carried out with caution, although to date there is no data on such interactions.

Pregnancy

During pregnancy and breastfeeding, the use of vinpocetine is contraindicated. Vinpocetine crosses the placenta, but appears in the placenta and fetal blood in lower concentrations than in the mother's blood. No teratogenic or embryotoxic effect was noted. In animal studies, administration of large doses of vinpocetine was associated in some cases with placental hemorrhage and miscarriage, mainly as a result of increased placental circulation. Breastfeeding. Vinpocetine passes into breast milk. In studies using labeled vinpocetine, the radioactivity of breast milk was ten times higher than that in the mother's blood. The amount excreted in milk within 1:00 is 0.25% of the administered dose of the drug. Since vinpocetine passes into mother's milk, and there is no data on the effect on the body of newborns, the use of vinpocetine during breastfeeding is contraindicated.

Synonyms of nosological groups