In the modern world, with a deteriorating environment and a fast pace of life, heart problems have become widespread. Even in the initial stages, they can cause inconvenience and lead to poor health. If diseases are neglected and left untreated, this can lead to disastrous consequences. One of the common forms of heart disease is hypertension - high blood pressure. There are many drugs that help fight this disease, one of them is Papazol. This remedy has been used in medicine for many years. When prescribing Papazol, the indications for use may vary. But the main goal for many people using this medication is to try to lower their blood pressure.
Composition and release form
Modern youth generally have no idea what Papazol helps with. But earlier this medicine was used in different situations. Even now, despite the fact that modern means have appeared, Papazol is often used in hospital settings.
This drug belongs to the group of cholespasmolytics. It is available only in tablets. They are sealed in blisters of 10 pieces. In Russia, the price of Papazol is 65 rubles per package.
One tablet contains 30 mg of elements such as papaverine and bendazole. The composition also includes additional substances and components:
- povidone;
- starch;
- lactose monohydrate;
- calcium stearate.
Analogs
A structural analogue of the drug is Papazol-UBF.
The following drugs are characterized by a similar mechanism of action and belong to the same pharmacological subgroup (“Papaverine and its derivatives”): Bioshpa, Vero-Drotaverin, Droverin, Drotaverin MS, Drotaverin forte, Drotaverin-UBF, Nikoverin, No-shpa, No-shpa forte, Nosh-Bra, Papaverine, Papaverine hydrochloride MS, Platyphylline with papaverine, Platyphylline hydrotartrate, Ple-Spa, Spasmol, Spasmonet, Spazoverine, Spakovin.
pharmachologic effect
The peculiarities of the action of the drug "Papazol" are determined by the properties of its constituent components. Papaverine hydrochloride is a medicine, an antispasmodic. It is often used in many areas of medicine. Papaverine relieves spasms and increases the tone of the smooth muscles of the body, reduces pain.
Bendazole is a component of many medications. Externally, it is a white powder with a slightly gray or yellowish tint, similar to flour. It has a salty-bitter taste. It has a vasodilating and immunostimulating effect, stimulates the activity of the spinal cord, and activates the formation of antibodies in the body. This substance helps lower blood pressure.
Povidone is a soluble powder, most often with a weak specific odor, white or yellowish in color. It binds with toxins and helps remove them from the body, also slowing down the absorption of harmful substances into the blood.
Lactose monohydrate is almost the same thing as lactose, only used in medicines and tablets. Thanks to this component, the drug is stored longer. Calcium stearate is a white to yellowish-white powder used in medicines as an emulsifier.
Therapeutic effect
Papaverine in the drug Papazol, which helps relieve hypertension, has an antispasmodic and hypotensive effect. According to the instructions, it is capable of:
- cause inhibition of PDE (phosphodiesterase);
- accumulate cAMP (cyclic adenosine monophosphate) in the cell; reduce calcium levels in the blood;
- reduce the tone and relaxation of the smooth muscles of the intestines, stomach, as well as the respiratory and genitourinary systems;
- reduce tone and relax smooth muscles and blood vessels.
Bendazole is an antispasmodic agent with a myotropic effect. It affects the body as follows:
- has a hypotensive and vasodilating effect;
- stimulates the immune system and spinal cord functions.
A large dosage of the drug can suppress cardiac excitability and slow down intracardiac conduction. The use of Papazol has almost no effect on the central nervous system, but at the same time, a significant dosage can cause a sedative effect. The therapeutic effect of using Papazol provides: dilation of blood vessels in the brain and heart; decrease in blood pressure; relaxation of the smooth muscles of the intestines and stomach.
"Papazol": instructions for use
You should not abuse this drug, although it does not have a sedative effect and does not cause serious negative reactions. Take 1-2 tablets orally 2-3 times a day. It is advisable to drink it only when necessary, and not constantly. The tablets should not be chewed; they should be taken with plenty of water. You need to drink them 1.5-2 hours before or after meals. The course of treatment is from 2 to 4 weeks. It is possible to increase or decrease the duration of treatment. Instructions for use of Papazol recommend its use for children from 1 year of age. The pediatrician prescribes the dosage for the child. Usually this is 0.5-1 tablet up to 2 times a day.
"Papazol": indications for use
Patients with hypertension often take this drug, although there are more effective medications. But this particular drug relieves spasms well, while simultaneously lowering blood pressure. It is often used as an “ambulance” for hypertensive crisis. When using Papazol, indications for use may be as follows:
- labial increase in pressure;
- spasm of peripheral arteries or cerebral vessels;
- pain in the abdomen due to colitis or ulcers;
- cholecystitis;
- hepatic colic;
- facial paralysis;
- headache;
- ailments due to nerves, stress and anxiety.
Contraindications
There are certain conditions under which taking Papazole tablets is prohibited. Contraindications include the following conditions:
- epilepsy;
- bronchial obstruction;
- liver or kidney failure;
- age under 1 year;
- allergy to the components of the drug.
Doctors also do not recommend it for children under twelve years of age or people with low blood pressure, as this can lead to weakness and poor health. By ignoring these facts, you can disrupt the effect of Papazol and bring yourself harm, not benefit.
List of contraindications
It is not recommended to take Papazol with low blood pressure. In addition, it is better to replace the antispasmodic with an alternative remedy in the presence of the following diseases:
- severe form of heart failure;
- peptic ulcer of the stomach and duodenum (in the presence of hemorrhages);
- glaucoma;
- hypothyroidism;
- disturbances of atrioventricular conduction;
- diabetes mellitus type 1 and 2;
- pathologies of the kidneys and liver.
The medication is not recommended if you are prone to constipation and decreased muscle tone. It is prohibited for use by elderly patients, pregnant women and children under 12 years of age.
Analogues of the drug
You can buy Papazole tablets and their analogues at any pharmacy. The low cost of the drug may be due to high competition. Similar products are often more expensive. But you need to choose not by price, but by the effect it provides.
You can replace the drug with Papaverine or Bendazole tablets, which have the same, but weaker effect. Antispasmodics based on drotaverine also have a similar effect: “Drotaverine”, “No-Shpa”, “Spazmol”.
If we talk about the analgesic, antispasmodic and hypotensive effect, it is worth noting the following popular analogues of Papazol:
- "Pentalgin" - used for headaches and spasms;
- "Andipal" - for high blood pressure;
- "Baralgin" - similar to "Pentalgin", an analgesic;
- "Corvaldin" - helps with problems with blood pressure.
Perhaps their main disadvantage is the price and list of restrictions on admission. "Papazol" has less harsh effects and side effects, and is much cheaper.
Interaction with other drugs
Simultaneous use of Papazole with antispasmodic drugs, sedatives, diuretics, tricyclic antidepressants, procainamide, reserpine, quinidine sulfate can enhance the manifestation of the hypotensive effect.
Papazole helps reduce the effect of anticholinesterase drugs on smooth muscle and reduces the antiparkinsonian effect of levodopa.
Concomitant use with nitrofurantoin may contribute to the development of hepatitis.
Adsorbents, drugs that have an astringent and enveloping effect, reduce the absorption of Papazol.
Side effect
Despite the fact that “Papazol” relieves the symptoms of hypertension well in case of high blood pressure, negative reactions of the body to the drug may occur:
- nausea;
- constipation, loose stools;
- weakness, lethargy, drowsiness;
- heart rhythm disturbance;
- dizziness;
- allergies, rashes, itching;
- sweating, cold sweat.
Side effects and overdose
When using the Papazol blood pressure pill, the following side effects may occur:
- nausea;
- constipation;
- arrhythmia;
- decreased myocardial contractility;
- allergic reactions;
- heavy sweating;
- dizziness;
- AV block.
If the body’s adverse reactions are not so dangerous for the patient, and he can tolerate them (temporary dizziness, mild nausea), the doctor does not stop taking the drug.
In this case, you should only limit activity for a while, refrain from activities that require concentration and caution (driving transport, staying at high altitudes). In cases where the side effects are more intense and dangerous (for example, heart function is disrupted), the doctor selects another drug instead.
If the dosage of the drug is exceeded, the patient may experience the following symptoms:
- increased sweating;
- hot flashes;
- weakness, drowsiness;
- double vision;
- nausea;
- headache;
- decrease in pressure.
In order to eliminate the symptoms of overdose, it is necessary to rinse the stomach, use sorbents, and give the patient milk. Pathological manifestations are treated with symptomatic therapy. At the first signs of an overdose, you should contact a medical facility or call an ambulance.
The drug can cause very dangerous negative reactions if used uncontrolled by small children, so the tablets should be stored in a place where children cannot reach it.
special instructions
You should take the drug after consultation with your doctor, because you should not ignore the possibility of allergies to components or other reasons that will not allow it to be used for treatment. When using Papazol, indications for use and contraindications for the characteristics of the body must be carefully studied.
Alcoholic beverages should not be taken together with the drug. This may increase sedation and the risk of side effects. The drug should be prescribed with caution to elderly people, women during pregnancy, patients with traumatic brain injury or with reduced intestinal motility.
When used together with antidepressants, barbiturates and some other drugs, the effect of Papazole is enhanced, and weakness and drowsiness may also appear. And if you take the drug at the same time as adsorbents, its effect will decrease.
Reviews from patients taking the drug
This is a good budget option for antispasmodics and tablets that help improve well-being, which has a place in the home medicine cabinet, because it does not have too strong an effect on the body after a single dose and is suitable for children, pregnant women (in consultation with a doctor) and the elderly. Many patients like that they can take it to relieve headaches and stomach pain. This drug is available in all pharmacies without a prescription for a low price.
Many patients, having learned what Papazol helps with, choose it for headaches and high blood pressure. Some note that it has a stronger analgesic and antispasmodic effect than other popular drugs. Patients often write that they did not experience any side effects after taking the drug. They like that it is a cheap and effective remedy that can be given even to children.
"Papazol" refers to those drugs that help fight the unpleasant painful symptoms of hypertension and treat it at the same time. The medicine is quite famous. There are many analogues and recommendations from doctors, but Papazol is still often present in the home medicine cabinet. A good budget option, however, has contraindications.
