Klion d with which tablets to take. Vaginal tablets "Klion-D" - reviews and analogues. Features of treatment with Klion D tablets

Composition and release form of Klion D

In pharmacies, Klion D can be purchased in the form of tablets (20 pieces). 1 tablet of the drug contains 250 mg of metronidazole. Additional ingredients include sodium lauryl sulfate, colloidal anhydrous silica, povidone, magnesium stearate, sodium bicarbonate, tartaric acid, crospovidone and sodium carboxymethyl starch, lactose monohydrate and hydroxypropyl methylcellulose 2910.

They also produce vaginal tablets Klion D 100, 10 pieces per package, which consist of 100 mg of metronidazole and 100 mg of miconazole nitrate. Klion D candles have a white color and a special almond shape, as well as an uneven surface.

In addition, Klion D is produced in the form of an infusion solution (1 bottle of 100 ml).

Reviews from women

Valentina, 22 years old : “I often suffered from thrush. I always treated her myself, but this time something went wrong. I went to the gynecologist for an appointment and he prescribed me vaginal tablets Klion-D 100. Already in the morning there was no more itching and burning. After another three days of using the drug, the discharge stopped. After a course of the drug Klion, it’s been 6 months now and I don’t remember about thrush.”

Ekaterina, 36 years old : “I always use these vaginal tablets. They very quickly remove the most unpleasant symptoms. Sometimes the drug Kliona-D 100 may cause pinkish discharge, but this is normal.”

Pharmacokinetics and pharmacodynamics

The instructions for Klion D note that when this drug is used intravaginally, metronidazole is completely absorbed into the blood.

Miconazole is not completely absorbed by tissues. After 8 hours, almost 90% of the miconazole nitrate is still in the vagina. This component of Klion D completely changes and dissolves, without manifesting itself either in the urine or in the blood.

The instructions for Klion D show that metronidazole, which is part of it, has an antiprotozoal effect and also fights various microbes and fungal formations. The drug cannot destroy only facultative anaerobes and aerobic microorganisms.

Miconazole is able to eliminate common dermatophytes, many fungi and yeasts in the body. Also, the instructions for Klion D indicate the antibacterial effect of miconazole against some gram-positive bacteria.

Reviews of Klion D show that this remedy is used to eliminate itching, which often leads to infection. Klion D suppositories are absolutely safe for the female body, because they do not change the pH of the vagina and the specific composition of the microflora.

pharmachologic effect

The antifungal effect that the drug Klion-D has is possible due to the content of two powerful components - miconazole and metronidazole.

The first active substance of vaginal tablets fights the fungus itself, by affecting the cell membrane of microorganisms.

They begin to weaken and soon die. Miconazole relieves the irritating itching that accompanies all fungal ailments.

This component of the drug is poorly absorbed into the blood if introduced into the vagina. Its presence is not detected either in the blood or in waste products.

The advantage of miconazole is that even after 8 hours, about 90% of the substance is in the vaginal environment, providing an antifungal effect all this time.

Metronidazole Klion-D 100 acts as an antibacterial and antiprotozoal agent. It penetrates the DNA of microbes and blocks the process of cell division. With the help of this substance, the pathogen stops growth and reproduction.

Video about the pharmacological action of the drug:

After intravaginal administration of vaginal tablets, it is absorbed into the blood and accumulates in maximum concentration after 6-12 hours.

Since the absorption of the drug Klion-D 100 is very high, the active ingredients of the drug enter breast milk, placenta, brain and spinal cord.

The drug Klion-D 100 is excreted in the urine from 60 to 80% through the kidneys. For this reason, urine may turn brown or red.

The remaining percentage accumulates in the intestines and is excreted along with the feces.

Indications for use of Klion D

Klion D is prescribed to eliminate infectious and inflammatory diseases, the cause of which is associated with the negative effect of a number of anaerobic bacteria. Such diseases include osteomyelitis, sepsis, brain abscesses, peritonitis, lung and pelvic abscesses, meningitis, endometritis and gas gangrene.

Klion D 100 is also used for preventive purposes to get rid of infectious complications (caused by anaerobic streptococci and bacteroides) after surgery in the abdominal cavity and pelvic organs.

In some cases, Klion D suppositories are used to treat local vaginal infections.

Is it possible to use during pregnancy?

During pregnancy, women are also often diagnosed with various infectious and inflammatory diseases that require urgent medical therapy, since if it is not carried out, it can negatively affect the health of the unborn child. And in this case, Klion D is also often used. However, there are some nuances here:

• The drug may cause local side effects such as itching, burning and irritation, which may also result in an increase in the amount of vaginal secretion released.
• When using Klion D, it is important to take into account the duration of pregnancy, since its active components have the ability to penetrate the placenta through the bloodstream and cause various defects in the fetus, and therefore at the time of the formation of internal organs and systems (this occurs throughout the first trimester), its use is contraindicated.

Important! If, while using Klion D, a pregnant woman begins to have brown or bloody discharge, you should definitely go to the doctor, as they may indicate spontaneous termination of pregnancy or the onset of premature birth!

Directions for use and dosage

Klion D tablets are prescribed in the following dosages:

• If the patient has trichomoniasis, take 1 tablet (250 mg) orally, 2 times a day for 10 days. One increased dosage in the evening is also prescribed - 8 tablets (2 g).
• If an adult patient has giardiasis, take 2 tablets orally in the morning and evening for a week.
• For amebiasis in adults - 2 tablets 3 times a day for 1-1.5 weeks.

The instructions for Klion D indicate that this drug is also used in the form of an infusion solution. In this case, children over 12 years of age and adults are administered Klion D by drip, 100 ml every 8 hours. The duration of treatment on average reaches a week. If an urgent need arises, intravenous administration of the drug can be continued. However, it is necessary to ensure that the daily dosage does not exceed 4 g. After completing the course of treatment, the patient is prescribed to take Klion D tablets (400 mg 3 times a day).

For children under 12 years of age, Klion D 100 is administered at the rate of 1.5 ml of solution per 1 kg of body weight (the same dosage remains the same for preventive treatment with this drug).

For prevention, adults and children over 12 years of age are prescribed 100 ml of solution during, before and after surgery. This dosage is repeated every 8 hours. After this, Klion D tablets are prescribed (200-400 mg each).

If the patient has trichomoniasis, she needs to insert 1 Klion D suppository, pre-moistened with water, deep into the vagina. This should be done once before bedtime for 10 days. Additionally, take 1 tablet orally 2 times a day.

Contraindications

Let's consider situations in which the use of Klion-D candles is prohibited. The instructions describe absolute contraindications when the drug cannot be used:

• diseases of the liver and central nervous system;
• renal failure;
• drug allergies;
• hepatitis of any etiology;
• severe liver damage;
• leukopenia;
• epilepsy (severe forms accompanied by convulsions and frequent seizures);
• pregnancy, 1st trimester (allowed to use for vaginal candidiasis, starting from 36-37 weeks);
• breastfeeding period;
• children under 12 years old.

Caution is required for diabetes mellitus and blood microcirculation disorders.

You should avoid drinking alcohol, even in small doses, during the period of treatment with Klion-D suppositories.

Side effects of Klion D

• Reviews of Klion D show that side effects most often include burning, itching and irritation in the vagina (thick, white, odorless discharge), frequent urination, a burning sensation in the partner’s penis;
• Nausea, dry mouth, change in taste preferences, decreased appetite, vomiting, abdominal pain, diarrhea or constipation;
• Reviews of Klion D indicate that rashes, hives, and itching may occur on the skin;
• Dizziness and headache;
• Leukocytosis and leukopenia. In reviews of Klion D, it is noted that quite rarely urine can turn red-brown.

Properties

When treated with Klion-D tablets, the therapeutic effect is achieved quite quickly, which is due to its multicomponent composition. Miconazole has a detrimental effect on harmful cells, destroying their membrane, which prevents their further reproduction and leads to their further death. The peak effect of this component occurs eight hours after using the drug. At the same time, the concentration of miconazole in the bloodstream is quite insignificant.

Metronidazole provides an effect due to its ability to act on microorganisms by penetrating their DNA. Such an invasion prevents the proliferation of bacteria, destroying them over time. Half-life occurs through urine, which may change color to reddish or brown.

A little later we’ll look at the price and reviews of Klion-D.

Contraindications for use

Klion D should not be taken in the following cases:

• If the patient is hypersensitive to some components of this drug;
• For blood diseases, leukopenia, problems with coordination of movement, liver failure, disorders of the central nervous system;
• Klion D should not be used during pregnancy (in the first trimester) and lactation;
• Patients with diabetes mellitus and problems with blood microcirculation require additional consultation.

special instructions

You should read some additional instructions before using Klion-D. The instructions give the following recommendations:

1. Candles should not be used if there are contraindications.
2. During treatment, women should abstain from sexual intercourse.
3. When carrying out antibacterial therapy, it is necessary to combine medications carefully so as not to cause adverse reactions.
4. In the case of therapy in conjunction with anticoagulants, spontaneous bleeding should not be allowed to occur.
5. Both sexual partners need to undergo a course of therapy to avoid re-infection and to achieve the full therapeutic effect.
6. Alcoholic drinks should be completely avoided so as not to provoke disulfiram-like reactions.
7. At the beginning and end of the treatment course, it is important to keep the number of leukocytes and the blood picture under control, because While taking metronidazole, minor leukopenia or immobilization of treponemes may occur.
8. It is better to give up driving a car, working with potentially dangerous mechanisms and other types of work for a while. Negativity from the nervous system may occur with the appearance of dizziness and headache.
9. Girls are only allowed to use Klion-D vaginal suppositories from the age of 12.
10. Impaired liver function and liver failure are absolute contraindications for the use of Klion-D 100.

Drug interactions of Klion D

Klion D 100 should not be taken together with disulfiram, as the patient may experience mental disorders.

Klion D increases the active substance of indirect anticoagulants, which slows down the formation of prothrombins.

In reviews of Klion D, it is noted that the drug cannot be combined with vecuronium bromide.

Concomitant use of barbiturates reduces the effect of metronidazole.

The use of cimetidine and Klion D 100 increases the concentration of metronidazole in the blood, which leads to the development of side effects.

The use of drugs containing lithium increases their content in the blood plasma.

Analogues substitutes

Complete analogues of the drug Klion-D 100 are Neo-Pentoran and Metromicon-Neo.

Partial ones include:

• Gaynomax;
• Clomegel;
• Vagisept;
• Ginalin;
• Vagiferon.

Photo gallery of analogues:

Geynomax Neo-Pentoran

Clomegel Vagiferon

Metromicon-Neo Ginalin

Vagisept

Storage conditions

Klion D should be stored in a dry place at a temperature of 15-25 degrees.

Vaginal suppositories

• — Cream 2%
• — Vaginal suppositories 300 mg
• — Cream for external use
• — Vaginal suppositories
• — Solution for external use
• — Vaginal tablets
• — Vaginal cream 2%; aluminum tube 30 g, 78 g, cardboard pack
• — Capsules mg; blister 3 pack cardboard 1
• — Vaginal suppositories
• — Gel for vaginal use
• — Gel for external use
• — Solution for intravenous administration
• — Suspension for oral use
• — Vaginal suppositories 100 mg + 750 mg + 200 mg
• — Vaginal suppositories 750 mg
• — Vaginal tablets
• - Pills
• - Pills
• — Tablets 500 mg
• — Solution for infusion 5 mg/ml
• — Tablets 250 mg
• — Vaginal tablets 500 mg

Indications for use of the drug Klion-D 100

Trichomonas, candidal and nonspecific vaginitis (local treatment).

Release form of the drug Klion-D 100

vaginal tablets; contour packaging without cells 10, cardboard pack 1;

Vaginal tablets 100 mg + 100 mg; strip 10, cardboard pack 1;

Vaginal tablets 100 mg + 100 mg; strip 10, box 100;

Composition Vaginal tablets 1 table. metronidazole 100 mg miconazole nitrate 100 mg excipients: sodium lauryl sulfate; colloidal silicon dioxide; magnesium stearate; povidone; sodium bicarbonate; tartaric acid; sodium carboxymethyl starch (type A); crospovidone; hypromelose; lactose monohydrate in contour-free packaging 10 pcs.; in a cardboard pack 1 package.

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Pharmacodynamics of the drug Klion-D 100

The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Metronidazole is a broad-spectrum antimicrobial and antiprotozoal agent. Active against Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia intestinalis as well as against obligate anaerobes (spore-forming and non-spore-forming) - Bacteroides spp. (Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Clostridium spp., Peptostreptococcus spp., sensitive strains of Eubacterium. Aerobic microorganisms and facultative anaerobes are not sensitive to metronidazole.

Miconazole has antifungal activity against common dermatophytes, yeasts and various other fungi and antibacterial activity against certain gram-positive bacteria.

Miconazole inhibits the biosynthesis of ergosterol in fungi and changes the composition of other lipid components in the membrane, which leads to the death of fungal cells. Quickly relieves itching that often accompanies infections caused by yeast and dermatophytes. Does not change the composition of the microflora and pH of the vagina.

Pharmacokinetics of the drug Klion-D 100

Metronidazole. When administered intravaginally, it is absorbed into the systemic circulation. Cmax in the blood is determined after 6–12 hours and is approximately 50% of the Cmax that is achieved (after 1–3 hours) after a single dose of metronidazole orally.

Miconazole. Systemic absorption of miconazole nitrate after intravaginal use is limited. 8 hours after application of the drug, 90% of miconazole is still present in the vagina. Unchanged miconazole is not detectable in either plasma or urine.

Use of the drug Klion-D 100 during pregnancy

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Contraindications to the use of the drug Klion-D 100

hypersensitivity to the components of the drug (including other nitroimidazole derivatives);

Blood diseases, leukopenia (including history);

Impaired coordination of movements, organic lesions of the central nervous system (including epilepsy);

Liver failure (in case of high doses);

Pregnancy;

Breastfeeding period.

Carefully:

Diabetes;

Microcirculation disturbance.

Side effects of the drug Klion-D 100

Local: itching, burning, pain and irritation in the vagina; thick, white, mucous vaginal discharge without odor or with a faint odor, frequent urination; a burning sensation or irritation of the penis in a sexual partner.

From the gastrointestinal tract: nausea, changes in taste, “metallic” taste and dry mouth, loss of appetite, cramping pain in the abdominal cavity; vomiting, constipation or diarrhea.

Allergic reactions: urticaria, itching of the skin, rash.

From the nervous system: headache, dizziness.

Other: leukopenia or leukocytosis. In rare cases, urine is colored red-brown (due to the presence of a water-soluble pigment formed as a result of the metabolism of metronidazole).

Method of administration and dosage of the drug Klion-D 100

Intravaginally (deeply), after moistening the tablet with water.

Trichomonas vaginitis - 1 table. per day for 10 days in combination with oral metronidazole.

Nonspecific vaginitis or candidal vaginitis - 1 table. 2 times a day for 10 days, if necessary in combination with oral metronidazole.

Treatment with metronidazole should not last more than 10 days and be repeated more than 2-3 times a year.

Interactions of the drug Klion-D 100 with other drugs

Like disulfiram, it causes ethanol intolerance. Concomitant use with disulfiram can lead to the development of various mental disorders and depression of consciousness.

Strengthens the effect of indirect anticoagulants (warfarin, etc.), which leads to an increase in the time of prothrombin formation.

Co-administration with barbiturates may accelerate the elimination of metronidazole, resulting in a decrease in its effect.

Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of side effects.

When taken simultaneously with lithium preparations, the concentration of the latter in plasma may increase.

Special instructions when taking the drug Klion-D 100

During the treatment period you should abstain from sexual intercourse.

If there are indications in the anamnesis of changes in the composition of peripheral blood, as well as when using the drug in high doses and/or with its long-term use, monitoring of a general blood test is necessary.

Metronidazole can immobilize treponemes, leading to a false-positive Nelson test.

Use with caution while working for drivers of vehicles and people whose profession is associated with increased concentration of attention (dizziness associated with taking the drug may occur).

Storage conditions for the drug Klion-D 100

List B.: In a dry place, protected from light, at a temperature of 15–30 °C.

Shelf life of the drug Klion-D 100

The drug Klion-D 100 belongs to the ATX classification:

G Genitourinary system and sex hormones

G01 Antiseptics and antimicrobials for the treatment of gynecological diseases

G01A Antiseptics and antimicrobials for the treatment of gynecological diseases (excluding combinations with corticosteroids)

G01AF Imidazole derivatives

In pharmacies you can often find medicines with almost identical names from the same manufacturer, but at the same time differing in action, purpose and even main active ingredients. The drugs Klion and Klion D 100 are just one of a series of such examples. They can be prescribed both together or separately, and the amount and duration of administration varies depending on the specific disease.

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The drugs are similar only in that they both contain metronidazole and are produced by the same company, Gedeon Richter.

Interaction with other drugs

If miconazole, when used intravaginally, is practically not absorbed into the systemic circulation, then another substance, metronidazole, is actively concentrated in the blood plasma. Klion-D 100 has good compatibility only with sulfonamides and antibiotics. In combination with other medications in tablets, various side effects are quite possible:

• Phenytoin, Phenobarbital (inducers of microsomal oxidation enzymes) provoke an acceleration of the elimination of Metronidazole from the liver.
• Ethanol causes disulfiram-like reactions in the body. May lead to nausea, abdominal cramps, vomiting, skin flushing, headache, vomiting, tachycardia.
• Disulfiram often causes psychotic reactions and confusion, because Inducers of microsomal oxidation enzymes begin to affect the body.
• Indirect anticoagulants provoke an increase in prothrombin time and the risk of bleeding.
• Non-depolarizing muscle relaxants increase the concentration of lithium in the blood plasma.
• Sulfonamides cause an increase in the antimicrobial effect of metronidazole.
• Cyclosporine accumulates in the blood plasma, so it is important to keep its combination with metronidazole under control and check the concentration of creatinine and cyclosporine in the blood plasma.
• Cimetidine increases the risk of side effects because increases the concentration of metronidazole in the blood plasma.

What is the difference?

The difference between Klion and Klion D 100 is that the latter is vaginal tablets of the appropriate form. They are called tablets, not suppositories, because of the forming substances that are not typical for suppositories. They are used exclusively as suppositories, inserted deep into the vagina once a day (preferably at night).

The main difference between Klion D and Klion is the composition. Vaginal tablets additionally contain 100 mg of miconazole. This substance is effective against fungi of the genus Candida, which cause thrush. Acting directly at the site of its manifestation, miconazole in combination with metronidazole is quite effective for mixed infectious vaginitis. Although for standard candidiasis (without other infections) Klion 100 is not the drug of choice, in such cases it is better to use safer drugs like Pimafucin, which fight only candida and do not affect the natural microflora.

The amount of metronidazole in “D” is also 100 mg, i.e. two and a half times less than in tablets for oral administration. The dosage has been reduced so that regular Klion and Klion D can be used simultaneously for candidiasis complicated by protozoal infections. Studies show that such a ligament is effective in 86% of mixed vaginal infections: 93% for trichomonas-bacterial vaginitis and 73% for bacterial-candidiasis.

Antibiotic or hormone?

Despite its local effect, Klion D is an antibiotic due to the content of metronidazole, so it should also be used with caution. Metronidazole and miconazole do not directly affect the endocrine system and are not hormones in themselves, therefore Klion D tablets are not hormonal.

Instructions for use. Contraindications and release form.

INSTRUCTIONS for using the drug KLION-D

Release form

Vaginal tablets are almost white, oval, biconvex, with a pointed end, with “100” engraved on one side.

Package

10 pieces. — aluminum strips (1) — cardboard packs.

pharmachologic effect

Klion-D 100 is a combined drug with antibacterial, antiprotozoal and antifungal effects for intravaginal use. Metronidazole, a derivative of nitro-5-imidazole. The mechanism of its action is the biochemical reduction of the 5-nitro group by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms. Metronidazole is an effective antimicrobial and antiprotozoal agent with a broad spectrum of action. Active against: Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia intestinalis, Obligate anaerobes (spore-forming and non-spore-forming): Bacteroides spp, Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus, Fusobacterium sp p, Clostridium spp, Peptostreptococcus spp. Facultative anaerobes and obligate aerobes are resistant to metronidazole. Miconazole has an antifungal effect against dermatophytes, yeasts, and also an antibacterial effect against certain gram-positive bacteria. Miconazole inhibits the biosynthesis of ergosterol and changes the composition of other lipid components in the membrane, which leads to necrosis of fungal cells. Miconazole relieves the itching that often accompanies infections caused by yeasts and dermatophytes. Does not change the composition of the microflora and pH of the vagina.

Indications

Local treatment of vaginitis of mixed etiology caused simultaneously by Trichomonas spp. and Candida spp.

Contraindications

leukopenia (including history); organic lesions of the central nervous system (including epilepsy); liver failure; pregnancy (first trimester); lactation period (breastfeeding); children under 12 years of age; hypersensitivity to the components of the drug; hypersensitivity to other azoles. The drug should be prescribed with caution for diabetes mellitus and microcirculation disorders.

Use during pregnancy and breastfeeding

The drug is contraindicated for use in the first trimester of pregnancy and during breastfeeding.

special instructions

During the period of use of the drug, you should not drink alcohol (risk of developing disulfiram-like reactions). During the period of use of the drug, it is recommended to abstain from sexual intercourse. Simultaneous treatment of sexual partners is recommended. Metronidazole can immobilize treponemes, resulting in a false-positive TPI test (Nelson test). Monitoring laboratory parameters When using Klion-D 100, slight leukopenia may be observed, so it is advisable to monitor the blood picture (the number of leukocytes) at the beginning and at the end of therapy.

Impact on the ability to drive vehicles and operate machinery

If side effects from the central nervous system occur, you should refrain from driving vehicles and working with potentially dangerous mechanisms.

Compound

1 tab. metronidazole 100 mg miconazole nitrate 100 mg Excipients: sodium lauryl sulfate - 0.5 mg, colloidal silicon dioxide - 7 mg, magnesium stearate - 13 mg, povidone - 26 mg, sodium bicarbonate - 90 mg, tartaric acid - 100 mg, sodium carboxymethyl starch (type A) - 100 mg, crospovidone - 100 mg, hypromellose - 190 mg, lactose monohydrate - 473.5 mg.

Directions for use and doses

Intravaginally. 1 vaginal tablet (pre-moistened with water) is inserted deep into the vagina in the evening before bed for 10 days in combination with taking the drug metronidazole orally.

Side effects

Local reactions: burning, itching, pain and irritation of the vaginal mucosa; thick, white, mucous vaginal discharge with little or no odor; burning sensation or irritation of the partner's penis. From the digestive system: nausea, vomiting, changes in taste, metallic taste in the mouth, decreased appetite, spastic abdominal pain, constipation or diarrhea. From the side of the central nervous system: headache, dizziness. From the hematopoietic system: leukopenia or leukocytosis. Allergic reactions: urticaria, itching of the skin, rash. From the urinary system: urine is colored red-brown due to the presence of a water-soluble pigment (metronidazole metabolite - 2 oxymetronidazole), formed as a result of the metabolism of metronidazole.

Drug interactions

Since the systemic absorption of miconazole is low, interactions with other drugs are caused by metronidazole. Metronidazole is compatible with sulfonamides and antibiotics. When consumed simultaneously, alcohol causes reactions similar to disulfiram (cramping abdominal pain, nausea, vomiting, headache, skin flushing). Concomitant use with disulfiram is unacceptable (additive effects, may cause confusion). The drug can enhance the effect of indirect anticoagulants. Prothrombin time may increase, so dose adjustment of indirect anticoagulants is necessary. It is not recommended to combine the drug with non-depolarizing muscle relaxants (vecuronium bromide). Inducers of microsomal oxidation enzymes in the liver (for example, phenytoin, phenobarbital) can accelerate the elimination of metronidazole, which leads to a decrease in its concentration in the blood plasma. Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of side effects. It is possible to increase the concentration of lithium in the blood plasma during the course of treatment with metronidazole, therefore, before starting to use Klion-D 100, it is necessary to reduce the dose of lithium or stop taking it for the duration of treatment.

Overdose

There are no data regarding overdose with intravaginal use of metronidazole vaginal tablets. However, when used concomitantly with metronidazole orally, systemic effects may develop. Symptoms of metronidazole overdose: nausea, vomiting, abdominal pain, diarrhea, generalized itching, metallic taste in the mouth, movement disorders (ataxia), dizziness, paresthesia, convulsions, peripheral neuropathy, leukopenia, dark urine. No symptoms of miconazole overdose have been identified.

Storage conditions

The drug should be stored in a place protected from light and moisture at a temperature of 15° to 30°C.

Best before date

5 years.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription

Women face problems with infectious gynecological diseases. Painful sensations and itching appear, creating the possibility of infecting a partner or child at the time of birth. The main danger is relapses and complications. Suppositories with metronidazole will help you cope, but it is important to read the instructions for the product.

Overdose

What effects does overdose of Klion-D cause? The instructions for use provide information that the drug is indicated for isolated intravaginal use, therefore, in principle, an overdose should not occur if used correctly according to the instructions. If Metronidazole, Klion-D 100 are taken in excessive doses or incorrectly (by accidental ingestion), then the following unpleasant signs may appear:

• convulsions;
• colic in the abdomen;
• diarrhea;
• generalized itching;
• metallic taste in the mouth;
• vomiting, nausea;
• peripheral neuropathy;
• disorientation in space.

There is no specific antidote to eliminate poisoning or overdose. The main goal is to quickly remove the remaining drug from the digestive system, i.e. rinse the stomach, drink 1.5-2 liters of clean water, give an enema to cleanse the intestines if necessary. Then take enterosorbent (white activated carbon, Polysorb, Enterosgel, Sorbex), lie down in bed, calm down, drink a warming drink if you are dehydrated.

You need to call an ambulance or go to a medical facility if the signs of an overdose do not go away. In a hospital setting, hemodialysis, supportive or symptomatic therapy can be performed.

Klion-D - indications

The drug in its release form (vaginal tablets) is used for the local treatment of gynecological infections caused by bacteria and fungi. Efficiency is determined by 2 effective elements in the composition. The following are active:

Klion-D are suppositories made as almond-shaped tablets, which are moistened with water before use and inserted into the vagina. Doctors recommend doing such procedures at night. What does Klion-D treat? First of all, gynecological infections. Indications for use of Klion-D are candidiasis or thrush, gardnerellosis. Features of the use of medicine for vaginitis:

• if the disease is caused by Trichomonas, in addition to suppositories, metronidazole is taken orally;
• for candidiasis infection, microflora imbalance, Klion suppositories are given twice a day.

What kind of drug?

Klion-D 100 are biconvex white suppositories for vaginal use. On one side there is an engraving “100”. The shape is oval with a pointed tip for ease of intravaginal insertion. The therapeutic effect of the combined drug is due to the active substances (metronidazole, miconazole) in the composition:

• improves 5-nitro groups inside infection cells;
• blocks RNA and DNA synthesis;
• provokes the death of anaerobic microbes, trichomonas, yeast fungi and dermatophytes, without modifying the pH, acidity, and normal vaginal microflora.

Klion-D is often prescribed after the first trimester of pregnancy for thrush. Reviews about the use of candles are mostly positive.

Klion-D candles - instructions for use

The main active ingredients of the drug are metronidazole and miconazole. Manufacturers add additional substances to the composition of candles:

• hydroxypropyl methylcellulose 2910;
• sodium bicarbonate;
• sodium lauryl sulfate;
• povidone;
• magnesium stearate;
• colloidal anhydrous silicon;
• lactose monohydrate;
• sodium carboxymethyl starch type A;
• crospovidone;
• tartaric acid.

In order to avoid complications and side effects, it is necessary to study the instructions for the Klion D suppositories. The instructions stipulate:

• contraindications for use;
• inadmissibility of consumption together with alcohol;
• avoiding use during breastfeeding due to the drug getting into milk;
• compatibility of the drug with antibiotics;
• enhancing the effect of anticoagulants;
• when used with ethanol, the appearance of mental disorders;
• careful use when driving vehicles.

According to the instructions, it is recommended to use vaginal suppositories once, at night. They are pre-moistened with water to facilitate deep insertion into the vagina. The package contains 10 suppositories, which are enough for a course of treatment. The drug Klion-D acts quickly, eliminating unpleasant symptoms in a short time. It is important to note that when using candles you need:

• carry out simultaneous treatment of a partner;
• refrain from working with complex units;
• exclude sexual contacts for this time;
• monitor leukocyte levels due to decreased values ​​during treatment.

Klion-D during pregnancy

The period of waiting for a baby is often accompanied by a drop in immunity and the occurrence of candidiasis, which can also cause harm to the child. During pregnancy, Klion-D should not be used in the early stages, when the fetus is developing organs and systems. Self-administration of medications during this period is excluded. With great caution, in case of serious problems, gynecologists prescribe Klion-D vaginal tablets in the last weeks of pregnancy. Before childbirth, suppositories are used to cleanse the birth canal so as not to infect the newborn.

Klion-D - side effects

When prescribing a drug, doctors must take into account that there is an individual intolerance to individual components. The instructions specify contraindications for use:

• epilepsy;
• breastfeeding period;
• blood diseases;
• leukopenia;
• impaired coordination of movements;
• 1st trimester of pregnancy;
• liver failure;
• children under 12 years of age;
• organic disorders of the central nervous system.

The patient should be warned by the doctor about the side effects of Klion-D. There is a high likelihood of the following symptoms:

• irritation of the mucous membrane;
• burning, itching in the woman’s genitals;
• headache;
• white discharge with mucus;
• skin rash;
• diarrhea;
• nausea;
• dizziness;
• constipation;
• abdominal cramps;
• vomit;
• irritation, burning of the partner’s penis;
• dark colored urine.

Features of application

To prevent the occurrence of side effects, including vaginal discharge, you must strictly follow the recommendations that are described in the instructions for the drug.

During the entire course of treatment, it is strictly forbidden to enter into intimacy with the opposite sex. In the event that complete refusal of intimacy is impossible, it is imperative to use contraception (condoms) during intercourse.

You cannot take tests for treponemes while taking Klion D, since due to the high concentration of the active substance metronidazole in the blood, the test may show false results, resulting in an incorrect diagnosis.

The drug reduces the level of leukocytes in the blood, and therefore, when taking it, you should periodically take a blood test. If leukopenia (low level of white blood cells in the blood) occurs, the use of tablets should be discontinued.

It should also be noted that even vaginal administration of Klion D can cause some disorders of the central nervous system. Therefore, during therapy, it is extremely undesirable to engage in activities that require increased concentration.

Under no circumstances should you combine the use of the drug with drinking alcoholic beverages, as this can lead to severe abdominal pain, nausea, skin flushing and other side effects.

When menstruation occurs, the course of treatment should be interrupted. This is due to the rapid removal of the drug from the vagina along with menstrual blood and a decrease in its effectiveness.