Gliatilin - instructions for use, analogs, reviews and release forms (capsules or tablets 400 mg, injections in injection ampoules) of a drug for the treatment of traumatic brain injuries and dementia

Instructions for using gliatilin method and dosage

Gliatilin injections (injections)

Gliatilin (tablets, capsules, ampoules): instructions for use, price, reviews from doctors and patients

For various problems with cerebral circulation, pathologies of the cardiovascular system and the central nervous system, there is a need to use nootropics.

One of the popular remedies is Gliatilin .

Radar

Information about Gliatilin is included in the system of medicines registered in the Russian Federation.

Basic information about the neuroprotector:

• name in Latin – Gliatilin;
• the basis of the composition is choline alphoscerate;
• anatomical-therapeutic-chemical classification – N07AX02, nootropics.

The last update was carried out on July 12, 2011.

Compound

The basis of the composition is the chemical compound choline alphoscerate.

The area of ​​action of the component extends to choline receptors in the central nervous system.

To ensure that the product is better absorbed by the body, the active ingredient is supplemented with:

• esithol;
• sodium ethyl parahydroxybenzoate;
• gelatin;
• sodium propyl parahydroxybenzoate;
• sorbitans;
• metahydroxide;
• titanium dioxide, iron.

To produce a liquid form, the active ingredient is supplemented with glycerin and liquid in the form of purified water.

Pharmacology

The therapeutic effect with high effectiveness is ensured due to the physical and chemical properties of the constituent chemical compounds.

Among the main ones:

• influence on systemic blood flow by accelerating blood circulation;
• activation of metabolic functions;
• stimulation of the reticular formation;
• restoration of lost functionality in case of various types of injuries (damage to brain tissue).

The nootropic corrects the factors of involutional psychoorganic syndrome.

This process is based on the suppression of cholinergic activity, as a result of which the amount of phospholipids in neuronal membranes changes.

Price and release forms

The cost of the medicine depends on the form of release and dosage:

• Capsules (400 mg, 14 pcs.) - price in the range of 720-780 rubles .
• Oral solution (600 mg/7 ml, 10 units) – price 520 rubles .
• Injection liquid (1000 mg, 4 ml ampoules, 3 units) - price in the range of 565-630 rubles .

You can buy a nootropic drug both in a pharmacy chain and in an online store.

One of the main conditions for dispensing a pharmacological product is the availability of a prescription.

When placing an order through an online pharmacy, you have the option of purchasing the medicine without a prescription.

Indications for use

In medicine, nootropic medicine is used for the following pathologies:

• disturbances of visual memory, speech functions;
• syndromes characterized by a decrease in intelligence, memory and other degenerative damage (when the cause of their development is cerebrovascular insufficiency);
• decreased cognitive activity, dementia.

The drug is highly effective in correcting psycho-emotional states, behavioral disorders, and other central nervous system pathologies.

Other uses of the medicine:

• for strokes to relieve acute symptoms;
• for rehabilitation after a stroke (promotes the restoration of physical skills and consciousness).

The neuroprotector is also used in therapy for children.

It is considered justified to use the medicine for the following problems:

• neuroses, nervous tics;
• autism;
• ADHD;
• hydrocephalic syndrome;
• cerebral palsy;
• with mental retardation, mental retardation;
• with birth injuries of the brain;
• during labor hypoxia.

Instructions for use

The injection liquid is designed to administer medication using a needle via the IV or IM route.

Intravenous injections (droppers) are performed with preliminary dissolution of 1 ampoule of the drug with 50 ml of saline solution.

The speed of liquid movement through the system is 80 drops/min.

• Treatment of acute forms of diseases begins with intramuscular injections. The daily dose is 600-1000 mg. Sometimes it is rational to use intravenous medication (up to 3000 mg).
• As soon as there is a positive trend in the patient’s condition, a switch to tablets is made. This takes on average 5-10 days.

The neuroprotector in capsules is taken orally. Taking time: 40-60 minutes before meals.

The treatment regimen involves taking the medicine 2-3 times, 1 tablet each, for 3-6 months (the duration of the course depends on the etiology of the disease, the intensity of its development, and the patient’s condition).

Instructions for use for children:

• It is better to take the medication in the morning before breakfast;
• You need to take the whole tablet only with purified water (100-150 ml);
• when prescribing intravenous drip infusions, the drug is pre-diluted with saline solution;
• IM injections are given into the muscle tissue (the shoulder or femoral part is most often involved);
• injection time – up to 12-14 hours.

For TBI, it is recommended to use 1 ampoule per day for 1 week. After this, a transition to capsules is made (1 unit twice a day for 2 months).

The duration of therapy for birth trauma/hypoxic encephalopathy is about six months. For 10-12 days, injections are given once a day (1-2 ml).

The daily norm for children 1-3 years old can increase to 2-3 ml, for the age group over 3 years old - 4 ml. The next stage of therapy is the use of tablets. Capsules are used according to the following scheme: 1 pc. 2 times a day.

After 2-3 months, treatment can be adjusted by a specialist under whose supervision the patient is.

Gliatilin during pregnancy and lactation

The neuroprotector is not prescribed to pregnant patients.

The simultaneous use of medication and breastfeeding of the child is excluded.

If there is a need to use Gliatilin, a nursing woman is advised to temporarily stop breastfeeding her baby.

Restriction on use

Those patients who are allergic to one of the components of the composition should refuse to use the drug.

The restrictions also apply to the age group under 18 years of age. Gliatilin is used with caution in pediatrics.

When administering an injection, a ban on mixing the neuroprotector with other medications in the same syringe is observed.

Side effects

In the course of a study conducted to study the effect of choline alfoscerate on the human body, rare cases of side effects were identified.

At the initial stage of therapy, nausea, mild confusion, and epigastric pain may appear.

The doctor who is seeing the patient is informed about unpleasant symptoms. The specialist will adjust the dose, select an analogue, and make other changes to the treatment course.

Overdose

An overdose of a drug is indicated by unreasonable nausea. Associated symptoms: belching, flatulence or loose stools.

The patient is asked to take the sorbent and reduce the daily dosage.

Reviews from neurologists

A. P. Stepanov, work experience 22 years:

Tatyana Mikhailovna Kuznetsova, practicing specialist with 12 years of experience:

Analogues of the drug

Any drug that is developed based on choline alfoscerate is hypothetically suitable for therapy.

In fact, a specialist chooses an analogue taking into account several important factors.

The most effective medications are:

• Cerepro;
• Nooholin Rompharm;
• Delecite;
• Cereton;
• Holitylin;
• Gleazer.

For children, the doctor suggests:

• Anvifen (capsules) – recommended from 3 years of age, active substance – aminophenylbutyric acid;
• Cortexin (in injection ampoules) – can be included in therapy for premature babies;
• Aminalon (in tablets) – the composition contains GABA, used from 1 year;
• Pantogam (in the form of syrup) - the composition is based on hopantenic acid, the drug is suitable for any age;
• Nootropil (various forms) - the composition is developed on the basis of piracetam, used from the age of one.

Source: //psihbolezni.ru/lechenie/gliatilin-tabletki-kapsuly-ampuly-instruktsiya-po-primeneniyu-tsena-otzyvy-vrachej-i-patsientov/

Release form, composition of the drug Gliatilin

Gliatilin is available in oval, yellow, opaque soft gelatin capsules that contain a viscous, colorless solution. One capsule contains 400 mg of the main active ingredient choline alfoscerate and auxiliary components: glycerol, purified water. The capsule shell consists of the following ingredients:

• Gelatin;
• Esitol;
• Sorbitan;
• Sodium ethyl parahydroxybenzoate;
• Sodium propyl parahydroxybenzoate;
• Titanium dioxide;
• Iron (III) metahydroxide.

A blister with fourteen capsules and instructions for use is placed in a cardboard box. The price of the drug and reviews about it are available on the Internet.

Gliatilin in ampoules is a transparent, colorless and odorless solution for intravenous and intramuscular administration. One ampoule has a volume of 1 ml. One milliliter of solution contains 250 mg of choline alfoscerate. 3 ampoules of colorless glass with a volume of 4 ml are placed in a blister contour packaging. The cardboard box contains 1 contour package and instructions for use of the drug Gliatilin. Reviews can be read on medical forums.

Gliatilin for children

General provisions

Gliatilin, like other nootropics, is often prescribed to young children to eliminate motor, mental or speech delays.

, or to eliminate the consequences of birth trauma and perinatal encephalopathy. In more rare cases, the drug is used to treat traumatic brain injury, concussion, or brain contusion. Children under 7 years of age are usually prescribed Gliatilin in the form of injections, since when using the solution, the required dosage of the drug can be measured, which is smaller than for adults.

With various options

In children of any age, Gliatilin is best used in the form of intramuscular injections for a number of reasons. Firstly, when using the solution, you can measure the dosage the child needs. Secondly, the course of therapy with Gliatilin injections is much shorter than when taking tablets (for example, injections are given for 5 - 14 days, and capsules are taken for 1 - 3 months). Finally, thirdly, Gliatilin injections are often much more effective than taking capsules.

In case of developmental delay, consequences of birth trauma or perinatal encephalopathy, children of the first year of life are administered intramuscularly with 1 - 2 ml of solution (250 - 500 mg) of Gliatilin once a day, for 10 - 12 days. For children aged 1 - 3 years, the solution is administered 2 - 3 ml once a day, for 10 - 12 days.

In case of developmental delay, consequences of birth trauma and perinatal encephalopathy, the drug can be used for children and in capsules. If a child over one year old can easily swallow a whole capsule of Gliatilin, then he should be given the drug 400 mg (1 capsule) 2 times a day for 1 to 3 months.

If a child older than one year cannot swallow the capsule, then you should carefully pierce its shell with a needle and draw its contents into a syringe. Then all the liquid contents drawn out from the capsule with a syringe should be poured into the child’s mouth (after first separating the needle from the syringe) and give him still water to drink.

For the same conditions, children under one year of age are strongly recommended to use Gliatilin injections rather than capsules. However, if for some reason you have to give a child under one year of age the drug in capsule form, then it is recommended to do so as follows. First, pierce the capsule with a needle attached to a syringe and draw out all its contents.

Then, having disconnected the needle, carefully pull back the child’s lower lip and drop 4–6 drops of the solution drawn from the capsule from a syringe into the space between the lip and gums. After this, you need to give the child something to drink. Thus, the child is given the drug 4 - 6 drops 2 times a day, for 1 - 3 months.

In case of traumatic brain injury, concussion or contusion, it is recommended to administer Gliatilin intravenously or intramuscularly at 1000 mg (1 ampoule) once a day for 7 days, starting from the first day of injury. Starting from the second week after injury, you can continue treatment by taking 400 mg capsules (1 capsule) 2 times a day for two months.

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Active ingredients

It is known that the brain is a complex, nonlinear open system with many redundant control and signal transmission circuits at various levels. The signal is a weak electric current, and its production is carried out using electrochemical reactions in which the energy of bonds between atoms in molecules is transformed into electron flows.

Without delving into pharmacology and biochemistry, we can say that this drug acts on the following areas of the brain and central nervous system, in which the corresponding cholinergic receptor structures are located:

neurohypophysis, medulla oblongata and cerebral cortex;

autonomic ganglia;

Renshaw cells in the spinal cord.

Acetylcholine is an active substance, a mediator. It is also involved in neuromuscular transmission: without acetylcholine we would not be able to move. Its predecessor is choline, which is several thousand times less active. It is choline in the form of alfoscerate (a complex salt of an organic acid) that is the active ingredient of Gliatilin. Glycerophosphate and choline are first released from it, and then acetylcholine is synthesized from choline, which is captured by specific receptors, exerting its effect.

In addition, and this is perhaps more important, choline alphoscerate, after undergoing several transformations, is also transformed into phosphatidylcholine. It has nothing to do with impulse transmission, but is a structural component of the neuron membrane and its myelin sheath, performing the function of an insulator, protecting the conductor during the “transportation” of current along the axons of neurons.

This helps to improve metabolic processes, blood flow in the brain, and activation of the reticular formation. Therefore, the indications for the use of the drug are quite extensive. For what diseases and conditions is Gliatilin prescribed?

Operating principle

The main component Choline alfoscerate stimulates central cholinergic receptors, improves cerebral circulation and metabolism in the central nervous system. This compound ensures the production of special components in neuronal membranes - phosphatidylcholine and acetylcholine. When taking Choline alfoscerate, reticular formation is stimulated and the plasticity of neuronal membranes increases.

The combination of the described effects leads to the following improvements in the patient’s condition:

1. Increased mood;
2. The emergence of emotional stability;
3. Optimization of behavioral reactions;
4. Increasing concentration, ability to perceive, remember and reproduce information received from outside.

In case of TBI, the main component of choline alfoscerate improves the bioelectrical activity of the brain and stimulates blood flow in the affected area. This helps reduce neurological symptoms.

In the body, choline alfoscerate is broken down into 2 components:

• glycerophosphate;
• choline

The substance is absorbed into tissues by 88%, concentrated mainly in the brain. It is excreted from the body by the lungs (85% is exhaled in the form of carbon dioxide) and by the kidneys and liver (up to 15%).

Side effects and overdose of gliatilin

After taking Gliatilin capsules, the drug may develop nausea, confusion and pain in the epigastric region. If undesirable effects develop, doctors at the Yusupov Hospital individually decide on the advisability of continuing the therapeutic course or adjust the dose of choline alfoscerate.

If a large amount of gliatilin capsules is ingested, nausea may develop. In this case, the patient’s stomach is washed and enterosorbents are given to drink. There is no specific antidote for choline alfoscerate. Gliatilin capsules are stored at a temperature not exceeding 25 degrees Celsius. The shelf life of the drug in capsule form is 3 years.

Get advice on using gliatilin capsules by phone. If there are contraindications to the use of the drug or if the drug is not available in the pharmacy chain, doctors will individually decide what to replace gliatilin capsules with.

Author

Vladimir Vladimirovich Kvasovka

Deputy General Director for Medical Affairs, general practitioner, gastroenterologist, candidate of medical sciences

Shelf life of the drug Gliatilin

3.5 years.

In accordance with the instructions, the medication should be stored in a place away from sunlight. The maximum storage temperature for the Healer should not exceed twenty-five degrees Celsius. The shelf life is three years.

According to the instructions, Gliatilin should be stored in a dark place, out of reach of children, at a temperature not exceeding 25 °C.

The shelf life of gelatin capsules is 3 years, and the solution for intramuscular and intravenous administration is 5 years.

Gliatilin is a nootropic neuroprotective drug that is used in neurological practice in complex rehabilitation therapy for cerebral circulatory disorders of various origins. The main active ingredient is choline. It stabilizes nerve conduction by influencing neuronal membranes and nerve receptors.

Both ampoules and capsules of Gliatilin should be kept at home in a place inaccessible to a small child, where the temperature does not rise above 25 degrees Celsius. The shelf life of capsules is 3 years, and the injection form is 5 years.

And serious diseases of the central nervous system.

To help the brain recover, they are taken, one of which is Gliatilin, a nootropic that is a centrally acting cholinomimetic.

Our specialists

Andrey Igorevich Volkov

Neurologist, Candidate of Medical Sciences

Daria Dmitrievna Eliseeva

neurologist, candidate of medical sciences

Tatyana Aleksandrovna Kosova

Head of the Department of Rehabilitation Medicine, Physiotherapy Physician, Neurologist, Reflexologist

Elena Gennadievna Petrova

Physiotherapist, Candidate of Medical Sciences

Maxim Vladimirovich Chulkov

Instructor-methodologist in physical therapy, kinesiotherapist

Sergey Olegovich Molchanov

Instructor-methodologist for physical therapy

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Release form

Solution for infusion and intramuscular administration, 1000 mg/3 ml. 3 ml in ampoules of neutral colorless glass, type I. 3, 5 or 6 amps. in blister packs. 1 blister pack is placed in a cardboard box.

3 amp. placed in a blister pack. 2 blister packs are placed in a cardboard box.

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Gliatilin is available in two pharmacological forms: solution for injection and capsules. Each 4 ml ampoule contains 100 mg of the active ingredient - choline alfoscerate and water for injection. The ampoule contains a transparent, colorless, odorless solution. It is administered intramuscularly or intravenously.

One capsule contains 400 mg of the main active ingredient and inactive ingredients: glycerin, purified water. The capsules are oval-shaped, soft, gelatinous. They contain a viscous, colorless solution. Capsules are taken orally before meals, washed down with clean still water, without chewing.

In acute conditions, the drug is administered intramuscularly at a dose of 1000 mg (1 ampoule) per day or intravenously from 1000 mg to 3000 mg per day. When administered intravenously, the contents of one ampoule are diluted in 50 ml of 0.9% sodium chloride solution. Infusion rate is from 60 to 80 drops per minute. The duration of treatment is usually 10 days.

For patients suffering from chronic cerebrovascular insufficiency, changes in the emotional and behavioral sphere and multi-infarct dementia, the drug is prescribed orally at 400 mg (1 capsule) 3 times a day. Medical staff closely monitors patients to take their medication in a timely manner. The duration of therapy varies from 3 to 6 months.

Active ingredient: choline alfoscerate, auxiliary components. It is sold in capsule form in a dosage of 400 milligrams and in the form of an injection solution of 1 thousand milligrams (volume - 4 milliliters).

Delecite and others

This is another analogue of Gliatilin. Available in the form of a ready-made solution for intramuscular injections and infusions, as well as capsules, the active substance of which is the same choline alfoscerate. Produced by Russian and Italian Catalent Italy S.p.A. The average price of a drug is 700 rubles (5 ampoules of standard dosage) and 550-600 rubles (standard capsules). "Deletit" acts in the same way as "Gliatilin".

• "Holitilin" - 420 rubles. (3 ampoules).
• "Cereton" (RF) - 520 rubles. (5 ampoules).
• "Cereton", capsules (RF) - from 800 to 1000 rubles. (28 pcs.).

How to choose the right drug? Is it possible to replace a medicine prescribed by a doctor with an analogue produced in another country?

This issue should only be decided by the attending physician. Since the medicine is sold exclusively by prescription, the pharmacy does not have the right to sell an analogue instead of the drug prescribed by a doctor.

Directions for use and dosage

Gliatilin capsules should be taken orally before meals. The solution must be administered intramuscularly or intravenously.

For various changes in the behavioral and emotional spheres, in cases of chronic cerebrovascular insufficiency or multi-infarct dementia, the drug is prescribed in capsule form. The standard dosage is 1 capsule (400 mg) three times a day. The duration of treatment ranges from 3 months to six months.

In acute conditions, Gliatilin is administered intramuscularly. The usual dosage is 1 ampoule (1 g) 1 time per day. When administered intravenously, the dose is 1-3 g per day.

Before intravenous administration, the contents of 1 ampoule, which corresponds to 4 ml, should be dissolved in 50 ml of physiological solution. In this case, the infusion rate should be from 60 to 80 drops per 1 minute.

The duration of treatment is usually 10 days. If necessary, therapy is continued until positive results appear, when it becomes possible to switch to oral use of Gliatilin.

How to use the drug Gliatilin for children

Reviews from experts claim that this nootropic drug is a potent medicine

Therefore, it is important to remember that under no circumstances should you self-medicate your child.

The instructions for use do not advise giving this nootropic drug if the small patient is not yet 2 years old. The drug "Gliatilin" (capsules) is difficult for children at this age to swallow. It should be noted that these pills should never be divided into several parts, since there is liquid in the middle.

Only under the close supervision of a neurologist can a child be given the medication “Gliatilin”. The dosage for children over 2 years of age is as follows: 1 capsule twice a day. The course of such therapy is 2 months.

Most often, for young patients, doctors prescribe the drug “Gliatilin” in a different form. Injections for children, namely the volume of injections and the required quantity, are prescribed by a neurologist in each case individually.

If the baby is in a coma, then, of course, he is prescribed intramuscular injections of the above nootropic drug. After recovery from this condition, the child is prescribed the drug “Gliatilin” in the form of capsules.

Storage conditions for the drug Gliatilin

The Gliatilin capsule should not be bitten or opened.
This form of medication is swallowed whole with a small amount of still water. The annotation contains a recommendation to take this drug before meals (best before breakfast). Gliatilin injections can be prescribed either intramuscularly (into the shoulder or thigh muscle) or as drip intravenous infusions, for which the ampoule is diluted with saline solution. It is recommended to give the injection before meals in the first half of the day. Any solution not used for injection must be discarded.

Dosage

If a child has a traumatic brain injury, then Gliatilin is prescribed 1 ampoule per day for 1 week. The drug can be administered either into a vein or intramuscularly. After 7 days from the start of treatment, you should switch to taking capsules. They should be taken for 2 months, 1 capsule twice a day.

In case of hypoxic encephalopathy or birth trauma, a child under one year old (for example, at 6 months) is prescribed 1-2 ml of Gliatilin by injection. The drug is administered daily once a day for 10-12 days. If the child is 1-3 years old, then the daily dosage is increased to 2-3 ml, and at the age of over 3 years the medication is administered as a whole ampoule (4 ml once a day).

For children who can swallow capsules, the drug is prescribed one capsule twice a day for a course lasting from one to three months. It is also possible to draw the solution from the capsule with a syringe and give it to the child to drink by removing the needle, after which the contents of the capsule can be washed down with water. However, this use of the drug is resorted to occasionally, since injections are considered more effective and are prescribed in shorter courses (from 5 to 14 days).

In a place protected from light, at a temperature not exceeding 25 °C.

Keep out of the reach of children.

3.5 years.

Do not use after the expiration date stated on the package.

Safety of Gliatilin for children, side effects and contraindications

The nootropic does not have a mutagenic effect and does not cause developmental disorders, so it can be considered safe for treating children.

But parents should remember that the drug has a potent effect, so self-medication is strictly prohibited. The dosage, duration of therapy and methods of administration are prescribed only by a doctor.

Gliatilin is generally well tolerated, but can sometimes cause side effects such as:

• nausea (goes away after reducing the dosage);
• allergic manifestations (urticaria, severe itching).

The only contraindication to the use of the drug is individual intolerance to its individual components.

When prescribing Gliatilin in the form of injections, it should be remembered that the solution must not be mixed in the same syringe with other drugs.

Indications for use

Gliatilin is indicated for use in the following conditions and diseases:

• Acute period of traumatic brain injury, in which the brain stem is predominantly affected and there are corresponding symptoms (impaired consciousness, coma, etc.);
• Acute and recovery period of ischemic stroke;
• Recovery period of hemorrhagic stroke;
• Degenerative and involutional psychoorganic syndromes, manifested by memory impairment, confusion, disorientation, decreased motivation, initiative and concentration;
• Chronic cerebral circulatory failure (dyscirculatory encephalopathy);
• Violations of emotional stability and behavior, such as emotional lability, irritability, low interest in life, senile pseudomelancholy;
• Dementia caused by various causes (Alzheimer's, senile, mixed forms);
• Alzheimer's disease;
• Huntington's chorea;
• Disorders of cognitive function (impaired thinking, memory and concentration in older people, as well as confusion, disorientation, decreased motivation and initiative).

Gliatilin capsules and injections are contraindicated for use if a person has the following conditions or diseases:

• Individual hypersensitivity or allergic reactions to the components of the drug;
• The period of pregnancy and breastfeeding.

The drug Gliatilin is prescribed for various disorders of cerebral circulation, deterioration of cognitive perception and psycho-emotional pathologies. It is recommended to consult an experienced physician before use.

for adults

The main conditions for which it is necessary to take Gliatilin in adult patients are:

• ischemic and hemorrhagic forms of cerebrovascular accident;
• period of exacerbation after a traumatic brain injury with brainstem lesions (for example, coma, disturbances of consciousness);
• unstable mood (emotional lability);
• presenile and degenerative mental disorders and the consequences of chronic cerebrovascular insufficiency (for example, memory impairment, disorientation, prolonged lack of initiative and motivation, decreased ability to concentrate, confusion);
• multi-infarct dementia;
• excessive irritability;
• senile dementia;
• loss of interest and inability to concentrate.

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for children

The drug can be taken by children of any age only as prescribed by a specialist. Indications for the use of Gliatilin in this category of patients are the following conditions:

• psychomotor development delays;
• treatment of the consequences of encephalopathy of perinatal origin or brain injury received during childbirth;
• traumatic brain injuries.

Patients during pregnancy and breastfeeding are contraindicated in taking Gliatilin. If information about the presence of pregnancy was obtained during drug therapy, you should immediately stop taking it and undergo an examination to identify abnormalities in the development of the fetus. Breastfeeding women taking medication as prescribed by a specialist should avoid breastfeeding.

The following conditions are prohibited from using the product:

• manifestation of allergic reactions due to intolerance to the components of the drug;
• pregnancy;
• period of breastfeeding.

Indications

Therapists, neurologists, gerontologists and even psychiatrists like to prescribe this drug. This remedy is used in the presence of the following indications:

traumatic brain injury in the acute period, severe, with impaired consciousness and dysfunction of the brain stem, in patients with serious brain contusion who are in a coma;

stroke, both ischemic and hemorrhagic. In case of ischemic damage, Gliatilin can be prescribed not only in the recovery period, but also in the acute period. In case of cerebral hemorrhage – purely for restorative purposes;

chronic cerebrovascular insufficiency. This is a broad indication and includes symptoms such as memory and attention disorders in old age with cerebral atherosclerosis, dizziness, noise in the head, insomnia disorders, melancholy in old age;

The drug is also indicated for decreased concentration and memory impairment. Therefore, it can be taken if there is a significant mental load, when developing or when learning skills are lost. Thus, the drug can be prescribed to a child after a general serious illness, such as pneumonia, in order to quickly adapt to school and reduce the period of asthenovegetative and cerebroasthenic syndromes;

Gliatilin can also increase motivation, reduce emotional lability and some autonomic disorders. The drug helps to establish a normal balance between parts of the autonomic nervous system;

dementia, Alzheimer's disease. The popular and authoritative annual pharmaceutical reference book (RPR) lists another indication - Huntington's chorea - as part of complex therapy.

Synonyms of nosological groups

The drug is prescribed only by the attending physician if indicated. The dosage is determined individually depending on the severity of the clinical case.

For adults, the drug should be injected intramuscularly in a dosage of 1 g or 1 ampoule for acute conditions requiring immediate assistance. The number of injections per day is 1. Intravenous administration is prescribed in a dosage of 1-3 g, based on the patient’s condition. If the patient has a tendency to be allergic to medications, it is recommended to start therapy with 600 mg. In the absence of a negative reaction from the body, increase the dosage to that specified in the instructions.

The duration of the therapeutic course is on average from 3 to 6 months.

If the patient’s general condition improves, the patient can be switched to the capsule form of the medication. Drink 1 capsule up to 3 times a day before meals.

Before intravenous injection, the contents of 1 ampoule must be diluted with 50 ml of saline solution. The infusion rate is from 60 to 80 drops per 1 minute.

Intramuscular administration of the drug is recommended in the lateral or anterior part of the thigh. For intramuscular injection, you can use the brachialis muscle (outer part). If the patient does not have a problem with excess weight and a thin layer of fat, injections can be given in the abdomen.

Injecting the drug into the buttock is not recommended. In this place, the muscles are deep, and there is a risk of the drug dissolving in the fat layer, which will slow down the absorption of the drug and reduce the therapeutic effect.

The medicine is characterized by minimal toxic effects on the body, due to which the likelihood of adverse reactions is practically absent if the dosage is followed correctly.

Rarely, the following side effects may occur during the use of Gliatilin:

• attacks of nausea;
• allergic reactions on the skin: rashes, hives, redness;
• painful sensations in the abdomen;
• confusion;
• feeling of lack of air.

This symptomatic picture indicates individual intolerance to the drug and is a reason to discontinue it. To eliminate allergic reactions, it is necessary to treat with antihistamines. In the future, therapy continues with analogue drugs.

Side effects and symptoms of gliatilin overdose

Most patients tolerate gliatilin well even with long-term use. As a consequence of dopaminergic activation, a side effect may occur - nausea. In this case, neurologists reduce the dose of the drug. If allergic reactions occur, the drug is discontinued and therapy is carried out with antihistamines and glucocorticoid hormones.

With an overdose of gliatilin, patients may experience nausea. When this symptom appears, the dose of the drug is reduced. There are no data on the interaction of gliatilin with other drugs. Gliatilin does not affect the patient's ability to drive or engage in potentially hazardous activities.

Gliatilin is available from pharmacies with a doctor's prescription. The drug should not be taken on its own. If you have symptoms of diseases that are treated with gliatilin, make an appointment by phone and get advice from an experienced specialist.

Author

Better than Gliatilin

In medical practice, there is no concept of “best” or “better” in relation to drugs. Instead, doctors use the term “optimal.” Optimal is understood as a drug that suits a person best and gives the most pronounced therapeutic effect at the current time.

This means that for one person Gliatilin will be optimal, for another - Pantocalcin, and for a third - Encephabol, etc. Moreover, for the same person at different times different drugs may be optimal, for example, two years ago it was Gliatilin, and now it is Pantocalcin.

Our specialists

Andrey Igorevich Volkov

Neurologist, Candidate of Medical Sciences

Daria Dmitrievna Eliseeva

neurologist, candidate of medical sciences

Tatyana Aleksandrovna Kosova

Head of the Department of Rehabilitation Medicine, Physiotherapy Physician, Neurologist, Reflexologist

Elena Gennadievna Petrova

Physiotherapist, Candidate of Medical Sciences

Maxim Vladimirovich Chulkov

Instructor-methodologist in physical therapy, kinesiotherapist

Sergey Olegovich Molchanov

Instructor-methodologist for physical therapy

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pharmachologic effect

The instructions call the drug “Gliatilin” the strongest neuroprotector, which contains about 40% of a substance such as choline. The latter in the human body transforms into its active form - phosphorylcholine.

88% is absorbed when taking Gliatilin orally. Use in children produces the following therapeutic effect:

• improves the quality of transmission of nerve impulses to neurons;
• has a positive effect on receptor functions;
• increases the elasticity of membranes (neuronal);
• improves cerebral blood flow;
• restores consciousness in cases where the patient has suffered traumatic brain damage;
• promotes activation of the structure of the reticular formation of the human brain;
• affects cholinergic and synaptic transmission of nerve impulses, that is, neurotransmission;
• enhances metabolic processes in the human brain;
• improves blood circulation;
• helps restore respiratory function;
• has a beneficial effect on human mental activity;
• promotes speech and memory restoration;
• During the period of cerebral strokes, the drug is effective for cognitive and motor disorders.

The above nootropic agent is a centrally acting cholinomimetic, which directly predominantly affects the central nervous system. It should be noted that choline is an active participant in the biosynthesis of acetylcholine. The latter is the main mediator of nervous excitation.

Therefore, experts suggest giving the drug “Gliatilin” to children. Reviews claim that this nootropic does not affect the reproductive cycle at all and does not cause genetic mutations or developmental disorders.

The above substance is excreted from the body by the lungs in the form of carbon dioxide (about 85%), the rest through the intestines and kidneys.

Pharmacological group

The drug Gliatilin belongs to the group of centrally acting cholinomimetics, which have a direct effect on the central nervous system. The product has pronounced nootropic properties. Choline alfoscerate has a powerful neuroprotective effect, stimulates cerebral circulation, improves metabolic processes and creates favorable conditions for the transmission of nerve impulses in acetylcholine receptors.

Due to the activity of the active substance, the plasticity of neuronal membranes and the functioning of receptors improves. Gliatilin helps stimulate cerebral circulation, restore natural metabolic processes and activate consciousness in various traumatic brain injuries.

Under physiological conditions of transporting nerve impulses, the drug stimulates the production of acetylcholine, which directly depends on the dosage of the active substance.

Absorption of the active element from the gastrointestinal tract averages 88%.

The drug easily penetrates the blood-brain barrier and accumulates in the tissues of the brain, liver and lungs.

Excretion of the drug occurs primarily through the lungs in the form of carbon dioxide (approximately 85%). The remaining 15% is excreted through the intestines and kidneys.

Contraindications and side effects

Gliatilin is well tolerated. Since the active substance is a precursor of acetylcholine and is found in the body of every person, there are very few contraindications for use: individual intolerance and allergies, as well as pregnancy and lactation.

The side effect registered in the instructions and actually occurring, according to doctors, is only one: nausea. And then, this is not connected with the gastrointestinal tract, but with the dopaminergic system of the brain, which is also activated under the influence of the drug. In this case, you can reduce the dose or use centrally acting dopaminolytics, which are used in medicine as “antinausea” and antiemetics. This is the well-known metoclopramide, or “Cerucal”. If there is no nausea, then this is a sure sign that the medication will be well tolerated.

Analogs

On the pharmaceutical market, almost every drug has analogues, which are divided into two types - synonyms and, in fact, analogues. Synonyms are drugs that, like Gliatilin, contain choline alfoscerate as an active substance. Analogues are drugs that contain other active substances, but have a spectrum of therapeutic action that is maximally similar to Gliatilin.

So, the following drugs are synonymous with Gliatilin:

• Gleatser solution for injection;
• Delecite capsules, oral solution and injection solution;
• Noocholin Rompharm solution for injection;
• Choline alfoscerate solution for injection;
• Holitylin capsules and solution for injection;
• Cerepro capsules and solution for injection;
• Cereton capsules and solution for injection.

• Amylonosar tablets and solution for injection;
• Acefen tablets;
• Bravinton concentrate for the preparation of solution for infusion;
• Vinpotropil capsules, tablets and concentrate for the preparation of solution for infusion;
• Vinpocetine tablets and concentrate for the preparation of solution for infusion;
• Vinpocetine Forte tablets;
• Vincetin tablets;
• Ginkgo Biloba tablets and capsules;
• Ginkoum capsules;
• Glycine tablets sublingual and buccal;
• Gopantam tablets;
• Demanol solution for oral administration;
• Idebenone capsules and tablets;
• Cavinton tablets and concentrate for the preparation of solution for infusion;
• Cavinton Forte and Cavinton Comforte tablets;
• Calcium hopantenate tablets;
• Carnitex capsules;
• Carnicetine capsules;
• Cogitum solution for oral administration;
• Combitropil capsules;
• Korsavin and Korsavin Forte tablets;
• Cortexin lyophilisate for the preparation of solution for injection;
• Lucetam tablets and solution for injection;
• Memotropil tablets;
• Minisem nasal drops;
• Neypilept solution for injection;
• Neuromet capsules;
• Noben capsules;
• NooCam capsules;
• Nooclerin solution for oral administration;
• Noopept tablets;
• Nootropil capsules, tablets and solution for injection;
• Omaron tablets;
• Pantogam syrup and tablets;
• Pantogam active capsules;
• Pantocalcin tablets;
• Picamilon tablets and solution for injection;
• Picanoyl tablets;
• Pikogam tablets;
• Pineamin lyophilisate for the preparation of solution for injection;
• Pyracesin capsules;
• Piracetam capsules, tablets, granules for the preparation of syrup for children, solution for injection;
• Pyriditol tablets;
• Semax nasal drops;
• Telektol tablets;
• Thiocetam tablets and solution for injection;
• Fezam capsules;
• Phenotropil tablets;
• Celestab capsules;
• Cellex solution for subcutaneous administration;
• Ceraxon solution for oral administration and injection;
• Cerebrolysate solution for injection;
• Cerebrolysin solution for injection;
• Encephabol tablets and oral suspension;
• Epithalamin powder for solution for injection;
• Escotropil solution for infusion.

• Gleatser solution for injection;
• Noocholin Rompharm solution for injection;
• Cerepro capsules and solution for injection;
• Cereton capsules and solution for injection.

• Vinpotropil capsules, tablets and concentrate for the preparation of solution for infusion;
• Vinpocetine tablets and concentrate for the preparation of solution for infusion;
• Ginkgo Biloba tablets and capsules;
• Glycine tablets sublingual and buccal;
• Gopantam tablets;
• Cavinton tablets and concentrate for the preparation of solution for infusion;
• Calcium hopantenate tablets;
• Korsavin and Korsavin Forte tablets;
• Lucetam tablets and solution for injection;
• Memotropil tablets;
• Noben capsules;
• Nooclerin solution for oral administration;
• Noopept tablets;
• Nootropil capsules, tablets and solution for injection;
• Omaron tablets;
• Picamilon tablets and solution for injection;
• Pikogam tablets;
• Piracetam capsules, tablets, granules for the preparation of syrup for children, solution for injection;
• Telektol tablets;
• Thiocetam tablets and solution for injection;
• Phezam capsules.

Instead of Gliatilin, the following drugs can be used:

1. Cereton is a complete analogue of Gliatilin. The drug is produced by PharmFirma Sotex CJSC, Russia in capsules and solution for parenteral administration. The medicine is contraindicated in minors, pregnant and lactating patients.
2. Noocholin Rompharm is a Romanian drug that is a high-quality analogue of Gliatilin. The drug contains choline alphoscerate as an active ingredient. It is produced in a solution that can be injected into a vein or muscle. Noocholin Rompharm should not be prescribed to persons under 18 years of age, to patients expecting a child, or while breastfeeding.
3. Cholitilin is a Russian drug that is a complete analogue of the drug Gliatilin. The nootropic drug is available in ampoules and capsules. The medicine can be injected into a muscle and vein. It is contraindicated for children, pregnant and lactating women.
4. Lucetam is a substitute for Gliatilin in the therapeutic group, which contains piracetam as an active ingredient. The drug is produced in tablets for oral administration and solution for parenteral administration. Lucetam can be prescribed to patients over 3 years of age, except pregnant women and breastfeeding women.