In this medical article you can familiarize yourself with the drug Neo Penotran. The instructions for use will explain in what cases the tablets can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.
In the article, doctors and consumers can only leave real reviews about Neo Penotran, from which you can find out whether the medicine helped in the treatment of vaginitis and candidiasis in women, for which it is also prescribed. The instructions list analogues of Neo Penotran, prices of the drug in pharmacies, as well as its use during pregnancy.
A local antibacterial and antifungal medicine is Neo Penotran. The instructions for use explain that vaginal suppositories No. 7, Forte L are in demand in the gynecological field.
Release form and composition
The drug Neo-Penotran is available in the form of suppositories for vaginal use (suppositories) in blisters of 7 pieces, 1 or 2 blisters in a cardboard box with detailed instructions included. The box contains fingertip applicators for easy insertion of the suppository into the vagina.
Each suppository contains the main active ingredients - Metronidazole 500 mg and Miconazole nitrate 100 mg, in addition, the drug contains excipients.
Also produce:
- Neo-Penotran Forte: metronidazole in an amount of 3/4 g + miconazole nitrate in an amount of 1/5 g + excipients (vitepsol 1.5 grams).
- Neo-Penotran Forte L: metronidazole in the amount of 3/4 g + miconazole nitrate in the amount of 1/5 g + lidocaine - excipients (vitepsol 1.44 grams).
Types of products in gynecology
For various disorders of the genitourinary system in women, gynecologists prescribe suppositories. They are presented in the form of candles, which begin to melt under the influence of human heat.
The suppositories contain active substances and an oil component. All drugs are divided into several groups.
- Rectal suppositories are presented in the form of a cone. They are inserted into the rectum through the anus.
- Vaginal suppositories have more rounded shapes in the form of a cone or cylinder. Due to this type, they are easily inserted into the vagina.
- Suppository sticks are inserted into the cervix or urethra.
Depending on the method of action, candles are divided into several types:
| anti-inflammatory drugs | Diclofenac, Terzhinan, Betadine |
| analgesics and antispasmodics | Papaverine, Indomethacin |
| antimycotic | Livarol, Pimafucin |
| regenerating | Methyluracil, with dexpanthenol, Longidaza for adhesions |
| immunostimulants | Sea buckthorn, Pyrogenal |
| antipyretic | Voltaren, Ketonal |
pharmachologic effect
The active ingredients (miconazole and metronidazole) of the drug Neo-Penotran have local antibacterial, antifungal and antiprotozoal effects. Thanks to this combination of components, suppositories are effective in treating diseases caused by the following pathogens:
- Gardnerella vaginalis.
- Trihomonas vaginalis.
- Pathogenic fungi (Candida albicans also).
- Anaerobic bacteria (including anaerobic streptococcus).
The medication is also effective against gram-positive bacteria.
Side effects and overdose
Known side effects of the drug include the following factors:
- skin rashes, abdominal pain, headache;
- vaginal itching, vaginal irritation;
- leukopenia, ataxia, peripheral neuropathy;
- hypersensitivity reactions, psycho-emotional state disorders;
- cramps, diarrhea, constipation, dizziness;
- change in taste, increased fatigue.
Symptoms of an overdose of Neo-Penotran L components are nausea, vomiting, diarrhea, and itching. The urine darkens, a metallic taste appears in the mouth, and dryness in the larynx. If you accidentally take an intravaginal drug orally from 12 g of metronidazole, you need to rinse your stomach; there is no special antidote; symptomatic therapy is prescribed.
Instructions for use
Neo-Penotran is prescribed 1 vaginal suppository at night and 1 vaginal suppository in the morning for 7 days. For recurrent vaginitis or vaginitis resistant to previous therapy, 1 vaginal suppository at night and 1 vaginal suppository in the morning are prescribed for 14 days.
The suppositories should be inserted deep into the vagina using the disposable finger tips contained in the package. When prescribing the drug to elderly patients (over 65 years of age), no change in dosage regimen is required.
Neo Penotran Forte L
Unless otherwise recommended by your doctor, 1 suppository is inserted deep into the vagina at night for 7 days. For recurrent disease or vaginitis resistant to other treatment, it is recommended to extend the course of treatment to 14 days. Suppositories should be inserted in a lying position deep into the vagina using the disposable finger tips provided.
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Neo-Penotran during pregnancy: rules for using the drug
During pregnancy, women often experience worsening illnesses that were previously asymptomatic. Against the background of changes in hormonal levels, fungal infections of the genital tract, vaginitis, various disorders of the flora of the vaginal mucosa, and candidiasis may develop.
Neo-Penotran forte is a fairly effective remedy and is often prescribed during pregnancy. However, it has a number of serious limitations when used, including during pregnancy.
What specific restrictions exist, and how exactly Neo-Penotran affects the female body during pregnancy, we will talk further.
Neo-Penotran: description of the drug
The drug is available in the form of vaginal suppositories (suppositories). Solid at room temperature, once introduced orally they begin to melt when exposed to heat.
The active ingredients of the drug are metronidazole and miconazole nitrate. In combination, both components affect microorganisms, destroying the main types of pathogenic fungi.
This local antibacterial drug is effectively used in the treatment of:
- vulvovaginitis;
- thrush;
- mixed vaginal infections;
- vaginosis (bacterial).
Also, in some cases, gynecologists advise using Neo-Penotran forte as a therapeutic and prophylactic agent for sanitizing the birth canal in late pregnancy.
Typically, drugs containing a lower dosage of active substances are used for these purposes.
However, in case of severe inflammation of the vaginal mucosa, Neo-Penotran suppositories will effectively destroy all pathogenic bacteria and will not harm the fetus.
The drug is released in plastic blisters containing 7 vaginal suppositories each. Additionally, each package includes disposable finger pads for the number of candles.
The drug has a fairly long shelf life: 3 years from the date of production.
Since Neo-Penotran is temperature sensitive, it is necessary to follow the recommendations for its storage conditions specified in the instructions for use.
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Like any other medicine, Neo-Penotran forte should be used with extreme caution during pregnancy. The drug has a number of limitations, including:
- liver problems;
- diseases of the central nervous system;
- age up to 14 years;
- individual intolerance to the drug;
- virginity;
- early stages of pregnancy (up to 12 weeks).
During treatment with Neo-Penotran, the consumption of alcohol-containing drinks is strictly prohibited. Violation of this rule may result in the following symptoms: vomiting, diarrhea, muscle weakness, rash, general poor health.
In addition, the therapeutic effect of using the medication is completely canceled.
If there is a need to combine Neo-Penotran with other medications, it is necessary to check the compatibility of the components and be sure to consult with your doctor.
Use of the drug during pregnancy
In accordance with the instructions for use, Neo-Penotran suppositories can be used during pregnancy from the second trimester.
The ban on the use of the drug in the early stages of pregnancy is due to the fact that one of the active ingredients (metronidazole) is absorbed into the blood and can affect the development of the fetus.
For the same reason, the medication should not be used while breastfeeding.
If, based on the research carried out, the gynecologist decides to use Neo-Penotran Forte suppositories, then the woman must interrupt breastfeeding for the entire period of treatment. All active substances are completely excreted from the body in the urine within 48 hours from the last use of the medicine. After this period, breastfeeding can continue as usual.
The high effectiveness of using Neo-Penotran during pregnancy is noted by reviews from most patients. The drug is successfully used to treat thrush and vaginitis in expectant mothers.
It is important to understand that Neo-Penotran Forte should be used during pregnancy not in accordance with patient reviews, but strictly as prescribed by the doctor. In this case, the specialist must compare the expected benefits of using the drug with the possibility of risks to the development of the fetus.
Even though the drug can be used in the second and third trimester without restrictions, self-administration of the drug without prior medical advice is unacceptable.
Before prescribing the drug, it is necessary to conduct a complete diagnosis in order to determine the specific type of genital tract infection in a woman. If any drug is used during pregnancy, the duration of treatment and dosage are determined by the attending physician in accordance with the diagnosis.
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As a rule, when using Neo-Penotran, a standard treatment regimen is used - one suppository at night for 10 days. If, in the opinion of the doctor, the dosage needs to be increased, then the drug can be administered 2 times a day - in the morning and in the evening. In this case, the duration of taking the medicine can be increased to 14 days. Do not be afraid of an overdose of the drug.
Medical studies, as well as existing experience with the use of the drug, have not revealed any negative consequences if the dosage is violated. However, during pregnancy, women need to be especially attentive to the doctor’s recommendations and strictly follow all instructions.
During this period, women are responsible not only for their own health, but also for the health of the unborn child.
Side effects
Neo-Penotran is a drug that has a wide range of side effects that may occur in some patients:
- burning and itching;
- indigestion;
- headache and dizziness;
- nausea;
- vomit;
- allergic reactions.
Important! If one or more symptoms of a side effect occur, you must immediately stop using the drug.
If signs of an allergy or individual intolerance to the drug appear, it is necessary to replace the drug.
The rash and other unpleasant consequences will disappear without additional treatment some time after discontinuation of use. If you are allergic to the active substances, the drug must be replaced with a similar product.
The selection of a more suitable medicine should be carried out by the attending physician, taking into account the individual characteristics of the patient’s body.
So, we can say with confidence that Neo-Penotran Forte suppositories during pregnancy have positive reviews about the effectiveness of their use from doctors and patients.
However, during pregnancy, like any other drug, it has a list of contraindications, including a ban on use in the early stages of pregnancy.
When completing the course, do not forget that the partner also needs to undergo preventive treatment in order to avoid re-development of the infection in the woman. Only with this approach can one confidently predict a rapid recovery of patients without the risk of relapse of the disease.
Source: https://MoeDitya.com/preparations/tabletki/neo-penotran
Contraindications
According to the instructions, Neo Penotran is contraindicated for use when:
- Hypersensitivity to metronidazole, miconazole nitrate or other components of the drug;
- Severe liver dysfunction, including porphyria;
- Diseases of the peripheral and central nervous system;
- Hematopoiesis disorders.
In the first trimester of pregnancy, Neo Penotran is contraindicated, and in the second and third trimesters, the use of the drug is possible only under strict indications. If treatment with suppositories is necessary during lactation, it is recommended to stop breastfeeding.
The drug is also contraindicated for use in children under 14 years of age.
special instructions
Studying the special instructions section of the instructions is useful, because there you can familiarize yourself with the rules for using candles:
- the medicine is not used by children and virgins;
- at the end of the course, it is not recommended to drink alcohol for 1-2 days to avoid the risk of disulfiram-like reactions;
- increased doses or prolonged use of the medication can cause peripheral neuropathy and seizures;
- when using suppositories together with condoms and latex diaphragms, damage to contraceptives is possible, so other methods of protection should be used during therapy;
- if the patient is diagnosed with trichomonas vaginitis, treatment of the sexual partner is required;
- in case of kidney failure or impaired renal function, the dose of suppositories is reduced;
- metronidazole can cause symptoms of encephalopathy, if it already exists, the dose is reduced to a third of the daily dose;
- with a decrease in liver function, the withdrawal period of lidocaine increases significantly;
- the drug does not affect the concentration and speed of mental reactions, therefore it can be used while driving.
Side effects
According to reviews, Neo-Penotran causes adverse reactions in the patient that are similar to signs of an overdose. These include itching, burning, and irritation of the vaginal lining. In addition, according to the instructions, Neo-Penotran suppositories provoke abdominal pain, loss of appetite, and dry mouth.
The above symptoms disappear after treatment for the disease is completed. If symptoms continue, you should consult a specialist. In rare cases, the drug can cause disorders of the nervous system: increased excitability or depression, headache, ataxia.
Drug interactions
When Forte Neo-Penotran is absorbed and combined with other medications, drug interactions may occur:
- oral anticoagulants enhance the anticoagulation effect;
- the medication increases the level of Phenytoin, which in parallel reduces the level of metronidazole in the blood (Phenobarbital acts similarly);
- Disulfiram leads to changes in the central nervous system;
- Cimetidine increases the level of metronidazole in the blood, increasing the risk of neurological side effects;
- when combined with lithium preparations, the risk of toxicity increases;
- components of the drug inhibit the metabolism of Astemizole and Terfenadine;
- Theophylline and Procainamide affect the levels of liver enzymes and blood glucose.
During pregnancy and breastfeeding
The use of Neo Penotran is contraindicated in the 1st trimester of pregnancy. In the 2nd and 3rd trimester of pregnancy, the use of Neo-Penotran is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
If it is necessary to prescribe medication during lactation, breastfeeding should be stopped, because Metronidazole is excreted in breast milk. Breastfeeding can be resumed 24-48 hours after the end of treatment.
Application in other cases
For what reasons do women get thrush? Its culprit is often the notorious weakening of the immune system, which leads to the uncontrolled proliferation of Candida fungi. Microorganisms actively spread when nothing suppresses them. This happens in the following cases:
- after illnesses;
- with the development of a chronic infection at the same time;
- when using antibiotics that treat other infections (including topical medications).
When such a feature was noted - the appearance of thrush after taking antibiotics - Neo-Penotran will be an excellent assistant in this situation. The drug has a wide range of effects and copes well with numerous genital infections and at the same time inhibits the causative agents of candidiasis.
According to the instructions and reviews, Neo-Penotran candles are very effective.
Suppositories belong to the new generation of medicines. Their wide spectrum of action has contributed to their popularity. Candles are effective in relation to:
- candida infection;
- nonspecific vaginitis and vulvitis;
- bacterial vaginosis;
- urogenital trichomoniasis.
Reviews about the use of Neo-Penotran are of interest to many.
Analogues of the drug Neo Penotran
Analogues are determined by structure:
- Metromicon-Neo.
- Neo-Penotran Forte.
- Klion-D 100.
Analogs have a similar effect:
- Pulsitex.
- Econazole
- Metrogyl Vaginal.
- Ginofort.
- Trichopolum.
- Ketonazole.
- Kandisan.
- Kandibene.
- Gravagin.
- Clevazol.
- Clomesol.
- Clotrimazole.
- Ginalgin.
- Metronidazole.
- Micogal.
- Livarol.
Pharmacodynamics and pharmacokinetics
The drug contains a number of components that have different effects on the vaginal microflora.
All components of the drug can be detected in blood plasma within 3 days. Miconazole is an antifungal agent. Inhibits the vital activity of the main pathogenic fungi, and is also active against some gram-positive bacteria. It is practically not absorbed into the bloodstream through the mucous membrane.
Metronidazole is harmful to anaerobic bacteria and some protozoa. Affects Trichomonas vaginalis, and Gardnerella vaginalis. 20% of the administered dose penetrates into the blood. Excreted from the body through the kidneys.
Neo-Penotran Forte L additionally contains lidocaine, which has an analgesic effect. Within 4-6 minutes after administration, the substance begins to act. The substance inhibits the process of nerve impulses passing through the membrane of neurons. It is then metabolized in the liver and slightly excreted through the kidneys.
Neo-Penotran - instructions for use in suppositories for the treatment of thrush, analogues and price
This drug is prescribed only to women; it is not intended for the male population. Neo-Penotran Forte, an analogue of the drug, that is, a substitute with similar therapeutic effects, is prescribed for the following diseases:
- bacterial vaginosis;
- trichomonas vaginitis;
- vaginal candidiasis;
- vaginitis caused by mixed infections.
But, as soon as the body’s protective functions fail, for example, after a long illness and treatment with antibiotics, beneficial bacteria can no longer control the growth of the fungus. This is where candida begins to attack in full force, multiplying and causing the appearance of candidiasis.
Very often, thrush also appears during a period of decreased protective functions of the immune system and during hormonal changes, for example, during pregnancy, diabetes, cancer, AIDS, and sometimes even during the most common flu.
Treatment of this disease should be carried out using complex methods in order to get rid of thrush and prevent relapses in the future, therefore gynecologists recommend suppositories for thrush in combination with tablets that have a centralized effect on candidiasis. In this article, we will look in detail at how to treat thrush using Neo Penotran Forte suppositories.
Symptoms of thrush
Thrush manifests itself in the form of itching and burning on the genitals and vagina, white cheesy discharge, and in the case of a firmly rooted disease, it can cause discomfort and pain when urinating and during sexual intercourse. The mucous membranes of the genital organs swell and become bright red after a bath or sleep, when the woman is warm.
Candidiasis can also affect the mucous membranes of the oral cavity, skin, nail folds, and in particularly advanced cases, even internal organs, causing disturbances in the functioning of various body systems, so as soon as you notice the first symptoms, immediately consult a doctor, take tests, confirm the diagnosis and get qualified help. Do not self-medicate as it may be dangerous to your health.
Neo Penotran Forte suppositories are very effective suppositories against thrush; moreover, they are successfully used to treat bacterial leishmaniasis, trichomoniasis, amebiasis, vaginosis and vulvovaginitis. Most often, gynecologists prescribe Neo Penotran Forte suppositories against thrush, since the spectrum of action of this drug is very wide and helps to begin treatment even before all tests are carried out.
Neo Penotran Forte should be used directly in areas where the fungus has accumulated, that is, injected into the vagina.
This drug is based on the active ingredients miconazole and metronidazole, so it has both antifungal and antibacterial effects at the same time.
Miconazole destroys fungal cells, and metronidazole, entering the blood, prevents microbes from producing their DNA and multiplying.
https://www.youtube.com/watch?v=bS3P6-ViNho
Neo Penotran Forte suppositories are a very effective remedy against thrush, but, nevertheless, the drug has a considerable number of contraindications.
Thrush begins to attack the body most often during pregnancy, since it is during this period that hormonal disruptions constantly occur.
As the baby moves through the birth canal, it may become infected with a fungal infection that lives in the mother's vagina.
Despite the fact that Neo Penotran Forte suppositories are excellent in treating candidiasis, their use in the first trimester of pregnancy is prohibited. This drug should not be used during lactation.
It should also not be used by people who have impaired liver function or the functioning of the central or peripheral nervous system.
It is not recommended to use candles for children under 14 years of age, as well as for people with epilepsy and diseases of the circulatory system.
Today, infectious diseases are found quite often in gynecology. And their timely and competent therapy is very important, because otherwise serious complications cannot be avoided.
Neo-Penotran is considered one of the most popular medications used to fight infections. This drug is highly effective in eliminating various types of infectious diseases.
- Overview of the drug and intended use
- Features of application
- Use during pregnancy
- Side effects
- Contraindications and cases of overdose
Is Neo-Penotran an antibiotic or not? This is a combined remedy that can effectively fight germs, parasites and other pathogenic microflora.
Essentially, it is a successful combination of an antibiotic drug with an antifungal agent. Today, this medicine is in most cases prescribed to combat infections of fungal and protozoal origin.
In addition, certain types of bacteria are also sensitive to the drug.
Miconazole nitrate. It is the active component of this drug and is a powerful antifungal agent that is effective in the treatment of Candida fungi, Criptococcus neoformans and other pathogens of a number of diseases.
- Lidocaine. This is an anesthetic component that provides local anesthesia.
- Metronidazole. Like Miconazole nitrate, it is an antiprotozoal and antimicrobial agent that allows the treatment of Trichomonas vaginalis fungi.
Neo-Penotran. An option where the classic medication recipe is followed. Miconazole nitrate (100 mg) and Metronidazole (500 mg) are the main active ingredients.
Neo-Penotran Forte. It is characterized by an increased dosage of the main active ingredients of the composition. Here the components have the following proportions: Metronidazole 750 mg and Miconazole 200 mg.
- Neo-Penotran Forte-L. The drug is a vaginal suppository. The proportions of active ingredients are similar to the previous version. The difference is the presence of lidocaine in the composition.
Neo-Penotran, as an antibacterial agent, is prescribed for the treatment of diseases associated with various gynecological infections. In particular, it is used to combat the following diseases:
- vaginal candidiasis, which intensifies due to the active proliferation of microorganisms of fungal origin;
- bacterial vaginosis;
- trichomonas vulvovaginitis;
- various vaginal infections of mixed type. We are talking about those diseases that arise as a result of the action of several varieties of pathogenic microflora.
The use of suppositories is carried out for local treatment. This drug is most often used without auxiliary agents, which in most cases is quite enough for a complete cure for the disease and a speedy recovery.
Important! Therapy using oral medications can be used in the most severe and advanced cases. Such combinations are determined by the doctor based on the results of a carefully conducted diagnosis.
With infections of the genitourinary system, alarming symptoms reduce the quality of life and become the main cause of internal discomfort. Effective suppositories with metronidazole provide positive dynamics of the disease and accelerate the process of complete recovery. Their prescription should be carried out by the attending physician; self-medication is excluded.
Neo-Penotran candles
For genital infections, a particularly effective form of release is vaginal suppositories, which act directly on the site of pathology.
The medicine Neo-Penotran, produced in the form of suppositories, has proven itself well. The drug is used in gynecology and has pronounced antibacterial, antifungal, and antiprotozoal properties.
Vaginal suppositories are not prohibited during pregnancy and lactation, but require medical attention.
The chemical formula of vaginal suppositories harmoniously combines two components - metronidazole and miconazole nitrate. The first synthetic substance disrupts the integrity of the membranes of bacteria and protozoa, promotes mass death and imperceptible removal from the body. The second component of Neo-Penotran demonstrates increased activity against fungi and acts on the same principle.
It turns out that Neo-Penotran is a combined treatment that can overcome any genital infection and is widely used in modern gynecology. The chemical composition of Neo-Penotran is complemented by a substance called vitepsol, as an auxiliary element to enhance the therapeutic effect and accelerate the natural healing process.
The effect of vaginal suppositories is immediate, but only for medical reasons. It is important not only to remove the signs of the disease, but also to promptly detect their cause. Only in this case, the prescribed dosage as soon as possible allows the patient to experience the long-awaited relief. So, local use of Neo-Penotran is appropriate in the following clinical situations:
- anaerobic vaginosis;
- vaginal candidiasis;
- bacterial vaginosis;
- nonspecific vaginitis;
- gardnerella vaginitis;
- mixed vaginal infections;
- trichomonas vulvovaginitis.
When a burning sensation occurs and specific vaginal discharge appears, patients resort to self-medication. Doing this is contraindicated, especially since Neo-Penotran vaginal suppositories have their own contraindications.
Before prescribing the specified medication, the doctor conducts a detailed diagnosis. So consultation with a specialist before intravaginal administration of the drug Neo-Penotran is mandatory.
Contraindications to the use of these vaginal suppositories are as follows:
- the body's sensitivity to synthetic components of suppositories;
- extensive damage to the central nervous system;
- pregnancy in the first trimester;
- porphyria;
- liver dysfunction;
- epilepsy;
- age restrictions up to 14 years;
- lactation period;
- hematopoiesis disorders;
- in combination with alcohol;
- virginity.
For genital infections, it is better to use vaginal suppositories rather than taking pills. This form of drug release demonstrates fewer side effects in the body and has a limited list of contraindications. The final word belongs to the attending physician. Side effects of Neo-Penotran are reflected in the instructions, but in reality they are represented by the following anomalies that arise at the very beginning of the treatment course:
- from the gastrointestinal tract: severe signs of dyspepsia, dry mouth, lack of appetite, nausea, vomiting;
- from the skin: irritation and redness of the vaginal mucosa, itching and burning, discomfort;
- from the central nervous system: migraine attacks, irritability, peripheral edema, dizziness, ataxia, convulsions;
- from the hematopoietic organs: leukopenia;
- from the skin: allergic, local reactions on the upper layer of the epidermis.
