Linex capsules are a modern drug necessary for normalizing intestinal microflora. One capsule contains at least 1.2x107 live lyophilized lactic acid bacteria, including Enterococcus faecium, Lactobacillus acidophilus, Bifidobacterium infantis. Based on lactic acid bacteria, intestinal functions are normalized.
Registration number: P N012084/01
Trade name of the drug: Linex®
Dosage form: capsules
Photo of the packaging of Linex capsules showing the composition
Composition and release form
The bacterial composition depends on the form of release. Beneficial microorganisms that are normally found in the gastrointestinal tract of a healthy person are used. The composition also contains excipients that facilitate the absorption of active components.
It is produced in the form of capsules, drops and powder.
Linex capsules
The powder form of the drug contains two hundred and eighty milligrams of the active ingredient called lebenin. This component contains fecal enterococci, bifidobacteria infantis and lactobacilli acidophilus belonging to the L. gasseri group. Also in capsule form contains: milk sugar, starch, magnesium salt of stearic acid.
Linex Forte capsules
The composition includes bifidobacteria animalis (subsp. lactis) and acidophilus lactobacilli. The capsule also contains the following chemical compounds: fiber, starch, magnesium salt of stearic acid, oligofructose.
Linex drops for children
Contains bifidobacterium animalis (subsp. lactis BB-12) as an active component. Additional ingredients: sucrose, molasses, sodium salt of ascorbic acid, sunflower oil, vitamin E, citric acid.
Child option packaging
Suitable for newborn.
Linex powder for children
The powder dosage form contains bifidobacteria animalis (subsp. lactis BB-12), belonging to the strain number DSM No. 15954. Molasses acts as an additional substance.
The powder can be added to milk, juice or other suitable drink. More details below in the instructions.
Linex capsules composition
1 capsule contains:
Active ingredient: Lebenin - 280.0 mg (1 g of the active ingredient Lebenin, powder contains: Lactobacillus acidophilus (species L.gasseri) - 300 mg, Bifidobacterium infantis - 300 mg, Enterococcus faecium - 300 mg, lactose - 50 mg, starch potato - 50 mg).
Excipients: magnesium stearate - 8.40 mg; capsule shell - methylhydroxybenzoate - 0.19 mg, propylhydroxybenzoate - 0.08 mg, titanium dioxide (E 171) - 0.98 mg, gelatin - up to 63.0 mg.
Description
Opaque capsules, white body - white cap. Contents: odorless white powder.
Pharmacotherapeutic group: eubiotic
ATX code: A07FA51
Pharmacological properties
Linex normalizes intestinal microflora.
One capsule of Linex contains at least 1.2 x 107 live lyophilized lactic acid bacteria: Lactobacillus acidophilus, Bifidobacterium infantis, Enterococcus faecium. Live lactic acid bacteria are a normal component of the natural intestinal microflora and are already found in the digestive tract of a newborn child.
These bacteria are of great biochemical importance for the human body:
- Fermentation of lactose shifts the pH to the acidic side. An acidic environment inhibits the growth of pathogenic and opportunistic bacteria and ensures optimal action of digestive enzymes;
- participate in the synthesis of vitamins B, K, ascorbic acid, thereby increasing the body’s resistance to adverse environmental factors;
- participate in the metabolism of bile pigments and bile acids;
- synthesize substances with antibacterial activity;
- increases the body's immune reactivity.
Therapeutic effect
Probiotic medications based on beneficial microorganisms restore a healthy intestinal microbiome. After oral administration, live bacteria take root in the intestine and perform their functions. The main components of Linex, lactic acid bacteria, are part of the natural microbiome. Other bacterial agents form a protective environment in the colon that prevents the spread of pathogenic microorganisms. Improves the synthesis of beneficial chemical compounds, including vitamins C and B12.
Normally, the human body is never “sterile”. The tissues necessarily contain beneficial, neutral, opportunistic and harmful microorganisms. Most often these are bacteria and fungi. Microorganisms are present in the colon from birth. First of all, these are lactobacilli. With age, the composition of the microbiome gradually changes.
The functions of the microbiome are not limited to the formation of useful substances and assistance in removing waste products. It has been proven that the functioning of the immune system depends on the composition of the microbiome. Also, many doctors associate conditions such as decreased mood, anxiety, weakness and irritability with microflora disturbances. More obvious negative consequences of microflora disorders include various dyspeptic symptoms, such as diarrhea, flatulence and abdominal pain.
Additional properties
- The children's version of the drug improves the functioning of the body's defense systems, prevents developmental delays, eliminates chronic diarrhea and reduces the risk of intestinal complications caused by taking antibiotics.
- Prescribing the drug to a child helps reduce the likelihood of infection of the body and the development of allergic/autoimmune disorders, including skin diseases.
- Beneficial bacterial agents present in dosage forms protect the intestinal mucosa from negative influences and normalize the formation of feces.
Medicines in this line have complex medicinal properties.
Pharmacokinetics
Lactic acid bacteria, such as LA-5 and BB-12, act directly in the gastrointestinal tract; when taken orally, the drug is not subject to systemic absorption. Standard pharmacokinetic studies are therefore not applicable. The resistance of LA-5 and BB-12 to gastric juice and bile allows the strains to remain viable in large numbers when passing through the stomach and duodenum. Both strains attach to the intestinal lining. Like other microorganisms, they are gradually eliminated from the gastrointestinal tract with feces.
After oral administration, lactic acid bacteria act in the human digestive tract.
Indications for use
The area of use depends on the specific drug. Various medications from this line are used in therapeutic and pediatric practice to restore the intestinal microbiome. Prescription may occur if signs of disturbance in the number and composition of bacterial agents appear. The patient may complain of abnormal bowel movements, discomfort in the abdominal area, increased gas formation and other symptoms. It is recommended to first consult a gastroenterologist.
Indications for use of Linex for children
- Restoring and maintaining a healthy microbiome in a child from the first year of life, including patients suffering from intestinal colic and other unpleasant symptoms.
- Preventing the occurrence of infectious pathologies that cause the formation of loose stools.
- Restoring and maintaining a healthy microbiome during and after taking antibacterial medications.
- Normalization of the body's defense systems and prevention of the formation of atopic dermatitis.
The choice of dosage form (powder or drops) depends on ease of administration and optimal composition.
Indications for use of Linex and Linex Forte
- Drug therapy for microbiome disorders or prevention of this condition.
- Prevention of stool retention in patients over twelve years of age.
- Adjuvant therapy for Helicobacter pylori infection in patients over twelve years of age.
- Elimination of increased gas formation and other digestive disorders that appear during the use of antimicrobial agents, radiotherapy and other factors.
Expiration dates for Linex for children
Diarrhea in children under 6 years of age should be treated under medical supervision.
Wikipedia indicates that the remedy can be used for children from birth. It is used to treat gastrointestinal disorders; some experts recommend that patients in adolescence take Linex for acne, for which they use the medicine according to a specific regimen.
The use of medications in children requires special responsibility and attention. Let's consider the issues of expiration dates of forms issued for use by children:
- Linex drops for oral administration. Subject to other conditions, the shelf life of unopened packaging is 2 years from the date of release indicated on the package and bottle. After opening, the shelf life is reduced to 28 days, subject to temperature conditions.
- Linex powder for oral administration. Available in sachet. The shelf life of an unopened sachet is 2 years. An opened bag of powder should not be stored.
- Linex capsules. Available in foil blisters. Shelf life: 2 years. The capsule cannot be stored outside the blister.
- Linex-Forte capsules. Also available in foil blisters. Shelf life: 2 years. The capsule cannot be stored without packaging.
Contraindications
There are certain factors in the presence of which the medicine should not be used. These are conditions associated with immunity and other characteristics of the body. It is advisable to consult a specialist before therapy.
Main contraindications:
- Sensitivity to chemical compounds included in the dosage form and lactic acid products.
- Impaired absorption and assimilation of glucose or galactose.
- Inability to digest fructose.
- Deficiency of the enzymes lactase or isomaltase.
The possibility of therapy in childhood should be discussed with a pediatrician.
Instructions for use
It is sold freely, but before therapy it is advisable to be examined by a gastroenterologist to select the correct treatment regimen. It can be used as monotherapy or together with other medications. All types of medications must be taken orally. To develop a medicinal effect, a course of therapy must be carried out.
Examination by a pediatrician before therapy
Using drops for a child
From the first days of life, you can add six drops per day to dairy products, juice and other liquids used in baby food, except hot drinks. Not earlier than three hours after taking antibacterial medications (if used). The duration of treatment is twenty-eight days.
A new course of treatment is allowed within a year.
Use of powder for children
Patients under seven years of age can take one sachet once a day during meals. Patients from seven to twelve years old receive two sachets. Mix with warm or cold baby drinks. When conducting antimicrobial therapy, take three hours or later after using the medicine. The course of treatment continues for a month. Therapy can be repeated in a month.
Using Linux
Oral administration after meals. Drink plenty of water. If a child under three years of age is unable to swallow the capsule form, the capsule may be opened and the powder mixed with a cold or warm drink. Patients under two years of age take one capsule three times a day. Patients from two to twelve years old take one or two capsules three times a day. Patients over twelve years of age take two capsules three times a day.
The duration of therapy will be determined by the doctor.
Using Linux Forte
As therapy or to reduce the risk of microbiome disruption: patients over twelve years of age, one capsule one to three times a day; patients from two to twelve years old, one capsule once or twice a day; patients under two years of age take one capsule once a day;
As an addition to the treatment of Helicobacter pylori infection: for patients over twelve years of age, one capsule three times a day. Can be used until the condition improves.
For a child under twelve months of age, it is better to choose another form of the drug.
Additional Information
- It is prohibited to mix the medications described in this article with hot foods and drinks. It is also prohibited to take ethanol during treatment.
- There are no documented effects of interaction between the probiotic and other medications. During antimicrobial therapy, you need to take the drug three hours after the antibiotic.
- Treatment should only be carried out under the supervision of a specialist if the following signs are detected: increased body temperature, loose stools for two days, loss of a large amount of fluid, weakness, dizziness, weight loss, bloody stools, chronic diseases, immunodeficiency.
- If the patient suffers from stool retention, the following preventive measures must be observed: physical activity, adding fiber foods to the diet, balanced meals, sufficient fluids, and bowel movements at the same time. Maintaining the condition for a week is considered grounds for medical examination.
- The medications described in the article do not reduce the speed of psychomotor reactions.
More detailed and accurate information is described in the official instructions, which can be found in the package.
Linex capsules dosage and method of use
Inside.
Linex should be taken after meals with a small amount of liquid. For children under 3 years of age and patients who cannot swallow a whole capsule, it must be opened, the contents poured into a spoon and mixed with a small amount of liquid.
- newborns and children under 2 years of age: 1 capsule 3 times a day;
- children from 2 to 12 years: 1-2 capsules 3 times a day;
- adults and adolescents over 12 years of age: 2 capsules 3 times a day.
The duration of treatment depends on the cause of the development of dysbiosis and the individual characteristics of the organism.
