Pimafucin: analogue. Pimafucin (suppositories): composition, instructions for use, description and reviews

Release form and composition

Pimafucin is a drug based on the broad-spectrum antimycotic natamycin. The product is available in three forms - vaginal suppositories, cream and tablets.

The cream is packaged in 30 g aluminum tubes. 1 g of the drug contains 20 mg of active substance. Pimafucin cream additionally contains: wax, sodium lauryl sulfate, propylene glycol and water.

Vaginal suppositories are available in packs of 3 or 6 pieces. Each candle contains 100 mg of active ingredient. Form-forming components in the composition of the drug: solid fat, cetyl alcohol, adipic acid. These components ensure rapid dissolution of the drug under the influence of body temperature.

Pimafucin tablets are produced in small polymer jars, 20 enteric tablets per package. Each tablet contains 100 mg of active ingredient. Additional components of the composition:

• starch;
• lactose;
• povidone;
• talc;
• kaolin;
• calcium;
• opagloss 600;
• sucrose.

The presence of auxiliary and formative substances in the composition of the drug must be taken into account by people with intolerance to lactose, starch or talc, in order to avoid the development of an allergic reaction. Ointments and vaginal suppositories contain alcohols, which can cause a short-term burning sensation.

Pimafucin is available in several dosage forms

Special instructions for the use of the drug Pimafucin

Vaginal suppositories quickly dissolve under the influence of body temperature, forming a voluminously spreading foamy mass, which contributes to the uniform distribution of the active substance. In case of chronic or recurrent infection, local treatment can be supplemented with tablets and cream. The use of natamycin in tablet form may be associated with the development of an acute attack of porphyria, therefore, the use of the drug is considered unsafe for patients with this disease. Cetyl alcohol, which is part of vaginal suppositories, can cause an allergic reaction. During menstruation, therapy is interrupted. When using suppositories, there is no need to avoid sexual intercourse. During pregnancy and breastfeeding

.
Pimafucin can be prescribed during pregnancy and lactation. Children
.
Natamycin in the form of film-coated tablets is used in children over 3 years of age; in the form of a cream - used in children of all age categories; in the form of vaginal suppositories - not used in children. The ability to influence reaction speed when driving vehicles and working with machinery
. Does not affect.

pharmachologic effect

Natamycin is an antifungal antibiotic (antimycotic). It has a pronounced antimicrobial and antiseptic effect. Preparations based on natamycin have a wide spectrum of antifungal action. First of all, Pimafucin is active against yeast fungi, including Candida, which makes this remedy very popular in the treatment of thrush and skin candidiasis.

The drug Pimafucin exhibits a fungicidal effect against pathogenic fungi. Treatment with Pimafucin is highly effective and safe.

During the use of the drug, not a single case of development of resistance of pathogenic microflora to the action of natamycin was recorded. The product is not addictive and does not lose effectiveness when used repeatedly in the event of a recurrence of the fungal infection.

The drug binds sterols in the cells of pathogenic and opportunistic fungi. This leads to disruption of further reproduction of fungal cells, death of adult individuals and a decrease in the size of the colony. The drug disrupts the integrity of fungal cells, causing their slow death.

Ointments and suppositories additionally contain alcohols, which provide the antiseptic effect of the drug. This prevents the spread of fungal spores to healthy skin and protects against secondary infection of the epidermis weakened by mycosis.

The drug acts locally. Pimafucin tablets have an enteric coating, so absorption of the drug occurs in the intestines, but not in the stomach. This determines the overall safety of the drug and makes Pimafucin tablets effective in the treatment of thrush in women.

Indications for use

Indications for the use of Pimafucin are any lesions of the skin and mucous membranes caused by yeast fungi of the genus Candida. The use of Pimafucin cream is indicated for the following disorders:

• candidiasis of smooth skin;
• candidiasis of the folds;
• damage to the groin areas by yeast fungi;
• thrush of the penis in men.

Pimafucin for thrush can be used by both women and men. Pimafucin for men is used in the form of an ointment; for severe forms of the disease, tablets are used. Pimafucin for women is a vaginal suppository.

Tablets of the drug are used as part of complex therapy for severe thrush of the genital organs, intestines, and for recurrent or generalized skin candidiasis.

The ointment is intended for the treatment of skin or genital organs in men. It is not suitable for treating thrush in women. The drug shows low effectiveness against dermatophytes and molds, therefore it is used only to combat various candidiasis.

The drug is effective against Candida fungus, which causes various candidiasis

Pharmacological characteristics

Antifungal polyene antibiotic of the macrolide group, which has a wide spectrum of action. The drug is active against yeast (Torulopsis, Rhoduturola), yeast-like fungi (Candida albicans), dermatomycetes (Trichophyton, Microsporum, Epidermophyton), other pathogenic fungi (Aspergillus, Penicillium), as well as Trichomonas.

Has a fungicidal effect. Pimafucin binds sterols of cell membranes, disrupting their integrity and functions, which leads to the death of microorganisms. Dermatophytes are less sensitive to natamycin, but resistance to natamycin does not occur in clinical practice. Not absorbed from the gastrointestinal tract, skin and mucous membranes.

Instructions for use

If the drug Pimafucin is prescribed, the instructions for use provide all the necessary recommendations on the treatment regimen. However, as prescribed by a doctor, the drug dosage regimen can be changed or supplemented. Self-therapy is allowed for 5-7 days. If during this time the severity of symptoms has not decreased, it is recommended to consult a doctor.

Independent use of Pimafucin is allowed due to its low toxicity and almost complete safety. Since the drug does not cause addiction or resistance of pathogenic microflora, the risk of deterioration in health when using it is minimal. The exact treatment regimen depends on the form of the drug used.

How to take the pills?

It is recommended to use Pimafucin tablets in the following cases:

• chronic thrush in men;
• severe form of fungal vaginitis in women;
• extensive fungal infection of the skin;
• candidiasis of the nail plates;
• low effectiveness of therapy with a local drug;
• intestinal candidiasis.

For intestinal candidiasis, the drug is taken 1 tablet 3-4 times a day. The duration of treatment is only 7 days.

Tablets cannot completely get rid of skin fungus, nails or thrush, so they should be taken in addition to therapy with external agents.

For thrush in women and men, the decision to prescribe tablets is made by the doctor. Pimafucin tablets are characterized by low bioavailability and are practically not absorbed by the intestines, providing a local antifungal effect, therefore, for severe forms of genital candidiasis, it is advisable to use ointment or suppositories. Additionally, you can take 1 tablet 4 times a day for two weeks.

If the skin is affected by yeast fungus, take 1 tablet three times a day. Sometimes it is allowed to increase the number of doses up to 4 times a day. Duration of treatment – ​​10 days.

In the treatment of nail fungus, Pimafucin tablets can be used as an adjuvant, while simultaneously treating the nails with ointment or a special antifungal solution. The recommended dosage regimen in this case is 4 tablets per day for at least two months.

Tablets are effective as an addition to local medications

Scheme for using candles

Pimafucin suppositories, the use of which is indicated only for women, should be inserted deep into the vagina at night. Suppositories treat candidiasis, Pimafucin suppositories can be used in the treatment of vaginitis against the background of thrush.

During menstruation, the use of suppositories should be discontinued. The instructions for suppositories for thrush Pimafucin say that during treatment there is no need to avoid sexual contact, since the drug does not reduce the effectiveness of latex contraceptives.

Treatment of thrush is carried out within three days. Suppositories should be inserted deep into the vagina before bedtime, and not get up for at least half an hour after insertion. For advanced thrush or fungal vaginitis, the drug should be used for 6 days. In some cases, it is advisable to supplement therapy with antifungal tablets.

Suppositories contain alcohol and may cause a burning sensation.

Rules for using the cream

Pimafucin cream or ointment is intended for the treatment of superficial skin lesions caused by yeast fungus. It can also be used for onychomycosis caused by Candida fungus.

If the skin is damaged, the cream should be used twice a day, morning and evening. Duration of treatment is 3-4 weeks.

Pimafucin cream for men is used in the treatment of penile candidiasis. The drug should be applied 2-3 times a day to the head of the penis, using gentle massage movements. Thrush is treated within 7-10 days.

For onychomycosis, the drug can be used up to 4 times a day. The product must be applied to the nails, periungual ridges and interdigital spaces. The duration of treatment depends on the severity of the fungal infection. Onychomycosis on the hands is treated for six months, on the legs – up to 10 months.

The cream can be used for both skin and nails

Analogs

1. Natamycin;
2. Primafungin.
3. Ecofucin

Similar antifungal drugs:

1. Alpha Normix,
2. Nystatin,
3. Livarol,
4. Clotrimazole.
5. Hexicon.

When choosing analogues, it is important to understand that the instructions for use of Pimafucin, the price and reviews of drugs with similar effects do not apply. It is important to consult a doctor and not change the drug yourself.

Which is better: Terzhinan or Pimafucin?

Terzhinan is produced in the form of vaginal tablets; it can be prescribed not only in the presence of the disease, but also for its prevention. The average duration of drug treatment is 10 days. It is also easily tolerated and can be used before childbirth.

Clotrimazole or Pimafucin - which is better?

Clotrimazole is available in the form of suppositories and cream. The course of treatment usually lasts about a week, the drug is well tolerated, which reduces the risk of side effects to a minimum. However, it may cause allergic reactions to any of its components.

If the disease is detected in a woman, thrush ointment for men is used. According to experts, Pimafucin is more effective when used topically and it almost does not enter the systemic bloodstream. Therefore, it can also be used to treat pregnant women.

Use during pregnancy

Pimafucin can be used during pregnancy regardless of the form of the drug. The drug is practically not absorbed by the mucous membrane, therefore it does not penetrate into the general bloodstream and does not have a systemic effect on the body. This drug cannot harm the child.

Suppositories can be used without restrictions to treat thrush in pregnant women. The cream is used for fungal infections of the nail plates, foot fungus or other types of skin candidiasis.

It is advisable to take the tablets for thrush or intestinal candidiasis. This form of the drug is also not prohibited for use during pregnancy.

The drug can be used during breastfeeding. The only limitation concerns the cream - it should not be applied to the mammary glands to avoid accidental ingestion of the medicine by the child.

Storage conditions and periods

The medicine in its entire package is stored at temperatures up to 25°C, avoiding direct sunlight, for 2 years.

Tradename:

Pimafucin ®

International nonproprietary name:

Natamycin

Dosage form:

Enteric-coated tablets.

Compound:

1 tablet contains: Active substance

: natamycin 100.0 mg;
excipients
: potato starch 79.2 mg, povidone K30 5.0 mg, magnesium stearate 2.5 mg, lactose monohydrate 66 mg;
shell
: cellacephate 18 mg, triacetin 2.7 mg, sucrose 122 mg, methyl parahydroxybenzoate 0.07 mg, calcium carbonate 30 mg, kaolin 14.2 mg, talc 21.7 mg, titanium dioxide 3 mg, acacia gum 7.3 mg , gelatin 3.3 mg, white beeswax 0.13 mg.

Description

Round, white or almost white, film-coated tablets.

Pharmacotherapeutic group:

antifungal agent.

ATX code:

A07AA03

Pharmacological properties

Pharmacodynamics

Antifungal polyene (tetraene) antibiotic of the macrolide group. It has a predominantly fungicidal effect. Natamycin irreversibly binds to ergosterol in the cell membrane of the fungal cell, which leads to disruption of its integrity, loss of cytoplasmic contents and cell death.

Most pathogenic yeasts and molds, including the genera Candida

, Aspergillus, Cephalosporium, Fusarium and Penicillium. Dermatophytes and P. boydii are less sensitive to natamycin. There are no cases of resistance to natamycin in clinical practice. Natamycin in enteric tablet dosage form acts only in the intestinal lumen.

Pharmacokinetics

Natamycin is not absorbed from the gastrointestinal tract and does not have a systemic effect.

Indications for use

• intestinal candidiasis;
• acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;
• sanitation of the intestinal reservoir of fungi of the genus Candida
  for candidiasis of the skin and mucous membranes, incl. for candidiasis vaginitis, vulvitis, vulvovaginitis.

Contraindications

Hypersensitivity to the components of the drug.

Dosage regimen and route of administration

Inside. Eating does not affect the effectiveness of the drug.

For persistent vaginitis caused by Candida

, together with local antifungal drugs (for example, Pimafucin ® suppositories), Pimafucin ® tablets are used to sanitize the focus of candidiasis infection in the intestines (1 tablet orally 4 times a day for 10-20 days).

The duration of the course of treatment is determined individually. After the symptoms of the disease disappear, it is recommended to continue treatment for several more days.

Precautions for use

Patients with rare congenital intolerance to galactose, fructose, Lapp lactase deficiency, glucose-galactose malabsorption or sucrase-isomaltase deficiency should take into account that the drug contains lactose monohydrate (66 mg) and sucrose (122 mg).

If you have one of the listed diseases, be sure to consult your doctor before taking Pimafucin ®.

Pimafucin ® in this dosage form is not recommended for use in infants due to possible difficulty in swallowing tablets.

Drug overdose

No cases of overdose of the drug Pimafucin ® have been reported.

Side effect

From the digestive system: nausea and diarrhea are possible, occurring in the first days of taking the pills and going away on their own during treatment. If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction with other drugs

No interaction of the drug Pimafucin ® with other drugs was detected.

Pregnancy and lactation

The use of the drug Pimafucin ® during pregnancy and lactation is possible.

Impact on the ability to drive vehicles and machinery

Pimafucin ® does not affect the ability to drive vehicles and machines.

Release form

Enteric-coated tablets 100 mg. 20 tablets in a brown glass bottle, closed with a metal screw cap. 1 bottle in a cardboard box along with instructions for use.

Best before date

4 years. Do not use after the expiration date stated on the packaging.

Storage conditions

Store at a temperature not exceeding 25 °C. Keep out of the reach of children.

Conditions for dispensing from pharmacies

Over the counter.

Side effects

When taking tablets, in the first days, nausea and impaired intestinal motility are possible, which is manifested by diarrhea. These symptoms do not require drug treatment and disappear on their own after a few days.

The cream may cause local skin irritation and burning sensation. When applied to the head of the penis, redness of the skin and quickly passing discomfort are possible, which is associated with the antiseptic properties of the drug.

Vaginal suppositories are generally well tolerated, but in some cases a short-term burning sensation and redness of the genitals may occur. Symptoms of hypersensitivity disappear after a few minutes and do not require specific therapy.

Side effects go away on their own

special instructions

Tablets are prescribed with caution to people with porphyrin disease, since natamycin can provoke an attack of porphyria. The tablets contain sucrose, which should be taken into account by people with diabetes. If you are intolerant to this substance, you should refrain from taking tablets.

The course of use of vaginal suppositories cannot be interrupted, but they are not used during menstruation. It is necessary to select the beginning of therapy in such a way as to complete the use of vaginal suppositories before the onset of menstruation.

The cream is effective for onychomycosis caused by yeast. If your nails are affected by mold, treatment with this drug will not bring the expected result.

Features of application

Instructions for use of vaginal suppositories indicate that Pimafucin should be used as follows:

• candles are carefully removed from packaging;
• one suppository is inserted into the vagina as deeply as possible;
• The suppository should be inserted from a lying position.

Use the drug once a day, before bedtime. The course of treatment depends on the degree of development of the disease. It can last from 3 to 6 days.

The decision to stop treatment is made by the doctor.

If fungal infections are persistent, along with suppositories, oral Pimafucin tablets are prescribed.

You should not interrupt the course of treatment on your own. The exception is the period of menstruation: during this time, candles cannot be used .

Important! During the therapeutic course, you need to abstain from sexual intercourse or use barrier contraception.

Price and analogues

If treatment with Pimafucin is necessary, the price is quite affordable. A package of vaginal suppositories (6 pieces) will cost approximately 550 rubles. This amount of the drug is enough to completely cure thrush in women. You can buy Pimafucin cream for 350 rubles per pack, tablets will cost about 600 rubles.

If Pimafucin is not available in the pharmacy, it will not be difficult to find analogues.

Among the drugs for thrush, but with a different active ingredient, substitutes for Pimafucin are Clotrimazole vaginal tablets, Livarol suppositories, Candide cream.