Lomexin: instructions for use, description, pharmacological properties, contraindications, overdose. Reviews from doctors, recommendations.

Lomexin release form

Lomexin is available in the form of 2% cream in an aluminum tube with a special dispenser containing 30 grams of cream. Lomexin cream contains 20 mg of fenticonazole nitrate per 1 gram of medication. You can purchase the drug Lomexin, produced in oval soft yellow capsules (Lomexin suppositories). Capsules contain a white, thick, homogeneous oily suspension. Each capsule contains 600 mg or 1000 mg of fenticonazole nitrate. The auxiliary substances contained in the preparation are liquid paraffin, soy lecithin, petrolatum. In the box, Lomexin suppositories are located in 1 or 2 pieces in a blister.

Pharmacological properties

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The drug Lomexin has fungicidal and fungistatic, as well as anti-inflammatory and antibacterial effects.

Allergic reactions: urticaria, erythema.

Local reactions: itching, burning, local irritation are possible.

There are no data on the specifics of the interaction.

Lomexin exhibits antifungal, antiviral, and anti-inflammatory effects. The drug is used in the treatment of sexually transmitted infections caused by candida albicans and trichomonas vaginalis. The main symptoms of vaginal trichomoniasis are the presence of vaginal discharge of an unusual color and odor (white or yellow with a nonspecific odor), itching and burning during urination, severe redness of the vaginal mucosa, external labia, pain during sexual intercourse, the vaginal mucosa is covered with purulent plaque and bleeds when touched lightly.

Symptoms of vaginal candidiasis are as follows: white vaginal discharge, reminiscent of curd mass with a sour smell, discharge is easily removed from the walls of the vagina, itching and burning of the mucous membrane, uncomfortable sensations during sexual intercourse. Cream and capsules help speed up the processes of regeneration and restoration of microflora without discomfort (itching and burning).

They have a gentle effect on the vulva and vagina. Treatment lasts up to two days, after which the microflora is saturated with beneficial bacteria. But the final process of restoration of microflora will occur after the next menstruation. After vaginal administration, the bioavailability of the active substance is good, the medicine immediately begins to have antifungal activity.

After vaginal administration, the drug undergoes systemic absorption. The activity of the main metabolite is thirty percent. Seventy percent is excreted unchanged from the body. The association with plasma proteins of the cream and capsules has not been studied. The medicine does not change consciousness or concentration, so you can drive vehicles during therapy.

Cream and capsules do not cause tolerance in the body. In men, symptoms of the disease manifest themselves in the form of discharge from the urethra, pain during urination, inflammation of the prostate gland, and blood discharge from the urethra (extremely rare). But sometimes the infection can occur without symptoms.

Lomexin has good interaction with other groups of medicinal substances. No adverse drug interactions were recorded. But it is worth remembering that only one medication is used vaginally during therapy.

Pharmacodynamics

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The active component of Lomexin is fenticonazole, a synthetic derivative of imidazole (its racemic mixture in the form of fenticonazole nitrate salt), an antifungal agent with a wide spectrum of effects. It has a local fungistatic and fungicidal effect. Also has antibacterial activity.

The mechanism of action of fenticonazole is explained by its ability to inhibit the synthesis of ergosterol, which regulates the permeability of the cell membrane of fungi.

Active against Trichomonas vaginalis, yeast fungi Candida spp. (including Candida albicans), gram-positive bacteria (Streptococcus spp., Staphylococcus aureus), dermatophytes Epidermophyton spp., Microsporum spp., P. ovale, Trichophyton spp. and Pityrosporum orbiculare.

Unlike most other commonly used azole compounds (eg, ketoconazole, miconazole, and econazole), fenticonazole inhibits the biosynthesis of proteases by Candida spp. at concentrations below the minimum inhibitory concentration - 0.25–16 μg/ml. This effect does not depend on the level of antifungal activity and is due to the fact that the drug inhibits one of the stages of the formation of proteolytic enzymes by yeast-like fungi.

Pharmacokinetics

Given the local method of administration of fenticonazole, it is practically not subject to systemic absorption. The degree of absorption by mucous membranes is extremely insignificant. With long-term use it is not detected in the blood.

As a rule, Lomexin is well tolerated, side effects are transient and do not require discontinuation of the drug.

The following disorders may develop during use of the drug:

Local reactions: irritation, itching and burning at the site of application;
Allergic reactions: rash, urticaria, erythema.

There are no data on the interaction of Lomexin with other drugs.

Directions for use and dosage

For treatment, Lomexin cream is injected deeply into the vagina. For one time of use you need to take approximately 5 grams of cream. Treatment is carried out once a day in the evening before bed, but if necessary, you can use Lomexin cream 2 times a day (usually this is done in the morning and evening).

Lomexin suppositories are also used once a day. The capsule or suppository must be inserted deeply into the vagina while lying down. It's better to do this before bed. If necessary, you can re-apply after 3 days. If the treatment is ineffective, you need to repeat the course after 10 days.

Why thrush is scary, general description of the drug

Candidiasis is a disease that causes many problems in everyday life. Even a timely visit by a woman to a specialist does not guarantee that the prescribed medications will help get rid of thrush forever. Fungi of the genus Candida, which are the causative agents of the disease, produce enzymes that ensure their tight attachment to the mucous membrane of the affected organ. It is also difficult to treat candidiasis due to the alkalization of the vaginal environment, which under normal conditions is acidic. Alkalinization is provided by actively reproducing fungi. The alkaline environment does not allow representatives of the normal vaginal microflora, such as lactobacilli, which support the body's defense systems, to multiply. The tone of the immune system decreases, opportunistic microorganisms of the vagina begin to exhibit negative properties. All these factors contribute to the re-development of thrush.

Lomexin is an imidazole derivative with antifungal, antitrichomoniacal, and antibacterial properties. The product is suitable for the treatment of superficial mycosis and various forms of vaginal candidiasis. Lomexin is a cream that, in addition to its antifungal effect, removes the symptoms of the inflammatory reaction. Due to their composition, the active components act on the site of the disease for a long time, providing long-term suppression of the fungus even after a single use.

Composition and instructions for use of Sebozol shampoo

Side effects of Lomexin

Reviews of Lomexin confirm that the drug is well tolerated when used vaginally. Very rarely, after topical application, a slight burning sensation, itching, or slight irritation may occur on the affected areas of the skin. As a rule, such unpleasant phenomena pass quickly. If the irritation is quite severe, you should stop using Lomexin and consult a doctor. In case of individual intolerance to the drug, local allergic manifestations may develop, so the use of the drug in such cases is not recommended. As reviews about Lomexin say, the drug does not have any strong side effects.

Indications for use

Lomexin ointment is usually prescribed for the treatment of fungal skin infections and genital fungal infections. It is great for getting rid of:

dermatomycosis;
skin candidiasis;
genital candidiasis;
pityriasis versicolor;
trichomoniasis.

Any treatment should begin after preliminary consultation with a specialist and according to his prescription. Independent use of Lomexin ointment and any other medications can aggravate the situation; if not treated correctly, the infection becomes chronic, in which case therapy becomes more complex, treatment takes a long period, and relapses are possible.

Important: before starting treatment, it is necessary to determine the causative agent of the infection using laboratory tests, otherwise the therapy will not be effective.

If a sexually transmitted infection occurs, treatment should be carried out together with a partner to avoid re-infection.

special instructions

It is possible that with prolonged use of the drug the development of sensitization. This condition requires discontinuation of Lomexin therapy and medical consultation is necessary.

If treatment is not effective for 3 weeks, Lomexin therapy should be interrupted and the diagnosis clarified. It is most advisable to start treatment after menstruation.

To exclude reinfection, it is necessary to simultaneously treat the partner with Lomexin in the form of a cream, applying it to the foreskin and directly to the head of the penis.

LOMEXIN (cream): reviews

For joint treatment with a guy. The disadvantage of the tube is that it is metal, and after use it needs to be closed quickly, because... under pressure the cream will continue to come out further. The applicator is similar to a syringe and has a plunger to help inject the cream. It is convenient to wash it: pull the piston out of the wide part and rinse it under water. For storage - a special case. The instructions are literally stupid, although detailed. First, it says to administer about 5 grams of cream (if the doctor has not prescribed a different dosage), and then - “squeeze out the contents of the tube until the applicator is COMPLETELY filled.” Now look at the photo of what the applicator looks like with the piston fully extended: this is a cow dose! The applicator really lacks a scale with divisions. Therefore, I am sharing my experience on how to use the cream correctly: - Place the applicator on the open tube and screw it on (there is a thread inside the applicator, like a lid) - thus secure it tightly - Hold the tube vertically, as in the photo, and press on it, the cream will fill the applicator itself and will push out the piston. It is better to do this in front of bright light to see how much you have gained. Dosage: there is no scale, grams can only be calculated approximately. I did this: I took the cream and compared it with a 5-ml syringe (I understand, syringes are for more liquid substances with a different density + in the applicator, a fraction of the volume is occupied by the tip of the tube fixed there) BUT the cream is safe and with a small miscalculation it will not cause an overdose. So, add the cream to the level so that the piston rises by 4-4.5 cm. - Lubricate the clitoris with the remaining cream, wash the applicator and go to bed. I had ACUTE thrush, which was first treated with Fluomizin (which has good reviews), but for some reason it - it didn’t completely cure it, but Lomexin worked the first time! So I have been receiving treatment for 4 days now and I feel great. There are a lot of bad reviews about Lomexin suppositories (such as itching, burning, flakes the next day), I speak as a person with a very sensitive body - nothing like this from the cream! Even my stomach doesn’t hurt, there is only a little discharge during the day, towards the evening in the form of water mixed with cream (and not as much as from suppositories). Do not forget about complex therapy with oral tablets. The drug is really good! I hope I helped someone with advice, don’t worry))

I haven’t found a good review of Lomexin cream anywhere, so I’m sharing my experience. Those who often suffer from thrush will understand how important kefir drinks and diets are... But this time - oh beauty! - the problem came of its own accord. And every time I want more and more to find a panacea for this nasty thing. So... The gynecologist prescribed the cream to me, she said that the cream is better than Lomexin suppositories (the doctor’s opinion is important + the cream can be used to treat the small lips + you can simultaneously treat your partner, if you have one)! True, such treatment will take longer - 7 days. The drug is new, foreign, mushrooms are unstable to the active substance. This is already good. The package includes a tube of cream and a plastic applicator. Unscented cream. The tube is large enough (see photo), which means it will be left for the next (God forbid, of course) case or for joint treatment with a guy. The disadvantage of the tube is that it is metal, and after use it needs to be closed quickly, because... under pressure the cream will continue to come out further. The applicator is similar to a syringe and has a plunger to help inject the cream. It is convenient to wash it: pull the piston out of the wide part and rinse it under water. For storage - a special case. The instructions are literally stupid, although detailed. First, it says to administer about 5 grams of cream (if the doctor has not prescribed a different dosage), and then - “squeeze out the contents of the tube until the applicator is COMPLETELY filled.” Now look at the photo of what the applicator looks like with the piston fully extended: this is a cow dose! The applicator really lacks a scale with divisions. Therefore, I am sharing my experience on how to use the cream correctly: - Place the applicator on the open tube and screw it on (there is a thread inside the applicator, like a lid) - thus secure it tightly - Hold the tube vertically, as in the photo, and press on it, the cream will fill the applicator itself and will push out the piston. It is better to do this in front of bright light to see how much you have gained. Dosage: there is no scale, grams can only be calculated approximately. I did this: I took the cream and compared it with a 5-ml syringe (I understand, syringes are for more liquid substances with a different density + in the applicator, a fraction of the volume is occupied by the tip of the tube fixed there) BUT the cream is safe and with a small miscalculation it will not cause an overdose. So, add the cream to the level so that the piston rises by 4-4.5 cm. - Lubricate the clitoris with the remaining cream, wash the applicator and go to bed. I had ACUTE thrush, which was first treated with Fluomizin (which has good reviews), but for some reason it - it didn’t completely cure it, but Lomexin worked the first time! So I have been receiving treatment for 4 days now and I feel great. There are a lot of bad reviews about Lomexin suppositories (such as itching, burning, flakes the next day), I speak as a person with a very sensitive body - nothing like this from the cream! Even my stomach doesn’t hurt, there is only a little discharge during the day, towards the evening in the form of water mixed with cream (and not as much as from suppositories). Do not forget about complex therapy with oral tablets. The drug is really good! I hope I helped someone with advice, don’t worry))

Rating: 4 4

Source:

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Contraindications

Vaginal trichomoniasis;
Vulvovaginal candidiasis.

Vaginal capsules

Childhood;
Pregnancy and lactation;
Hypersensitivity to the components of the drug.

Vaginal cream

First trimester of pregnancy;
Hypersensitivity to the components of the drug.

Do not use Lomexin cream during menstruation.

Lomexin in capsule form is prescribed for women. Indications are the presence of an infectious disease of the genitourinary system, which is caused by Trichomonas vaginalis. Medicine is also prescribed for an infectious disease that infects the genital organs (vulva and vagina) with yeast-like fungi of the genus Candida. The medicine in the form of a cream is prescribed to women and can be prescribed to men.

Contraindications for Lomexin: allergy to the constituent components, pregnancy, lactation, increased sensitization to the components.