Pharmacological group
Pyridoxine belongs to the medicinal group of vitamin preparations. The only active ingredient of the drug is vitamin B6. The component takes an active part in metabolic processes in the human body; the element is part of intracellular enzymatic systems. This substance ensures the normal functional activity of the central nervous system and is directly involved in the metabolism of essential amino acids. It has a direct effect on histamine metabolism and slows down the manifestation of allergic reactions.
After consuming the product in tablet form, the active substance is quickly absorbed and rapidly penetrates into the systemic bloodstream from the lumen of the small intestine. Metabolism of the component occurs in the liver, the substance is excreted in urine and feces. The substance penetrates the placental barrier and has an effect on the development of the fetus in the woman’s body. Vitamin B6 can also pass into breast milk.
Interaction with other substances
Corticosteroid hormones easily remove vitamin B6 from the body. The absorption of vitamin B6 worsens with regular use of alcohol-containing drugs. Complexing compounds bind and block B6. Severe vitamin B6 deficiency occurs when taking estrogen-containing, anticonvulsant and anti-tuberculosis drugs. Vitamin B6 may reduce the effectiveness of medications in treating Parkinson's disease.
Indications for use
The use of Pyridoxine in any form of release is indicated for vitamin deficiency and hypovitaminosis, that is, for any conditions accompanied by a deficiency or complete absence of vitamin B6 in the human body.
The vitamin component is often used as an additional agent in the treatment of the following pathological conditions:
- ulcerative lesions of the stomach and duodenum;
- vascular parkinsonism;
- hypochromic anemia;
- mycocytic anemia;
- chorea;
- hepatitis or other inflammatory liver damage;
- toxicosis, which manifests itself during pregnancy;
- neurodermatitis;
- exudative diathesis.
The vitamin can also be used as one of the components of complex therapy for psoriasis.
for adults
The drug can be prescribed to patients if there is a suspected lack of vitamin B6 in the body. It is often used as an auxiliary element in complex therapy for diabetes mellitus.
for children
Pyridoxine is used in pediatric practice when indicated. The dosage is determined privately by a specialist.
for pregnant women and during lactation
The drug is often used during pregnancy. In some cases, the vitamin component helps eliminate the symptoms of early and late toxicosis in women. Dosages and optimal form of use are discussed with your doctor depending on the situation.
During breastfeeding, the product can also be used to eliminate signs of hypovitaminosis associated with a lack of vitamin B6 in a woman’s body. Often, such a composition helps speed up the process of restoring hormonal levels after childbirth and positively contributes to the elimination of unpleasant manifestations of the postpartum period. By eliminating hypovitaminosis, normalization of the condition of a woman’s hair, nails and skin is achieved.
The benefits of vitamin B6: why the body needs pyridoxine
Vitamin B6 (pyridoxine) is the most essential vitamin from group B. It is vital for the hormonal balance of the female body, the prevention of diabetes and cardiovascular diseases, strengthening the immune system and treating arthritis. Pyridoxine is used more often than others, since it is involved in many biochemical reactions to maintain the life of the body, and its official norm is clearly insufficient. Vitamin B6 is also beneficial for the heart in that it easily and quickly neutralizes homocysteine, an amino acid whose elevated level indicates a risk of heart attack and stroke. Pyridoxine deficiency leads to increased blood clotting. It has a diuretic effect, reducing blood pressure. Increases immunity: with pyridoxine deficiency, the number of T cells decreases, the number of which indicates the level of functioning of the immune system.
Pyridoxine is involved in the conversion of estradiol to estriol, the least carcinogenic form of this hormone. The indication for the use of vitamin B6 is the prevention of cancer in women. The name vitamin B6 is well known to those who suffer from fibroids and mastopathy - it is often prescribed for the treatment of these diseases. Pyridoxine reduces the symptoms of migraine. In people with increased excitability and insomnia, it acts as a sedative. Prevents attacks of nausea during pregnancy and seasickness. The need for vitamin B6 increases during pregnancy. This B vitamin is used to treat pathologies of the retina, optic nerve, and inflammatory eye diseases. For candidiasis, pyridoxine must be taken additionally, since the fungus disrupts the metabolism of pyridoxine in the body. Pyridoxine acts as a diuretic for edema. It prevents tooth decay.
Why else does the body need vitamin B6? Pyridoxine is essential for normal brain function. It is needed to maintain normal levels of magnesium in the blood and tissues of the body. Pyridoxine and magnesium interact very well. Pyridoxine with magnesium orthophosphate (or any other form of magnesium) reduces the formation of oxalates in urolithiasis. The use of pyridoxine can have a beneficial effect in epilepsy, schizophrenia, and autism. Pyridoxine treats arthritis and reduces pain in the hands. For seborrheic dermatitis, ointments with pyridoxine help better.
Note. Taking the entire B group in combination with magnesium is the basic rule. To enhance the effect, you need to take pyridoxine separately in one of the meals, and the rest of the B vitamins later, with another meal. Pyridoxine is destroyed when cooked in an acidic, alkaline environment and when exposed to light. Products that contain vitamin B6 are bran, dry yeast, wheat germ, beans, some types of fish and vegetables.
Vitamin inositol (B8)
Inositol (B8 - prolonged form of B3) is a little-known vitamin from group B, which has an anti-stress effect. It is a natural sleeping pill. Inositol levels in severe depression are below average. It can have a positive effect in cases of pangesic disorder, the symptoms of which often resemble those of damage to the cardiovascular system; it is also effective in cases of fear of appearing in public. It does not have the side effects typical of medications. In patients with Alzheimer's disease, speech and spatial orientation improve. Inositol molecules disappear from nerve cells in diabetes mellitus, and diabetic neuropathy appears with pain in the extremities. Vitamin C prevents the loss of inositol by nerve cells. Inositol, choline and methionine are lipotropic substances that burn fat. The use of this B vitamin is effective for obesity.
Inositol deficiency causes constipation, dermatitis, and visual impairment. The fact that its accumulation occurs in the lens of the eye indicates the importance of inositol in normalizing vision. It also accumulates in the myocardium.
Of all the B vitamins, only inositol activates intestinal motility.
Also, the name of this B vitamin is well known to those who have hair problems. Inositol affects hair growth and prevents hair loss, lowers blood cholesterol levels.
Note. Inositol is found in liver, yeast, wheat germ, as well as whole grain bread, oats, corn, and beans.
What is folic acid (B9) for?
B9 (folic acid) - the number one vitamin deficiency is associated with its lack. This vitamin reduces mortality from heart attacks by 10% and prevents the occurrence of 75% of congenital deformities, serious defects of the spinal cord and brain. The biggest deficiency in our diet is folic acid. The officially established dose is long outdated. Women should know that their body requires constant intake of folic acid, not only during pregnancy, but throughout the entire childbearing period of life. Because the first weeks after conception are important, when a woman may not yet know about pregnancy.
Folic acid is necessary for the division of all cells in the body, as well as for the synthesis of RNA and DNA, which transmit hereditary information.
Homocysteine is a blood protein whose high levels are associated with an even greater risk of cardiovascular disease than cholesterol. Both the arteries and veins of the legs and retinal vessels are affected, and sudden loss of vision is possible. The effect of this protein can be neutralized by taking folic acid along with vitamins B6, B12 and betaine.
Folic acid is necessary for normal reproduction of intestinal cells. Drugs used to treat Crohn's disease and colitis remove folic acid from the body, although in these diseases it is already in short supply.
Cerebrospinal fluid contains large amounts of folic acid, which is necessary for the brain. When the level is low, senile dementia and depression develop.
Folic acid is responsible for emotional balance. Indications for the use of this B vitamin are precancer in gynecology; folic acid reduces the risk of intestinal cancer. In psoriasis, folic acid deficiency is detected. It is effective for acne and many other diseases.
Note. Optimal levels of folic acid in the body are very rare. These B vitamins are found in foods such as liver, kidney, cabbage, beets and corn. To improve acid absorption, you need to prescribe a probiotic (bifidobacteria), then the bacteria of the large intestine additionally help the production of folic acid. The vitamin is destroyed in light. 90% of it is destroyed during heat treatment.
Applications and dosages
Pyridoxine in tablet form is recommended to be taken 30 minutes after meals. The element should not be chewed; the tablet should be swallowed whole with a sufficient amount of clean water.
for adults
The daily dosage of the drug for patients with hypovitaminosis is 80 mg of the drug 4 times a day; in order to prevent vitamin deficiency, the composition is used in smaller doses - 40 mg per day. In the case when the component is used as one of the elements of complex therapy for pathology, the dose is adjusted individually.
The permissible dose for subcutaneous or intravenous solution is 50-150 mg per day.
for children
The permissible dosage for children should not exceed 80 mg of the drug per day. In order to prevent vitamin deficiency, the composition is used in a dosage of 40 mg, this volume is divided into 2 doses for better absorption.
for pregnant women and during lactation
The optimal regimen for use, ensuring the elimination of toxicosis in the first and third trimester of pregnancy, is determined by the doctor. The dosage regimen is adjusted depending on changes in the concentration of vitamin B6 in the blood.
Use during pregnancy and compatibility with other drugs
Pyridoxine is really effective for the female body. It is prescribed for problems with the gastrointestinal tract during pregnancy, fatigue and excessive weakness, muscle spasms and pain, as well as increased irritability.
It is especially useful in the initial stages of pregnancy . Taking the substance during such an important period eliminates the occurrence of many diseases, simplifies the course of toxicosis, and prevents an increase in the tone of the uterus.
When taking the drug, it is worth considering the features of its combination with other medications:
- Thus, the action of isoniazid, cycloserine and penicillin negatively affects the effectiveness of vitamin B6.
- Pyridoxine also has some activity. Its action is aimed at reducing the effectiveness of levodopa and the level of phenytoin in the blood.
- Taking the vitamin simultaneously with hormonal contraceptives leads to an increase in the dosage of the former in plasma.
- It is also prohibited to mix B6, B1 and B12 in one injection.
Side effects
In extremely rare cases, it is possible to activate the process of producing hydrochloric acid in the stomach.
In most cases, the vitamin is well tolerated; however, the risk of an allergic reaction in the patient cannot be completely excluded. The list of possible occurrences includes:
- Quincke's edema;
- hives;
- generalized skin itching;
- skin rash.
If any of the above reactions occur, you should consult a doctor.
Deficiency and excess
An unbalanced diet can lead to failure in various body systems. A deficiency or excess of B6 can cause a variety of symptoms and make your life unpleasantly difficult.
Hypovitaminosis
If you are deficient in B6, you may experience the following symptoms:
- increased nervousness, anxiety, poor sleep, depression, slow reaction, irritability;
- malfunctions of the immune system;
- loss of appetite, nausea or vomiting;
- persistent headaches;
- seborrhea, dermatitis, stomatitis, cheilosis;
- conjunctivitis, polyneuritis of the extremities.
Hypervitaminosis
An excess of B6 may have the following symptoms:
- intoxication;
- increased acidity of gastric juice;
- allergic reactions on the skin (urticaria, itching);
- tingling sensation, numbness, loss of sensation in the arms and legs.
Important! It is possible to diagnose a deficiency or excess of vitamin B6 using a general blood test.
special instructions
Before you start using the product, you should carefully study the instructions for use of the composition. The list of special instructions that you should pay attention to first is as follows:
- The vitamin component is prescribed with particular caution to patients with ulcerative lesions of the stomach and duodenum; such caution is associated with the ability of the drug to increase the secretion of hydrochloric acid.
- The use of the vitamin component during pregnancy and breastfeeding is possible only under the supervision of a specialist.
- It is not recommended to take Pyridoxine for severe liver disorders.
- The active component may interact with some medications, so you should notify a specialist about using the vitamin as a dietary supplement.
- The drug does not affect the functional activity of the cerebral cortex, so the patient can independently drive vehicles during the treatment period.
The vitamin component belongs to the list of over-the-counter products and is sold to the public through a network of pharmacies for free sale. Patients should be aware and remember that only a doctor can determine the appropriate course of therapy.
Dosage forms of pyridoxine
Vitamin B6 comes in 2 forms:
- in ampoules - “Pyridoxine”, “Pyridoxine Bufus”, “Pyridoxine-Vial”;
- in tablets - “Pyridoxine hydrochloride”, “Pyridoxine”.
In addition to monocomponent preparations, B6 is also found in various vitamin complexes. All of them are divided into preventive and therapeutic. Preventative (“Supradin”, “) is a set of most vitamins and minerals for use by people without special diseases or completely healthy in order to strengthen the general condition of the body.
Therapeutic drugs contain only 2-5 vitamins, but in large dosages for the treatment of various diseases. Important! Before starting to take a vitamin complex, consult your doctor. Self-medication can be dangerous to your health!
ATX codes for PYRIDOXINE
J04AM (Combinations of anti-tuberculosis drugs) A11AA03 (Multivitamins with other minerals) J04AC51 (Isoniazid in combination with other drugs) A11EX (B vitamins in combination with other drugs) A11HA02 (Pyridoxine) J04AK03 (Terizidone) M01AB55 (Diclofenac in combination with other drugs ) J04AM02 (Rifampicin in combination with isoniazid) A11JA (Combinations of vitamins) A11BA (Multivitamins) J04AB01 (Cycloserine) A05BA (Drugs for the treatment of liver diseases) A12CC30 (Combination of various magnesium salts) A11JC (Vitamins in combination with other drugs) A11EC (Vitamins of the group B in combination with minerals) A11EA (B vitamins) N07XX (Other preparations for the treatment of diseases of the nervous system) A11DB (Combination of vitamin B1 with vitamins B6 and/or B12) B03AE03 (Iron preparations in combination with multivitamins) A11JB (Combination of vitamins with minerals) A11AB (Multivitamins in other combinations) A12CC04 (Magnesium citrate) A12AX (Calcium preparations in combination with other drugs) B05XC (Vitamins) A05C (Combination of drugs for the treatment of diseases of the liver and biliary tract) B05BA01 (Amino acids) A11AA04 (Multivitamins with microelements) A11AA02 (Multivitamin with calcium) R02AA20 (Other preparations) A11AA01 (Multivitamin with iron) J04AM06 (Rifampicin in combination with pyrazinamide, ethambutol and isoniazid) A11AA (Multivitamin with minerals)
