Cereton is a Russian-made nootropic drug. It is a centrally acting cholinomimetic. Prescribed to stimulate brain activity in encephalopathies of various etiologies. Available in the form of a solution for intramuscular or intravenous administration.
Registration number: LS-002652
Trade name: Cereton®
International nonproprietary name: choline alfoscerate
Dosage form: solution for intravenous and intramuscular administration
Photo of the Cereton solution showing the composition of the ampoule
Cereton solution composition
1 ampoule (4 ml) contains as an active substance: choline alfoscerate polyhydrate (in terms of anhydrous choline alfoscerate) - 1000 mg.
Excipients: water for injection - up to 4 ml.
Description
Transparent colorless liquid.
Pharmacotherapeutic group: nootropic agent
ATX code: N07AX02
Pharmacological properties
Pharmacodynamics
Nootropic drug. Central anticholinergic stimulant, which contains 40.5% metabolically protected choline. Metabolic protection promotes the release of choline in the brain. Provides the synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation. Increases the linear speed of blood flow on the side of the traumatic brain injury, promotes the normalization of the spatio-temporal characteristics of spontaneous bioelectrical activity of the brain, regression of focal neurological symptoms and restoration of consciousness; has a positive effect on the cognitive and behavioral reactions of patients with vascular diseases of the brain (dyscirculatory encephalopathy and residual effects of cerebrovascular accident). It has a preventive and corrective effect on the pathogenetic factors of involutional psychoorganic syndrome, changes the phospholipid composition of neuronal membranes and reduces cholinergic activity. Stimulates the dose-dependent release of acetylcholine under physiological conditions; participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission, plasticity of neuronal membranes, and receptor function. Does not affect the reproductive cycle and does not have a teratogenic or mutagenic effect.
Pharmacokinetics
Easily penetrates the blood-brain barrier, 85% is excreted by the lungs in the form of carbon dioxide, the rest (15%) is excreted by the kidneys and intestines.
Storage conditions
The average cost of Cereton (1 g injections No. 3) in Moscow is 367 rubles. The price of 14 capsules of 400 mg is 522 rubles. In the pharmacy chain, capsules are available with a prescription.
To prevent complications and negative health consequences, their independent use is excluded. Store in a place protected from light, at temperatures up to 25 C. Keep away from children. Shelf life: capsules – 3 years; solution - 5 years.
A drug
should be stored out of the reach of children, protected from light at a temperature not exceeding 25°C.
Cereton indications for use
- acute and recovery periods of severe traumatic brain injury and ischemic stroke, recovery period of hemorrhagic stroke, occurring with focal hemispheric symptoms or symptoms of brain stem damage;
- psychoorganic syndrome against the background of degenerative and involutional changes in the brain;
- cognitive disorders (impaired mental function, memory, confusion, disorientation, decreased motivation, initiative and ability to concentrate), including dementia and encephalopathy;
- senile pseudomelancholia.
Cereton contraindications
- hypersensitivity to the drug or its components;
- hemorrhagic stroke (acute stage);
- children under 18 years of age;
- pregnancy;
- breastfeeding period.
Use during pregnancy and breastfeeding
The use of Cereton® during pregnancy and breastfeeding is contraindicated. During treatment with Cereton®, breastfeeding should be stopped.
special instructions
When treating older people, no dosage adjustment of Cereton is required - patients are prescribed a standard dose.
If a patient has severe renal or liver failure, this nootropic drug must be prescribed with extreme caution. The medicine is taken with regular medical supervision.
Choline alfoscerate is not able to influence psychomotor function, so during the treatment period the patient can drive vehicles and play sports.
Doctors note that while taking this anticholinergic stimulant you should not drink alcoholic beverages. Interaction with ethanol can negatively affect the patient's condition. On the one hand, the effect of the medication can be neutralized, so there will be no medicinal effect. On the other hand, the risk of developing adverse reactions increases.
During the period of gestation, women are not prescribed Cereton injections, since the active substance can negatively affect the health and development of the fetus.
Treatment is not recommended during breastfeeding, since a small amount of the medication can pass into the mother's milk and enter the baby's body. If it is impossible to postpone therapy, then lactation is recommended to be interrupted.
Children and adolescents between 0 and 18 years of age should not take choline alfoscerate. This is explained by the fact that there is no medical data on the effect of this drug on the child’s body. To avoid unpleasant consequences, Cereton injections are contraindicated.
Before taking this anticholinergic stimulant, you should take into account its compatibility with other medications:
- Sedatives or antidepressants. Simultaneous use most often leads to an increase in the sedative effect of the former. For this reason, such complex therapy should be abandoned or the dosage adjusted.
- Other drugs from the group of nootropics (including in tablet form). Cereton is a nootropic substance, so its combined use with other drugs in this group most often causes adverse reactions and overdose.
- Tablets for arterial hypertension. With a simultaneous course of these medications, the risk of side effects that affect the nervous system increases sharply. If complex treatment is necessary, the dose is adjusted.
No information available.
Cereton side effects
From the digestive system: constipation, diarrhea, dry oral mucosa, pharyngitis. From the nervous system: headache, drowsiness, insomnia, aggressiveness, anxiety, nervousness, cerebral ischemia, convulsions, dizziness. From the skin: rash, urticaria. Other: pain at the injection site, increased urination. Allergic reactions. Nausea may occur (mainly as a consequence of dopaminergic activation), in which case the dose of the drug is reduced.
Overdose
Nausea may occur. Treatment: symptomatic therapy.
Interaction with other drugs
No significant interactions with other drugs have been identified.
special instructions
Cereton® does not affect the speed of psychomotor reactions.
Impact on the ability to drive vehicles and machinery
Cereton® does not affect the ability to drive vehicles and machines.
Release form
Solution for intravenous and intramuscular administration 250 mg/ml.
4 ml in ampoules of colorless neutral glass type I with a colored break ring or with a colored dot and notch. The ampoules are additionally coated with one, two or three colored rings and/or a two-dimensional bar code, and/or an alphanumeric coding, or without additional color rings, a two-dimensional bar code, or an alphanumeric coding.
3 or 5 ampoules in blister packs.
1 or 2 strip packaging along with instructions for use in a cardboard pack.
Photo of ampoules of Cereton solution 5 ampoules of 4 ml each
Storage conditions
Store in a place protected from light at a temperature not exceeding 25 °C. Keep out of the reach of children.
Photo of Cereton solution with price indicated
Best before date
5 years. Do not use after expiration date.
Photo of the Cereton solution on which the series is indicated and to what extent this solution is valid
Vacation conditions
On prescription.
Manufacturer: CJSC Farm 141345, Russia, Moscow region, Sergiev Posad municipal district, hundred ks rural settlement Bereznyakovskoye, village. Belikovo, 11 Tel./fax: (495) 956-29-30 Registration certificate holder: CJSC Pharm. Consumer complaints should be sent to the manufacturer's address.
Photo of Cereton solution with the manufacturer indicated on it
Analogs
If Cereton does not help or causes side effects, the doctor replaces the drug. Below are the analogues and their brief characteristics:
- Mexidol. White tablets with nootropic, anticonvulsant, anti-stress, antihypoxic effects in the body. Treatment begins with 1 tablet. 3 times a day, then increase to 2 tablets. at a time. The course is no longer than 6 weeks.
- Actovegin. A colorless solution for injection, the use of which prevents oxygen starvation in tissues. The recommended daily dosage for intravenous administration is from 5 to 20 ml per day, for intramuscular administration - no more than 5 ml per 24 hours. The course of treatment is up to 14 days.
- Gliatilin. This is a solution for parenteral administration and capsules for oral use. According to the instructions, the recommended dosage for the second release form is 400 mg (1 tablet) 2-3 times per day. The course of drug therapy is 3–6 months.
- Cerepro. This is a nootropic drug, an analogue of Cereton in the form of capsules for oral use. According to the instructions, the recommended dose is 1 tablet. three times a day. According to the instructions, the course of treatment varies from 3 to 6 months.
Cereton solution summary (instructions for use) in photographs
Photo of instructions for use of Cereton solution, part 1
Photo of instructions for use of Cereton solution, part 2
Release form
Instructions for use of the drug Cereton informs that there are several forms of release of the characteristic medication, including a solution for intravenous injections and capsules for oral administration. In the first case, the healing liquid is placed in glass ampoules of 3, 5 and 10 pieces per package. In the second, the pills have an oblong shape, oil content, and are packaged in 14, 28, 42 or 56 pieces for one package. Cereton of the required dosage can be easily purchased in an online store or a real pharmacy - the choice is up to the patient.
capsules.
14 capsules in a blister pack.
1 or 2 contour packages in a cardboard pack. Vacation category.
Cereton solution: reviews of the drug
Polina Shashkova, Novouralsk I am already 56 years old, and in recent years my memory has begun to rapidly deteriorate. My relatives also began to notice this and were even afraid to let me go out alone, because they also had difficulties with orientation. At the insistence of family members, she began treatment. The doctor prescribed Cereton injections. I completed the course and my health improved. I should note that when I was undergoing treatment, I had a headache, but I endured everything. Now everything is fine. My memory has been restored, my head doesn’t hurt. Two months have passed since the treatment. David Doronin, Perm A misfortune happened to me. I was in a car accident. He suffered fractures and a traumatic brain injury. The treatment was long and serious. It took a long time to recover, about a year. It would seem that everything had returned to normal, but frequent dizziness and insomnia continued to torment me. Then the doctor who treated me prescribed Cereton. Now my head doesn't bother me. The medicine helped. My ability to work has returned. Kira Evdokimova, Vladimir My mother is 68 years old. One night while sleeping she suffered an ischemic mini-stroke. Of course, we made every effort to begin treatment immediately. We injected Cereton, there is a noticeable improvement, now we have switched to taking Cereton capsules. We really hope for a favorable outcome, because positive dynamics are noticeably visible, however, we are still far from a normal state. Coordination of movements has not yet been fully restored, and concentration is far from normal. Larisa Seliverstova, Noyabrsk My husband’s character changed a lot after a concussion. He began to behave very aggressively, suffers from insomnia, experiences constant intense headaches and some kind of incomprehensible anxiety, and it has become difficult to communicate with him. It was not easy to convince him to start treatment, but in the end he was persuaded. The doctor advised me to pierce Cereton. A month has passed since the treatment, my sleep has become much better, but the other symptoms still remain at the same level. Matvey Matvienko, Zelenodolsk I, like my comrades, wanted to restore my memory with the help of Cereton. They praised him greatly. But nothing worked out for me. After the first injection I began to feel very sick, the doctor canceled the injection. Grigory Gushchin, Krymsk My father was overtaken by senile dementia at a fairly advanced age. Became worse than a child. He doesn’t remember anything, where he is, he doesn’t know, it became dangerous to leave him alone, because at any moment he could leave in an unknown direction or do something that, as they say, “doesn’t fit into any framework.” We turned to a doctor for help, he recommended Cereton injections. They pierced him, some time passed and his condition improved. Now he began to understand and remember what you say to him. Of course, it is completely unlikely to return to normal. But even this state of his suits us. Anna Orekhova, Murmansk I have been working as a dispatcher for a large transport company for 23 years. Lately I've been getting headaches towards the end of the work week and it's become difficult for me to concentrate. And in my work this is unacceptable. I had to look for a way to restore my health so as not to lose my job. We recommended Cereton. Not enough time has passed since the treatment to draw final conclusions, but I already feel a significant improvement.
