Teraligen tablets 5 mg No. 50. Check the price with the manager

Description and composition

Teraligen is available in the following dosage forms:

film-coated tablets: dark pink, with a stripe on one side and an embossed symbol on the other, without any other damage to the sides and edges (10 or 25 pieces in blisters, 1, 2 or 5 blisters in a cardboard pack) ;
solution for infusion and intramuscular administration: slightly colored or colorless, transparent or with slight opalescence (5 ml in light-protective glass ampoules, 10 ampoules in cardboard boxes covered with a parcel label, or 5 or 10 ampoules in blister packs made of polyvinyl chloride films, in a cardboard box 1 or 2 blister packs).

Composition per 1 tablet:

active ingredient: alimemazine tartrate – 5 mg;
auxiliary components: refined sugar, tapioca starch, magnesium stearate, milk sugar, wheat starch, colloidal silicon dioxide, talc;
film shell: macrogol 6000, talc, hypromellose, Osprey R110 pink dye, titanium dioxide.

Composition per 1 ml of solution:

active ingredient: alimemazine tartrate – 5 mg (in terms of dry matter);
auxiliary components: sodium sulfite, ascorbic acid, water for injection.

The drug Teraligen is sold in the form of tablets for oral use. The drug is produced in blisters of 10 or 25 units of medication each. There can be 1, 2 or 5 blisters in a cardboard pack.

Teraligen tablets are characterized by a dark pink color, a score line on one side and an embossed symbol on the other. There is also a film shell that covers each unit of the drug.

The main component of the drug is alimemazine tartrate in a dosage of 5 mg.

The medication also contains a number of auxiliary components included in the following list:

colloidal silicon dioxide;
lactose;
talc;
wheat starch;
magnesium stearate;
sucrose;
tapioca;
titanium dioxide;
hypromellose;
pink dye;
macrogol 6000.

- film-coated tablets.

Packaging: 10 or 25 pieces in blister packs made of aluminum foil and polymer materials, 1, 2 or 5 blister packs are included in a cardboard box.

contains alimemazine tartrate 5 mg.

Excipients: lactose, colloidal silicon dioxide, refined sugar (sucrose), wheat starch, tapioca starch (tapioca), talc, magnesium stearate.

Shell composition: hypromellose, macrogol 6000, titanium dioxide, Osprey R110 pink dye, talc.

Pharmacological group

Among the properties that the drug has are:

antispasmodic;
antihistamines;
antiemetics;
sleeping pills;
antipsychotic;
antitussives.

Teraligen belongs to a number of neuroleptics. The product begins to act after 10-15 minutes and its duration, as a rule, is from 6 to 8 hours.

The antipsychotic properties of the drug are not clearly expressed; this fact determines the low effectiveness of the drug in psychotic conditions at the acute stage.

The medicine has a good level of tolerability, which explains the justification for its use in people classified as elderly, children and adolescents.

Absorption of the drug occurs completely. The maximum concentration in the blood serum is observed 60-120 minutes after administration. It is excreted within two days through the kidneys in the form of metabolites.

Pharmacodynamics

Teraligen is an antipsychotic that has antispasmodic, antihistamine, hypnotic, antitussive, antiemetic, sedative, moderate alpha-blocking and serotonin-blocking effects. Alimemazine, the active component of the drug, is a phenothiazine derivative.

The antipsychotic effect is due to the blockade of dopamine D2 receptors in the mesocortical and mesolimbic systems; the vegetative stabilizing and antiemetic effect is associated with the blockade of D2 receptors located in the trigger zone of the vomiting center; the anxiolytic and sedative effect is caused by blockade of adrenergic receptors in the reticular formation of the brain stem;

the hypothermic effect occurs as a result of blockade of dopamine receptors in the hypothalamus; the antipruritic effect is due to the effect of the drug on H1-histamine receptors. The therapeutic effect of alimemazine occurs 15–20 minutes after taking the drug and lasts for 6–8 hours.

Teraligen is ineffective in acute psychosis, since the antipsychotic activity of alimemazine is low.

The antihistamine effect of the drug allows it to be used in the treatment of allergic diseases, especially the respiratory tract, as well as itchy skin. In terms of antihistamine and sedative activity, Teraligen is superior to Diprazine.

The drug is effective for obsession, phobia and senesthopathy. It is prescribed to patients with psychosomatic manifestations developing as a result of neurovegetative disorders, as well as traumatic, infectious and vascular disorders of the central nervous system. In patients in this category, alimemazine normalizes sleep.

The drug is gentle and well tolerated, so it can be used in children, adolescents and the elderly.

Pharmacokinetics

Alimemazine is quickly and completely absorbed regardless of the route of administration. Maximum plasma concentration is achieved after 1–2 hours. The drug is 20–30% bound to plasma proteins. The half-life is 3.5–4 hours. About 70–80% of alimemazine is excreted by the kidneys in the form of sulfoxide (metabolite) within 2 days.

Reviews of Teraligen

Increasingly, modern psychotherapists, psychiatrists and neurologists recommend their patients to take Teraligen tablets. This is due to the fact that people often face difficult situations in their lives when the nervous system needs external support.

The trials that accompany our journey in life are often unpredictable, and their consequences for a person’s character and mental stability can be so far-reaching that it is impossible to even predict in advance.

To get rid of fears, phobias, obsessions, to eliminate irritability and normalize sleep, use Teraligen tablets.

Contraindications

The medication is used for various types of neurological disorders.

for adults

For the adult category of patients there is the following list of indications for use:

state of anxiety in somatic diseases;
sleep disorders;
psychopathy with disorders of asthenic and psychoasthenic nature;
senestopathic depression;
somatized mental disorders;
allergic reactions;
neuroses and neurosis-like disorders of organic or endogenous nature with psychovegetative, phobic, hypochondriacal and senestopathic disorders;
anxiety-depressive pathologies.

for children

Teraligen is used in children over 7 years old according to pediatrician indications.

Use during pregnancy or breastfeeding is strictly contraindicated.

There is a list of conditions and pathologies in the presence of which a patient is contraindicated to take the drug Teraligen, these include:

individual intolerance to one of the components of the drug;
child's age up to 7 years;
pregnancy period;
myasthenia gravis;
use of MAOIs;
lactation period;
Reye's syndrome;
parkinsonism;
serious disorders of the kidneys and liver;
angle-closure glaucoma.

For the following diseases, therapy is carried out with extreme caution:

epilepsy;
bladder neck obstruction;
arterial hypotension;
jaundice;
open-angle glaucoma;
chronic alcoholism;
susceptibility to urinary retention.

Film-coated tablets are recommended for the treatment of the following diseases/conditions:

states of anxiety and excitement in somatic diseases;
neurosis-like conditions and neuroses of organic and endogenous origin with a predominance of hypochondriacal, psychovegetative, senestopathic and phobic disorders;
anxiety-depressive conditions that do not go beyond the scope of vascular and borderline endogenous diseases;
sleep disorders of various etiologies;
psychopathy with psychoasthenic and asthenic disorders;
somatized mental disorders;
senestopathic depression;
allergic reactions (for symptomatic therapy).

Teraligen solution for infusion and intramuscular administration is used in the following cases:

relief of symptoms of psychovegetative and neurotic disorders (as an anxiolytic and sedative);
premedication before surgery (as a sedative);
symptomatic treatment of allergic reactions of various etiologies (conjunctivitis, rhinitis, urticaria, itching, angioedema);
complex treatment of alcohol withdrawal syndrome.

Absolute:

severe kidney and/or liver disease;
Reye's syndrome (acute liver failure and encephalopathy);
closed-angle form of glaucoma;
myasthenia gravis;
prostatic hyperplasia;
sleep apnea syndrome;
acute intoxication with narcotic analgesics and hypnotics;
alcohol intoxication;
episodic appearance of vomiting in children of unknown etiology;
parkinsonism;
coma and deep depression of the central nervous system;
children under 7 years of age;
period of pregnancy and breastfeeding;
simultaneous therapy with monoamine oxidase inhibitors (alimemazine can be used no earlier than 2 weeks after the end of treatment with monoamine oxidase inhibitors);
hypersensitivity to individual components of the drug or phenothiazines.

Relative (Teraligen is used with caution):

jaundice;
chronic alcoholism;
arterial hypotension;
open-angle form of glaucoma;
predisposition to urinary retention, obstruction of the bladder neck;
suppression of bone marrow function;
epilepsy;
indications in the anamnesis of complications during treatment with phenothiazine derivatives.

Indications for use of the drug

— neuroses and neurosis-like conditions of endogenous and organic origin with a predominance of senestopathic, hypochondriacal, phobic and psychovegetative disorders;

— psychopathy with asthenic and psychoasthenic disorders;

— anxiety-depressive conditions within the framework of borderline endogenous and vascular diseases;

- senestopathic depression;

— somatized mental disorders;

— states of excitement and anxiety in somatic diseases;

— sleep disorders of various origins;

- allergic reactions (symptomatic treatment).

Contraindications to the use of the drug

are: angle-closure glaucoma; prostatic hyperplasia; severe liver disease; severe kidney disease; parkinsonism; myasthenia gravis; Reye's syndrome; simultaneous use of MAO inhibitors; pregnancy; breastfeeding period; children under 7 years of age; hypersensitivity to the components of the drug.

The drug should be used with caution in chronic alcoholism if there is a history of complications when using phenothiazine drugs, obstruction of the bladder neck, predisposition to urinary retention, epilepsy, open-angle glaucoma, jaundice, suppression of bone marrow function, arterial hypotension.

Adverse reactions and overdose

Alimemazine in the correct dosage is quite easily tolerated, but, like most medications, there are side effects.

Side effects, as for such a powerful drug, are relatively insignificant and are quite rare - among other things, when taking Teraligen, the following negative reaction from various body systems is observed more often than others:

Nervous system : lethargy, drowsiness, fatigue. Such side effects are observed, as a rule, only at the beginning of the course. There is no need to rush to discontinue or replace the drug with another similar one. A restless and even excited state, irritability, and nightmares may also appear. In medical practice, the following “side effects” were also noted: disturbances of consciousness, anxiety, tremor; In children, sleep apnea (breath holding) and convulsions are possible.
Sense organs : blurred vision, tinnitus.
Cardiovascular system : a decrease in blood pressure is often observed, so the drug is not recommended for patients with hypotension. Tachycardia may also occur.
Digestion : Quite often, patients note dry mouth, decreased peristalsis and tone of the gastrointestinal tract, stool disorders, and loss of appetite.
Respiratory system : dryness in the nasopharynx.
Urinary system : decreased bladder tone, urinary retention.
Others : allergies, hyperhidrosis, muscle relaxation, increased sensitivity to light.

Symptoms that occur during an overdose: side effects increase, consciousness is depressed (fainting, collapse, coma).

In case of overdose, symptomatic treatment is prescribed.

Mode of application

A drug

should be taken orally, dividing the daily dose into 3-4 doses.

The onset of action of the drug is after 15-20 minutes, the duration of action is 6-8 hours.

For adults, to achieve a hypnotic effect, 5-10 mg/day; to achieve an anxiolytic effect, 60-80 mg/day. For psychotic conditions - 200-400 mg/day.

Children over 7 years of age (depending on age and body weight) to achieve a hypnotic effect, 2.5-5 mg/day; as a symptomatic treatment of allergic reactions, 5-20 mg/day; to achieve an anxiolytic effect, 20-40 mg/day; in psychotic conditions, it is possible to increase the daily dose of the drug to 60 mg/day.

Symptoms of drug overdose

: depression of consciousness, increased adverse reactions.

Treatment: symptomatic.

An overdose of alimemazine manifests itself in depression of consciousness and intensification of side effects. There is no specific antidote, which necessitates symptomatic treatment of the consequences of an overdose.

Teraligen tablets are taken orally. The daily dose of the drug is divided into 3-4 doses.

Recommended doses for adult patients: as an anxiolytic – 60–80 mg per day; as a hypnotic – 5–10 mg per day; for the treatment of psychotic conditions – 200–400 mg per day.

For children 7 years of age and older, Teraligen tablets are prescribed in the following daily doses (depending on body weight and age):

anxiolytic effect – 20–40 mg;
hypnotic effect – 2.5–5 mg;
treatment of psychotic conditions – up to 60 mg;
symptomatic treatment of allergic reactions – 5–20 mg.

Teraligen in solution form is administered intramuscularly (in the form of injections or infusions), with caution. Subcutaneous injections of the drug are prohibited, as they can cause necrosis at the injection site.

The dosage is selected by the doctor individually for each patient. The maximum dose of the drug is 200 mg per day.

In psychiatric practice, as well as in acute cases (to relieve symptoms), Teraligen is administered at a dose of 25 mg once or twice a day.

During the premedication period, the dose of the drug is 25–50 mg, it is administered once 1–2 hours before the start of surgery.

For allergic reactions, 25 mg of the drug is administered, and for alcohol withdrawal syndrome - 50 mg 1-2 times a day.

In case of an overdose of the drug, the manifestations of the side effects described above (except for allergic reactions) intensify.

Treatment consists of discontinuing Teraligen and prescribing the necessary symptomatic therapy.

Patients leave quite a lot of reviews about Teraligen, and they more often mention the advantages of the drug than its disadvantages. Thus, according to users, Teraligen is a good calmer, treats insomnia, relieves irritability, improves the response to stress, removes phobias and fears, eliminates skin itching and rashes, and acts gently and quickly.

However, the drug is not suitable for everyone and can cause unwanted side reactions, as also mentioned in reviews (cases of weakness, drowsiness, dizziness, tachycardia, increased blood pressure, convulsions and panic attacks have been reported).

The cost of the drug depends on the form of release and packaging. Approximate prices for Teraligen in pharmacies:

film-coated tablets 5 mg: 25 pcs. in packaging – 590 rubles; 50 pcs. in packaging – 870 rubles;
solution for intramuscular administration 5 mg/ml, 10 ampoules per package – 1020 rubles.

Applications and dosages

Teraligen tablets are for oral use. The dosage directly depends on the effect aimed at using the drug.

for adults

For adult patients, the dosages listed below are available.

To activate the hypnotic properties of the drug: 5-10 mg.

To obtain an anxiolytic effect: 60-80 mg.

In a psychotic state: 0.2-0.4 g.

for children

For children over 7 years of age, the following dosages apply.

To activate the hypnotic properties of the drug: 2.5-5 mg.

To obtain an anxiolytic effect: 20-40 mg.

For allergies: 5-20 mg.

In a psychotic state, the daily dose can be up to 60 mg. It needs to be divided into several steps (3-4).

Side effects

Undesirable side effects develop extremely rarely and their severity is insignificant:

digestive system: loss of appetite, dry oral mucosa, constipation, atony of the stomach and intestines;
cardiovascular system: tachycardia, decreased blood pressure, dizziness;
respiratory system: dryness in the throat and nasal cavity, increased viscosity of bronchial secretions;
nervous system: fatigue, drowsiness and lethargy (occur mainly at the beginning of treatment and rarely require cessation of therapy), anxiety, irritability, nightmares, agitation, confusion, tremor, hypokinesia, restlessness;
sense organs: ringing or noise in the ears, blurred vision;
urinary system: urinary retention, bladder atony;
other reactions: increased sweating, increased sensitivity to light, inhibition of hematopoiesis in the bone marrow, muscle relaxation, allergies.

Alimemazine enhances the therapeutic effects of hypnotics, antihypertensive and antipsychotic drugs, narcotic analgesics, m-anticholinergic drugs and drugs for general anesthesia (dosages of these drugs must be adjusted); weakens the effect of dopamine, ephedrine, amphetamine, levodopa, m-cholinergic stimulants and guanethidine.

When used simultaneously with ethanol and drugs that suppress the central nervous system, depression of its functions is observed; with barbiturates and antiepileptic drugs – the threshold for convulsive activity is reduced (dose adjustment is necessary); with beta-blockers - there is a mutual increase in plasma concentrations (arrhythmias may occur, blood pressure decreases);

Teraligen increases serum prolactin concentrations and weakens the effect of bromocriptine. The M-anticholinergic activity of the drug is enhanced in combination with anticholinergics and tricyclic antidepressants.

Phenothiazine derivatives and monoamine oxidase inhibitors increase the likelihood of extrapyramidal disorders and the risk of developing arterial hypotension.

From the central nervous system and peripheral nervous system: drowsiness, lethargy, fatigue (occurs mainly in the first days of taking the drug and rarely requires discontinuation of the drug), paradoxical reaction (restlessness, agitation, nightmares, irritability); rarely - confusion, extrapyramidal disorders (hypokinesia, akathisia, tremor); increased frequency of night apnea, increased seizure activity (in children).

From the senses: blurred visual perception (accommodation paresis), noise or ringing in the ears.

From the cardiovascular system: dizziness, decreased blood pressure, tachycardia.

From the digestive system: dry mouth, gastrointestinal atony, constipation, loss of appetite.

From the respiratory system: dry nose, throat, increased viscosity of bronchial secretions.

From the urinary system: bladder atony, urinary retention.

Other: allergic reactions, inhibition of bone marrow hematopoiesis, increased sweating, muscle relaxation, photosensitivity.

The drug is usually well tolerated by patients. Side effects are rare and mild.

Analogues of the drug Teraligen

The drug can enhance the effect of anxiolytics, hypnotics, antipsychotics, narcotic analgesics, general anesthesia, antihypertensive drugs and m-anticholinergic drugs. In such cases, it is necessary to adjust the dose.

The M-anticholinergic activity of alimemazine increases when taking anticholinergics and tricyclic antidepressants.

Teraligen reduces the effectiveness of m-cholinergic stimulants, dopamine, ephedrine, amphetamine, levodopa, guanethidine. Significant depression of the central nervous system is observed when taken simultaneously with drugs that suppress central nervous system functions and ethanol. Combination with barbiturates and antiepileptic drugs leads to a decrease in the threshold of convulsive readiness.

The analogue of Alimemazine tartrate is determined by its structure.

Antipsychotics include analogues:

Abilify.
Haloperidol.
Normiton.
Chlorpromazine.
Tiapride.
Betamax.
Servitel.
Clopixol.
Triftazin.
Thioridazine.
Truxal.
Majeptyl.
Ketilept.
Tison.
Galoper.
Eglek.
Olanzapine.
Azaleptin.
Serdolect.
Aripiprazole.
Propazin.
Seroquel.
Ketiap.
Fluanxol.
Rezalen.
Zyprexa.
Droperidol.
Solian.
Etaperazine.
Trazyn.
Leptinorm.
Quetiapine.
Olanex.
Senorm.
Chlorprothixene.
Risperpet.
Closasten.
Victoel.
Moditen.
Prolinate.
Parnasan.
Sulpiride.
Nantharid.
Sonapax.
Aminazine.
Ridonex.
Rispen.
Tizercin.
Torendo.
Limipranil.
Zilaksera.
Zeldox.
Speridan.
Leponex.
Eglonil.
Rilept.
Clozapine.
Risperidone.
Thiodazine.
Prosulpin.

There are often situations in life in which the nervous system is subjected to serious tests. Obsessive fears, unpleasant sensations, and irritability appear. There are medications that help cope with these conditions. One of them is Teraligen.

When is Teraligen prescribed?

Neuroleptic

Teraligen is a drug from the group of antipsychotics (neuroleptics). The main active ingredient is alimemazine tartrate. The drug is well tolerated by patients and is prescribed for mild nervous and mental disorders, since in severe disorders its effectiveness is not enough.

The leaflet that comes with the medicine states that Teraligen and alcohol are not compatible. The functions of the medicine help fight depression, which in itself is dangerous.

If being in a depressed state is supplemented by drinking alcohol, which is a powerful toxic antidepressant, then depression only becomes even more serious.

Thus, drinking alcohol will complicate treatment and may even aggravate the development of the disease.

Combining alcohol with Teraligen can have fatal consequences for the patient. Doctors have found that taking the medication in combination with alcohol can cause inappropriate actions.

The consequences of combination may be as follows:

fear for no reason and psycho-emotional anxiety;
incoherent speech;
memory impairment;
disorientation;
serious overstrain of the nervous system, which can further worsen the symptoms of the disease.

In addition, Teraligen in combination with alcoholic beverages can provoke problems in the functioning of the cardiovascular system: tachycardia or arrhythmia, high blood pressure, vascular spasms in the brain, etc.

The kidneys and liver can also be affected, since they break down and excrete the body as substances formed as a result of the breakdown of both medicine and alcohol.

special instructions

With prolonged therapy with the drug, it becomes necessary to monitor liver function.

Teraligen is able to mask the manifestation of the ototoxic effects of other medications when used together.

During the course of therapy, women may receive false positive pregnancy test results.

During the course, alcohol consumption must be completely avoided.

The drug has a certain effect on a person’s ability to drive vehicles and engage in other activities that require increased concentration and intensive use of cognitive abilities.

While taking alimemazine, the need for vitamin B2 (riboflavin) increases.

The drug is able to mask the ototoxic effects (dizziness, tinnitus) of drugs used simultaneously with it.

Teraligen should be discontinued 72 hours before allergy testing because it may interfere with allergen skin testing results.

Sulfites contained in the injection solution may enhance anaphylactic reactions.

During treatment with the drug, false positive results for pregnancy may occur.

Teraligen is not compatible with alcohol.

While taking Teraligen, you should not drive cars or other vehicles, or work with moving or potentially dangerous machinery.

Drug interactions

With the simultaneous use of alimemazine with amphetamine derivatives, m-cholinomimetics, ephedrine, guanethidine, levodopa, dopamine, the effect of the latter is weakened.

When alimemazine is used concomitantly with ethanol and drugs that depress the central nervous system, central nervous system depression is observed.

With the simultaneous use of alimemazine with antiepileptic drugs and barbiturates, the threshold for convulsive readiness is reduced (dose adjustment of the drug is required).

Terms and conditions of storage

Store in a dark place at a temperature not exceeding 25 °C. Keep away from children.

Shelf life – 3 years.

Dispensed by prescription.

Medicines are dispensed from pharmacies according to a prescription.

The product should be stored in a dark, dry place out of reach of children at a temperature not exceeding 25 °C.

The shelf life of Teraligen is 3 years. Use of the drug after the specified period is prohibited.

The drug should be stored out of the reach of children, in a dry place, protected from light, at a temperature not exceeding 25°C. Shelf life: 3 years.