Baclosan is a muscle relaxant from a group of drugs that have an anti-inflammatory and analgesic effect. Active ingredient: Baclofen.
Centrally acting muscle relaxant; GABAB receptor agonist. By reducing the excitability of the terminal sections of afferent sensory fibers and suppressing interneurons, it inhibits mono- and polysynaptic transmission of nerve impulses; reduces pre-tension of muscle spindles.
Does not affect the transmission of impulses at neuromuscular synapses. For neurological diseases accompanied by spasticity of skeletal muscles, it weakens painful spasms and clonic convulsions.
Increases the range of motion in the joints, facilitates passive and active kinesitherapy (physical exercises, massage, manual therapy).
Available in tablets of 10 mg and 25 mg. Baclosan 10 mg tablet is marked with a dividing line. The 25 mg tablet has no dividing risks. The shape is round, biconvex, white.
Baklosan tablets composition
1 tablet contains:
Active substance: baclofen 10 mg or 25 mg. Excipients: lactose, potato starch, gelatin, talc, magnesium stearate, ethylcellulose.
Photo of the packaging of baclosan 10 mg tablets, which shows the composition
Photo of the packaging of baclosan 25 mg tablets, which shows the composition
Description
Tablets are white, round, biconvex. 10 mg tablets have a dividing line.
Pharmacotherapeutic group: centrally acting muscle relaxant
CodeATKH: M03VHO1
pharmachologic effect
Pharmacodynamics
A centrally acting muscle relaxant, a derivative of gamma-aminobutyric acid (GABAb-stimulator). By reducing the excitability of the terminal sections of afferent sensory fibers and suppressing interneurons, it inhibits mono- and polysynaptic transmission of nerve impulses; reduces pre-tension of muscle spindles. Has no effect on neuromuscular transmission. For neurological diseases accompanied by spasticity of skeletal muscles, it weakens painful spasms and clonic convulsions; increases the range of motion in the joints, facilitates passive and active kinesitherapy (physical exercises, massage, manual therapy).
Pharmacokinetics
Absorption is high. The maximum concentration in blood plasma is achieved 2-3 hours after taking the drug. Connection with blood plasma strips - 30%. Penetrates the placental barrier and is excreted in breast milk. Metabolized in the liver. Excreted by the kidneys (mainly unchanged).
Baklosan contraindications
Hypersensitivity, epilepsy, convulsions (including history), psychosis, Parkinson's disease, peptic ulcer of the stomach and duodenum, lactase deficiency, lactose intolerance, glucose-galactose malabsorption, pregnancy and lactation, children under 3 years of age.
Carefully
Cerebrovascular insufficiency, cerebral atherosclerosis, chronic renal failure, old age, children under 12 years of age.
Baklosan tablets dosage and method of administration
Inside, during meals. If you miss the next dose, you should not take a double dose of the drug.
Adults: Initial dose - 5 mg (1/2 tablet of 10 mg) 3 times a day, followed by increasing the dose every 3 days by 5 mg until a therapeutic effect occurs (usually up to 30-75 mg per day). The maximum daily dose is 100 mg. The final dose is set so that the decrease in muscle tone does not lead to excessive myasthenia gravis and does not impair motor function. For hypersensitivity, the initial daily dose is 5-10 mg, followed by a slower increase. For chronic renal failure and during hemodialysis - daily dose - 5 mg (1/2 tablet of 10 mg). In patients requiring high doses of bacpofen (from 75 mg to 100 mg per day), the drug should be used in 25 mg tablets. In patients over 65 years of age, the dose of the drug should be increased with caution, due to the increased risk of side effects.
Children: Initial dose - 5 mg (1/2 tablet of 10 mg) 3 times a day. If necessary, the dose can be increased with caution every 3 days by 5 mg until a therapeutic effect occurs. The following doses are usually recommended: For children from 3 to 6 years old, 120-30 mg per day, from 6 to 10 years old - 30-60 mg per day. In children over 10 years of age, the maximum daily dose is 2.5 mg/kg body weight; initial dose -1.5-2.0 mg/kg body weight. The drug is withdrawn gradually (over 1-2 weeks).
Interaction with other drugs
The attending physician must be aware of other medications the patient is taking in parallel.
Together with other drugs that affect the central nervous system and alcohol, the sedative effect of the active substance increases.
If lithium salts are present in another medicine, the patient will experience hyperkinetic symptoms.
Muscle tone decreases when taken together with antidepressants. When taking drugs to lower blood pressure in parallel, it is necessary to adjust the doses of both drugs.
Kidney failure can occur when taking Baclofen with Ibuprofen (Nurofen). When taken together with Levodopa, problems with clarity of thinking and consciousness are noted.
Baklosan side effects
Depending on the frequency of occurrence, the following groups of side effects are distinguished: very rare - less than 0.01%, rare - more than 0.01% and less than 0.1%, infrequent - more than 0.1% and less than 1%, frequent - more than 1 % and less than 10%, very common - more than 10%.
From the nervous system: very common - drowsiness, sedation; frequent dizziness, weakness, fatigue, confusion, gait disturbance, insomnia, euphoria, depression, asthenia, ataxia, tremor, hallucinations, nightmares, nystagmus, dry mouth; rare - paresthesia, dysarthria.
From the cardiovascular system: frequent - decreased cardiac output, arterial hypotension.
From the gastrointestinal tract: very common - nausea; frequent, vomiting, constipation, diarrhea, dyspeptic symptoms; rare - abdominal pain, dysgeusia, liver dysfunction.
From the respiratory system: frequent - respiratory depression.
From the musculoskeletal system: frequent - myalgia.
From the senses: frequent - accommodation paresis, visual disturbances.
From the skin and subcutaneous tissue: common - hyperhidrosis, rash.
From the kidneys and urinary system: frequent - polyuria, enuresis, dysuria; rare - urinary retention.
From the reproductive system: rare - erectile dysfunction.
General disorders: very rare - hypothermia.
In isolated cases, an increase in spasticity was observed, which was regarded as a paradoxical reaction to the drug.
Overdose
Symptoms: muscle hypotension, depression of the respiratory center, confusion, coma; After the return of consciousness, muscle hypotension may persist for 72 hours.
Treatment: plenty of fluids, diuretics; in case of respiratory depression - artificial ventilation. There is no specific antidote.
Interaction with other drugs
Enhances the effect of drugs that depress the central nervous system, antihypertensive and anti-gout drugs, ethanol. Tricyclic antidepressants increase the decrease in muscle tone; Levodopa, carbidopa in combination with levodopa increase the risk of hallucinations, confusion, and agitation.
special instructions
Side effects are often transient in nature, they should be distinguished from the symptoms of the disease for which treatment is being carried out: with concomitant epilepsy, treatment is carried out without discontinuation of anti-epideptic drugs. In patients with liver disease and diabetes mellitus, it is necessary to periodically monitor the activity of liver transaminases, alkaline phosphatase, and blood glucose concentration. During treatment, you should refrain from potentially dangerous activities associated with the need for increased attention and rapid mental and motor reactions.
Release form
Tablets 10 mg, 25 mg. 50 tablets in a polypropylene jar, closed with a plastic lid without first opening control.
Photo of a bottle of baclosan tablets 50 tablets of 10 mg each
The jar, along with instructions for use, is placed in a cardboard box.
Photo of a bottle of baklosan tablets 50 tablets of 25 mg each
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.
Best before date
3 years. Do not use after the expiration date stated on the packaging.
Photo of baklosan tablets indicating the series, date of manufacture and expiration date of these tablets
Conditions for dispensing from pharmacies
On prescription.
Photo of baklosan tablets with the price indicated
Manufacturer: Pharmaceutical JSC, Poland st. Pelplinska 19, 83-200 Starogard Gdanski, or MEDANA PHARMA Joint Stock Company, Poland 98-200 Sieradz, W. Lokietka Street 10, Organization that accepts consumer complaints JSC "Chemical and Pharmaceutical Plant "AKRIKHIN" 142450, Moscow region, Noginsk district, Staraya Kupavna, st. Kirova, 29 Tel.; Fax
Photo of baklosan tablets showing the manufacturer
special instructions
In general, while using the medication, you should limit your activities to activities that require high concentration. Especially when it comes to activities that additionally require physical activity. Driving vehicles, and especially various types of equipment, and operating machinery is strongly not recommended during the treatment process.
The drug should be taken only outside the period of daytime activity, or use public transport and minimize work processes that require increased concentration.
Diseases of the liver and kidneys (especially the liver) require careful periodic monitoring of glucose levels and other parameters. As mentioned earlier, Baclofen has a negative effect on the functions of internal organs when taken for a long time.
It is especially worth noting the presence of addiction, which makes people dependent on taking Baclofen. You should discontinue use by gradually reducing the dose and then do not resume use unless necessary.
It is worth noting that Baclofen is often used to obtain a narcotic, intoxicating effect. Over time, the person using it gets used to it; constant overdoses disrupt the functioning of internal organs, reduce immunity and severely undermine health, including death.
If you have difficulties with drug addiction, you should seek help from a specialist.
Baklosan tablets summary (instructions for use) in photographs
Photo of instructions for use of baklosan tablets, part 1
Photo of instructions for use of baklosan tablets, part 2
Photo of instructions for use of baklosan tablets, part 3
Photo of instructions for use of baklosan tablets, part 4
Baklosan tablets: reviews of the drug
Petr Mironov, Orenburg I have problems with my back. In my youth I was actively involved in sports, which resulted in pinched vertebrae. From time to time this problem makes itself felt, and very strongly. I’m just lying there, I can’t move, I’m dying to go to the toilet. Regular painkillers don't help much. The doctor prescribed Baklosan tablets. For me they turned out to be a real find, I would even say a miracle! Not only do they relieve pain, but they also treat the nerve itself. Dmitry Bashkirov, Tomsk After a serious accident, I suffer from problems with my spine. More precisely, with a pinched nerve. Now, after rehabilitation, I feel much better, but there was a time when I could not move normally due to pain. Thanks to Baklosan tablets, I feel like a full-fledged person. I'm not a doctor, I can't say how it works. For me, in fact, it doesn’t matter how, the main thing is what the result is. I recommend it to anyone who suffers from neurological diseases. Svetlana Prokopyeva, Moscow The doctor prescribed this for the child for muscle tone. I decided to read the instructions, I was very surprised that my one-year-old son was prescribed a drug that is suitable for children from 3 years old, and even better from 12. After reading the side effects, I was outraged that they even decided to prescribe it to children. Drowsiness, depression, hallucinations - this is just a small part of everything that can appear while taking the pills. Yes, it would be better for me to remove the tone using other methods than to expose the child to danger. Svetlana Vasilyeva, Kemerovo My shoulder, or rather the muscle, began to hurt. I couldn't understand the reason. The neurologist said that the muscle is toned and cannot relax. A massage course and Baklosan tablets are required. When I started taking these pills, I began to feel strangely confused. The feeling that I am moving away from my body is impossible to convey in words. It seems like I exist, but it seems like I don’t. Of course, I knew about the side effects, but I didn’t even imagine that this would happen to me. I stopped taking it and decided it was better with a sore shoulder, but with a healthy head. In the end, thanks to the massage, everything returned to normal. My shoulder stopped hurting. Olga Karlova, Novosibirsk I developed pain in the muscles of my legs, such that I woke up at night. It didn’t cramp, but it hurt and pulled the muscle. The doctor prescribed Baclosan tablets. It took a long time to drink; they won’t help in a week. I want to say that the pain is gone. But at times I was attacked either by insomnia or, on the contrary, by a constant desire to sleep. Their price is low. Inna Fomina, Khabarovsk My niece has cerebral palsy. They undergo comprehensive treatment, rehabilitation, and various massage therapists. I actively participate in her life and treatment, I know many of the drugs that are used to treat her. Among them are Baclosan tablets. During massage courses they are always prescribed to her. They relax muscles well, reduce spasms and pain. She tolerates them well, without side effects or allergic reactions. Elena Trofimova, Kazan Baklosan tablets relieve muscle tone and reduce pain. After the injury I had health problems. My legs couldn’t walk, to achieve results, I was prescribed Baklosan tablets along with massage courses, swimming and other types of rehabilitation. You need to take the drug for a long time; you should not skip it or stop abruptly. There was an effect. There were no adverse reactions.
Contraindications and side effects
The product is prohibited from use under certain conditions. Contraindications include the following:
- epilepsy;
- frequent seizures;
- allergic reaction to the active ingredients of the drug;
- mental disorders;
- idiopathic parkinsonism syndrome.
During gestation and lactation, the drug is prohibited from being used, since it penetrates the protective lining of the uterus and also enters the mother’s milk, thereby affecting the child’s fragile body.
In case of drug overdose, various side effects may occur:
- vomit;
- hard breath;
- hallucinations;
- low muscle activity;
- convulsions;
- lack of orientation in space;
- severe drowsiness;
- apathy;
- depression;
- disorders of the digestive tract;
- problems with the functioning of the kidneys and heart;
- decreased blood pressure;
- allergic reactions in the form of rash, itching;
- increased sweating.
If any of these symptoms are present, you should stop using the drug. Negative manifestations after an overdose of Baclofen can be reduced by performing a number of manipulations:
- drink plenty of fluids;
- take medications that inhibit the reabsorption of water and salts in the kidney canals;
- artificial ventilation.
Doctors often noted the appearance of side effects at the beginning of the therapeutic course. A gradual increase in dosage could cause nausea and drowsiness.
- In the field of the psyche (delirium, agitation, euphoria, insomnia, confusion, depression, nightmares, hallucinations);
- In the area of the central nervous system (speech impairment, respiratory disorders, drowsiness, vertigo, fatigue, tinnitus, taste disorder, paresthesia, headaches);
- In the area of the cardiovascular system (increased heart rate, decreased blood pressure, chest pain, decreased cardiac output, feeling of suffocation);
- In the area of the visual organs (impaired accommodation, nystagmus);
- In the gastrointestinal tract (dry mouth, diarrhea, aversion to food, abdominal pain, vomiting, constipation, nausea);
- Skin manifestations (itching, increased sweating, hives, rashes);
- In the respiratory system (nasal congestion, depressed breathing);
- In the area of the musculoskeletal system (muscle tremors, pain in muscle fibers, tremors, weakness);
- In the area of the urinary system (anuria, pain when urinating, polyuria, nocturnal enuresis, hematuria, free urination, urinary retention);
- In the area of the reproductive system (impaired erection, ejaculation, possible impotence);
- In the area of metabolism (weight gain).
