pharmachologic effect
Donormil tablets
According to medical statistics, every fifth person complains of problems falling asleep. A person who does not get enough sleep experiences loss of ability to work, lethargy and weakness throughout the day.
To normalize sleep and reduce the time it takes to fall asleep , special medications are prescribed. Their list is quite extensive, and many of them can be bought at the pharmacy without a prescription.
One of them is Donormil. It is considered one of the most effective drugs. In addition, to obtain the desired effect, a minimum dosage and short-term use of Donormil is sufficient.
Donormil shortens the period of the sleep phase and increases the duration of sleep itself. Donormil has been known on the pharmaceutical market since 1948. Initially, Donormil was developed as a drug that eliminates allergies.
During clinical trials, it turned out that in addition to the antiallergic effect, Donormil provides a fairly effective sleeping pill. In addition, it significantly exceeds the antihistamine. Therefore, Donormil was classified as a sleeping pill.
Donormil is produced in the form of effervescent tablets and coated tablets by the French pharmaceutical concern Bristol-Myers Squibb. The main active ingredient of the drug is doxylamine succinate . The drug shortens the period of time required to fall asleep, but does not affect the sleep phases. Donormil lasts up to eight hours without waking up at night.
When taken orally, Donormil is absorbed from the gastrointestinal tract and is maximally concentrated in the blood after three hours. Donormil is metabolized by the liver and excreted by the kidneys and partially by the intestines after 20 hours.
Analogs
Medicines based on doxylamine succinate are considered synonymous with Donormil, but not similar. Sedatives that have other active ingredients as active ingredients that, when used, have a blocking effect on the sensitivity of brain cells to histamine, are analogues of Donormil. These include:
- Alluna;
- Tavegil;
- Reslip;
- Valdispert;
- Sondox;
- Bellaspon;
- Dormiplant;
- herbal mixture Phytosedan.
Release form of the drug
There are two release forms of Donormil:
- the drug is in white rectangular tablets with notches on both sides, with an amount of active ingredient of 15 mg, 15 and 30 pieces each;
- the drug is in the form of effervescent soluble tablets with a flat cylindrical shape with a notch on one side, a tube with ten tablets.
Storage conditions for the drug: in a dark, inaccessible place with a temperature not exceeding 25C°. Regular tablets are stored for 5 years, effervescent tablets for 4 years.
Indications for use by doctors
Recommendations
The main indications for the drug are the treatment of sleep disorders
Insomnia most often occurs with cervical osteochondrosis, especially when the disease occurs together with other diseases. For example, people suffering from VSD with cervical osteochondrosis become victims of insomnia.
Sleep is also disturbed during depression due to osteochondrosis. It is in such cases that doctors prescribe sedatives; Donormil is a priority on the list of these medications, but they prescribe it only if it is not contraindicated for the patient.
You can see a list and review of sedatives in this article.
The main indication of the drug Donormil is the treatment of sleep disorders of various origins. Insomnia can manifest itself in different ways: a person cannot fall asleep for a long time, sleep is interrupted by frequent awakenings, or there is no way to fall asleep at all.
A healthy person's sleep can be disturbed due to simple poor health or anxiety. Often this is facilitated by a labile psyche. In all these cases, the sedative sleeping pill Donormil is indicated.
Doctors can prescribe the drug to treat allergies, because in addition to its hypnotic effect, it also has antiallergic properties. Donormil is indicated for the treatment of colds, severe cough and runny nose.
Contraindications
The sleeping pill has several contraindications. Among the most common contraindications is a tendency to allergic reactions specifically to the components of Donormil.
It is forbidden to take Donormil during pregnancy and lactation.
Only as prescribed by a doctor, in special cases, Donormil can be used to treat insomnia in people suffering from kidney and liver failure.
Donormil is not prescribed to pediatric patients. Donormil is approved for the treatment of sleep disorders only after 15 years.
Donormil is contraindicated for people suffering from diseases of the biliary tract. If a man has diseases of the prostate gland and urethra, Donormil is also contraindicated.
Contraindications
The drug Donormil has contraindications:
- hypersensitivity;
- angle-closure glaucoma;
- lack of lactase;
- congenital galactosemia;
- diseases of the pancreas and urethra, accompanied by a disorder of urine outflow;
- glucose-galactose malabsorption;
- lactation period;
- children under 15 years of age.
Carefully:
- liver and kidney failure (probably increased T1/2);
- with a history of apnea, since the properties of doxylamine succinate complicate sleep apnea syndrome (in sleep, unexpected cessation of breathing is possible);
- persons over 65 years of age - after taking sleeping pills, when waking up at night, an increase in T1/2 or a danger of falling is possible (the cause of which is dizziness and slow reactions).
Side effects
The manufacturer of Donormil warns patients in the instructions that uncontrolled use and overdose of Donormil and other drugs for insomnia can be fatal.
Despite the fact that Donormil can be dispensed without a prescription and is considered one of the drugs that does not pose a threat to the patient’s health, it should be remembered that it has side effects.
Donormil has a hypnotic and sedative effect, and therefore has a depressing and inhibitory effect on the central nervous system.
Before taking Donormil, you should definitely consult with your doctor.
The danger of sleeping pills (and Donormil) lies in the fact that their main blocking substance acts for quite a long time.
After uncontrolled use, a person may experience constant drowsiness throughout the day. The person becomes inhibited.
He is bothered by headaches and dry mouth. Long-term use may result in urinary retention, constipation, and constant nausea.
Symptoms of an overdose of Donormil:
- feeling of anxiety, trembling in the limbs;
- fever;
- excessive sweating;
- heart rhythm disturbances;
- hypotension;
- depression of respiratory functions (shortness of breath, lack of air);
- facial skin hyperemia, possible rashes;
- convulsions, twitching of limbs and head;
- inhibited mental reactions.
Deep intoxication disrupts the functioning of higher nervous activity and leads to mental disorders.
It is prohibited to take Donormil with alcoholic beverages and alcohol-containing medications.
Alcohol increases the effect of sleeping pills several times, and in combination with Donormil, drug dependence can develop.
Help with overdose
If someone near you has taken too many pills and is experiencing side effects from the drug, first ask what they have been taking. The maximum dosage of Donormil without mixing with other drugs differs from the dosage when mixed with alcohol and tranquilizers.
If a person took only Donormil, the likelihood of death is much lower. In any case, be sure to call a team of doctors. It doesn’t matter which pills caused the poisoning. In any case, it is necessary that the victim’s intestines are freed from tablets that have not yet been processed. To do this, induce vomiting several times.
A person who has received an overdose of Donormil has a sharp rise in temperature and uses more liquid than usual. The risk of dehydration is high, so the victim should be given regular water to drink periodically. But do not let him drink too much water, otherwise the body will not cope, and in addition to an overdose, doctors will struggle with excess water in the body.
It is advisable to give a person 50 g of activated carbon. In severe cases of overdose and inability to breathe, artificial ventilation is necessary.
Related article: Symptoms of Paracetamol overdose: can you die from Paracetamol?
Donormil tablets instructions for use
Donormil instructions
According to the instructions for the drug, the Donormil tablet should be taken a quarter of an hour before going to bed. The standard dose is considered to be half a Donormil tablet or one whole tablet.
If, after the initial dose, Donormil does not produce an effect, the single dosage can be doubled as prescribed by a doctor.
Take a regular Donormil tablet with a glass of water, while the effervescent tablet will dissolve in a glass of water at room temperature.
The course of treatment with Donormil lasts up to five days. A course of taking the drug exceeding five days can be prescribed by a doctor individually, for special indications.
If Donormil does not give the desired effect, and the patient is still bothered by insomnia, treatment will be carried out with another drug.
Video on the topic:
Features of using Donormil
Sleeping pill Donormil should be used with caution during pregnancy, after consulting with a gynecologist. But during lactation such treatment is strictly contraindicated.
During treatment, driving should be limited and intellectual activities should be excluded.
Do not take Donormil on a low-salt diet.
Donormil is incompatible with alcohol.
There are also restrictions on drug interactions. In combination with neuroleptics, barbiturates, clonidine, benzodiazepines, opioid analgesics, and anxiolytics, depression of the central nervous system is observed. May reduce the emetic reaction to apomorphine. Co-administration with M-anticholinergics increases the risk of exacerbation of side effects.
Analogues substitutes
Drugs similar to Donormil are divided into two groups:
- drugs with identical active ingredients;
- drugs with identical therapeutic effects.
Valocordin-Doxylamine
Valocordin-Doxylamine (an analogue of Donormil based on the main active ingredient) is a drug for sleep correction. Produced by the pharmaceutical concern Krewel Meuselbach GmbH Germany. The drug is available in the form of drops.
The main active ingredient of the drug is doxylamine (25.0 mg). Taking Valocordin-Doxylamine gives a sedative and hypnotic effect. The patient's period of falling asleep is reduced, sleep becomes deep and long.
The therapeutic hypnotic effect of the drug appears after half an hour and lasts about six hours.
The duration of treatment for insomnia with Valocordin-Donormil usually lasts about two weeks. Contraindications and side effects are the same as for Donormil.
Sondox (an analogue of Donormil in terms of the main active ingredient) has a hypnotic and relaxing effect on the nervous system.
Produced at the Chemical-Pharmaceutical Plant in Ukraine. Indicated for insomnia, organic sleep disorders and nervous system disorders. The drug has the same indications, contraindications and side effects as Donormil.
Trivalumen is an analogue of Donormil with identical therapeutic effects, a combined substance on a plant basis. Produced at the Borshchagovsky Chemical Plant in Ukraine. The drug is used in the treatment of insomnia due to chronic fatigue and stress.
In addition to the hypnotic and sedative effect, the drug improves appetite in neurocirculatory vegetative-vascular dystonia. The drug also normalizes heart rate and blood pressure.
Alora is a plant-based sedative and sedative, similar to Donormil in terms of therapeutic effect. Produced by the Nobel Ilach Sanai Ve Ticaret concern in Turkey and Kazakhstan (Almaty FF).
Plant components reduce the tone of smooth muscles, slow down the speed of nerve impulses, and reduce the excitability of the nervous system. In addition to its hypnotic effect, taking the drug improves mood, relieves anxiety and psycho-emotional stress.
Alora does not cause drowsiness during the day, the patient retains clear consciousness and performance. Alora is available in tablets and liquid dosage form in the form of syrup.
Indications for prescribing the drug: autonomic disorders of the nervous system, depressive states, recovery period after prolonged stress, menopausal syndrome, recovery period after exacerbation of chronic diseases.
Photo gallery of drugs:
Alora
Trivalumen
Sondox
Relaxozan is an analogue of Donormil in terms of therapeutic action on a plant basis from Russia. Available in tablets. Prescribed as a mild hypnotic.
Used to treat excessive nervous excitability. In complex therapy, Relaxozan is indicated for functional disorders of the cardiovascular system and spastic conditions in the digestive organs.
Reslip is an analogue of Donormil based on the main active ingredient doxylamine. FP "Obolenskoe" is produced in Russia. As a histamine receptor blocker it has a pronounced hypnotic and sedative effect.
It is also used to treat insomnia and allergies. Indications, contraindications and side effects are the same as for Donormil.
Persen is an analogue of Donormil in terms of therapeutic action. Produced in Slovenia by the LEK DD concern in tablets and capsules. The drug consists of plant extracts. Sedative, hypnotic, antispasmodic effect is mild.
Indicated for insomnia, neuroses, withdrawal syndrome of potent sedatives, for the prevention of psychosomatic disorders, vegetative-vascular dystonia. Prescribed in the complex treatment of diseases of the cardiovascular system.
Persen is recommended to be taken if the patient has psychologically difficult situations in order to stabilize the emotional background. The drug relieves anxiety, irritability, and improves sleep.
Photos of drugs:
Relaxozan
Reslip Persen
special instructions
Donormil can be used throughout pregnancy. However, when prescribing tablets in the later stages, it is necessary to take into account the sedative and atropine-like effect of the active component of the drug.
To date, it is unknown whether the active substance of the drug passes into breast milk. Therefore, when using tablets during breastfeeding, the child may develop an stimulating or sedative effect. In this regard, if it is necessary to use the drug during lactation, you should switch to artificial feeding.
It must be taken into account that sleep disturbances can be caused by various reasons for which there is no need to use Donormil.
Since the drug can cause drowsiness during the day, during treatment with the drug it is necessary to refrain from driving vehicles, as well as operating potentially dangerous mechanisms and engaging in activities that require high concentration.
Reviews
Katerina, 34 years old: When I took Donormil for the first time as prescribed by a doctor, I fell asleep quickly and did not wake up at night. But in the morning the condition was strange. The feeling that I continue to sleep, a feeling of some kind of intoxication for the whole day. In the evening I had a headache, and after the second pill I fell asleep, but woke up often. The doctor canceled it and prescribed Valocordin. Everything has returned to normal. I sleep at night and feel energetic during the day.
Svetlana, 41 years old: After several sleepless nights due to stress, I turned to my family doctor, and he advised me to take Donormil. I started falling asleep after about an hour and woke up only once during the night. The drug was good, in the morning I felt truly rested.
Aisha, 37 years old: Problems with nerves and sleep began when I changed jobs. After six months, I began to have trouble sleeping and waking up frequently from night shifts. I decided to start treating my insomnia with a herbal remedy. I started taking Relaxozan. It worked on the second night. The next morning my head is clear and I don’t feel like sleeping during the day. The drug is good, did not give any side effects. Insomnia is gone.
