Depantol: instructions, application, reviews

Compound

One vaginal suppository contains 0.1 g of dexpanthenol and 0.016 g of chlorhexidine bigluconate + additional substances ( macrogol, 1500, macrogol 400 ).
One gram of Depantol cream contains 0.0525 g of dexpanthenol and 0.00802 g of chlorhexidine digluconate + propylene glycol, cetyl alcohol, liquid paraffin, propylene glycol, petroleum jelly, sodium dodecahydrate hydrogen phosphate, potassium dihydrogen phosphate, water .

Pharmacodynamics and pharmacokinetics

Chlorhexidine , which is part of the drug, has a strong antibacterial effect . Inhibits the vital activity of dermatophytes , various fungi and protozoa, bacteria Chlamydia spp., Neisseria gonorrhoeae Bacteroides fragilis, Staphylococcus spp., Treponema pallidum, Ureaplasma spp., Gardnerella vaginalis, Escherichia coli, Streptococcus spp. However, the substance is static or ineffective in combating acid-fast strains of bacteria, their spores and strains of Pseudomonas spp. and Proteus spp.

Dexpanthenol is a B vitamin that enters the body and is converted into pantothenic acid , which takes part in acetylation and metabolic processes (fat and carbohydrate). The substance takes part in the synthesis of acetylcholine , glucocorticosteroids, and porphyrins . Dexpanthenol also has the property of accelerating mitosis and stimulating the regeneration processes of mucous membranes.

Both active components of the drug are quite active in the presence of pus, blood and other secretions. The substances penetrate into the systemic circulation in very small quantities.

Depantol: side effects and contraindications for use

According to expert reviews, the drug in the form of vaginal suppositories “Depantol” is tolerated quite well by women. If there is hypersensitivity to the components that make up the drug, in some cases it is possible to develop local side effects such as:

• discomfort, vaginal itching;
• burning sensation in the vagina;
• sensation of a foreign body inside the genital tract.

Usually such manifestations are not dangerous and go away on their own after 20 minutes. If they occur, discontinuation of therapy is not required.

As for cases of overdose, these are not described in the instructions. But to prevent the development of side effects, it is extremely undesirable to exceed the dose of the drug, as well as independently increase the duration of the permissible course of therapy.

The drug is based on antiseptic components. They actively protect the cervix and vagina from infections, a large number of germs and microorganisms. To some extent they also help with fungi, preventing their proliferation, and with viruses. They have a healing, antiseptic and anti-inflammatory effect.

This is of great importance, since with erosion there is actually an open wound on the cervix. Through it, inflammatory and infectious agents easily enter the blood. Therefore, during this period the probability of contracting any infection is very high.

The same applies to the condition after cauterization of erosion. Since during the healing process, a woman’s reproductive system is also very susceptible to infections, antiseptics are important.

Dosage forms

Depantol for cervical erosion is available in the form of suppositories for intravaginal administration. Candles are light in color, usually white or grayish, sometimes yellowish. A slight marbling shade is possible. The shape is torpedo-shaped, with a funnel-shaped depression at the wide end.

Each candle is placed in a separate cell in a blister. The blister contains five suppositories. The blister and instructions for use are placed in a cardboard package. The cost of such packaging is about 550 rubles. No other dosage forms have been developed. Available without a prescription, shelf life is two years from the date of production (at a temperature of no more than 20 degrees and in a dry place).

Compound

The drug is complex, has two active components with antimicrobial, anti-inflammatory and regenerating effects. One candle contains the following active ingredients:

• Dexpanthenol 100 mg;
• Chlorhexidine bigluconate 16 mg.

Chlorhexidine is presented in the form of a 20% solution, of which there is 85 mg in one suppository.

Macrogol 400 and Macrogol 1500 are used as auxiliary components. The weight of excipients in one suppository is 2814.8 mg.

Indications

In what cases do gynecologists prescribe Depantol suppositories? Since they accelerate tissue regeneration and have an antiseptic effect, this makes them applicable for many diseases in which there is a violation of the integrity of the external epithelium of the vagina and the exit of the cervical canal. Candles are used for the following diagnoses:

1. Acute and chronic vaginitis;
2. Vaginosis caused by microorganisms sensitive to the drug;
3. Ectopia of the cervix;
4. Erosive processes on the cervix;
5. Endocervicitis;
6. Exocervicitis;
7. After surgical interventions and destructive cauterizations to accelerate regeneration;
8. After childbirth for the same purposes.

Candles can only be used on the recommendation of a doctor.

Contraindications

Depantol suppositories have almost no restrictions on their use. The only limitation to their use is the presence of individual intolerance to the substances in the composition. Overdoses are not possible with topical use of the medicine.

Side effects can sometimes include burning and itching. Usually, they are weakly expressed. And they go away completely on their own after stopping the drug.

Cannot be used simultaneously with soaps administered intravaginally. The product is also incompatible with detergents of the anionic group.

Pregnancy

The drug does not in any way affect the course of pregnancy. It does not have a negative effect on the fetus during any period of gestation (of course, when used correctly). Can also be used during lactation.

Mode of application

Depantol for cervical erosion can be used in different ways, in accordance with the recommendations of the attending physician. However, there is a standard dosage - two suppositories per day.

You need to insert it after a shower, deep into the vagina, while lying down and bending your knees. It is better to leave the candle in the body overnight, and install the next one in the morning or in the middle of the day.

Do not use during menstruation.

The duration of treatment is 7-10 days. But according to the doctor’s instructions, in an individual case, it can be extended up to 20 days.

Types and clinic

Before treating erosion, including with Depantol suppositories, it is necessary to determine its clinical variant. Gynecologists identify the following types of erosion, which are detected in women of different age groups.

True

Occurs when the cervical epithelium is damaged as a result of traumatic factors. This defect looks like a wound on the surface of the cervix. True erosion lasts up to two weeks and then heals on its own.

Pseudo-erosion

Appears if improper healing of the epithelial wound is observed. As a result, the damaged area is covered with cylindrical cells, which normally line the cervical canal. Pseudo-erosion is also called acquired ectopia.

Congenital

It is a stage in the development of the genital organs. During the period of intrauterine development, the covering of the vaginal part of the cervix is ​​due to cylindrical cells.

Under the influence of hormones, a gradual regression of the columnar epithelium occurs. However, if certain hormones are deficient, this process may occur with a delay.

In this case, congenital ectopia or cervical erosion is diagnosed.

The appearance of different types of erosion is due to the following factors:

• infections;
• inflammatory processes;
• early debut of sexual activity;
• intimate relationships with multiple sexual partners;
• hormonal fluctuations;
• congenital developmental anomalies;
• heredity;
• weakening of the immune system.

The progression of erosion is also facilitated by the absence of a clinical picture. However, it is worth noting that in the vast majority of cases the defect is accompanied by other pathologies of an inflammatory and hormonal nature.

With complicated erosion, the following symptoms occur:

• discharge and leucorrhoea indicating infection;
• bleeding;
• pain;
• shortening or lengthening the cycle.

If erosion occurs as an independent process, the only symptom may be mucous and contact discharge. Mucous discharge is caused by the functioning of the glands of cylindrical cells located on the surface of the ectopia. Bloody discharge appears after sexual intercourse and examination by a gynecologist.

Erosion requires diagnosis, observation, and, if indicated, treatment. Since there are no symptoms, preventive examinations are essential, which allow timely identification of the defect and differential diagnosis.

Modern medicine considers Depantol suppositories as one of the most effective and most harmless drugs of combined action.

The product has several positive effects on the patient’s body:

• antibacterial;
• regenerating;
• metabolic.

As a rule, the action of the components of the Depantol composition is aimed at bringing the mucous membranes to normal condition as a result of treatment to cauterize erosion, especially if it bleeds, when removing the human papillomavirus (including during pregnancy), as well as during breastfeeding .

The drug Depantol is absolutely safe during menstruation. Depantol is distinguished by its composition; the components in this case are:

• chlorhexidine - is a local antiseptic with a bactericidal effect;
• dexpanthenol - a B vitamin used to treat diseases associated with the mucous membranes and the upper layer of the epidermis;
• excipients - a mixture of macrogols.

In addition, Depantol suppositories are actively used to eliminate vaginitis of acute and chronic etymology, as well as in late pregnancy to carry out the procedure for cleaning the birth canal, since the components of the drug help get rid of the possible presence of harmful microorganisms that can adversely affect the child’s body during his birth. Depantol suppositories are considered no less effective in the treatment of inflammatory processes and the fight against human papillomavirus.

The suppository is administered twice a day for a week or 10 days. If necessary, the course can be repeated. However, do not forget that the dosage and duration of use are determined together with the attending physician based on the individual characteristics of the patient’s body. Depanthol is available in the form of vaginal suppositories without a prescription.

Like any other medicines, Depantol suppositories have their own individual contraindications.

First of all, the drug is prohibited for use if the patient has hypersensitivity or intolerance to individual components of the composition.

For this reason, before carrying out a course of treatment, you should check your body, carefully listening to the so-called “signals” of your body during the first few days of treatment. The body's reaction mainly manifests itself in the form of itching or burning.

As side effects from taking Depantol, experts note:

• the occurrence of vaginal discharge that has a white or slightly pinkish tint - as a rule, blood discharge is observed when using suppositories for the purpose of sanitation, and this factor indicates the presence of concomitant diseases that require additional examination;
• the appearance of bloody discharge - may externally resemble menstruation, however, due to the fact that the drug does not affect the menstrual cycle, these disorders may indicate diseases of gynecological or venereal etymology, which in turn requires immediate investigation;
• injury - in the case of use immediately before sexual intercourse, since despite the fact that suppositories dissolve relatively quickly, small fragments still occur, however, the resulting minor injuries do not require separate treatment and are eliminated naturally;
• termination of pregnancy - this factor is directly related to the emotional state of the woman, which can be caused by the appearance of bloody discharge or against the background of prolonged stressful situations.

Indications for use

Vaginal suppositories:

• from erosion (with a specific etiology of the disease);
• for acute and chronic vaginitis ;
• with endocervitis and exocervitis ;
• after cryodestruction , laser destruction , diathermocoagulation (in gynecology).

Depantol suppositories may be prescribed after cauterization of erosion to improve the restoration of the vaginal and uterine mucosa.

Suppositories are often prescribed after childbirth, gynecological and obstetric operations.

The cream is prescribed:

• for abrasions, cuts, cracks, bites, burns, scratches, if there is a risk of infection;
• for the treatment of eczema, atopic dermatitis and other dermatoses ;
• scratches and abrasions with signs of infection in children;
• for the treatment of cracks and inflammation of the nipples of the mammary glands in nursing mothers;
• for treating wounds after operations.

Depanthol candles, instructions for use, composition, reviews, analogues

According to the instructions for use, Depantol candles have a torpedo-shaped shape with a funnel-shaped depression, as well as a white, grayish or yellowish color (sometimes marbling is present) without the presence of any pronounced odor.
Vaginal suppositories go on sale in two blister packs of five pieces, which are placed in a cardboard box along with detailed instructions.

Depantol suppositories contain two active components:

• dexapanthenol;
• chlorhexidine bigluconate.

The local medicine also includes excipients in the form of a base for the preparation of suppositories and macrogol.

Depanthol is a combined product for local use that has an antimicrobial effect, participates in metabolic processes and promotes tissue regeneration.

Vaginal suppositories include:

• chlorhexidine bigluconate;
• dexpanthenol.

Chlorhexidine digluconate is active against various types of bacteria, yeast, protozoa and dermatophytes.

Dexpanthenol has a regenerating effect on mucous membranes, normalizes metabolic processes at the cellular level, accelerates mitosis and helps increase the strength of collagen fibers.

Sold in the form of torpedo-shaped suppositories for vaginal administration, white (gray and beige shades are acceptable).

Candles are prescribed for the treatment of:

• vaginitis in acute and chronic course;
• endocervicitis and exocervicitis;
• cervical erosions.

• The drug is also used for regeneration of the mucous membrane of the cervix and vagina after destructive therapeutic measures, in the postoperative and postpartum periods.
• Used strictly for vaginal insertion!
• Before using the drug, it is recommended to perform toilet procedures without using alkaline hygiene products (soap, gels).

It is necessary to remove the suppository from the cell immediately before administration. The suppository should be inserted lying on your back deep into the vagina. After use, it is recommended to remain in a horizontal position for 10-15 minutes for complete dissolution and absorption of the drug.

The product is stored in a dry, ventilated place, protected from direct sunlight. The storage temperature should not go beyond 5-20C. Do not freeze!

Side effects from the use of the drug are uncommon and include burning and itching in the vagina and external genital area, skin rashes and other manifestations of allergies.

Vaginal suppositories are contraindicated for women with hypersensitivity to the active or auxiliary substances of the drug, as well as girls under the age of 12 years.

Suppositories are incompatible with detergents containing saponins, sodium carboxymethylcellulose or sodium lauryl sulfate.

No other drug interactions have been identified.

The official annotation for the drug allows the use of Depantol by women during pregnancy and breastfeeding. The active components do not have a negative effect on the fetus.

• Ligenten;
• Betadine;
• Hexicon;
• Vagotil.

1. Is it possible to use Depantol suppositories after cauterization of cervical erosion?
2. The drug is effective for the treatment of small erosions, and is also recommended as an additional therapeutic agent after cauterization of ectopia.
3. Is it possible to have sex after Depantol suppositories?
4. Experts allow sexual activity, but with the use of a condom.
5. Why does it itch after using depanthol?

Itching during use of the drug is one of the side effects caused by an allergic reaction. As a rule, itching is felt on the 2-3rd day of using the suppositories and goes away after discontinuation of the drug. Itching also occurs when active ingredients interact with soap and other detergents.

In case of mild symptoms, therapy must be continued; in case of pronounced manifestations of allergy, treatment is stopped. After self-cancellation of the drug, additional consultation with a specialist is necessary who will prescribe another method of treatment.

After taking depanthol I started bleeding, what is it?

Bloody discharge while taking these vaginal suppositories is normal, but only in case of minor bleeding. In case of extensive bleeding, which is accompanied by pain and deterioration in well-being, urgent discontinuation of the drug and mandatory consultation with a doctor are necessary.

Is it just me or is Depanthol leaking out?

Due to the fact that suppositories, in addition to active substances, contain oil bases, when they enter the body, they quickly dissolve.

Depanthol is a drug that is intended for local treatment and is not absorbed into the blood. Dissolving in the vagina, the active substances destroy pathogenic flora, and the remains flow out. The product should be used before bedtime. If twice daily use is prescribed, in the morning after administration, it is necessary to remain in a lying position for as long as possible.

• Is it possible to take Depantol after childbirth?
• Use after childbirth is permitted.
• Is it possible to take Depantol during menstruation?
• During menstruation, beneficial substances that are contained in suppositories and have a therapeutic effect are removed from the body along with bleeding, which leads to a decrease in the effectiveness of the drug.
• Is it possible to take Depantol during pregnancy?
• Pregnancy is NOT a contraindication for use.
• Is it possible to drink alcohol while using depantol?
• No interaction of the drug components with alcohol has been identified.

The drug Depantol is produced in the form of suppositories for vaginal use. The suppository itself is solid, white-gray or yellowish in color, without a pronounced odor. It is oblong in shape, cone-shaped with a funnel-shaped recess, which ensures comfortable insertion and relative safety of use.

The manufacturer (JSC Nizhpharm, Nizhny Novgorod) produces candles in separate contour packages in quantities of 5 or 10 pieces, under the trade name DEPANTHOL. According to the ATC classification code, this drug belongs to antimicrobial and antiseptic drugs that are used in gynecology (code G01AX).

Depantol is a combination drug.

Consists of two active ingredients:

• Dexpanthenol (per one suppository) – 100 mg.
• Chlorhexidine bigluconate (per one suppository) – 16 mg.
• And also a polyethylene glycol base - macrogol, as an auxiliary ingredient.

Dexpanthenol is a derivative of pantothenic acid, one of the anhydrous vitamins. Participates in the metabolic process, interacting with B vitamins. Upon penetration into tissue, it becomes part of coenzyme A (coenzyme), which promotes acetylation processes, oxidation of fatty acids, carbohydrate and lipid metabolism.

In other words, Dexpanthenol helps restore mucous tissues, normalize metabolism at the cellular level, and accelerates cell division (reproduction). It has a regenerating, anti-inflammatory effect. Chlorhexidine bigluconate or simply chlorhexidine is an antiseptic.

Chlorhexidine actively affects a number of different bacteria that cause ureaplasmosis, chlamydia, gonorrhea, trichomoniasis, syphilis, as well as diseases caused by streptococci and staphylococci. Viruses, fungal organisms, and acid-resistant bacteria are not sensitive to it.

Instructions for Depantol (Method and dosage)

Depantol suppositories, instructions for use.

Suppositories are used intravaginally . First, the candle is released from its packaging and inserted deep inside. Adults are prescribed one suppository, twice a day. The course of treatment is usually from a week to 10 days. If necessary, it can be extended to 20 days.

The medicine can be used during menstruation, as the active substances retain their activity. But it is better to start treatment at the end of menstruation or immediately after it ends.

Instructions for the ointment.

Externally. The cream is used in accordance with the doctor's recommendations.

The ointment is applied in a thin layer to the damaged areas, gently rubbing in. If necessary, the wound can be treated surgically. It is not recommended to apply the drug under an occlusive dressing .

After using the cream, wash your hands well.

For children with diaper dermatitis, the drug is applied after taking a bath and changing clothes.

To treat breasts in nursing women, rub a thin layer of ointment onto the nipples after each feeding. Before the next feeding, it is important not to forget to thoroughly clean the breasts of any remaining ointment.

Pharmacological characteristics

What are Depantol suppositories? The instructions attached to this drug contain information that such suppositories are a universal remedy that is very often recommended to women for the prevention and treatment of various gynecological diseases.

The active components included in the medication have a pronounced regenerating and antimicrobial effect. In addition, they are able to relieve inflammation and suppress the activity of pathogenic microflora.

In the process of absorption of active substances in the mucous membranes of the genital tract, the renewal of their epithelial layer improves and local metabolism is restored.

Depantol's analogs

Level 4 ATX code matches:
Hexicon

Citeal

Bepanten Plus

Chlorhexidine bigluconate

Analogues of suppositories: Betadine, Verno Kit, Ginoflor, Kolposeptin, Osarbon, Furazolidone, Eucolek, Chlorhexidine, Ecovag, Povidin, Macmiror, Klioron, Hexicon, Betadine .

Reviews

Reviews of Depantol candles.

The reviews are mostly good, the drug helps. Doctors often prescribe it, and the cost is consistent with its effectiveness. Some people have a problem using a candle in the morning, as it quickly melts and leaks. Side effects such as burning and itching rarely occur, but they disappear after a while.

Reviews of the ointment.

The ointment is usually used by parents to combat diaper dermatitis. The reviews are good, the product helps.

Depantol price, where to buy

The price of Depantol candles in Ukraine is about 110 UAH for 10 pieces.

It is possible to buy the drug in Russia for 400 rubles for the same amount.

The price of Depantol ointment in Ukraine is 70 UAH for 30 g.

Buying cream in the Russian Federation will cost about 203 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Depantol suppositories vaginal.
  10 pcs. JSC "Nizhpharm" 542 rub. order

Pharmacy Dialogue

• Depantol (sup. vag. No. 10) Nizhpharm JSC

  608 rub. order

Europharm* 4% discount using promo code medside11

• Depantol vaginal suppositories n10Nizhpharm OJSC

  RUR 699 order

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Pharmacy24

• Depantol No. 10 candles VAT "Nizhpharm", m. Nizhny Novgorod, Russian Federation
  222 UAH. order

PaniPharmacy

• Depantol suppository Depantol suppository No. 10 Russia, Nizhpharm

  259 UAH. order

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Analogues of candles

What can replace the drug in question? What analogues does it have? The instructions for using Depantol suppositories do not provide answers to these questions. To select a similar medication for the treatment of gynecological diseases, you should consult a specialist.

Typically, such a drug is replaced with the following drugs: Miramistin, Hexicon, Livarol, Chlorhexidine. The forms of such drugs may differ from the one in question, but they all have similar properties and therapeutic effects.

The development of the pharmacological industry leads to the fact that almost every drug has its own “substitute”, an analogue. Depantol is no exception.

Although there is no exact combination of active ingredients (dexpanthenol chlorhexidine), according to its pharmacological characteristics, a number of drugs can replace it. For convenience, we will divide them by active ingredients.

And so, Depantol candle analogues:

• Betadine (Hungary);
• Vokadin (India);
• Povidone-Iodine (Serbia).

These drugs basically contain the substance povidone-iodine. Indications for use are similar to Depantol: vaginal infections in the acute and chronic stages, trichomoniasis, prevention of infection during gynecological operations.

The peculiarity is that I use it with caution in patients who have problems with the thyroid gland, as it can cause hyperthyroidism.

Venro-kit (India)

The same applies to antiseptics that are used in gynecology. They treat diseases caused by various types of bacteria, including vaginitis, cervicitis, etc.

The active ingredients of this drug are promestriene and chloroquinaldol. Effective for bacterial infections of the vagina, as well as after destructive treatment of cervical ectopia.

The first consists of chlorhexidine, the second osarol and boric acid. They are used in the treatment of infectious vaginosis, cervical ectopia, and colpitis.

If we consider the price component, then the average price in Russia is 550 rubles. Depanthol candles, analogues, the price ranges from 160 rubles. up to 820 rub. depending on the country of origin.

When choosing Depantol suppositories or its analogues for treatment, be sure to read the instructions and consult a gynecologist.

Indications

Contraindications