Motilak

Release form and composition

Available in tablet form.

Film-coated tablets are produced in blister packs (10 tablets each), which are placed in cardboard packages of 1 and 3 pieces, as well as in cans and containers made of polymer materials (30 tablets and 2 or 2.5 kg respectively), placed in cardboard packs of 1 pc.

Lozenges are produced in blister packs (10 tablets each) and glass jars (30 tablets each), placed in cardboard packages of 1 and 3 pieces.

When is Motilak prescribed?

This drug eliminates almost any dyspeptic disorder . That is why the main indications for its use are the following conditions:

increased gas formation;
belching of air or pieces of food;
burning sensation in the esophagus;
nausea and vomiting of absolutely any etiology.

Motilak helps cope with nausea and vomiting caused by infection, radioactive therapy, drug therapy, and chemotherapy.

It is especially noteworthy that Motilak is able to eliminate disorders that are a consequence of taking antiparkinsonian drugs (for example, Levodopa and the like).

My son-in-law suffered from nausea and belching for a long time. He regularly complained of flatulence. When such symptoms finally tormented him, he went to see a gastroenterologist. My son-in-law was diagnosed with gastroesophageal reflux disease. This is a pathology in which the contents of the stomach are constantly thrown into the esophagus. To reduce discomfort, my son-in-law was prescribed treatment, which included the drug Motilak. What exactly helped him, I don’t know. But a couple of weeks later, when we met again, he was enjoying the food and did not remember the previous discomfort.

Video: When to take antiemetic medications

Indications for use

A complex of dyspeptic manifestations, often associated with esophagitis, slow gastric emptying, gastroesophageal reflux:

flatulence, belching;
heartburn with reflux of stomach contents into the oral cavity (or without);
a feeling of bloating and fullness in the epigastrium, pain in the upper abdomen;
nausea and vomiting of any origin (organic, functional, infectious), as well as provoked by drug therapy, radiotherapy, poor diet, intoxication, use of dopamine agonists in Parkinson's disease (for example, Bromocriptine and Levodopa).

Characteristics of the medicine

Motilak (in Latin Motilak) belongs to the group of antiemetics . The active ingredient of this drug is domperidone.

The medicine has a number of useful properties, namely:

effectively eliminates the feeling of nausea and instantly stops the urge to vomit, this happens by increasing the force of contraction of the lower esophageal sphincter;
promotes the disappearance of flatulence and a feeling of heaviness, this is achieved by lengthening the time of contraction of muscle fibers in the walls of the esophagus;
promotes timely bowel movement.

Motilak quickly stops gagging and eliminates the feeling of nausea

Release forms

There are two dosage forms:

coated tablets - have a special enteric coating;
tablets capable of dispersing (dissolving) in the mouth - they react with saliva and do not require drinking water.

In both cases, the tablets are packaged in aluminum blisters of 10 pieces. Blisters are placed in cardboard boxes of 1 or 3 pieces.

Composition of the drug

Motilak (one tablet) consists of 10 mg of domperidone as the main component and a number of auxiliary components.

Composition of additional substances of the enteric-coated drug:

potato starch;
lactose;
microcrystalline cellulose and hydroxypropylcellulose;
Aerosil;
magnesium stearate;
polyvinylpyrrolidone;
sodium carboxymethyl starch;
twin 80;
titanium dioxide and colloidal silicon dioxide.

Motilak tablets are coated with a white coating that dissolves in the intestines

Lozenges contain:

fructose and sucrose;
dextrose;
crospovidone;
Primogel;
magnesium stearate;
peppermint oil.

Video: possible causes of nausea and vomiting

Instructions for use Motilak (method and dosage)

The tablets are taken half an hour before meals.

In acute conditions, adult patients are prescribed 20 mg 3-4 times a day. One dose should be taken before bedtime. Children over 5 years old are prescribed 5 mg per 10 kg of body weight 3 times a day.
For the treatment of chronic dyspeptic symptoms, 1 tablet (10 mg) is prescribed 3-4 times a day. If necessary, the dosage should be doubled. In the absence of a therapeutic effect, it is possible to increase the dosage by 2 times.

Children over 5 years of age are prescribed at a dosage of 2.5 mg per 10 kg of body weight 3 times a day.

For patients with renal impairment, when re-prescribed, the dosage is reduced by 2 times.

Contraindications

Before taking it, you need to take into account contraindications . This drug should not be used in the following cases:

presence of allergies to the components of Motilak;
internal bleeding in the digestive tract;
obstruction of the gastrointestinal tract caused by any object;
perforation (through damage) of the intestine.

Treatment with Motilak is prohibited for those patients who suffer from prolactinoma, a tumor that secretes prolactin.

Use by pregnant and lactating women

The instructions for use of the drug indicate the lack of reliable data on the safety of using Motilac during such a crucial period for a woman. When conducting relevant studies on experimental animals, no teratogenic effects were identified. Therefore, it can be assumed that taking the drug by pregnant women is possible.

The use of Motilac during pregnancy is discussed individually with your doctor.

Is the drug allowed for breastfeeding women? It was found that after a mother takes Motilak, the medicine can pass into breast milk. At the same time, the concentration of the active substance in it is low. It makes up a small part of its amount in the blood plasma. However, the medicine is present in milk and it is not known for certain how it may affect the baby. Therefore, when treating with Motilak during lactation, it is recommended to temporarily stop breastfeeding the baby.

Use in children

The main criterion for assessing the possibility of taking Motilac in children is not the age, but the weight of the child. Officially, the drug is approved for use from 5 years of age. But if a five-year-old child weighs less than 20 kg, this medication cannot be taken.

Motilak is allowed from the age of 5, but only if the child weighs more than 20 kg

Side effects

The use of Motilak can cause the following side effects:

Central nervous system: rarely - reversible extrapyramidal signs in children and with increased permeability of the BBB (spontaneously disappear after cessation of treatment).
Endocrine system: rarely - gynecomastia, galactorrhea, dysmenorrhea as a result of hyperprolactinemia.
Digestive system: in some cases - transient intestinal spasms.
Allergic manifestations: rarely - rashes, urticaria.
Symptoms of overdose: disorientation, drowsiness and extrapyramidal reactions (mainly in children).

Motilak side effects

Negative symptoms accompanying domperidone therapy are extremely rare. Motilak side effects:

spasms in the intestines that randomly disappear and appear;
skin rashes;
extrapyramidal disorders;
galactorrhea;
increased concentration of the hormone prolactin in plasma;
gynecomastia;
anaphylactic condition;
hives.

A number of undesirable clinical phenomena may occur due to an overdose of Motilak:

disorientation in time, space;
drowsiness;
motor disorders.

When using the drug, it is important to study its interaction with other pharmacological agents. The bioavailability and effectiveness of the drug is reduced or completely neutralized if the following is taken simultaneously: . antisecretory drugs; M-anticholinergics; antacids; cimetidine; sodium bicarbonate.

antisecretory drugs;
M-anticholinergics;
antacids;
cimetidine;
sodium bicarbonate.

Acceleration of absorption of the active ingredients of Motilak and an increase in its concentration in the blood are facilitated by:

drugs from the azole group;
antifungal medications;
human immunodeficiency virus protease inhibitors;
macrolide antibiotics;
antidepressants, especially those based on nefazodone.

The active component is well compatible with some drugs, because they do not mutually affect the content of active chemicals in biological fluids:

dopaminergic receptor agonists;
digoxin;
neuroleptics;
paracetamol and its derivatives.

special instructions

Domperidone is metabolized in the liver, so it should be administered with caution to patients with liver failure.
Combined use with antisecretory or antacid drugs is not recommended.
A small amount of the drug is excreted unchanged by the kidneys, so patients with renal failure require almost no single dose adjustment. However, when re-prescribed, the frequency of dosing should be reduced depending on the severity of renal failure. A dose reduction may be necessary.
During long-term treatment with the drug, patients with renal impairment require regular monitoring.
Does not affect the speed of psychomotor reactions.

Analogues of Motilium

Domperidone is an affordable, but far from the most effective antiemetic. Drugs such as Cerucal, Dramina, Zofran and Onicit are much more effective in treating nausea. These drugs are widely used in oncological practice, and their cost is much higher than Motilium.

To eliminate pain in the upper abdomen, instead of Motilium, it is recommended to use antacid drugs - Almagel, Gastal, Phosphalugel and others. They neutralize the increased acidity of gastric juice and reduce the effect of hydrochloric acid on the gastric mucosa.

If you experience prolonged discomfort in the pit of the stomach, you should be examined by a specialist.

Drug interactions

Anticholinergic drugs neutralize the therapeutic effect of domperidone.

Antisecretory and antacid drugs reduce bioavailability. Inhibitors of the cytochrome P450 CYP3A4 isoenzyme increase the concentration of domperidone in the blood plasma.

In this article you can read the instructions for use of the drug Motilak

. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Motilak in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Motilak in the presence of existing structural analogues. Use for the treatment of nausea, vomiting and heartburn in adults, children, as well as during pregnancy and lactation.

Motilak

- antiemetic drug. The mechanism of action is due to a combination of peripheral action and antagonism to dopamine receptors in the chemoreceptor trigger zone.

Motilak increases the duration of peristaltic contractions of the antrum of the stomach and duodenum, accelerates gastric emptying if this process slows down, increases the tone of the lower esophageal sphincter, and eliminates the development of nausea and vomiting.

Domperidone (the active ingredient in Motilak) does not penetrate the blood-brain barrier well, so the use of Motilak is rarely accompanied by extrapyramidal side effects, especially in adults, but domperidone stimulates the secretion of prolactin by the pituitary gland, which is located outside the blood-brain barrier (BBB).

Domperidone has no effect on gastric secretion.

Compound

Domperidone + excipients.

Pharmacokinetics

After taking the drug orally, domperidone is quickly absorbed from the gastrointestinal tract. Bioavailability is low - about 15%. Reduced acidity of gastric contents reduces the absorption of domperidone. Plasma protein binding is 91-93%. Domperidone is widely distributed in body tissues. The concentration of domperidone in brain tissue is small. It is subjected to intensive metabolism in the intestinal wall and in the liver. Excreted through the intestines (66%) and kidneys (33%), incl. unchanged 10% and 1%, respectively.

Indications

A complex of dyspeptic symptoms, often associated with delayed gastric emptying, gastroesophageal reflux, esophagitis:

a feeling of fullness in the epigastrium, a feeling of bloating, pain in the upper abdomen;
belching, flatulence;
heartburn with or without reflux of stomach contents into the oral cavity.

Nausea and vomiting of any etiology, incl. functional, organic, infectious origin, caused by radiotherapy, drug therapy, intoxication or poor diet, as well as against the background of dopamine agonists when used in Parkinson's disease (such as levodopa and bromocriptine).

Release forms

Film-coated tablets 10 mg.

Lozenges 10 mg.

There are no other dosage forms, be it suspension or syrup.

Instructions for use and dosage regimen

For chronic dyspeptic symptoms, adults are prescribed 10 mg (1 tablet) 3 times during the day and, if necessary, additionally before bedtime.

If the effect is insufficient, the indicated dose is doubled.

Children over 5 years old are prescribed 2.5 mg/10 kg body weight 3 times during the day and, if necessary, additionally before bedtime.

For acute and subacute conditions, primarily with nausea and vomiting, adults are prescribed 20 mg (2 tablets) 3-4 times during the day and, if necessary, additionally before bedtime.

Children over 5 years old are prescribed 5 mg per 10 kg of body weight 3-4 times during the day and, if necessary, additionally before bedtime.

When taking the drug after a meal, absorption slows down somewhat.

With constant use (for chronic symptoms), it is preferable to take the drug orally 15-30 minutes before meals.

In case of renal failure, depending on the severity, it is recommended to reduce the frequency of taking the drug to 1-2 times a day.

Side effect

transient intestinal spasms;
extrapyramidal symptoms in children and with increased BBB permeability (completely reversible and spontaneously disappear after cessation of therapy);
galactorrhea;
gynecomastia;
dysmenorrhea due to hyperprolactinemia;
rash;
hives.

Contraindications

prolactinoma;
children under 5 years of age;
hypersensitivity to domperidone.

Use during pregnancy and breastfeeding

The use of the drug in the 1st trimester of pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk for the fetus. To date, there is no evidence of an increased risk of developmental defects in humans.

In women, the concentration of domperidone in breast milk is 4 times lower than the corresponding concentration in plasma. It is unknown whether domperidone at this concentration has adverse effects in neonates. Therefore, during lactation (breastfeeding), the use of Motilac is not recommended, except in cases where the expected benefit of therapy for the mother outweighs the potential risk for the infant.

Use in children

The drug is contraindicated in children under 5 years of age.

special instructions

Since domperidone is metabolized in the liver, the drug should be administered with caution to patients with hepatic impairment.

Because a very small amount of the drug is excreted unchanged by the kidneys; patients with renal failure require virtually no single dose adjustment. However, when re-prescribed, the frequency of taking the drug should be reduced depending on the severity of renal failure, and a dose reduction may also be required. During long-term therapy, patients with impaired renal function require regular monitoring.

Motilak should not be used when stimulation of the motor function of the stomach is unacceptable, i.e. with gastrointestinal bleeding, mechanical obstruction or perforation.

When prescribing Motilak with antacid or antisecretory drugs, they should not be taken simultaneously with Motilak.

Impact on the ability to drive vehicles and operate machinery

Motilak does not interfere with the speed of psychomotor reactions.

Drug interactions

When used simultaneously, anticholinergic drugs can neutralize the effect of Motilak.

When used simultaneously, antacids and gastric secretion inhibitors reduce the bioavailability of Motilak.

Based on studies, it is assumed that with simultaneous use of drugs with Motilak that significantly inhibit the CYP3A4 isoenzyme (antifungals of the azole group, antibiotics from the macrolide group, HIV protease inhibitors, the antidepressant nefazodone), an increase in the level of domperidone in plasma may be observed.

Domperidone does not affect the level of paracetamol and digoxin in the blood.

It is possible that Motilak may affect the absorption of drugs with a delayed release of the active substance or enteric-coated ones used simultaneously orally.

Analogues of the drug Motilak

Structural analogues of the active substance:

Damelium;
Domet;
Domperidone;
Domstal;
Motizhekt;
Motilium;
Motinorm;
Motonium;
Passengers.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Content

Are you worried about your gastrointestinal tract? Do you often suffer from dyspepsia, manifested by heartburn, abdominal pain, and flatulence? A well-known medicine, Motilak, will help significantly alleviate the condition. Find out more about the indications for use of the drug, familiarize yourself with the peculiarities of administration by adults and children.

Motilak during pregnancy

The use of the drug is possible only after the doctor’s permission and only occasionally to relieve a specific symptom. We are talking about nausea in the first trimesters, heartburn, which develops in the last months due to the large size of the fetus, belching, gas formation, etc. There is no information about an increased risk of developing defects in a child after using Motilak.

In women, when taking the drug, the concentration of the active component in breast milk is several times lower than in the blood, but even such a small amount has a negative effect on the child, so the drug should be avoided during breastfeeding.

Medicine Motilak

The drug is known for its wide range of effects and quick results. Immediately after taking the medicine, Motilak begins to affect the area of the brain responsible for the functioning of the digestive tract. As a result, the motility of the gastrointestinal tract is normalized, and nausea, hiccups, and bloating disappear in a person. In addition, the stomach empties from the food bolus, and heartburn disappears. The medicine copes well with dyspeptic-type symptoms without impairing the speed of psychomotor reactions. Use is permitted for both children and adults.

Motilak - composition

In pharmacies, the medicine can be purchased in two versions. These can be regular coated tablets or lozenges. Both variants are white in color and have a biconvex shape. In the composition of Motilak you can see domperidone, an active substance that can block dopamine receptors. Contains 10 mg per tablet. In addition to domperidone, the product contains excipients: magnesium stearate, lactose, cellulose, silicon dioxide, potato starch.

Reviews about Motilak

Nausea is a common symptom of completely different diseases. Therefore, reviews of Motilak are left by patients with various diagnoses. Some patients use this remedy occasionally, but others have to take it frequently. For example, a 35-year-old woman writes: “I constantly feel nauseous. I was diagnosed with chronic gastritis, and I have already learned to eat properly and not run into exacerbations. I don’t observe any other symptoms, but the nausea does not allow me to live in peace. I have to drink Motilak all the time.” In other words, this remedy helps this patient get rid of attacks of nausea.

Doctors who commented on this message noted that Motilak cannot be taken constantly. The fact is that it has a stimulating effect on the muscles of the stomach and esophagus, which can impair health and aggravate the course of certain diseases.

There are also individual reviews in which patients complain that Motilak did not help them at all to relieve the feeling of stomach fullness, bloating, and nausea.

If you feel an unpleasant feeling of heaviness, a urge to feel sick, this can be both a symptom of overeating and a sign of illness. Therefore, if this condition recurs frequently, you must seek medical help. Taking Motilak and similar drugs must be agreed with your doctor.

Motilak - instructions

Relief from the condition occurs by strictly following Motilak's instructions. There is a standard dosage of the drug: 10 mg 3 or 4 times a day for adults. If vomiting and diarrhea are severe, an increase to 20 mg is acceptable. If the patient has renal failure, the dose must be adjusted. How to take Motilak? According to the instructions, the medicine should be taken 30 minutes before meals, coated tablets should be taken whole, without chewing. If taken after a meal, absorption is significantly impaired.

Motilak - indications for use

According to the annotation for the product, the main indication for use of the drug is vomiting. The drug is effective for symptoms resulting from poisoning, diseases, and radiation therapy. In addition, it helps with vomiting associated with dietary errors and taking medications. It is recommended that patients take the drug before an endoscopic examination. Other indications for use of Motilak:

Motilak during pregnancy

As you know, many pregnant women suffer from severe nausea and vomiting. There are no medications that they can take on their own without harming the fetus. Motilak during pregnancy, like many other drugs, is not recommended. A doctor may prescribe it according to strict indications if use is appropriate. In other cases, pregnant women are recommended to use safer methods to alleviate the condition.

Motilak for children

In the instructions you can see that the medicine is contraindicated for children under 5 years of age. From 6 years of age, the drug can be given in an amount of 2.5 mg per 10 kg of weight 3 times a day in the presence of chronic dyspeptic symptoms. To eliminate vomiting and nausea, a single dose is recommended - 5 mg per 10 kg of weight. Motilak should not be used for children if there is an allergy. Side effects are possible, for example, disorders of the central nervous system.

FSP 42-0521-7416-06

Tradename:

International Nonproprietary Name (INN):

Domperidone

Dosage form:

Lozenges.

Compound:

Active substance: domperidone – 0.01 g. Excipients: fructose (advantose FS 95), sugar (sucrose), glucose, polyplasdon IKS EL-10 (crospovidone), sodium carboxymethyl starch (Primogel), magnesium stearate, peppermint oil.

Description

Tablets are white or almost white, round, biconvex with a characteristic odor.

Pharmacotherapeutic group:

antiemetic – dopamine receptor blocker central

ATX code

: A03FA03

Pharmacological properties:

pharmachologic effect

Increases the duration of peristaltic contractions of the antrum of the stomach and duodenum, accelerates gastric emptying if this process slows down, increases the tone of the lower esophageal sphincter, and eliminates the development of nausea and vomiting.
Domperidone does not penetrate the blood-brain barrier well, so the use of domperidone is rarely accompanied by extrapyramidal side effects, especially in adults, but domperidone stimulates the release of prolactin from the pituitary gland. Its antiemetic effect may be due to a combination of peripheral (gastrokinetic) action and antagonism of dopamine receptors in the chemoreceptor trigger zone. Domperidone has no effect on gastric secretion. Pharmacokinetics
Absorption after oral administration, on an empty stomach is rapid (taking after meals, reduced acidity of gastric juice slows down and reduces absorption). Maximum concentration in blood plasma (TCmax) – 1 hour. Bioavailability – 15% (first pass effect through the liver). Communication with plasma proteins – 90%. Penetrates into various tissues and does not pass well through the blood-brain barrier (BBB). Metabolized in the liver and in the intestinal wall (by hydroxylation and N-dealkylation). 66% is excreted through the intestines, 33% by the kidneys, incl. unchanged - 10 and 1%, respectively. The half-life (T1/2) is 7-9 hours, and with severe chronic renal failure (CRF) it is extended.

Indications for use

a) A complex of dyspeptic symptoms, often associated with delayed gastric emptying, gastroesophageal reflux, esophagitis; - a feeling of fullness in the epigastrium, a feeling of bloating, pain in the upper abdomen: - belching, flatulence: - heartburn with or without reflux of gastric contents into the oral cavity. b) Nausea and vomiting of functional, organic, infectious origin, caused by radiotherapy, drug therapy or dietary disorders, as well as against the background of dopamine agonists when used in Parkinson's disease (such as L-dopa and bromocriptine)

Pregnancy and lactation

The use of the drug in the first trimester of pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk for the fetus. To date, there is no evidence of an increased risk of developmental defects in humans. In women, the concentration of domperidone in breast milk is 4 times lower than the corresponding concentration in plasma. It is unknown whether domperidone at this concentration has adverse effects in neonates. Therefore, during lactation (breastfeeding), the use of Motilac is not recommended, except in cases where the expected benefit of therapy for the mother outweighs the potential risk for the infant.

Contraindications

Hypersensitivity, bleeding from the gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines, prolactinoma, children (up to 5 years and children weighing up to 20 kg).

Directions for use and doses

Tablets: should be dissolved 15-20 minutes before meals. Adults and children over 5 years old with chronic dyspeptic symptoms - 10 mg 3-4 times a day and, if necessary, additionally before bedtime. For severe nausea and vomiting - 20 mg 3-4 times a day and before bedtime. For patients with renal failure, dose adjustment is necessary; the frequency of administration should not exceed 1-2 times a day.

Side effect

From the digestive system:

transient intestinal spasms.
From the nervous system:
extrapyramidal disorders (in children and in persons with increased permeability of the BBB).
Allergic reactions:
skin rash, urticaria.
Other:
hyperprolactinemia (galactorrhea, gynecomastia).

Interaction

Cimetidine and sodium bicarbonate reduce the bioavailability of domperidone. Anticholinergic and antacid drugs neutralize the effect of domperidone. Increase the concentration of domperidone in plasma: azole antifungal drugs, macrolide antibiotics, HIV protease inhibitors, nefazodone (antidepressant). Compatible with the use of antipsychotic drugs (neuroleptics), dopaminergic receptor agonists (bromocriptine, L-dopa). Simultaneous administration with paracetamol and digoxin had no effect on the concentration of these drugs in the blood.

Carefully

Renal/liver failure, lactation, pregnancy.

Overdose

Symptoms: drowsiness, disorientation, extrapyramidal disorders (especially in children). Treatment: taking activated charcoal, for extrapyramidal disorders - anticholinergic drugs, antiparkinsonian or antihistamine drugs with anticholinergic properties.

Release form

10 tablets per blister pack; 1 or 3 blister packs along with instructions for use per pack. 30 tablets in a light-protective glass jar. Each jar is placed in a pack along with instructions for use.

Best before date

3 years. Do not use after the expiration date.

Storage conditions

At a temperature not exceeding 30 °C. Keep out of the reach of children.

Conditions for dispensing from pharmacies

On prescription.

Legal address:

Russia, 107023, Moscow.
Barabanny lane, 3. Address of production and acceptance of claims:
Russia. 308013. Belgorod, st. Rabochaya, 14.

Antiemetic. Drug: MOTILAK®

Active substance of the drug:

domperidone ATC coding: A03FA03 KFG: Centrally acting antiemetic drug that blocks dopamine receptors Registration number: LS-002036 Registration date: 09.22.06 Registration owner. credential: VEROPHARM JSC {Russia}

Motilak release form, drug packaging and composition.

White or almost white film-coated tablets, biconvex; on a cross section, 1 or 2 layers are visible, the inner layer is white or white with a yellowish tint. 1 tab. domperidone 10 mg Excipients: potato starch, lactose, microcrystalline cellulose, colloidal silicon dioxide, povidone, magnesium stearate, sodium carboxymethyl starch, hydroxypropylcellulose, Tween-80 or polyethylene glycol 4000, titanium dioxide, talc.

Lozenges are white or almost white, round, biconvex. 1 tab. domperidone 10 mg Excipients: fructose (advantose FS 95), sugar (sucrose), dextrose, polyplasdon IKS EL-10 (crospovidone), sodium carboxymethyl starch (Primogel), magnesium stearate, peppermint oil. 10 pieces. — cellular contour packages (1) — cardboard packs. 10 pieces. — cellular contour packages (3) — cardboard packs.

DESCRIPTION OF THE ACTIVE SUBSTANCE. All information provided is provided for information only about the drug; you should consult your doctor about the possibility of use.

Pharmacological action Motilak

Antiemetic. It has an antiemetic effect, soothes hiccups and eliminates nausea in some cases. The action is due to the blockade of central dopamine receptors. Thanks to this, the inhibitory effect of dopamine on the motor function of the gastrointestinal tract is eliminated and the evacuation and motor activity of the stomach increases.

Pharmacokinetics of the drug.

Absorption after oral administration on an empty stomach is rapid (taking after meals, reduced acidity of gastric juice slows down and reduces absorption). Cmax is reached after 1 hour. Bioavailability is 15% (first pass effect through the liver). Plasma protein binding - 90%. Penetrates into various tissues and does not pass through the blood-brain barrier. Metabolized in the liver and in the intestinal wall (by hydroxylation and N-dealkylation). 66% is excreted through the intestines, 33% by the kidneys, incl. unchanged - 10% and 1%, respectively. T1/2 - 7-9 hours, with severe chronic renal failure - lengthens.

Indications for use:

Nausea, vomiting, hiccups of various origins (with toxemia, radiation therapy, diet disorders, taking certain medications (morphine), endoscopic and radiopaque studies, in the postoperative period. Postoperative hypotension and atony of the stomach and intestines, biliary dyskinesia, flatulence, reflux esophagitis, cholecystitis, cholangitis, various types of dyspepsia.Nausea and vomiting caused by taking dopaminomimetics.

Dosage and method of administration of the drug.

Adults and children over 5 years old - 10 mg 3 times a day 15-30 minutes before meals, and if necessary, an additional 10 mg before bedtime. In acute cases of nausea and vomiting, severe dyspepsia - 20 mg 3-4 times a day. In case of renal failure, the frequency of use should be reduced.

Side effects of Motilak:

From the side of the central nervous system: rarely - increased excitability and/or extrapyramidal disorders, headache. From the digestive system: spasms of smooth muscles of the gastrointestinal tract, dry mouth, thirst. Allergic reactions: itching, rash, urticaria. Other: increased plasma prolactin levels, galactorrhea, gynecomastia.

Contraindications to the drug:

Gastrointestinal bleeding, mechanical intestinal obstruction, perforation of the stomach or intestines, prolactinoma, children under 1 year of age (up to 5 years and children weighing up to 20 kg - for tablets), hypersensitivity to domperidone, pregnancy, lactation (breastfeeding) ).

Use during pregnancy and lactation.

Domperidone is contraindicated for use during pregnancy and lactation. There are no adequate and strictly controlled studies of the safety of domperidone during pregnancy. It is not known whether domperidone is excreted in breast milk. If use is necessary during lactation, breastfeeding should be discontinued.

Special instructions for the use of Motilak.

Use with caution in case of impaired liver and kidney function.

Interaction of Motilak with other drugs.

When used simultaneously with antacids, antisecretory drugs (including cimetidine, sodium bicarbonate), the bioavailability of domperidone decreases. When used simultaneously with anticholinergic drugs, the effect of domperidone is inhibited. Since domperidone is metabolized mainly with the participation of the CYP3A4 isoenzyme of the cytochrome P450 system, it is believed that with the simultaneous use of domperidone and inhibitors of this isoenzyme (including antifungals of the azole group, macrolide antibiotics, HIV protease inhibitors, nefazodone), an increase in domperidone levels is possible in blood plasma.

Similar drugs:

Metoclopramide Solution for injection
Itomed Oral tablets
Osetron (Osetron) Solution for injection
Motinorm Oral tablets
Motizhekt Oral tablets
Cerucal Solution for intravenous and intramuscular administration
Motinorm Syrup
Motilium Oral suspension
Aminazine Dragee
Damelium Oral tablets

** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Motilak, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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Adverse reactions

Like any other medicine, Motilak has a number of unpleasant side reactions. Patients may experience the following symptoms:

the occurrence of an allergic reaction, which manifests itself in the form of an itchy rash on the skin;
the appearance of minor cramping pain in the stomach and/or intestines;
the release of colostrum from the nipples and an increase in the volume of the mammary glands (this is dictated by the fact that Motilak significantly increases the level of the hormone prolactin in the blood);
development of tremor or the appearance of involuntary movements of the limbs.

These disorders are temporary and disappear quickly after discontinuation of the drug.

Indications of the medicine

Motilac helps against various symptoms that are caused by reflux esophagitis, GED (gastroesophageal reflux disease), and slow upper gastrointestinal motility. It is used for the following symptoms:

The drug is especially often recommended to be taken for nausea that occurs for any reason - due to infections, after poisoning, taking a number of drugs, or undergoing chemotherapy. The medicine can be taken for functional and organic diseases, including Parkinson's disease, if treated with dopamine agonists, which provoke nausea.

Instructions for the drug

The dosage and how long to take the drug are determined depending on the patient’s age and type of disease.

Typically, Motilak is prescribed 1 tablet (10 mg) three times a day, the medicine is distributed throughout the day at approximately equal time intervals.

If necessary, take another, fourth Motilac tablet immediately before bed.

The dose of the medicine can be doubled in case of severe disease, but only with the approval of a doctor and under his supervision (the risk of side effects increases). It is also permissible to take 2 tablets at a time for acute illnesses, severe vomiting and nausea. For children over 5 years of age, the dose is calculated as follows: 2.5 mg of the drug for every 10 kg of the patient’s weight, this dose is taken three times a day.

In severe cases, the dosage for a child will be 5 mg/10 kg up to 4 times a day (last time before bedtime). In case of renal failure, the number of doses is 1-2 per day, 1 tablet. It is better to take the medicine before meals. However, you can also take a tablet after a meal, but absorption will be reduced. For a long course, it is better to consume the drug 15-30 minutes before meals. The course is up to 28 days; in severe cases, the doctor can extend it.