Nimesulide - instructions for use, indications, doses

Nimesulide canon is produced in the form of tablets and powder for the preparation of a suspension. Tablets are used according to the standard scheme. The powder is used to prepare a suspension. Take one packet of powder and dissolve in 100 milliliters of chilled boiled water. After vigorous shaking, it is recommended to take the suspension orally after meals. The suspension is used for children if their age is more than 12 years. The course of treatment with the drug is 2 weeks.

It is recommended to apply the gel to the affected area after cleansing and drying the skin. The drug should be used 2-3 times a day.

Nimulid is another name for a medicine that is produced in the form of syrup. The medicine is used for children before meals. If there is a problem with the digestive system, the doctor will prescribe medication during or after meals. It is recommended to drink syrup for children with boiled water, which is at room temperature. The dosage of the medication is determined by the doctor. Nimesulide topic should be used according to the standard scheme.

Nimesulide and nimesil

Nimesulide and nimesil are non-steroidal anti-inflammatory drugs that are developed based on the same active ingredient. Nimesil is produced in the form of granules, from which a suspension is prepared. Nimesulide is characterized by the presence of various release forms, which allows you to choose an acceptable option for the patient and provide comfortable treatment.

Composition and action

The active ingredient has the following name in Latin: Nimesulidum.

Belongs to the class of sulfonanilides.

Additional substances:

lactose monohydrate;
calcium hydrogen phosphate dihydrate;
pyrogenic colloidal silicon dioxide;
croscarmellose sodium;
talc;
stearic acid;
sodium dodecyl sulfate.

NSAIDs quickly relieve pain, relieve inflammation and reduce fever.

The drug quickly reduces fever.

Composition of the ointment: 1000 mg contains 10 mg Nimesulidum.

Additional substances:

non-toxic gelling agent;
polyethylene glycol 400;
ethanol;
dimexide.

Reviews about Nimesulide

The vast majority of reviews about Nimesulide are positive. The medicine is very effective in relieving pain symptoms, fever, and various types of inflammation. The drug helps quickly and its effect is long-lasting.

In rare negative comments there are references to the side effects of the medication.

According to reviews of Nimesulide-MBF found on medical websites, it is an effective and relatively inexpensive remedy that relieves acute pain in the joints, lower back, back, dislocations and bruises, and painful menstruation. Patients also note that the drug helps cope with inflammation and relieves high fever.

The disadvantages of Nimesulide-MBF include a large number of contraindications and the development of side effects.

Release form of nimesulide

In pharmacies the drug is presented in the following forms:

pills;
powder;
ointment.

Medicines in the form of ampoules are not provided.

Pills

Small in size and yellow in color, have a convex shape. The dosage of the active ingredient is 100 mg. They are used for severe pain in complex therapy with other drugs aimed at directly treating the pathology.

The drug Nimesulide is produced in the form of tablets.

Ointment

Prescribed to a patient for local application if necessary to relieve pain and swelling. The ointment is transparent and has a slight yellow tint. It is quickly absorbed, due to which the anti-inflammatory effect occurs within 5 minutes after applying the ointment.

The advantages of the ointment over other forms of this drug are as follows:

direct effect on the source of inflammation;
has the least number of side effects;
ease of use.

The drug should be applied to the affected area in a thin layer, avoiding open wounds.

Granules or powder

In this release version, the drug is presented in the form of lemon-colored granules with a specific odor. When dissolved in water, the suspension acquires a white tint.

The medicinal effect from the powder occurs faster than from tablets, but has a negative effect on the gastric mucosa.

The drug is also available in powder form.

Indications for use

A non-steroidal anti-inflammatory drug is an excellent way to quickly get rid of pain and swelling inside the body. It is important to understand that medicine with nimesulide will relieve you of the symptoms of the disease, but will not eliminate the disease itself. According to the instructions for use, the substance has three main areas of work:

anti-inflammatory effect;
elimination of fever;
anesthesia.

The medicine has received a large number of positive reviews and is actively used in medicine. If you don't know what nimesulide helps with, check out this list:

osteochondrosis;
tendon inflammation;
rheumatism;
musculoskeletal problems;
muscle pain.

Pharmacological properties

The drug has the following pharmacological properties:

relieves inflammation;
reduces fever;
relieves pain.

Pharmacodynamics

At the site of inflammation and in the ascending pathways, the drug reversibly inhibits prostaglandin E2. There is a decrease in prostaglandin concentration, which leads to a decrease in the activity of EP receptors. This provides a reduction in pain and inflammation.

Inhibits the release of histamine and inhibits the combination of interleukin-6 and urokinase, which reduces the process of cartilage destruction. Reduces platelet aggregation.

When applied, the ointment reduces pain and reduces joint pain in a state of calm and during physical activity, and relieves swelling of the joints. Facilitates the onset of increased physical activity.

Nimesulide relieves joint swelling.

Pharmacokinetics

The powder is quickly absorbed from the gastrointestinal tract, reaching its highest concentration after 1-2 hours. The distribution of the drug occurs in conjunction with the following elements:

plasma proteins - 96%;
red blood cells - 2%;
lipoproteins - 1%;
acidic alpha1-glycoproteins - 1%.

The saturation of the drug in the female genital organs after 1 dose is 40%. The drug reaches the site of inflammation by 45% and the synovial fluid by 43%.

NSAIDs are broken down in the liver using the cytochrome isoenzyme. The main substance responsible for the breakdown is hydroxynimesulide.

The drug elimination time is 2-5 hours; it is excreted from the body:

kidneys by 65%;
with bile by 35%.

The drug in tablet form is easily absorbed from the gastrointestinal tract, reaching its highest degree of saturation in the body 3 hours after administration. Distributes in the same way as powder. The breakdown takes place in the liver. Complete elimination of drugs from the body occurs within 5 hours from the moment of administration.

The highest concentration of the gel found in the blood plasma after application is extremely low, approximately 300 times less than when taking oral medications.

Nimesulide: instructions, composition, indications, action, reviews and prices

Nimesulide is used in medicine as an analgesic drug from the group of non-steroidal anti-inflammatory drugs.

Eliminates toothache, cephalalgia, discomfort in the joints and other types of pain.

Therapy should be carried out in a short course with minimal effective dosages to reduce the risk of side effects. Prescribed to patients over twelve years of age.

Medicines from the NSAID group effectively relieve pain and fever. They fight inflammatory processes in the body. During drug therapy, it is necessary to take into account the possible negative effect of the drug on the body.

Composition of Nimesulide

Nimesulide is the active ingredient. Various dosage forms contain auxiliary chemical compounds. It is recommended to consult a specialist to choose the appropriate form of the drug.

Sold in the form of tablets, granules and gel.

Nimesulide tablets

One tablet form contains one hundred grams of the substance. For oral administration to patients over twelve years of age.

Package

Nimesulide granules

A suspension for oral administration is prepared from this dosage form. One sachet contains one hundred milligrams of the substance.

Patients over six years of age.

Gel Nimesulide

One hundred grams of the dosage form contains one gram of the active ingredient. For external use only. For children and adult patients.

Therapeutic effect

The main medicinal properties of the drug include relief of pain, lowering body temperature during a febrile state and suppressing inflammatory reactions in tissues. Has a moderate antiplatelet effect. Belongs to the group of NSAIDs that inhibit type 2 cyclooxygenase. This mechanism helps prevent the production of inflammatory mediators.

Less risk of adverse reactions due to the lack of influence on COX-1. It is one of the safest non-steroidal anti-inflammatory drugs.

Pharmacokinetic features

It overcomes the barrier of the intestinal mucosa well and penetrates the bloodstream after oral administration. Nutrition does not reduce the degree of absorption of the active component.

The highest level of the substance in the blood occurs within two and a half hours from the moment of administration. The degree of binding to plasma proteins reaches ninety-five percent.

It easily penetrates into inflamed tissues with an acidic environment and joint fluid. Overcomes various histological barriers of the body.

Transformed in liver tissue. The metabolite has a medicinal effect. The body is cleansed of the active component with the help of kidneys and bile. The half-life is four to five hours.

Indications for Nimesulide

Pain in the joints due to immunopathological processes.
Unpleasant sensations in ligaments, muscles or tendons.
Headache.
Odontogenic pain syndrome.
Pain syndrome during the menstrual period.
Unpleasant sensations after injury or surgery.
Inflammation in the joint area.

This is a symptomatic remedy that does not eliminate the cause of pain.

Contraindications

Negative reaction to aspirin or NSAIDs in the presence of asthma or multiple nasal polyps.
Age up to twelve years for tablet form.
Age up to six years for other forms of medication.
Hemorrhage in the digestive tract.
Liver diseases, including liver failure.
Heart disease with the phenomenon of decompensation.
Alcohol addiction.
Severe renal impairment.
Erosion or ulceration in the gastrointestinal tract.
Hemorrhage in the vessels of the brain or other anatomical areas.
Drug addiction.
Increased levels of potassium in the body.
Intestinal inflammation during an exacerbation.
Blood coagulation disorder.
Liver damage when using the drug.
Progressive pathologies of renal tissue.
Use of other drugs that negatively affect the kidneys or liver.
Rehabilitation after coronary bypass surgery.
Carrying a child.
Breast-feeding.
Intolerance to components.

Factors in the presence of which it is advisable to consult a specialist and take the medicine with caution: IHD, long-term use of NSAIDs, risk of ulceration in the gastrointestinal tract, vascular pathologies of the central nervous system, taking glucocorticosteroids, use of antiplatelet agents or drugs that interfere with coagulation, arterial pathologies, severe diseases of any organs, chronic heart failure, lipid imbalance, smoking, renal failure, Helicobacter pylori, taking medications from the SSRI group.

Instructions for Nimesulide

Tablets and granules are for oral administration only. The gel can be applied to the skin at the site of pain. Granules should be added to clean water in a volume of eighty to one hundred milliliters.

For patients from twelve to eighteen years of age and adults, it is advisable to take one hundred milligrams of the substance no more than twice a day after meals. No more than two hundred milligrams per day. Elderly patients can take the same dosage.

If there is impaired renal function, it is advisable to reduce the daily dose to one hundred milligrams.

It is better to entrust the doctor with dosage selection and therapy control

Should not be taken for longer than fifteen days. It is necessary to take the smallest dosage for a short amount of time to reduce the likelihood of complications. If any adverse reactions occur, you should stop therapy and consult a doctor.

Additional Information

If the patient accidentally swallows a large dose, you should seek medical help as soon as possible. Severe complications may occur from the digestive system, heart, blood vessels, liver tissue, liver and other organs. These are liver damage, impaired renal function, hemorrhage in the gastrointestinal tract, increased blood pressure, respiratory failure and other unpleasant effects.
You should definitely consult your doctor about medications you take with the drug, as dangerous interaction reactions sometimes occur. Nimesulide interacts with drugs that disrupt coagulation, antibiotics, corticosteroids and other groups of drugs. All possible effects of mutual use are described in the official instructions.
The medication should be stopped immediately in the following cases: hemorrhage in the digestive tract, allergies, increased activity of enzymes of liver origin, kidney damage according to laboratory or symptomatic indicators, increased body temperature, vomiting and abdominal discomfort, dark coloration of urine, ulceration of the gastrointestinal tract. If there is a risk of such complications, treatment is controlled by a doctor.
If the patient takes the drug for more than two weeks according to indications, it is necessary to discuss with a specialist the possibility of monitoring the condition of the organs, including regular blood tests. Elderly patients constantly need therapy monitoring.
The degree of binding of the active component to plasma proteins decreases with liver damage, impaired renal function, decreased albumin levels and increased bilirubin levels.
The use of the medicine can cause temporary infertility in patients, so therapy is not carried out during the planning period for conception.
If undesirable effects on the brain and nervous system as a whole occur while taking the medication, you should refrain from hazardous activities such as driving.

Full instructions with detailed information are included in the packaging.

Side effects

Integumentary and soft tissues: rashes, soreness, increased sweating, skin inflammation, erythema, Quincke's edema, Steven-Johnson disease, swelling of the facial area, Lyell's syndrome and others.
CNS organs: headache, anxiety, excitability, nightmares, dizziness, drowsiness, inflammation of brain tissue.
Digestive organs: nausea, vomiting, formation of loose stools, lack of appetite, stool retention, bloating, discomfort in the abdominal area, inflammation of the gastric mucosa, tarry stool, inflammation of the oral mucosa, disruption of the integrity of the wall of the digestive tract, hemorrhage or ulceration in Gastrointestinal tract.
Excretory system: swelling, urination disorder, bleeding in the urine, impaired urine outflow, increased potassium levels in the body, impaired renal activity, decreased urine production, kidney inflammation.
Liver and gallbladder: damage to the liver tissue with disruption of its functions, inflammation of the liver, jaundice, increased activity of enzyme substances of hepatic origin, stagnation of bile.
Hematopoietic organs: increased level of eosinophils, purpura, decreased platelets or leukocytes, pancytopenia, anemia, delayed blood coagulation.
Respiratory system: respiratory failure, bronchospasm, increased asthma symptoms.
Cardiovascular system: rapid heartbeat, increased blood pressure, hemorrhages and others.
Other: decreased visual acuity, allergic reactions, decreased body temperature, fatigue.

You can reduce the risk of complications during treatment by eliminating allergies and intolerance to NSAIDs, as well as taking the drug in small doses for a short period of time.

Analogs

There are medications containing the same substance. These are Nise, Nimika and Nimulid. In the pharmacy you can find different dosage forms of these medications. You should pay attention to the composition and content of the chemical compound.

Analogue

Reviews and prices

Doctors aware of the risks of using NSAIDs are more likely to prescribe this drug when necessary due to its good safety profile compared to other nonsteroidal anti-inflammatory drugs. Patients report that this remedy provides good pain relief and rarely causes complications.

The average price of ten tablets is seventy rubles.

Thus, this is a representative of the relatively safe painkillers of the NSAID group. It is advisable to consult a specialist before your appointment.

Product type	Analgesic and antipyretic
Release form	Tablets, granules, gel
Method of administration	Oral, external
Other names	Nimesil, Nise

Source: https://nimesulidum.ru/

Application of nimesulide

Medicines in all medicinal forms are prescribed for symptomatic therapy aimed at relieving discomfort and inflammation.

Adults and children over 12 years of age need to take the product 2 times a day, 1 tablet, or 0.1 g of powder 2 times a day. The maximum daily dosage of the drug is 0.2 g.

NSAIDs should be taken 20-30 minutes after eating.

The drug in the form of an ointment is applied only externally and directly to the site of pain. The use of ointment is necessary if the patient experiences pain and stiffness when moving, as well as swelling.

NSAIDs in powder and tablet form are intended for oral administration. Used by patients in the following cases:

for toothache and headache;
during painful periods;
relieving the consequences of various injuries;
increased body temperature;
inflammation of ligaments and tendons.

Nimesulide is often used for painful periods.

Methods of application

The permissible daily dose of the drug is 200 mg. The standard dosage for Nise™ type tablets is 100 mg (accordingly, the daily allowable dose is two tablets). The maximum daily dose for adults is 400 mg. The tablets are taken with enough water, preferably after meals.

Method of application for gel

Apply externally. Approximately 3 cm of gel is applied to the affected area and rubbed in lightly; The procedure is repeated 3-4 times a day. Do not rub the gel vigorously or use bandages. The duration of therapy is determined individually; The effectiveness of treatment is recommended to be assessed after 4 weeks.

Under the name "nimesil" it is also sold in the form of a powder for the preparation of a suspension.

Contraindications

Contraindications to the use of NSAIDs orally:

hypersensitivity;
asthma;
gastrointestinal erosions;
bleeding in the gastrointestinal tract;
intestinal diseases;
severe liver failure;
for pain in the kidneys;
pregnancy and lactation;
children's age up to 12 years.

Erosion of the gastrointestinal tract is a contraindication to the use of this drug.

The ointment should not be applied if the patient has:

infectious skin lesions;
open wounds at the site of inflammation;
included in the list for the use of oral forms of drugs.

Applications

Indications

Treatment of acute pain:
Rheumatoid arthritis;
osteoarthritis with pain syndrome;
arthritis of various etiologies;
arthralgia;
myalgia;
post-traumatic pain;
bursitis;
tendinitis;
algodismenorrhea;
toothache.

Previously, indications included hyperthermic syndrome, but currently nimesulide manufacturers recommend stopping taking the drug if body temperature rises or cold symptoms appear.

Indications for use in gel form

osteoarthritis;
periarthritis;
tendinitis;
tenosynovitis;
lumbago;
sprained muscles, ligaments and other pathologies of the musculoskeletal system.

Contraindications

Hypersensitivity
erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), a history of ulcers, perforation or bleeding in the gastrointestinal tract
bleeding from the gastrointestinal tract, “aspirin” asthma
liver failure
renal failure (creatinine clearance less than 30 ml/minutes)
pregnancy
lactation period
fever due to colds and acute respiratory viral infections.
Alcoholism, drug addiction

Taking nimesulide is prohibited for children under 12 years of age

[1] due to possible hepatotoxicity. However, according to the results of a large number of studies (based on 2 million prescriptions for the period 1997-2001), the total incidence of hepatopathy was 29.8 per 100 thousand patient-years and was associated to a greater extent with other NSAIDs (diclofenac - 39.2 per 100 thousand patient-years, ketorolac - 66.8), including those approved for use by children (ibuprofen - 44.6), than with nimesulide (35.3 per 100 thousand patient-years).[2]

Carefully

Arterial hypertension, heart failure, type 2 diabetes.

special instructions

When prescribing the drug to elderly patients, no dosage adjustment is required. With long-term use, systematic monitoring of liver and kidney function is necessary.

Side effects

Undesirable reactions of the body to taking NSAIDs in oral forms occur with varying frequency.

Reactions in the form of anaphylactic shock, urticaria and hepatitis are extremely rare.

Rarely formed:

anemia;
itching;
intestinal bleeding;
rash;
increased sweating;
dizziness;
headache;
visual impairment;
fluid retention;
swelling;
constipation;
tachycardia.

A headache may occur as a side effect.

Patients often experience diarrhea, nausea, asthenia, drowsiness and increased blood pressure after taking the drug.

Patients may experience individual intolerance after applying the gel. If the gel is used for a long time and over large areas of the body, there is a risk of side effects characteristic of the drug in oral forms.

Side effects

During the use of Nimesulide, disturbances from certain body systems may be observed, occurring with varying frequencies (≥1/10 - very often; > 1/100, <1/10 - often; > 1/1000, <1/100 - infrequently; > 1/10,000, <1/1000 – rare; < 1/10,000, including individual reports – very rare):

Cardiovascular system: uncommon – hypertension; rarely – palpitations, tachycardia;
Allergic reactions: infrequently - skin rash and itching; rarely – exanthema, erythema; very rarely - severe skin phenomena, including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, anaphylactic shock, bronchospasm;
Gastrointestinal tract: often – heartburn, vomiting, nausea, diarrhea; uncommon – bloating, constipation, gastritis; very rarely - ulceration of the mucous membrane of the gastrointestinal tract, stomach pain, melena, tarry stools, increased activity of liver transaminases, toxic hepatitis (including fatal);
Nervous system: infrequently – dizziness; rarely – irritability, sleep disturbance, anxiety; very rarely - encephalopathy, headache, Reine's syndrome, drowsiness;
Blood and lymphatic system: rarely – eosinophilia, anemia, prolonged bleeding time; very rarely - agranulocytosis, thrombocytopenia, purpura, pancytopenia;
Kidneys and urinary tract: rarely - hematuria, dysuria, fluid retention; very rarely - renal failure, oliguria, interstitial nephritis;
Other: infrequently - edema; rarely – hyperkalemia, asthenia, vertigo, visual impairment, malaise; very rarely - hypothermia.

If any of the described side effects develop, as well as in cases of other disorders, you should consult your doctor.

Overdose

If the maximum dose of a drug is exceeded, the patient must:

rinse the stomach;
drink activated carbon;
temporarily stop further use of the drug.

Overdose symptoms:

drowsiness;
coma;
anaphylactic shock;
pain in the upper abdomen;
increase in blood pressure.

Drowsiness is a symptom of overdose.

Nimesulide overdose

Symptoms: apathy, drowsiness, nausea, vomiting, pain in the epigastric region. These symptoms are usually reversible. Gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, and coma may occur. However, such phenomena are rarely observed.

Treatment: symptomatic; there is no specific antidote. There is no data on the elimination of nimesulide by hemodialysis, but taking into account the high degree of binding of nimesulide to plasma proteins (up to 97.5%), it is unlikely that dialysis will be effective. Gastric lavage and the use of activated carbon are indicated.

special instructions

The drug has many side effects. The effect on children under 12 years of age has not been studied. Before taking an oral medication, you should carefully read the instructions.

During pregnancy and lactation

NSAIDs should not be taken during pregnancy or breastfeeding. If the drug is drunk, stop breastfeeding immediately.

The drug has a negative effect on the ability to conceive, so you should not drink it while planning a pregnancy.

Use in childhood

If the child is under 12 years of age, the drug is prohibited, but children 12 years of age and older and weighing more than 40 kg can take NSAIDs in accordance with the instructions.

For impaired renal function

If kidney function is impaired, then before use you should consult a specialist. NSAIDs can cause kidney failure.

Alcohol compatibility

Drinking alcohol together with the drug is prohibited.

If the child is under 12 years of age, the drug is prohibited, but children 12 years of age and older and weighing more than 40 kg can take NSAIDs in accordance with the instructions.

Use in old age

Nimesulide-MBF can only be used to treat persons over 12 years of age.

When treating elderly patients, the attending physician may adjust the daily dose, taking into account the possibility of interaction of nimesulide with other drugs received.

In older adults, the risk of adverse reactions to NSAIDs increases, including life-threatening gastrointestinal bleeding and perforation, as well as deterioration of the liver, kidneys and heart. When using Nimesulide-MBF in this category of patients, clinical monitoring is required.

Drug interactions

NSAIDs in oral forms exhibit a specific effect from interaction with certain groups of drugs:

GCS and anticoagulants increase the likelihood of bleeding in the gastrointestinal tract;
the effect of diuretics is reduced;
NSAIDs reduce the effect of antihypertensive drugs;
causes a hepatotoxic effect when used simultaneously with antifungal, antiepileptic and antituberculosis drugs.

The ointment does not cause clinically important effects when used concomitantly with other drugs.

Interaction

Nimesulide - what is it?

Non-steroidal, anti-inflammatory drug. The medication has antiplatelet, antipyretic, analgesic and anti-inflammatory effects.

https://www.youtube.com/watch?v=ytadvertiseru

The use of the drug Nimesulide can cause a number of side effects.

Central nervous system: Reye's syndrome, headache, nightmares, fear, anxiety, dizziness, nervousness.

Skin: increased sweating, itching, rashes, dermatitis, erythema, angioedema, toxic epidermal necrolysis, erythema multiforme exudative, urticaria, Stevens-Johnson syndrome.

Urinary system: interstitial nephritis, renal failure, hematuria, dysuria, urinary retention, oliguria.

Digestive tract: cholestasis, gastritis, flatulence, constipation, increased levels of liver enzymes, bleeding from the gastrointestinal tract, vomiting, nausea, diarrhea, jaundice, fulminant hepatitis, pain in the epigastric region, perforation and ulcerative lesions of the stomach walls.

Hematopoietic organs: increased bleeding time, hemorrhage, purpura, pancytopenia, thrombocytopenia, anemia.

Respiratory system: bronchospasm, shortness of breath, possible exacerbation of existing bronchial asthma.

Sense organs: visual disturbances in the form of blurred vision.

Cardiovascular system: “flushes” of blood flow to the skin of the face, a drop in blood pressure, rapid heartbeat. Hypothermia, general weakness, and increased levels of potassium ions are also noted.

The risk of hepatotoxicity increases significantly with the simultaneous use of hepatotoxic medications. The drug increases the effectiveness of anticoagulants. When taking furosemide, there is a decrease in the severity of its diuretic effect.

Nimesulide displaces salicylic acid, fenofibrate and furosemide from their bonds with proteins. The drug increases the level of lithium ion concentration in the blood plasma.

The drug can increase the toxicity of methotrexate and enhance the nephrotoxic effect of cyclosporine. The risk of gastrointestinal bleeding increases with simultaneous therapy with selective serotonin reuptake inhibitors and glucocorticosteroids.

Medicine Nimulid

Analogs

Manufacturers of this NSAID are Ozon LLC and Makspharma CJSC. The medicine has other trade names, for example:

Nimesulid-Teva;
Nimesulide-canon.

Pharmacies offer a number of drugs (both cheaper and more expensive) that are analogues of this NSAID, for example:

Nise;
Nimesil;
Arthrox;
Vipratox.

Before using the analogue, you should consult with a specialist.

Nimulid - instructions for use, release form, dosage, side effects, analogues and price

The price of Nimesulide for a package of 20 tablets of 100 mg is 60-135 rubles.

Gel with nimesulide, which is produced under the trade name Nimulid, costs about 200-250 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Nimesulide gran. for prig. susp. for oral administration 100 mg packet 2 g. 10 pcs. JSC “AVVA RUS”
Nimesulide-MBF gran. for cooking susp. for internal intake 100 mg package 2 g 5 pcs. JSC Marbiopharm
Nimesulide-Teva tablets 100 mg 20 pcs. Blupharma-Industry Pharmaceuticals
Nimesulide-Teva tablets 100 mg 30 pcs. Blupharma-Industry Pharmaceuticals
Nimesulide tablets 100 mg 20 pcs. Ozon LLC

Pharmacy Dialogue

Nimesulide (100 mg tablet No. 20) Ozon LLC
Nimesulide-Teva (100 mg tablet No. 20)Bluepharma
Nimesulide-Teva tablets 100 mg No. 30Bluepharma
Nimesulide (100 mg tablet No. 20)Replekpharm/Berezovsky f.

Europharm* 4% discount using promo code medside11

Nimesulide 100 mg 30 tabletsBlupharma – Industry Pharmaceutical
Nimesulide-teva 100 mg 30 tabletsBlupharm-Industry Pharmaceuticals S
Nimesulide-teva 100 mg 20 tabletsBlupharm-Industry Pharmaceuticals S

Pharmacy24

Nimesulide-Darnitsa 100 mg No. 30 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine
Nimesulide 0.1 g No. 30 tablets PrAT “Lekhim-Kharkiv”, Kharkiv, Ukraine
Nimesulide 100 mg No. 12 tablets PRAT “Fitofarm”, Ukraine

PaniPharmacy

NIMESULIDE tablets Nimesulide tablets. 100 mg No. 30 Ukraine, Lekhim-Kharkov CJSC
Nimesulide tablets Nimesulide tablets. 0.1g No. 30 Ukraine, Lubnyfarm PJSC
Nimesulide tablets Nimesulide tablets. 0.1g No. 30 Ukraine, Darnitsa ChAO
NIMESULIDE tablets Nimesulide tablets. 100 mg No. 12 Ukraine, Fitofarm ChAO

BIOSPHERE

Nimesulide 100 mg No. 20 tablet Lekpharm LLC (Belarus)

Medicine Nimulid

Reviews from doctors

Tereshkin R.V., Rostov-on-Don, orthopedic dentist: “An excellent pain reliever with a clear effect, which I prescribe in dentistry for patients with severe pain. Tested and proven drug. I do not recommend using it for people with hypersensitivity to this NSAID or with gastrointestinal pathologies.”

Maryasov A.S., Krasnodar, surgeon, 12 years of experience: “It’s good that the medicine is available in the form of granules. NSAIDs have a lasting effect and do not act as aggressively on the gastrointestinal mucosa as other drugs in this group. The low price makes the drug accessible to patients. In practice, I have not encountered a body reaction in the form of an allergy to this drug. An excellent NSAID that I often prescribe to patients.”

Lee D.G., Voronezh, neurologist, 10 years of experience: “The medicine is excellent, it has an optimal effect that reduces pain and inflammation. The medication is easy to take in all forms. The unwanted reactions of the body that arise in practice are associated with the gastrointestinal tract. I have been writing a prescription for this drug for about 10 years of my practice. I prescribe it to patients complaining of moderate pain, or in complex treatment for spinal pathologies.

Rodionov E.A., Krasnodar, therapist, 10 years of experience: “My patients note that this NSAID is more effective than other drugs in this group. The effect of the medicine appears 20 minutes after administration. I prescribe the drug for short-term use after simple operations. I do not recommend long-term use of the drug, because Chronic gastrointestinal diseases often worsen.”

Reviews

We have selected some reviews from people who have used the drug Nimesulide:

Katerina. Nimesulide is an analgesic and anti-inflammatory drug, for it to help, you need to take it not just once, but over a period of time - if you have sciatica (I have three hernias) - after 2-3 days of using nimesulide, the effect begins, toothache - depending on what kind severity: after tooth extraction and implantation, nimesulide helped me partially relieve the pain immediately after the operation and completely relieved the pain a week after the operation. Headache - depending on who you are, and depending on what kind of pain (muscle spasm - tension headache - will help in an hour and a half, if the headache is caused by something else, it may not help, another drug is needed). Therefore, it is important to know what you are treating, and what specific drug is treating it, and everything will be cured in the end. And don’t write that it doesn’t help – it still helps!
Olga. An excellent cure for everything. I think it should be a must have in the first aid kit. Our whole family has been using it for a couple of years now. Perfect for pain or fever. When I’m sick, I dissolve 1 pack of powder in half a glass of water, drink it at night, sweat a lot under a warm blanket, and the next morning the temperature drops and the headache goes away. I also use Nimesulide for headaches. I take it in tablets or powder form. I think one of the big advantages is that this medicine is universal and inexpensive, so it can be used for different symptoms.
Nastya. I used to buy Nise, but then, based on reviews, I chose the domestic analogue - nimesulide. It also helps very well, but costs 3 times less. Great after surgery. The stitches don't hurt at all. You can sleep peacefully all night. The only pity is that the drug has many contraindications, so you need to strictly follow the instructions for use.

Instructions for use

Patients with chronic renal failure should not take more than 100 milligrams of Nimesulide per day. In old age (with normal renal function), no dose adjustment is required.

The maximum duration of taking the drug is 15 days. However, if possible, you should adhere to the minimum doses at which the therapeutic effect is manifested and take the drug no longer than required.

The standard dose of tablets for adults and children over 12 years of age is 50-100 mg. This dose should be taken twice daily. For children, you can also calculate a single dose at the rate of 1.5 mg/kg body weight and take it 2-3 times a day.

When using granules, one sachet should be dissolved in 100 ml of water. The usual dose in this case is the same as when taking tablets - one sachet twice a day.

Although food does not affect absorption of the drug, tablets and granules are best taken after meals to reduce the chance of side effects.

The maximum permissible daily dose of Nimesulide for adult patients is 400 mg, for children (over 12 years old) – 5 mg/kg.

When using the gel, it should be squeezed out of the tube by about 3 cm and lightly rubbed into the area of inflammation. Do not rub the gel forcefully, and it is also not recommended to use bandages. The procedure can be repeated up to 3-4 times a day. The duration of use of the gel is determined individually. If there are no positive changes within 4 weeks, you should consult a doctor.

Nimesulide tablets represent the clinical and pharmacological group of non-steroidal anti-inflammatory drugs. They are used to reduce the severity of the inflammatory reaction and pain of various origins.

Compound

Nimesulide tablets are round in shape and yellow-green in color. The main active compound of the drug is nimesulide, its content in one tablet is 100 mg. It also contains auxiliary chemical components, which include:

Magnesium stearate.
Corn starch.
Microcrystalline cellulose.
Lactose monohydrate.
Anhydrous colloidal silicon dioxide.
Talc.

Nimesulide tablets are packaged in blister packs of 10 pieces. A cardboard pack contains 2 (20 tablets) or 3 (30 tablets) blisters, as well as instructions for use.

Action

The main active component of Nimesulide tablets is an inhibitor of the enzyme cyclooxygenase 2 (COX-2). The enzyme catalyzes the chemical conversion of arachidonic acid into prostaglandins, which are the main mediators of the inflammatory response.

At the site of the inflammatory process, prostaglandins have an irritating effect on sensitive nerve endings, lead to the development of pain, increase the permeability of the walls of microcirculatory vessels with swelling of soft tissues, and also contribute to blood stagnation.

After nimesulide penetrates into the focus of the inflammatory reaction, the concentration of prostaglandins decreases, as a result of which several therapeutic effects are realized:

Analgesic effect.
Reducing the severity of soft tissue swelling.
Reducing hyperemia (redness of tissues) caused by blood stagnation.

To a lesser extent, nimesulide reduces the concentration of prostaglandins in the center of thermoregulation, so during fever it practically does not contribute to the normalization of body temperature.

Due to the fact that the active component of the drug predominantly affects the functional activity of the COX-2 enzyme, practically without affecting COX-1, it minimally reduces the concentration of prostaglandins in the stomach, which are responsible for protecting the mucous membrane.

After taking the Nimesulide tablet orally, the active ingredient is quickly and almost completely absorbed into the blood from the intestinal lumen.

It is well and evenly distributed in various peripheral tissues, where it has therapeutic effects.

Metabolism of nimesulide occurs in hepatocytes (liver cells) with the formation of inactive breakdown products, which are predominantly excreted from the body in the urine.

Indications

The main medical indication for taking Nimesulide tablets is to reduce the severity of pain and inflammatory response in certain pathological conditions, which include:

Gout in the stage of exacerbation of the inflammatory process in the joints with severe pain.
Osteochondrosis, accompanied by radicular syndrome with pain of varying intensity.
Ankylosing spondylitis.
Muscle pain (myalgia) of various origins.
Psoriatic arthritis (specific inflammation of the joints).
Previous trauma, which may include post-traumatic soft tissue inflammation.
Inflammatory processes affecting various structures of the musculoskeletal system (ligaments, tendons, cartilage, bursae and joint capsules) with severe pain.
Toothache of moderate intensity.
Algodysmenorrhea (painful menstruation) in women.
Headache, including moderate migraine attacks.
Pain syndrome of moderate severity in the postoperative period.

The drug can also be used to reduce body temperature in cases of severe fever of infectious-toxic origin.

Contraindications

Taking Nimesulide tablets is contraindicated if the patient has certain pathological processes or physiological conditions, which include:

Erosive-ulcerative pathology, characterized by a violation of the integrity of the mucous membrane in the stomach or duodenum.
Previous bleeding from various parts of the gastrointestinal tract.
Severe liver or kidney failure, which is accompanied by a significant decrease in the functional activity of the relevant organs.
Severe hemostasis disorders, which are accompanied by a deterioration in the blood coagulation process.
Severe failure of the functional activity of the heart.
The presence in the past of bronchospasm (reactive narrowing of the walls of the bronchi, resulting from increased smooth muscle tone), inflammation of the nasal mucosa, as well as urticaria (characteristic changes on the skin, reminiscent of a nettle burn), the development of which was provoked by taking acetylsalicylic acid. It also belongs to the pharmacological group of non-steroidal anti-inflammatory drugs.
The recovery period after coronary artery bypass surgery.
Pregnancy at any stage, as well as the period of breastfeeding (lactation period).
Individual intolerance to any of the components of the drug.
The child's age is up to 12 years.

Nimesulide tablets are used with caution in the presence of relative contraindications, which include coronary heart disease, congestive heart failure, lipid metabolism disorders, pathology of peripheral arterial vessels, smoking, chronic diseases of the digestive system in remission (improved condition), elderly patient, renal or mild to moderate liver failure, concomitant use of drugs of certain clinical and pharmacological groups (antiplatelet agents, anticoagulants, non-steroidal anti-inflammatory drugs, glucocorticosteroids). Before starting to use Nimesulide tablets, it is important to ensure that there are no absolute or relative contraindications.

Nimesulide tablets are intended for oral administration by adults and adolescents over 12 years of age. It is advisable to take them after meals, whole, without chewing and with a sufficient amount of water.

The average recommended therapeutic dosage is 1 tablet 2 times a day. The maximum daily dosage should not exceed 200 mg. The recommended duration of therapy should not exceed 10 days.

If necessary, the dosage and duration of taking Nimesulide tablets is determined by the attending physician individually.

Side effects

While taking Nimesulide tablets with varying frequencies, negative reactions from various organs and systems may develop:

Cardiovascular system - the frequency of heart contractions rarely increases (tachycardia), a feeling of a “rush” of heat develops in the facial area, which is provoked by changes in the autonomic regulation of blood vessel tone.
Nervous system – dizziness, less often develops a feeling of fear, nervousness, nightmares, headache, drowsiness, Reye’s syndrome (specific brain damage or encephalopathy) may bother you.
Digestive system – nausea, periodic vomiting, diarrhea. More rarely, pain in the abdominal area (pain is predominantly localized in the upper abdominal cavity), bloating (flatulence), bleeding from various parts of the digestive tract, accompanied by weakness, tarry dark stools.
Sense organs – blurred vision may rarely occur.
Respiratory system - shortness of breath rarely occurs; in isolated cases, bronchospasm, as well as exacerbation of bronchial asthma, have been recorded.
Liver and hepatobiliary tract structures – increased activity of liver transaminase enzymes in the blood, which indicates an increase in the functional load on hepatocytes or their damage.
Urinary system - relatively rarely, swelling of peripheral tissues may develop, blood may appear in the urine (hematuria), discomfort in the form of a burning sensation during urination, which indicate dysuria.
Blood and red bone marrow - rarely develops anemia (anemia), a decrease in the number of platelets in the blood (thrombocytopenia) with an increase in the time required for the formation of a blood clot when a vessel is damaged (decreased coagulation).
Skin and subcutaneous tissue - rash, itchy skin, development of severe reactions with death of skin areas (Stevens-Johnson syndrome, Lyell syndrome).
Allergic reactions - the development of angioedema with severe swelling of peripheral tissues, mainly in the face and external genitalia. Rarely, shock-type anaphylactoid reactions with a sharp and critical decrease in systemic blood pressure and multiple organ failure may occur.
Changes in general condition - weakness, decreased ability to work, rarely develops hypothermia (decrease in body temperature below normal values).

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Peculiarities

Before you start taking Nimesulide tablets, it is important to carefully read the instructions. It indicates several features of the correct use of the drug, which include:

The tendency to bleeding is the basis for extremely careful use of the drug.
With the development of moderate renal or hepatic failure, as well as for older people, dosage adjustment of the drug may be necessary. In this case, the average therapeutic dose and duration of taking the tablets are usually reduced.
Patients with high blood pressure, as well as the development of heart failure in the early stages while taking Nimesulide tablets, need to control water-salt metabolism, since the development of edema of peripheral tissues cannot be ruled out.
To reduce the likelihood of developing negative reactions, complications and unpleasant health consequences, the drug should be used in the minimum effective dosage, as well as a short course of treatment.
Pregnant women should not take Nimesulide tablets, since its negative effect on the developing fetus cannot be ruled out.
The active component of the drug passes into breast milk during lactation. If it is necessary to use the drug, breastfeeding of the child is temporarily stopped (the milk is expressed and poured out, and the child is transferred to an adapted artificial milk formula).
The drug may interact with medications from other clinical and pharmacological groups, therefore, in case of their possible use, you should warn your doctor.
During the use of the drug, the development of negative reactions from the structures of the central nervous system is possible, therefore, when performing work that requires increased concentration of attention and speed of psychomotor reactions, special care should be taken.

In the pharmacy chain, Nimesulide tablets are dispensed with a doctor's prescription. Their independent use is not recommended, as this may cause unpleasant and serious complications or health consequences in the future.

Pharmacodynamics

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits the action of cyclooxygenase-2 and, to a lesser extent, cyclooxygenase-1. In this regard, the synthesis of physiologically active substances that indirectly affect pain receptors is suspended and, thereby, inflammatory processes do not allow the development of inflammatory processes in nerve tissues.

At the same time, the active substance has little effect on the enzymes of other organs, thereby minimizing negative side effects. This is especially important in relation to the gastrointestinal tract.

Due to the complex biological interactions of various agents in the blood and other body systems, the drug relieves inflammation, has an analgesic effect, reduces temperature, prevents and restores damage to the cartilage tissue of the joints.

Why is Nimesulide prescribed?

The drug does not treat the disease, but relieves acute pain symptoms, reducing signs of inflammation. Most often, Nimesulide is used for pathologies of the musculoskeletal system that cause acute pain. Among them:

arthritis of various origins;
osteoarthritis, arthrosis;
osteochondrosis;
rheumatism;
radiculitis;
bursitis.

The medicine is also used for other pathologies accompanied by acute pain. This:

toothache (acute and after treatment);
neuralgia;
post-traumatic feelings;
arthralgia;
headache;
myalgia;
postoperative pain;
stretching and inflammation of muscles, tendons;
painful periods.

In addition, the gel is used for:

tendinitis;
lumbago;
sprained ligaments, muscles;
osteoarthritis;
periarthritis.

Pharmacological action, pharmacodynamics and pharmacokinetics

A characteristic feature of sulfonamides, to which the drug belongs, is the ability to quickly block pain receptors. This effect is achieved by influencing the synthesis of prostaglandins through the enzyme cyclooxygenase. The most pronounced anesthetic and anti-inflammatory effects of the drug. But nimesulide does not reduce fever as effectively as many other NSAIDs. Yes, and taking it during a fever of infectious origin or during a cold is prohibited.

Absorption of oral forms of the drug occurs very quickly: it begins immediately in the oral cavity through the mucous membrane. The maximum concentration in plasma is observed after one and a half to two hours. Duration of action - up to 6-7 hours. The gel is quickly absorbed and almost instantly numbs the affected area. It almost never enters the bloodstream. The substance is excreted in the form of liver metabolites and unchanged by the kidneys.

During pregnancy and lactation

Pregnant women are most at risk of contracting various diseases. After all, immunity in this state is often weakened. Fever, body aches, pain of various origins are signs of the onset of the inflammatory process. Is it possible to eliminate them with Nimesulide? Doctors do not advise starting this treatment, because the drug is too strong. Doctors recommend weaker means of the same action.

In the first trimester, when all fetal systems develop, the drug can cause pathologies. It is possible to use the medicine in the second trimester, when the child’s organs have already formed, but only under the supervision of a doctor.

And taking the medication in the last trimester can lead to serious complications for the mother and fetus:

pressure changes that threaten premature birth;
renal failure;
the likelihood of premature closure of the ductus arteriosus;
reduction in the amount of water;
stopping uterine contractions;
bleeding;
swelling.

During lactation, Nimesulide should also not be used for pain relief. The substance passes into milk and has a negative effect on infants.