Duspatalin: indications for use and instructions for use

Duspatalin is a myotropic antispasmodic that reduces the tone and contractile activity of the smooth muscles of the gastrointestinal tract. Instructions for use explain how to take capsules 200 mg retard, tablets 135 mg for the treatment of spasms of the gastrointestinal tract in adults, children and pregnancy. What Duspatalin helps with, information on prices, analogues and patient reviews will also be presented in the article.

Release form and composition

Duspatalin 200 is available in the form of hard capsules for oral administration. On the body of the Duspatalin capsule there is the inscription “245”, and on the cap - “S7”. Duspatalin capsules containing 135 mg of the active substance are also available on the market.

One capsule of Duspatalin contains 200 mg or 135 mg of mebeverine hydrochloride. The capsule also contains the following excipients.

The drug is packaged in blisters of 10 or 15 pieces in a cardboard box with a detailed description attached.

Duspatalin or Meteospasmil - which is better?

Manufacturer: Laboratories MAYOLY-SPINDLER (France)
Release form: capsules

Active ingredients: alverine, simethicone

Duspatalin and its analogue Meteospasmil have different active substances and mechanisms of action, but the same treatment result. The choice of medication depends on the functional state of the digestive system.

Duspatalin will be best if the pain comes from the liver, pancreas, or gall bladder. That is, the basic drug has broader indications compared to its analogue.

Pharmacological characteristics

Antispasmodic myotropic action, has a direct effect on the smooth muscles of the gastrointestinal tract (mainly the large intestine), eliminates spasm, does not affect normal intestinal motility. Duspatalin does not have an anticholinergic effect.

Its mechanism of action does not depend on the autonomic nervous system, so the use of Duspatalin eliminates the occurrence of dry mouth, weakness, problems with stool and urination, and tachycardia. It can be taken for prostate hypertrophy, glaucoma, and insufficient urination.

How long can you take duspatalin?

For spastic pain, antispasmodics are considered effective drugs. Medicines in this group differ in the mechanism and localization of action, so it is important to choose an effective remedy in each specific case. What does Duspatalin, which is an antispasmodic, help with, and what kind of pain is it used for, we will consider further.

Duspatalin - composition of the drug

The drug Duspatalin, produced by a Dutch pharmaceutical company, is produced in the form of capsules and tablets.

What these two forms have in common is that the active component in them is the compound mebeverine (mebeverine hydrochloride). In this case, capsules contain a larger amount of active substance - 200 mg, and tablets - 135 mg.

These release forms also differ in the list of auxiliary components. Thus, the tablets additionally include the following substances:

• lactose monohydrate;
• potato starch;
• magnesium stearate;
• povidone K25;
• talc;
• gelatin;
• sucrose;
• carnauba wax;
• acacia gum.

The auxiliary components in the capsules are:

• magnesium stearate;
• methyl methacrylate copolymer;
• ethyl acrylate copolymer;
• titanium dioxide;
• hypromellose;
• triacetin;
• gelatin;
• shellac;
• iron oxide;
• soy lecithin;
• defoamer.

Duspatalin - indications for use

What Duspatalin helps with and for what pathological conditions it is recommended is known to people suffering from problems with the digestive system.

This drug belongs to the group of myotropic antispasmodics, the action of which is aimed directly at the muscle tissue of the body.

Duspatalin, due to its main component, selectively affects the smooth muscles of the gastrointestinal tract, eliminating painful spasms without suppressing intestinal peristaltic activity. The mechanism of action of the drug is associated with the following processes:

• blocking sodium channels of cell membranes, which helps to delay the penetration of sodium and potassium ions into cells, thereby reducing smooth muscle contractions and eliminating pain;
• blockade of replenishment of potassium stores from the extracellular space, which leads to limited release of potassium from cells, preventing a reflex decrease in muscle tone.

Taking into account the described effects achieved when taking the drug in question, Duspatalin has the following indications:

• spasmodic pain in the abdominal area;
• intestinal colic;
• biliary colic;
• discomfort with irritable bowel syndrome;
• conditions after cholecystectomy;
• gallbladder dysfunction;
• secondary spasms of the digestive organs associated with diseases of other organs (pancreatitis, cholecystitis, etc.).

Duspatalin for IBS

Irritable bowel syndrome (IBS) is a common pathology nowadays, which is a functional disease of the intestinal tract. One of the main symptoms may be frequent pain in the abdominal area, a feeling of fullness, seething, and flatulence. Patients are concerned about stool disturbances, which can be loose or absent for a long time.

It is extremely difficult to cure this disease, since in most cases its causes are not clear, but taking medications can significantly improve your well-being, including a short course of antispasmodic drugs. With this diagnosis, Duspatalin saves from bloating, discomfort, to improve the motor-evacuation function of the digestive tract.

Duspatalin - side effects

According to patient reviews and doctors' observations, the medicine is often well tolerated and does not cause negative reactions in the body.

On the contrary, many note its high effectiveness and safety, including due to the drug’s ability to quickly exhibit therapeutic activity while maintaining normal intestinal motility.

In addition, Duspatalin does not affect smooth muscle vascular walls and has no systemic effects. The components of the drug do not accumulate in tissues and are excreted in urine and bile.

Even with an increase in the dose of Duspatalin, adverse reactions occur with minimal probability, and these include:

• allergic manifestations (urticaria, Quincke's edema);
• headache;
• dizziness;
• nausea.

With an overdose of mebeverine, there are cases of development of hyperexcitability of the central nervous system.

It is worth noting that due to the existing risk of developing side effects during treatment with this drug, it becomes necessary to abandon activities that require increased concentration and speed of psychomotor reactions (for example, driving a car). You also need to keep in mind that when taking alcohol together, the effectiveness of the medicine is significantly reduced.

Source: https://za-dolgoletie.ru/info/kak-dolgo-mozhno-prinimat-djuspatalin/

Why is Duspatalin prescribed?

For symptomatic treatment, Duspatalin helps in the following situations:

• During the development of colon syndrome to relieve various unpleasant sensations due to disorders of the intestinal structures and abdomen.
• During the occurrence of biliary colic.
• Spasms of secondary origin that occur in the stomach and intestinal tract with pancreatitis or cholecystitis.
• When gallbladder dysfunction occurs or during various conditions in patients after removal of this organ.
• Various disorders of the digestive system, which are functional in nature and occur with pain in the abdominal area. The medicine in this case is used for children over 12 years of age.
• Various pain sensations caused by abdominal cramps.
• Colic in the intestinal tract.

This drug can be used for the symptomatic treatment of pain, discomfort and spasmodic phenomena in the intestinal tract.

How to take the drug?

The tablets are taken whole, without chewing or biting, 30 minutes before meals three times a day. It is recommended to drink them with plenty of water. The course of treatment lasts until the pain stops.

Capsules should be taken 20 minutes before meals in the same manner as tablets. If an overdose occurs, it can be expressed by increased excitability. In this case, you need to rinse your stomach as quickly as possible by drinking a large amount of water, and immediately take several tablets of activated carbon.

How to take Duspatalin for children ? The child often experiences pain in the intestines. This drug is taken only from the age of 12 and for no more than a week. Dosage - one tablet daily. If the child has impaired bile flow, then two capsules should be taken per day until the condition normalizes.

Instructions for use

Duspatalin capsules must be taken orally before meals, without opening, with a sufficient amount of liquid. The dose of the drug is determined by the doctor individually; according to the instructions, patients over 18 years of age are prescribed 1 capsule 1-2 times a day.

The duration of therapy depends on the severity of the pain and spastic syndrome. The patient does not develop addiction to the drug, so if necessary, Duspatalin can be used for a long time.

If you miss the next dose of the drug, you should not double the dose during the next dose; it is enough to take only 1 capsule.

DUSPATALIN

– mebeverine hydrochloride (mebeverine)

Release form, composition and packaging

Extended-release capsules

hard gelatin, size No. 1, opaque, white, marked “245” on the capsule body; the contents of the capsules are white or almost white granules.

Excipients: magnesium stearate – 13.1 mg, methyl methacrylate and ethyl acrylate copolymer [1:2] 30% dispersion (30% polyacrylate dispersion) – 10.4 mg, talc – 4.9 mg, hypromellose – 0.1 mg, methacrylic acid and ethyl acrylate copolymer [1:1 ] 30% dispersion – 15.2 mg, triacetin – 2.9 mg.

Composition of hard gelatin capsule:

gelatin – 75.9 mg, titanium dioxide (E171) – 1.5 mg.
Ink composition:
shellac (E904), propylene glycol, aqueous ammonia, potassium hydroxide, black iron oxide dye (E172).

10 pieces. – blisters (1) – cardboard packs. 10 pcs. – blisters (2) – cardboard packs. 10 pcs. – blisters (3) – cardboard packs. 10 pcs. – blisters (5) – cardboard packs. 15 pcs. – blisters (2) – cardboard packs. 15 pcs. – blisters (4) – cardboard packs.

15 pcs. – blisters (6) – cardboard packs.

pharmachologic effect

Antispasmodic myotropic action, has a direct effect on the smooth muscles of the gastrointestinal tract without affecting normal intestinal motility.

The exact mechanism of action is unknown, but multiple mechanisms, such as decreased ion channel permeability, blockade of norepinephrine reuptake, local anesthetic effects, and changes in water absorption, may cause mebeverine to act locally on the gastrointestinal tract. Through these mechanisms, mebeverine has an antispasmodic effect, normalizing intestinal motility and without causing constant relaxation of the smooth muscle tissue of the gastrointestinal tract (hypotension).

Systemic side effects, incl. anticholinergic, none.

Pharmacokinetics

Suction

Mebeverine is rapidly and completely absorbed after oral administration. The modified release dosage form allows the use of a dosage regimen of 2 times a day.

The average relative bioavailability of the drug in the form of modified-release capsules is 97%.

Distribution

When taking repeated doses of the drug, significant accumulation does not occur.

Metabolism

Mebeverine hydrochloride is mainly metabolized by esterases, which in the first stage split the ester into veratric acid and mebeverine alcohol. The main metabolite circulating in plasma is demethylated carboxylic acid.

T1/2 of demethylated carboxylic acid in the steady state is approximately 5.77 hours. When taking repeated doses (200 mg 2 times / day), Cmax of demethylated carboxylic acid in the blood is 804 ng/ml, the time to reach Cmax of demethylated carboxylic acid in the blood (Tmax) is about 3 hours

Removal

Mebeverine as such is not excreted from the body, but is completely metabolized; its metabolites are almost completely eliminated from the body. Veratric acid is excreted by the kidneys. Mebeverine alcohol is also excreted by the kidneys, partly as a carboxylic acid and partly as a demethylated carboxylic acid.

Indications

- symptomatic treatment of pain, spasms, dysfunction and discomfort in the intestinal area associated with irritable bowel syndrome;

— symptomatic treatment of spasms of the gastrointestinal tract (including those caused by organic diseases).

Contraindications

- hypersensitivity to any component of the drug;

— pregnancy (due to insufficient data);

- age under 18 years (due to insufficient data on effectiveness and safety).

Dosage

For oral administration. The capsules must be swallowed with a sufficient amount of water (at least 100 ml). Capsules should not be chewed, because their shell provides prolonged release of the drug.

Take 1 capsule. 2 times a day (1 in the morning and 1 in the evening) 20 minutes before meals. The duration of taking the drug is not limited.

If the patient forgets to take one or more doses, the drug should be continued with the next dose. Do not take one or more missed doses in addition to your regular dose.

Dosing regimen studies have not been conducted in elderly patients or patients with renal and/or hepatic impairment.

Available data on post-marketing use of the drug have not identified specific risk factors for its use in elderly patients and patients with renal and/or hepatic insufficiency.

Changes in dosage regimen in elderly patients and patients with renal and/or hepatic impairment

not required.

Reports of the following adverse events were received during post-marketing use and were spontaneous in nature; There are insufficient data to accurately estimate the incidence of cases.

Allergic reactions were observed mainly from the skin, but other manifestations of allergies were also noted.

From the skin:

urticaria, angioedema, incl. face, exanthema.

From the immune system:

hypersensitivity reactions (anaphylactic reactions).

Overdose

Symptoms

Theoretically, in case of overdose, an increase in the excitability of the central nervous system is possible. In cases of mebeverine overdose, symptoms were either absent or mild and, as a rule, quickly reversible. The observed symptoms of overdose were neurological and cardiovascular in nature.

Treatment

A specific antidote is unknown. Symptomatic treatment is recommended. Gastric lavage is necessary only if intoxication is detected within approximately 1 hour after taking several doses of the drug. Measures to reduce absorption are not required.

Drug interactions

Only studies have been conducted to study the interaction of this drug with ethanol. Animal studies have demonstrated the absence of any interaction between Duspatalin and ethyl alcohol.

special instructions

Impact on the ability to drive vehicles and operate machinery

Studies of the effect of the drug on the ability to drive a car and other mechanisms have not been conducted. The pharmacological properties of the drug, as well as the experience of its use, do not indicate any adverse effect of mebeverine on the ability to drive a car and other mechanisms.

Pregnancy and lactation

There are only very limited data on the use of mebeverine in pregnant women. Animal studies are insufficient to assess reproductive toxicity. It is not recommended to use Duspatalin during pregnancy.

There is insufficient information on the excretion of mebeverine or its metabolites into breast milk. Studies of mebeverine excretion in milk have not been conducted in animals. Duspatalin should not be taken while breastfeeding.

There are no clinical data on the effect of the drug on fertility in men or women, but known animal studies have not demonstrated any adverse effects of Duspatalin.

Use in childhood

Contraindicated in people under 18 years of age (due to insufficient data on efficacy and safety).

For impaired renal function

No changes to the dosage regimen are required in patients with renal failure.

For liver dysfunction

No change in dosage regimen is required in patients with liver failure.

Use in old age

No change in dosage regimen is required in elderly patients.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

RUDUS183710 from 12/05/2018

Contraindications to the use of Duspatalin

There are practically no contraindications, rather recommendations:

• increased sensitivity of the body to the chemicals contained in the composition - may manifest itself in the form of urticaria;
• the use of Duspatalin for the treatment of children is prohibited - the manufacturer did not conduct tests on this age group;
• They advise nursing mothers to be careful not to take it, the reason is that there are no laboratory studies regarding its passage into breast milk;
• pregnant women should use only in exceptional cases (unavailability of other painkillers, inability to go to a medical facility);
• Be careful with it for people suffering from kidney and liver diseases.

Read also: Tablets, drops Corvalol: instructions for use, reviews and price in pharmacies

Compound

Before talking about the composition, it is worth mentioning the type of tablets itself. As a rule, they have the shape of a capsule. Melon capsules are made from a mixture of gelatin, which makes them easier for the body to absorb.

The capsules have a white tint and are practically opaque. The medicine itself also has a white undertone. It has flowability and the granules are very small, practically invisible to the human eye.

Duspatalin powder contains magnesium, methacrylic acid, triacetin, hypromellose and some other components. All of them are present in the drug in equal doses, which also casts doubt on the possibility of an allergic reaction.

Side effects

Very rare side effects:

• Vertigo syndrome.
• Drowsiness.
• Confusion.
• Nausea.
• Hypersensitivity.
• Allergic shock.

Possible side effects of the drugs include dry mouth, dizziness and blurred vision. In studies, about 5 out of every 100 people reported such side effects.

The lack of subjective pleasure makes it a drug with low addiction potential. Old age is an important risk factor for side effects and overdose.

Signs of overdose:

• Breathing disorders.
• Increased body temperature.
• Mydriasis and therefore hypersensitivity to bright light (photophobia).
• Loss of visual placement leading to blurred vision or cycloplegia.
• Diplopia.
• Increased heart rate (tachycardia).
• Paralytic ileus.
• Increased intraocular pressure.

Side effects

Unfortunately, like many other medications, Duspatalin has side effects. As a rule, the most common deviation in use is an allergic reaction to substances contained in the drug . Therefore, prescribing medicine for yourself is a big risk. Contact your healthcare provider for help.

Sometimes, as a result of an overdose, a person may develop hypersensitivity as a side effect, which will irritate both the skin and the immune system, adding a few more unpleasant aspects to your illness.

Analogs

1. Mebeverine hydrochloride.
2. Niaspam.
3. Sparex.
4. Buskopan.
5. Dibazol.
6. Papaverine.
7. No-Shpa.
8. Trimedat.
9. Dicetel.

When choosing analogues, it is important to understand that the instructions for use of Duspatalin, price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.

Trimedat or Duspatalin?

These drugs have almost the same effect on the human body. Their only difference is that Trimedat is aimed at treating more complex diseases of the gastrointestinal tract, for which Duspatalin tablets will not help. Very often, doctors offer these two drugs as a choice. It should be noted that the price of Trimedat is noticeably lower.

Duspatalin or No-Shpa?

These drugs differ in that No-Shpa is a broad-spectrum drug, while Duspatalin has a narrow focus. The difference in price is also noticeable: No-Shpa costs several times less.

Which is better: Duspatalin or Dicetel?

If you have problems with the gastrointestinal tract, you should take a course of Duspatalin. How long can you take this medicine? It is best for a doctor to answer this question and prescribe specific course dates.

If you have a single spasm, this drug will not help; in such a situation, Dicetel is best suited, which will eliminate the pain. For disorders associated with poor nutrition, Dicetel is also more suitable.

Analogues of Duspatalin

The pharmacological industry produces a wide range of analogues and substitutes for Duspatalin. These drugs are sold in pharmacies under the guise of:

• generics;
• synonyms;
• mono- and combined drugs.

A large selection of Duspatalin substitutes from Russian and foreign manufacturers significantly expands the therapeutic capabilities of the doctor. This allows him to take into account all the nuances of gastrointestinal diseases in both adults and children when prescribing medication.

Table of Duspatalin analogues with price and country of origin.

Prices for Duspatalin analogues vary widely and depend on the manufacturer and the ingredients that make up the medicine. A large selection of drugs with similar indications allows you to purchase Duspatalin substitutes at a budget cost, but with a high therapeutic effect.

What else can replace Duspatalin, what analogues? The list of medications used to relieve spasms in various gastrointestinal diseases can be supplemented with the following drugs:

• Duphalac;
• Creon;
• Hilak forte;
• Dutan;
• Acipol.

From this list of Duspatalin analogues, some drugs can only be purchased with a prescription, and some drugs can be purchased without it. In pharmacies you can find Duspatalin analogues cheaper than their base drug.

Kolofort

Manufacturer: NPF MATERIA MEDICA HOLDING (Russia)
Release form: lozenges

Active ingredient: antibodies to human TNF, to brain-specific protein S-100, to histamine

The combination of active substances in the combined preparation helps to normalize the nervous and humoral regulation of intestinal function. As a result of the action of Kolofort, the negative manifestations of the disease are stopped. This occurs due to the relaxation of smooth muscles and a decrease in the tone of the wall of the digestive organ.

An analogue of Duspatalin is prescribed, 1-2 tablets 2 times a day by completely resolving them. The duration of treatment is 1–3 months, which can be extended according to indications.

Drotaverine

Manufacturer: UPDATE (Russia)
Release form: tablets

Active ingredient: drotaverine hydrochloride

Drotaverine is a Russian analogue of Duspatalin and is classified as a myotropic antispasmodic. It is similar to Papaverine in its chemical structure and pharmacological action. But it differs from it in a stronger and longer-lasting effect.

The analog relieves spasm of the smooth muscles of internal organs, reduces intestinal motility, dilates blood vessels and reduces blood pressure. The drug is prescribed 1-2 tablets 2-3 times a day.

Espumisan

Manufacturer: BERLIN-CHEMIE, AG (Germany)
Release form: capsules

Active ingredient: simethicone

Espumisan belongs to the group of carminatives, which helps reduce gas formation in the intestines, preventing bloating and the occurrence of intestinal colic. This analogue of Duspatalin is included in the preparation of the patient before instrumental methods of examining the gastrointestinal tract and pelvic organs (ultrasound, MRI, radiography).

The medication is prescribed 2 capsules 3-5 times a day, depending on the indications. It is possible to adjust the dosage of the drug. The duration of its use is determined by the doctor.

Ganaton

Manufacturer: ABBOTT LABORATORIES (Germany)
Release form: tablets

Active ingredient: itopride

Ganaton, an analogue of Duspatalin in tablets, is a stimulator of gastrointestinal tone and motility. As a result of the action of the medication, accelerated evacuation of food contents from the stomach occurs, suppression of the gag reflex, and elimination of heaviness and discomfort in the abdomen.

The analogue is prescribed 1 tablet 3 times a day. According to indications, it is possible to adjust the dosage towards its reduction. The course of treatment with the drug can be up to 2 months.

Odeston

Manufacturer: ADAMED PHARMA (Poland)
Release form: tablets

Active ingredient: hymecromone

Odeston belongs to the group of medications that have a choleretic effect. Duspatalin analogue stimulates the formation and secretion of bile. Acting as an antispasmodic on the bile ducts and sphincter of Oddi, the drug does not reduce gastrointestinal motility and blood pressure.

The analog prevents the stagnation of bile and the formation of cholesterol crystals, that is, the formation of stones in the gallbladder. The drug is prescribed 1-2 tablets 3 times a day, lasting 15-20 days.

De Nol

Manufacturer: ASTELLAS PHARMA EUROPE (Netherlands)
Release form: tablets

Active ingredient: bismuth tripotassium dicitrate

Duspatalin analog De-Nol has an antibacterial effect against a number of pathogens, including Helicobacter pylori. Due to the active ingredient included in the medication, the resistance of the gastric mucosa to the aggressive action of pepsin increases. The drug relieves negative symptoms in the following conditions:

• with exacerbation of stomach and duodenal ulcers;
• chronic gastritis;
• with irritable bowel syndrome accompanied by diarrhea.

The analogue is prescribed 1 tablet 4 times a day or 2 tablets 2 times a day. The duration of treatment is determined by the doctor.

Duspatalin contraindications

1. Hypersensitivity to any component of the drug.
2. Age up to 18 years (due to insufficient data on effectiveness and safety).
3. Pregnancy (due to insufficient data).

Use during pregnancy and breastfeeding

Pregnancy There is insufficient data on the use of mebeverine in pregnant women. It is not recommended to use Duspatalin® during pregnancy.

Breastfeeding Period There is insufficient information on the excretion of mebeverine or its metabolites into breast milk. Duspatalin® should not be taken while breastfeeding.

Fertility There are no clinical data on the effect of the drug on fertility in men or women, however, animal studies have not demonstrated any adverse effects of Duspatalin®.

Duspatalin or Dicetel - which is better?

Manufacturer: ABBOTT LABORATORIES (Germany)
Release form: tablets

Active ingredient: pinaveria bromide

Both medications have an antispasmodic effect. Dicetel is able to reduce the concentration of hydrochloric acid in the stomach and stimulate the evacuation of its contents. Its use is effective for mild gastrointestinal disorders accompanied by eating errors and pain.

The effectiveness of Duspatalin will be higher in the treatment of diseases of the pancreas, gall bladder, and irritable bowel syndrome.

Properly selected analogues of Duspatalin for children and adults with organic and functional pathologies of the gastrointestinal tract will allow the doctor to effectively carry out treatment and relieve negative symptoms.

Mode of application

Take one tablet three times a day, half an hour before meals. The duration of the course of therapy usually does not exceed two weeks. The tablets should be taken with at least half a glass of water, without chewing.

Take one capsule twice a day before meals. Missed dosages should not be taken - continue using the regimen without additional doses.

Standard recommended dosages are given. They can be corrected by the attending physician, who will take into account the individual characteristics of the pathologies.