Phenotropil - instructions for use and indications, release form, composition, side effects and price

Phenotropil - the best of nootropics, a placebo or dangerous pills with a bunch of side effects? Let's try to understand this issue.

Modern society, with all its development, the presence of high technologies and medical knowledge, is not protected from the negative influence of the environment and society as a whole.

Constant movement, haste, and the need to perform duties negatively affect the nervous system. A person gradually loses the ability to control his emotions, feelings of anger or apathy appear more and more often, and nervous tension increases.

In this case, it becomes clear that you cannot do without special drugs. The central nervous system requires drug treatment. To alleviate the negative manifestations of the external environment and to strengthen the blood vessels of the brain, the drug Phenotropil is prescribed.

The drug is available in tablet form. There are 10 pcs or 3 pcs in a package, depending on the option chosen. The active active substance is the substance phenotropil, auxiliary substances included in the composition:

• milk sugar;
• potato starch;
• calcium stearate.

The packs are made of thick cardboard, the packaging for tablets is made of PVC.

The best neurotransmitter in the world

Phenopropyl belongs to the group of nootropic drugs, neurotransmitters and psychostimulants.
It is actively used in neurological medical practice, since it has a pronounced anti-amnestic effect. In general, a group of nootropic drugs is intended to affect higher brain functions. This drug is recommended for use not only at the time of sudden disruptions in the functioning of the central nervous system or brain, but also in cases of intense activity that requires concentration, attention and concentration.

That is why examination by a specialist is a necessity for scientists and people involved in complex industries, as they experience great emotional and mental overload, which can trigger the development of central nervous system diseases.

Release form and composition

Available in the form of tablets with a flat-cylindrical shape of white or cream color.

Phenotropil is produced in the form of tablets: flat-cylindrical, white to white with a creamy or yellowish tint (10 pieces in blister packs, 1 or 3 packs in a cardboard pack).

Composition of 1 tablet:

• active ingredient: N-carbamoylmethyl-4-phenyl-2-pyrrolidone (phenotropil) – 50 mg or 100 mg;
• auxiliary components: potato starch, lactose monohydrate, calcium stearate.

The tablets appear to be flat-cylindrical in shape, creamy, white or yellowish in color. Packs of 30 and 10 pieces.

• One tablet contains the active substance (phenotropil) - 100 mg;
• Excipients: potato starch - 46.48 mg; lactose monohydrate (milk sugar) - 51.52 mg; calcium stearate - 2 mg.

Clinical and pharmacological group: nootropic drug.

pharmachologic effect

Since the drug has a gentle but effective effect on the body, it activates the integrative activity that occurs in the brain, taking it in doses prescribed by the doctor promotes memory consolidation.

The product can also significantly improve concentration readings. Mental work and activities related to scientific work, which require great dedication on the part of a person, become better.

The pharmacological action of the drug is aimed directly at influencing higher brain impulses sent by neurons and perceived by cells, which has a beneficial effect on the processes of learning new skills, making this process easier and faster.

In the process of taking the drug, there is a significant acceleration of the processes of information transfer occurring between the hemispheres of the brain, which in turn increases the resistance of brain tissue to such negative phenomena as hypoxia and toxic effects.

Additionally, Phenotropil tablets have an anticonvulsant effect and anxiolytic activity, effectively and efficiently regulate the processes of activation and inhibition of the central nervous system, which is a necessity for people with complex brain lesions. In particular, it helps epileptics cope with seizures.

The product also improves mood, relieving depression and neurotic manifestations.

The drug improves memory in general, enhances the ability to concentrate and remember.

Additional capabilities of the drug are expressed in reducing the toxic effect of some drugs and the hypnotic effect exerted on the body by ethanol and hexobarbital, lowering the threshold of pain sensitivity and increasing physical activity and human performance.

Pharmacokinetics of the drug

After entering the body, the drug is quickly absorbed and penetrates various organs and tissues. Its distinctive feature is absolute bioavailability, so if you take it orally, it will reach 100%.

Improvements will be noticeable within 1 hour after administration, and the maximum effect will occur after 2 hours. The effect of the product lasts on average 4 hours. Also, Phenotropil is not metabolized in the body. It is completely excreted from the body unchanged, about 40% in urine and 60% in bile and sweat.

Use during pregnancy and lactation

Phenotropil should not be prescribed during pregnancy and lactation (breastfeeding) due to the lack of clinical trial data.

Phenotropil does not have teratogenic, mutagenic or embryotoxic effects.

The use of Phenotropil during pregnancy and breastfeeding is undesirable, since there is no data from clinical studies on the use of the drug in pregnant and lactating women.

Phenotropil does not have mutagenic, embryotoxic or teratogenic effects.

Not recommended as there is not enough information about the safety of this product.

Mechanism of action

The drug has a pronounced anti-amnestic effect and has a direct activating effect on the activity and bioprocesses occurring in the brain. It has a positive effect on metabolic processes and blood circulation occurring in its cells.

Stimulates all biological processes necessary for proper functioning, including those associated with redox reactions. Taking the drug allows you to utilize glucose. An important feature of the use of the drug is the ability to increase the content of norepinephrine and serotonin without affecting other elements and substances.

Metabolic processes are normalized as a result of taking the medicine, since the drug has a beneficial effect on this area of ​​the body. The mechanism of action is also aimed at improving the supply of blood to brain cells, which contains the oxygen and nutritional components necessary for its stable and complete functioning.

The effect of the drug is mild, which is why it does not affect the functioning of the human respiratory system. The stimulating effect of substances is manifested in the ability to have an average effect in relation to motor functions and reactions, which, first of all, can be observed in increasing physical performance, the body’s resistance to stressful and other negative situations.

According to studies, some patients who used the drug to treat the nervous system had a positive effect on vision (improved indicators of acuity, brightness and clarity of perception).

The drug also improves blood flow and circulation in the lower extremities. Stimulates the body's natural production of antibodies - immunostimulating properties, without allergic manifestations on the part of the body. If the drug is used as a course of treatment, it does not lead to dependence and is not a cause for withdrawal syndrome.

The positive effect appears immediately with a single dose - this is very important when the need for emergency assistance arises. Does not have negative effects on the body, such as mutagenic or carcinogenic effects.

At the same time, it has low toxicity indicators, and a dangerous overdose of Phenotropil for life (lethal dose), identified experimentally, is 800 mg/kg.

And yet he exists: the strange story of Phenotropil

But in 2020, the cooperation between the company and the copyright holder - the author of the patent Valentina Akhapkina - ceased: she revoked the production license. Instead of the drug in pharmacies, consumers now found counterfeits, Chinese copies on iHerb (without proven equivalence) or fraudulent schemes on the Internet. According to Valentina herself, she made this decision due to the fact that the manufacturing company did not take active steps to further develop and research the drug, preferring to use existing data and developments. “The drug was not introduced into pediatric practice, new dosage forms were not developed and introduced,” she clarifies.

It is logical to assume that the story will end with Valentina Akhapkina creating her own company to produce the drug. She declared her foundation. 80% of the company’s shares belonged to Valentina herself, 10% each went to the second copyright holder, Roman Akhapkin, and the former general director of Valenta, Alexander Itin. But Phenotropil in their version never appeared on the shelves of pharmacies. A number of sites, such as this one, try to accept orders for the drug on behalf of the company. But they don’t inspire confidence at all. Reviews from angry anonymous people who paid money but never received their order also warn against them. And although angry comments, like advertising, may turn out to be fakes, this does not add credibility to the site.

Many other, no less dubious, sites, when asked whether Phenotropil will appear in pharmacies, without hesitation declare: “This will never happen.” This is explained by the fact that Valenta Pharm withdrew the drug from sale at the request of the copyright holder in 2020, which, as we found out, actually happened. But in fact, this story has a continuation.

Looking for a replacement

Since Valenta Pharm was a platform for the production of large quantities of the drug, and not the holder of a license, now the rights to the drug belong to Valentina Akhapkina. But, although this may seem paradoxical, this does not mean that no one else has the right to produce this substance. The fact is that the patent for Phenotropil allows the creation of generic drugs based on the same active substance called phenylpiracetam.

Indeed, on the website of the Russian Medicines Register you can see several similar analogues of the drug. “Entrop” from Latvia, which has the same active ingredient, is not imported to us, and Slim Story Prof from Teva, although registered in 2016, was never put into circulation. , “Mosmedpreparaty”, “Northern Star” at different times also conducted bioequivalence studies of their substances to show that their drugs are no worse than the original and act in the same way as it. Pharmstandard is now suing the Akhapkins for a patent.

Scope of application

Phenotropil is a substance that works with the most complex diseases related to pathologies of the brain and central nervous system. That is why the list of indications is formed mainly from diseases directly or indirectly related to the neurological profile.

Main indications for use of Phenotropil:

• various diseases of the nervous system;
• vascular diseases of the brain;
• metabolic disorders in the brain;
• post-traumatic disorders and central nervous system intoxication;
• chronic cerebrovascular insufficiency;
• impairment associated with physical activity;
• problems with attention, memory and ability to concentrate;
• neurotic problems (lethargy, decreased psychomotor capabilities);
• learning disorder;
• depressive states in different forms and degrees of severity;
• psychoorganic syndromes (including schizophrenia);
• tendency to seizures (epilepsy, convulsive syndrome);
• obesity;
• preventive measures (resistance to stressful situations);
• relieving the negative consequences of hypoxia;
• maintaining the body in extreme situations;
• disruption of natural biorhythms (including treatment of insomnia);
• alcohol dependence in chronic form.

The problems solved by the drug are complex and require special attention, so it is impossible to use the drug without prior consultation with a specialist.

special instructions

Long-term use of Phenotropil does not provoke dependence and addiction. A person does not need to increase the dosage of the drug, and does not suffer from withdrawal syndrome. When using the drug, there is no carcinogenic or mutagenic effect due to the long course in the standard dosage. The medicine is not toxic.

The results of experimental studies showed that the lethal dosage for humans is 800 mg/kg. The medication has absolutely no carcinogenic effect. The medicine greatly increases the beneficial effect of nootropics, as well as other drugs for the treatment of depressive conditions. Although combinations of such drugs must be approved by the attending physician.

Limitations for use

Since Phenotropil is a specific remedy that can fight complex diseases affecting the brain and central nervous system, it has a number of contraindications for use. They are taken into account by the doctor, so the drug is not always present in the treatment regimen for the above diseases.

Prohibited appointments are:

• the body's sensitivity to the components of the drug;
• pregnancy (as well as the period of feeding);
• childhood;
• severe damage to the kidneys and liver;
• severe forms of hypertension;
• atherosclerosis (in severe form);
• early panic attacks;
• acute mental disorders (anxiety, panic, hallucinations, delusions);
• allergic reactions.

Taking the drug in each of these cases is possible, but only under the constant supervision of a doctor. It is necessary to constantly take tests to prevent a negative response from the body.

Indications for use

Among the indications are neurotic conditions accompanied by:

• excessive lethargy and fatigue;
• deterioration of psychomotor activity;
• decreased memory quality;
• impairment of cognitive functions.

Depressive conditions and pathologies of the central nervous system, characterized by impaired blood supply and metabolism in the brain, are also indications for taking the drug.

The drug is prescribed for diseases characterized by impaired intellectual-mnestic function; if necessary, invert sleep and wakefulness; for convulsive diseases; with schizophrenia in a flaccid course, as well as with nutritional-constitutional obesity.

It is used in the process of prevention in stressful situations, hypoxia, as well as to stimulate physical and mental performance.

The indication for Phenotropil is psychoorganic syndrome, which is accompanied by apathy, lethargy and mental disorders.

The drug is prescribed for chronic alcoholism in order to reduce depression, asthenia, and also to improve intellectual and mnestic functions.

Should not be used in case of individual hypersensitivity to the components included in its composition.

Use with extreme caution in patients with impaired renal and liver function, atherosclerosis, acute psychotic conditions, and severe arterial hypertension.

Contraindicated for children and women during pregnancy and breastfeeding.

Various diseases of the nervous system, heart and vascular diseases, failure of metabolic functions in the brain, toxic effects on brain tissue, conditions after traumatic brain injury, atherosclerosis (blockage of cholesterol plaques) of brain vessels, deterioration of mental abilities, decreased muscle activity.

This also includes neurasthenic conditions of a person, decreased motivation, weakened psychomotor functions in various diseases, amnesia, any violations of short-term and long-term memory, difficulty learning and memorizing information.

Many psychological disorders, depressive episodes of varying duration and severity, apathy, schizophrenia, tremors (convulsions) of the limbs.

It is used to prevent disorders of oxygen saturation of brain tissue, for resistance to stressful situations, to increase the functionality of the body in extreme conditions, to restore biological

The drug is indicated for alcohol abuse, in order to reduce the negative impact on mental functions and suppress depression in alcoholism.

According to the results of some studies, taking Phenotropil has a positive effect on the results of recovery after a stroke. There were more patients with a history of stroke, and they did better than people in the control group taking a placebo in a “double-blind” study (neither the doctor nor the patient knows that the drug is a dummy drug and has no effect , if we are talking about the control group)

Hypersensitivity to the components of the drug, allergic reactions. During pregnancy and during lactation, the drug is prohibited, since the effect of Phenotropil on the course of pregnancy and the effect on the fetus has been poorly studied. The drug is contraindicated for children.

Particular caution should be observed when using the nootropic for people with severe renal and liver failure, with high blood pressure, with severe atherosclerosis, with exacerbations of panic, anxiety, schizophasia and hallucinatory-delusional syndromes.

• diseases of the central nervous system of various etiologies, especially of vascular origin or associated with intoxication and metabolic disorders in the brain (including chronic cerebrovascular insufficiency and post-traumatic conditions), in which there is a decrease in motor activity and a deterioration in intellectual and mnestic functions;
• learning disability;
• neurotic conditions, manifested by increased exhaustion, memory impairment, lethargy, impaired attention and decreased psychomotor activity;
• psychoorganic syndromes with apathetic-abulic symptoms and disorders in the intellectual-mnestic sphere;
• sluggish states in schizophrenia;
• depression of moderate and mild severity;
• convulsive conditions;
• chronic alcoholism (to reduce symptoms of depression, asthenia and intellectual-mnestic disorders);
• nutritional-constitutional obesity;
• increasing stress resistance;
• prevention of hypoxia;
• correction of daily biorhythms and regulation of the sleep-wake cycle;
• correction of the functional state of the body under conditions of extreme stress at work in order to prevent fatigue and increase physical and mental performance.

Phenotropil is contraindicated in case of hypersensitivity to its components.

The drug is prescribed with caution to patients with the following diseases and conditions:

• severe arterial hypertension;
• severe atherosclerosis;
• severe organic damage to the kidneys and liver;
• previous panic attacks and acute psychotic states with psychomotor agitation (possible exacerbation of panic, anxiety, delirium and hallucinations);
• tendency to allergic reactions to pyrrolidone nootropic drugs.

In accordance with the instructions for Phenotropil, this product should not be used in cases of increased individual sensitivity to the components included in its composition.

Instructions for use

The dosage and regimen of taking the medicine is determined by the doctor. Here you should take into account the characteristics of the body, the disease and its stage, and individual recommendations. The drug should be taken orally immediately after meals, as part of it is absorbed through the gastrointestinal tract.

The average dosage (based on 24 hours, unless otherwise stated in the recommendations) is 200-300 mg, no more than 200 mg can be taken at a time.

The maximum daily dose is 750 mg in any case, even if the disease is complex. In order to reduce the impact of components on the body, it is recommended to divide the total daily dose into two parts. The first appointment should be in the morning, the second – before 15.00.

The course of treatment lasts from 14 to 90 days (calculated by the doctor based on the patient’s examination). Repeating the course is possible after resting the body for 30 days.

To increase the body's performance in normal cases, 100-200 mg is prescribed once a day, with a course duration of 3-14 days.

If Phenotropil is taken for weight loss, the same dose should be taken for 1-2 months.

Reviews from our visitors who took Phenotropil provide some understanding of how to take the drug and why it is taken in practice.

I noticed that I had no strength to work, and apathy set in. After an examination, the doctor prescribed this drug. After a month of taking it, I somehow forgot that before I had to force myself to get up; motivation is not required for work.

a lion

There was a difficult period in my life - moving, getting a loan. Constant nerves and worries had a negative effect - irritability appeared. Now I have been treated with a course of the drug. I notice that I feel calmer about many things now.

Stas

Overdose and additional instructions for use

An overdose of Phenotropil has not been recorded in practice. On the first day of taking the drug, increased drowsiness may occur.

Side effects from taking Phenotropil:

• insomnia (if taken after 15.00);
• psychomotor agitation;
• hyperemia of the skin;
• feeling of warmth;
• increase in pressure.

You can use the drug together with alcohol, since the medicine is non-toxic, but it is important to observe moderation in drinking alcohol.
Phenotropil, when taken together, enhances the effect of drugs that themselves are intended to affect the central nervous system. Also, the effectiveness of various antidepressants and other drugs belonging to the groups of nootropics and neurotransmitters taken increases.

Price issue

The price of Phenotropil varies depending on the region and the number of tablets in the package, the average cost is from 475 to 1100 rubles.

Storage conditions for the drug are standard for most drugs - optimal conditions at room temperature (not higher than 30 degrees), out of the reach of children, protected from heat, light and water. The shelf life is no more than 5 years from the date of issue.

It is dispensed from pharmacies only upon presentation of a prescription, since the medicine is intended for the treatment of complex and specific diseases.