Ketoconazole suppositories - instructions for use, indications, dosages, side effects and analogues

Release form and composition

Ketoconazole, part of the imidazole chemical group, is highly sensitive to most opportunistic and pathogenic fungal microorganisms. Therefore, it is not only the main active component of the drugs of the same name, but is also part of many common antifungal medications, for example, Mycozoral and Nizoral ointments or Keto Plus and Sebozol shampoos.

You can buy Ketoconazole in pharmacies in the following dosage forms:

• 2% cream - a homogeneous white substance in tubes of 10, 15, 30 or 60 g,
• vaginal suppositories 2% - cylindrical suppositories of light yellow color, 5 pieces in plastic blisters,
• 200 mg tablets - round, white or cream-colored, 10 pieces in a blister.

The drugs are packaged in individual cardboard boxes, which also include detailed instructions for use.

Ketoconazole cream and suppositories are freely available, and tablets are available only with a doctor's prescription.

Approximate prices for medicine:

• cream – from 60 rubles for 15g,
• candles - from 400 rubles,
• tablets – from 150 rubles.

If the medication is stored in a cool, dark place, the shelf life is 36 months.

Ketoconazole during pregnancy

This antifungal medication is often prescribed to women during pregnancy, since in their case thrush progresses twice as often. Vaginal suppositories Ketoconazole are not recommended in the first trimester (up to the 12th obstetric week), since at such a short period they can disrupt intrauterine development and provoke a miscarriage. In the second and third trimesters, a synthetic antifungal agent is not prohibited, but the prescription should be carried out exclusively by the leading gynecologist. There are no absolute restrictions on breastfeeding in the instructions.

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pharmachologic effect

Penetrating inside pathogenic cells, ketoconazole destroys ergosterol, which makes up their membranes. This makes further reproduction of the fungal flora impossible and leads to the death of the entire colony.

Even with a single application to the affected areas, the drug has a fungistatic effect, preventing the spread of infection . The use of Ketoconazole for a long period has a fungicidal effect, destroying the spores and mycelium of the fungus.

The drug exhibits the greatest activity against the following microorganisms:

• Epidermophyton floccosum,
• microsporum,
• Trichophyton,
• Pityrosporum
• Candida.

Using the cream for external treatment does not lead to absorption of the active substance into the systemic bloodstream. When Ketoconazole suppositories are administered intravaginally, a slight presence of the active component in biological fluids is observed.

In the case of oral administration of tablets, the best penetration is observed when they are taken simultaneously with food. The maximum concentration of the active substance is observed after 1.5 – 2 hours.

Metabolism of the components occurs in liver cells, and the medicine is excreted from the body with bile and feces.

Reviews

Marina, 32 years old

I was prescribed these suppositories during pregnancy. The drug has a rather temporary effect: while you are using it and 2 weeks after, no unpleasant symptoms of thrush are observed. Time passes, and the disease recurs again. After giving birth, I no longer encountered this problem, so I cannot give an objective assessment of the treatment.

Svetlana, 35 years old

I regularly use these vaginal suppositories for candidiasis and am very pleased with the results of the treatment. There is no addictive effect, and after 3 suppositories at night, the unpleasant itching and burning sensation in the vagina imperceptibly disappears. The price of the suppositories is affordable, so I am all for such an effective treatment of a fungal infection, especially since everything is fast.

Ulyana, 29 years old

After Ketoconazole, my thrush situation only got worse. The itching became unbearable, and a skin rash also appeared. Seeing such side effects, the attending physician replaced my suppositories with Livarol vaginal tablets. I was very pleased with this appointment, since the symptoms of thrush disappeared after the second session at night.

Indications for use

Each form of the drug is used to treat certain fungal diseases:

• the cream is effective against dermatomycosis and skin candidiasis, pityriasis versicolor and versicolor, inguinal athlete's foot, seborrhea,
• suppositories are used for vaginal candidiasis,
• tablets are used to treat onychomycosis, dermatophytosis, microsporia, and coccidioidomycosis.

Ketoconazole tablets and cream can be used as a prophylactic agent to prevent fungal infections in immunocompromised individuals, including those infected with HIV.

What and how to take for thrush?

Thrush is a disease caused by a fungal infection called Candida albicans. These are yeast fungi that can live almost anywhere - the mucous membrane of the oral cavity, intestines, vagina, and skin surface.

And this is considered normal, since these fungi, with moderate growth, protect the body from external unfavorable factors and help improve immunity, breaking down and helping to absorb vitamins and minerals. Thrush occurs when these microorganisms grow uncontrollably.

Contraindications

People over 60 years of age and those suffering from adrenal or pituitary dysfunction should take the drug with caution.

The use of any of the dosage forms of Ketoconazole should be discontinued if the patient has an individual intolerance to one or more components. Each of them has its own contraindications.

Candles:

• the first three months after conception,
• lactation period,
• age less than 12 years.

Cream - the presence of open wounds, ulcers or boils at the site of intended application.

Pills:

• pregnancy,
• lactation,
• children up to 3 years old,
• the presence of pathologies of the liver and bile ducts.

Price for Ketoconazole suppositories

There are many real reviews in which patients praise Ketoconazole treatment. One of the arguments is the affordable price of the antifungal drug and its constant availability in city pharmacies. Below are retail prices for Moscow, which help women quickly make their choice and not delay the start of intensive care. So:

Directions for use and dosage

The dosage and method of using the drug Ketoconazole depend on the diagnosis, severity of the disease, the presence of concomitant pathologies in the patient and other factors. Therefore, a doctor should prescribe the drug after a thorough examination and study of laboratory test results.

You can find out how to use each type of medication in the instructions for use.

Cream

The product is applied to clean, dry skin in a thin layer, lightly rubbing in with your fingertips. In this case, it is necessary to capture not only the lesion, but also healthy skin around the perimeter in order to stop the spread of infection. For onychomycosis, the cream is applied to the affected nail and left for 5 minutes to absorb.

Frequency of procedures: for dermatomycosis, athlete's foot and lichen – 1 time per day, for seborrhea – 2 times per day.

Approximate duration of treatment for various diseases:

• dermatomycosis of smooth skin – 1-1.5 months,
• epidermophytosis of the inguinal zone – 3-4 weeks,
• fungal infections of the extremities – 6-8 weeks,
• seborrheic dermatitis – 2-3 weeks,
• candidiasis – 3-4 weeks.

Doctors recommend applying Ketoconazole cream for preventive purposes for another week after all symptoms of the disease have disappeared.

Suppositories

To treat vaginal candidiasis, suppositories are administered 1 piece per day for 5-7 days. It is best to do this while lying down so that the drug can penetrate as deeply as possible.

Pills

For uncomplicated diseases, it is recommended to take 1 tablet (200 mg) once a day. You need to drink the medicine during meals for better absorption of the main active ingredient.

If the disease has progressed to an advanced form, as well as for vaginal candidiasis, the daily dose is 400 mg or 2 tablets.

Duration of treatment for oral administration:

• dermatomycosis – 1-1.5 months,
• candidiasis of the skin and mucous membranes – 3 weeks,
• systemic mycoses – up to 3 months,
• lichen – 2 weeks,
• onychomycosis – from 2 to 12 months.

For preventive purposes, the dosage of the drug is 1 tablet per day for 10-15 days.

In children

Suppositories and cream are not used to treat fungal infections in children under 12 years of age.

Ketoconazole tablets are used in pediatric practice only from the age of three. In this case, for children weighing less than 30 kg, the daily dose is halved, amounting to 100 mg or ½ tablet.

For patients with a body weight of more than 30 kg, the dosage does not differ from that for adults.

During pregnancy and lactation

You can use the cream for external treatment of fungal lesions during the entire period of pregnancy.

During lactation, do not apply the product to the mammary glands before feeding the baby. The slightest possibility of the cream getting into the baby’s mouth should be excluded.

Vaginal suppositories are not used in the first 3 months after conception. In the future, their use is possible only as prescribed by a dermatologist and under the supervision of a supervising physician.

It is strictly forbidden to take tablets during pregnancy and breastfeeding.

Is it possible to use pimafucin suppositories rectally?

When treating thrush, they most often resort to the use of local remedies in various forms. Suppositories (candles) are the most popular. They can be vaginal or rectal. The first type of drugs is used in the presence of thrush in women. Rectal suppositories can also be used for men, since candidiasis can affect the intestines and many other organs.

Rectal suppositories for thrush are used in many cases, which include:

• for women as an additional measure in the presence of candidiasis affecting the genitourinary system;
• if yeast-like fungi are found in the intestines. Candles will be effective when the problem is localized in its lower sections;
• as a preventive procedure for a potential sexual partner. In this way, you can influence some hidden pathologies and protect yourself from them.

In many cases, rectal suppositories are prescribed specifically in the presence of intestinal candidiasis. This disease has the ability to quickly spread to other parts of the digestive system or affect the entire body. Therefore, it needs to be quickly diagnosed, and then specific treatment must be started.

If you have the following symptoms, you should consult a doctor who can correctly assess the current situation and prescribe the best medications for a quick recovery:

• the appearance of painful sensations in the abdominal area, the development of significant discomfort, a feeling of fullness;
• a person complains of poor appetite;
• after each meal there is a feeling of heaviness;
• the chair changes its character. Very often a person develops diarrhea, white lumps or flakes are found in the stool;
• even after going to the toilet, a person does not leave the feeling of fullness in the intestines;

• increased gas formation is observed;
• a person suffers from colic, abdominal cramps;
• the patient usually sweats a lot;
• due to poor health, a person may become irritable and suffer from insomnia;
• if candidiasis has spread to the outer covering, a white coating is found near the anus. In this case, the anus will itch;
• With the development of a chronic pathological process in a person, acne and inflamed areas of the skin are found throughout the body.

Intestinal candidiasis occurs only when certain pathological processes are present in the human body or some external influence is observed. Based on this, the following causes of thrush are identified:

• pathological change in intestinal microflora. This can happen due to poor diet, after taking antibiotics and due to other reasons;
• decreased protective functions of the body;
• the presence of concomitant diseases of various organs - gastrointestinal tract, genitourinary system, endocrine disorders and others;
• specific allergic reactions;

• the development of oncology or the appearance of certain problems with the circulatory system;
• defeat by various infections of the digestive system. For example, these include intestinal flu;
• sudden climate changes;
• poor environmental conditions;
• stress, prolonged depression, which negatively affects human immunity.

When treating a fungal infection that has affected the intestines or other organs, an integrated approach should be used. It is necessary not only to relieve all the unpleasant symptoms of the disease, but also to eliminate the cause of its occurrence. Otherwise, candidiasis will return over time, which indicates the development of its chronic form.

When treating thrush, local remedies are often preferred. Unlike systemic drugs, they do not affect the body as a whole, which eliminates many negative consequences.

Rectal suppositories are relatively safe. They are characterized by a local effect on problem areas, which guarantees a quick cure.

Another advantage of these products is that most of their active components are excreted from the body along with feces.

The most popular and effective drugs are those that contain the following active ingredients:

When using rectal suppositories for thrush, you should adhere to the following rules:

• These drugs are considered potent, so only a doctor can prescribe them. Self-medication may not only not bring a positive result, but also often causes harm.
• Before using suppositories, you should carefully study all their contraindications and side effects. If you have concomitant diseases, you must inform your doctor about them.
• When prescribing antifungal suppositories, you should complete the entire course of treatment. Stopping these medications prematurely often leads to relapse of the disease.

• Women using rectal suppositories do not need to interrupt treatment during menstruation.
• The positive result from therapy for thrush with suppositories is noticeable already 1-2 years after its start. This is explained by the elimination of the source of infection, which is localized in the lower intestines.
• Suppositories for thrush are affordable drugs. They are sold from pharmacies at a low price and without a prescription.

• Using rectal suppositories for candidiasis will not cause difficulties for any person.
• Many suppositories for thrush contain substances that can destroy not only yeast-like fungi, but also other pathogenic microorganisms.
• Depending on the degree of development of thrush, the course of treatment with rectal suppositories ranges from 3 days to 3 weeks. In the chronic form of candidiasis, therapy can be carried out several times with short breaks. In any case, the duration of treatment should be determined only by a doctor.

Regardless of the active ingredient of suppositories and their properties, the use of these drugs is carried out as follows:

1. Before using candles, you should thoroughly wash your hands and anal area.
2. Suppositories melt upon contact with hands. Therefore, before use, it is recommended to hold them under running cold water directly in individual packaging. You can also pre-put the candles in the refrigerator for 30-40 minutes.
3. For better penetration into the anus, the tip of the candle should be lubricated with a lubricant that does not contain petroleum jelly. If you don't have it, you can use cool water. The anus is moistened with it before inserting a rectal suppository.
4. To use suppositories, you should lie on your side, extend your lower leg, and tuck your upper leg as close to your stomach as possible. The suppository should be inserted as deeply as possible to achieve the best treatment result.
5. Most medications are recommended to be used once a day at bedtime. In more severe cases, another treatment regimen is used - 2 times a day (morning and evening).
6. After inserting the suppository into the anus, you should take a horizontal position for several minutes. There is no need to remove the remaining suppositories, since they leave the intestines on their own during bowel movements.

When using rectal suppositories to treat thrush, it should be taken into account that they have some contraindications. Many drugs are prohibited for use in the following cases:

• the presence of individual intolerance to certain components of the drug;
• childhood;
• in the presence of severe diseases of the liver, kidneys, thyroid gland;
• pregnancy and lactation (some drugs are allowed);
• in the presence of serious intestinal pathologies.

In some cases, when using rectal suppositories to treat thrush, the following negative consequences occur:

• itching, burning sensation and discomfort near the anus;
• the development of allergic reactions that manifest themselves on the skin as rash, itching, inflammation, swelling, etc.;
• increased sweating;
• chills;
• slight changes in body temperature;
• general malaise, the appearance of causeless fatigue;
• development of pain in the lower abdomen;
• bowel disorder. Diarrhea or, conversely, constipation may appear.

If such negative consequences occur, you should interrupt the course of treatment and consult a doctor. He will select another drug that will not cause such side effects. The disappearance of unpleasant symptoms when using inappropriate suppositories usually occurs 1-3 days after their discontinuation. Relief comes on its own, without the use of auxiliary means.

There are many rectal suppositories that are considered quite effective in treating thrush in men and women.

Pimafucin is an effective antifungal drug that belongs to the macrolide group. It contains natamycin, which provides a fungicidal effect. When using such rectal suppositories, the absorption of their active substances by the intestinal walls is completely excluded. They have an exclusively local effect on problem areas, which is an important feature.

After administration of suppositories, they dissolve quite quickly under the influence of body temperature. As a result, the mucous membranes are enveloped in a foamy mass, which leads to an increase in the effectiveness of the product.

Given the content of cetyl alcohol in the suppositories, they may cause a slight burning sensation. Despite this, Pimafucin can be used to treat pregnant women and those who are breastfeeding.

Ginesol is an effective antifungal drug that contains miconazole (the main active ingredient). The advantage of this drug is that it is poorly absorbed by the intestinal walls. Miconazole is not detected in urine or blood.

When using Ginezol as a treatment in the presence of diabetes mellitus, you should regularly undergo appropriate tests to monitor the patient’s condition. If any indicators worsen, it is recommended to interrupt therapy. Also, such rectal suppositories are contraindicated in the presence of herpes and in the first trimester of pregnancy.

Viferon is a modern remedy that is used to treat thrush at any stage of its development. It differs significantly in composition from many other drugs for candidiasis.

Viferon is made with the addition of cocoa butter, vitamins E and C, and interferon.

This composition allows rectal suppositories to directly affect all pathogenic bacteria and fungi, naturally enhancing the body’s protective functions.

Such suppositories are most often used as part of complex therapy for candidiasis.

When using Viferon, you can significantly reduce the dose of aggressive agents that have a negative effect on the human body (antibiotics, hormonal drugs, etc.).

These rectal suppositories have almost no contraindications. They are just not recommended for use in the first trimester of pregnancy and in the presence of individual intolerance.

Contains ketoconazole, which provides an antifungal effect. These suppositories have an exclusively local effect and produce almost no systemic effects.

In addition to the deadly effect on some fungi, the drug is active against streptococci and staphylococci. Therefore, it can also be classified as an antibacterial drug.

Therefore, Livarol will be effective when the disease has a mixed etiology.

These suppositories are characterized by a minimal number of contraindications and side effects, so they can be taken without fear if candidiasis develops.

The main active component of Clotrimazole is a substance that produces an antifungal effect.

Even in a minimal dosage, this drug slows down the proliferation of pathogenic microorganisms, and when sufficient, it completely destroys them.

The advantage of these suppositories is their selectivity of action. The suppositories completely destroy Candida fungi, but do not in any way affect the beneficial microflora.

When using Clotrimazole, you should completely avoid alcohol and not combine it with other antifungal agents, which can significantly worsen the quality of treatment. It is also not recommended to take this drug if you have serious liver problems, during pregnancy or while breastfeeding.

source

Have you been fighting thrush for many years without success?

Head of the Institute: “You will be amazed at how easy it is to cure thrush by taking it every day.

Suppositories for thrush during pregnancy are the most effective method of local treatment. The effectiveness of this treatment is based on the profound effect of the active antifungal substance. Local drug therapy allows not only to destroy the pathogen and relieve the symptoms of candidiasis, but also to quickly eliminate inflammation.

Source: //rustland.ru/raznoe/mozhno-li-primenyat-svechi-pimafutsin-rektalno/

Overdose

Exceeding the amount of cream applied to the skin does not affect the general condition of the body, since the active substance does not enter the circulatory system with this form of use. The same applies to Ketoconazole vaginal suppositories.

If the patient accidentally swallows suppositories or cream, it is necessary to induce vomiting and apply symptomatic treatment, including enterosorbents such as Sorbex, Enterosgel, and activated carbon.

An overdose of a tablet drug is extremely undesirable, as it can lead to the development of adverse reactions from all body systems. Gastric lavage and symptomatic therapy are recommended. In particularly severe cases, it is necessary to seek medical help.

Adverse reactions

In some cases, when using the cream, redness and dryness of the skin, itching and slight burning may occur. After discontinuation of the drug, these symptoms usually disappear without a trace.

Intravaginal use causes irritation of the genital mucosa and itching in some patients, which also do not require special therapy.

Taking pills can cause serious consequences from almost all body systems, including:

• indigestion, vomiting, diarrhea,
• acute liver and kidney failure,
• anaphylactic shock,
• headache, insomnia, nervous agitation,
• sexual dysfunction,
• dermatitis, alopecia, urticaria,
• painful sensations in joints and muscles.

In all of these cases, you must immediately stop using the drug and consult a doctor to change the medication.

Are there any contraindications and side effects?

Thrush is an infection that affects the mucous membranes and skin. Microscopic yeast-like fungi of the Candida species exist in a dormant state, without showing activity, in the body of almost every person, and only with the appearance of provoking factors do they begin to multiply intensively. From our article you will learn how to quickly and effectively get rid of thrush.

Effective treatment

If you experience early symptoms of thrush, you must immediately see a doctor and begin treatment so that the infection does not become chronic. Only a doctor can prescribe an effective remedy for thrush. It should also be remembered that thrush often affects nearby organs, such as the intestines or bladder, that is, treatment must be carried out comprehensively and completely get rid of the fungus, eliminating all predisposing factors. Capsules, suppositories, ointments and tablets are used to treat candidiasis.