Instructions for use of Gepazolon suppositories

Gepasolone in suppositories and ointments is considered one of the affordable and effective ways to get rid of hemorrhoids. The peculiarity of this medication is the insignificant manifestation of side effects on the body.

In pharmacology, there are many different medications for hemorrhoids, in the form of:

• suppository (suppositories),
• gels,
• ointments.

Release form, composition and packaging

Gepazolon has two forms of release - ointment and suppositories:

1. The ointment is used in the treatment of hemorrhoidal tumors localized on the surface of the anus.
2. The drug Hepazolon in the form of suppositories is used in case of intraintestinal hemorrhoids.

The main components of the medicine are:

• prednisolone (1.7 mg.),
• heparin sodium (120 IU.),
• lidocaine hydrochloride (20 mg.).

These basic substances have a general beneficial effect on this type of disease and contribute to the formation of the suppositories.

The candles are distributed into blister cells of 5 pieces. and packed in cardboard packs of two blisters. The ointment is filled into aluminum tubes.

Composition of the drug

Regardless of the release form (ointment, suppositories), the content of active substances is identical:

1. Lidocaine hydrochloride. It is a local anesthetic by blocking sodium channels.
2. Prednisolone. Known as an anti-inflammatory component, it effectively fights itching and discomfort, and has an antihistamine effect.
3. Heparin. Aimed at eliminating edema and blood thickening, preventing blood clots. Effectively heals damaged surfaces of tissues and blood vessels.

pharmachologic effect

Antithrombotic, combined agent Gepazolon, its pharmacological property has an anti-inflammatory effect on the affected area.

Component Heparin:

• Prevents the formation of blood clots.
• Stops blood coagulation in hemorrhoids.
• Has an anti-edematous effect.
• Has a beneficial effect on the regeneration of connective tissue.
• Promotes healing.
• Reduces relapses.

Prednisolone is related to synthetic glucocorticosteroids. The component cleanses tissues of toxins and affects areas of inflammation.

Due to this:

• the release of exudate decreases,
• the feeling of pain disappears,
• the burning sensation is eliminated.

Prednisolone also treats other unpleasant symptoms caused by tissue inflammation.

Lidocaine is an anesthetic component of the drug Gepazolon, which copes well with pain. It is an obstacle due to inhibition of conductivity by sodium blockade in nerve fibers and endings. The antiarrhythmic effect lies in the ability to increase the permeability of membranes to potassium.

Pharmacodynamics

Heparin enters the wall of the anal intestine for some time. After which it enters the liver, subsequently into the kidneys and is excreted naturally (heparin -1.5 hours, prednisolone, 18–36 hours).

In this method, the use of lidocaine - about (35%) is introduced into inflammatory foci. A significant concentration in the blood occurs within 2-2.5 hours, is quickly absorbed in the liver, and is excreted through urination, some with feces.

According to recent studies, 80% of modern people over 25 years old have hemorrhoids. For some it is already clearly expressed and even causes some inconvenience, for others it is just developing. One day, a moment comes when the pain becomes unbearable, and the person still has to go to the clinic. To avoid having to undergo surgery, people who have learned through bitter experience use to treat hemorrhoids at home... Read more >,>,

Pharmacological properties of the drug

Suppositories are inserted into the rectal cavity. The therapeutic effect of the drug is based on reducing pain caused by progressive inflammation of hemorrhoids, relieving swelling and inflammation, and preventing the formation of blood clots.

Heparin, which is part of the drug, thins the blood in inflamed hemorrhoids, which helps prevent the development of thrombosis and congestion. This substance relieves swelling well, enhances the regeneration processes of rectal tissue, accelerates the healing process and significantly reduces the risk of relapse.

Prednisolone, which is part of the drug, is a semi-synthetic glucocorticosteroid and helps reduce the severity of the inflammatory process. Under the influence of this substance, swelling and pain are eliminated, itching, burning and the sensation of a foreign body in the anus are reduced - symptoms characteristic of progressive hemorrhoids.

Lidocaine, which is part of the suppository, has a pronounced analgesic effect. Thanks to the combination of 3 active ingredients of the suppository, the drug quickly cures hemorrhoids and serves to prevent the development of relapses of the disease.

Indications for use

Gepasolone - a medicine in the form of suppositories is used in the treatment of hemorrhoids regardless of gender and age category (excluding children under 12 years of age, pregnant and breastfeeding women).

Depending on the course of the disease, namely:

1. If itching or burning occurs in the anus as a result of inflammation.
2. Before surgery for the purpose of preparation.
3. With exacerbation of internal and external hemorrhoids.
4. Thrombophlebitis of the veins in the anus.
5. Rectal fistulas connecting the area of ​​inflammation of the rectum.
6. Anal fissures.
7. Eczema in the anorectal area.
8. Complex therapy in the treatment of hemorrhoids.
9. Superficial application to the anus.

Method of administration and dosage of the drug

The duration of the course of therapy with suppositories and the daily dose of the drug are determined by the doctor individually, depending on the severity of hemorrhoids, the characteristics of the body and a number of other factors.

According to the instructions for the treatment of acute inflammation of hemorrhoids, the suppository is administered into the rectum 2 times a day after preliminary bowel movement. If the patient suffers from constipation, then doing cleansing enemas is contraindicated for hemorrhoids! In this case, the patient is prescribed a mild laxative based on lactulose.

If the inflammatory process spreads outward or hemorrhoids prolapse, the suppository is inserted only halfway, leaving its tip outside. The patient is recommended to lie down for 40 minutes after inserting the suppository to ensure even distribution of the medicine over the affected area.

According to the instructions, treatment with the drug can last no more than 7-10 days; in some cases, according to the doctor’s indications, Gepazolon therapy is extended to 2 weeks.

Use of the drug during pregnancy and lactation

The use of the drug hepazolon while a woman is carrying a child is unacceptable. In medicine, there is no data on the safety of the effect of the active ingredients of the drug on the intrauterine development of the fetus. If hemorrhoids become inflamed or anal fissures develop, the expectant mother is advised to consult a doctor to prescribe an alternative medicine that is not dangerous to the fetus.

The use of Gepazolon suppositories during breastfeeding is prohibited. If therapy with this drug is necessary for a nursing mother, it is recommended to stop lactation and transfer the child to artificial feeding.

Contraindications

But it is also important to know that Gepazolon has its contraindications, namely:

• fungal,
• viral.

Not used for infectious processes of the anorectal area. Cannot be used due to impaired coagulation function, with a tendency to frequent manifestations of blood.

It is also not advisable to use Gepazolon:

• period of breastfeeding and pregnancy,
• before reaching 12 years of age,
• allergic reaction to the components.

You should take into account everything that is contraindicated, and also use the medicine without a doctor’s recommendation.

Analogs

There are no analogues identical to the active substance, substitutes according to the mechanism of action:

Aurobin

Available in the form of suppositories, ointments, active ingredients - prednisolone, dexpanthenol, lidocaine, triclosan.

Combined drug for the treatment of anal fissures, fistulas, inflammation, eczema, itching, redness, pain in the anal area.

Use 2 suppositories 2 times a day for 7 days. The duration of treatment is determined by the doctor depending on the patient’s condition and the severity of the pathology.

Side effects: suppression of adrenal function, allergic reaction, headache, sleep disturbances, vasodilation.

Contraindications: hypersensitivity to the drug, fungal, viral, bacterial lesions of the skin, vaccination period, skin tumors, pregnancy up to 12 weeks, Cushing's syndrome, age up to 1 year.

Gepatrombin G

Available in the form of suppositories and ointments, the active ingredients are prednisolone acetate, sodium heparin, lauromacrogol 600.

The medicine belongs to a group of drugs with venosclerosing, antithrombotic and anti-inflammatory effects. Gepatrombin G is prescribed for the treatment of internal and external hemorrhoids, thrombophlebitis of the anal veins, itching, eczema, fistulas, fissures in the anus.

For adults, suppositories for hemorrhoids are prescribed 1 piece 1-2 times a day after bowel movements, depending on the severity of the pathology. The course of treatment is 7 days.

Side effects: hyperemia of the skin, allergic reaction in the form of redness, rashes, itching.

Contraindications: fungal, bacterial, viral lesions of the skin, syphilis, tuberculosis, skin tumors, bleeding tendency, reaction to vaccination, pregnancy up to 12 weeks, intolerance to the active and auxiliary components of the drug.

Nigepan

Available in the form of suppositories, the active ingredients are sodium heparin and benzocaine.

A combined drug with a pronounced antithrombotic and local anesthetic effect. Prevents the formation of blood clots, reduces vascular permeability, improves microcirculation, relieves swelling and inflammation. It is used for burning and itching in the anus, prolapse of hemorrhoidal cones, pain and bleeding, thrombosis of internal and external nodes.

Used rectally after defecation, 1 suppository twice a day. Duration of therapy is 10-14 days. Before administration, you need to moisten the suppository in water for 15-20 seconds.

Side effects: allergic reaction.

Contraindications: tendency to bleeding, intolerance to the components of the drug, pregnancy, lactation.

Instructions for use

The drug is used for:

• treatment of fistulas,
• eczema of the anorectal area,
• thrombophlebitis of hemorrhoidal veins,
• anal fissures.

Use of the medication Gepazolon in the form of an ointment is used for external hemorrhoids.

This requires applying 2-3 times a day to the affected area.

In this case, before application, you should resort to hygiene procedures:

• washing the anal area with warm water and soap,
• dry with a towel,
• then apply Gepazolon.

Suppositories are used for internal administration; before the procedure, the intestines are completely emptied of feces, using an enema or naturally. You can also use ointment for internal education.

The duration of therapy lasts 7 days; before increasing the course of treatment, you should consult a specialist.

Pharmacological properties of the drug

Before using Gepazolon suppositories, the patient should carefully study the instructions. Indications for the use of this drug are the following conditions:

• Inflammation of hemorrhoids – external and internal hemorrhoids;
• Weeping anal fissures that heal poorly and cannot be treated with other drugs;
• Fistulas caused by the progression of the inflammatory process (proctitis, paraproctitis);
• Thrombophlebitis of hemorrhoidal veins;
• As a prophylactic agent in preparation for operations on the perianal area;
• Eczema of the perianal zone;
• Prolapse of hemorrhoids.

Side effects

Side effects caused by one of the components of Gepazolon appear in the form of an allergic reaction.

Allergies cause:

• swelling,
• itching,
• burning.

With such indicators, it is necessary to complete therapy and be sure to contact a proctologist.

Adverse side effects from Gepazolon ointment and suppositories can be caused by the prednisolone component as a result of therapy for about a month.

If you ignore the instructions and use Gepazolon suppositories for a long time, pathologies appear:

1. Sweating.
2. Dizziness.
3. Hypokalemia.
4. Itsenko-Cushing syndrome.
5. High blood pressure.
6. Decreased calcium in the blood.
7. Suppression of the adrenal cortex.
8. Steroid diabetes mellitus.

Failure to comply with the rules for using the medication Gepazolon leads to serious consequences and before self-medication, you should immediately consult your doctor.

Action

The therapeutic effect is due to the active components that are included in the drug:

• Heparin - prevents the formation of blood clots, relieves swelling and inflammation, thins the blood, reduces the number of exacerbations of the disease, accelerates tissue regeneration.
• Prednisolone is a synthetic glucocorticosteroid with an average duration of action. It reduces the secretion of exudate, reduces the risk of developing allergies, relieves inflammation, relieves burning, itching and pain in the anorectal area.
• Lidocaine – has a local analgesic effect.

Use during pregnancy and breastfeeding

In this case, the drug Gepazolon is excluded due to the content of glucocosteroids. Prednisolone crossing the placental barrier can negatively affect the fetus.

During pregnancy it is better to use other means, for example:

• Natalsid.
• Candles with sea buckthorn oil.

While breastfeeding, it is advisable to refrain from using Gepazolon. Glucocosteroids that pass into mother's milk can harm the baby's health.

If using medication, it is better to switch the baby to infant formula.

Side effects

If you follow the instructions for use, the likelihood of side effects is low. Unpleasant symptoms occur with an overdose of prednisolone, more often if the treatment lasts about a month.

With prolonged use, disorders of the nervous, cardiovascular and endocrine systems appear. Possible side effects:

• excess production of adrenal hormones;
• metabolic disease;
• decreased levels of calcium and potassium in the body;
• adrenal dysfunction;
• diabetes;
• increased sweating;
• arrhythmia or bradycardia;
• increased blood pressure;
• weakness, sleep disorder;
• headache and dizziness;
• local allergic reaction in the form of skin rash, irritation, itching and burning.

With prolonged use, changes in heart rhythm are noticeable on the ECG.

If you follow the regimen developed by your doctor, the drug is well tolerated. If unpleasant symptoms occur, the dosage should be adjusted.

Interaction with other drugs

The main caveat in using Gepazolon is that it cannot be combined with other medications.

They can also thin the blood, which can lead to a risk of severe bleeding in the rectal area.

The combined use of Hepazolon with hormonal medications is undesirable.

Interaction with this group of drugs involves a sharp increase in the likelihood of pathologies occurring in the adrenal cortex.

Alcohol compatibility

Many people believe that hemorrhoids and alcohol have nothing in common. But this is not so, its use during the course of use slows down the healing process.

May cause worsening of the disease. Alcohol is also a provoking agent for its appearance.

What to do if you become a victim of an insidious disease

First of all, don’t panic and don’t give up. It should be remembered that nerves are one of the root causes of the development of many ailments. “The enemy is not as terrible as he seems,” says popular wisdom. And indeed it is! But still, before starting treatment, you should consult with a specialist who will tell you about the disease itself and how to eliminate it. What is this “terrible enemy”?

Hemorrhoids can be described as a disease characterized by dilation of the veins in the lower part of the rectum, resulting in the formation of nodes that may bleed from time to time. According to statistics, every fourth person is susceptible to this disease. All this is due to the presence of a huge number of sedentary professions: office worker, accountant, driver, programmer. In addition, people spend a lot of time in front of TV, without thinking at all about what this can lead to. The disease can develop due to dysfunction in the flow of blood to the cavernous bodies (vascular factor), which can be caused by a sedentary lifestyle. You can get sick if you have enlarged hemorrhoids (mechanical factor).

The main problem is that this disease begins unnoticed in many cases. It may take months or even years until it is discovered. Therefore, it is very important to undergo timely examinations in order to find out about this disease in the early stages of its development.

1. First stage: internal hemorrhoids. This stage goes unnoticed, and can only be discovered by chance, when presenting with complaints not related to hemorrhoids.
2. The second stage is characterized by itching and burning in the anus, and minor bleeding occurs.
3. Third stage: external hemorrhoids. The distinctive symptom is prolapse of hemorrhoids, requiring manual reduction.
4. Last stage: acute hemorrhoids. Here it is no longer possible to reduce the nodes; the course of the disease is also complicated by thrombosis. As a rule, surgical intervention is recommended in such situations.

Nowadays, the following methods of treating this disease are available:

• photocoagulation;

• sclerotherapy;
• latex ligation;
• suture ligation;
• mucosal resection;
• hemorrhoidectomy;
• conservative treatment.

Experts inform: when blood becomes noticeable in the stool, you should immediately visit a proctologist, since blood can be observed not only in the case of hemorrhoids, but also in malignant intestinal tumors.

We can draw the following conclusion: if you notice symptoms that indicate an imbalance in the functioning of the body, you should immediately see a doctor, because in the early stages you can avoid complications and prevent the development of the disease with medication. This is where Gepazolon can come to the rescue.

special instructions

People who have had an allergy to selective 5-HT3 receptor blockers in the past have a high likelihood of developing them against the background of ondansetron, which slows down the motility of the large intestine, and therefore a patient with intestinal constipation requires special attention.

Before using Gepazolon ointments and suppositories, it is recommended to follow hygiene rules, if possible, do not lift or carry heavy objects yourself.

Do not chill the anal passage; in case of sedentary work, get up and walk as often as possible.

The use of the drug Gepazolon must be agreed upon with a proctologist. You also need to observe precautions and contraindications.

Conditions for dispensing from pharmacies

Gepazolon is available in all pharmacies without a prescription. Since it is not a narcotic or psychotropic drug.

Storage conditions and shelf life

Gepasolone and all medications must be stored dry and protected from direct light.

The storage temperature should be 25°C and it should be kept out of the reach of children. The shelf life is no more than 2 years from the date of manufacture.

Description and composition

Medical practice provides for drug treatment only of the first and, with some convention, the second stage of hemorrhoidal inflammation. If the third stage occurs, surgery is required.

To alleviate the patient's condition, proctologists prescribe various medications, which may include ointment, gel, rectal suppositories and tablets for internal action. The choice of drug depends not only on the stage of the disease and the individual characteristics of the patient, but also on its type. For hemorrhoids, Gepazolon is usually used for both external and internal inflammatory processes.

Rectal suppositories are produced in a form convenient for administration and contain the components necessary for the treatment of hemorrhoids:

• sodium heparin,
• lidocaine,
• prednisolone.

The combination of these three components is the key to successful treatment of hemorrhoidal inflammation, both external and internal. It is their combination that determines the pharmaceutical effect of the drug as a whole. Heparin is the main substance used to prevent the formation of blood clots. It prevents blood from thickening and thins it. In this regard, the resulting hemorrhoids are reabsorbed, within which inflammation occurs. In addition, with the help of heparin, tissue in the anal area is restored, and swelling is also relieved. In the presence of cracks and damage to the anal mucosa, heparin actively promotes their healing.

As an anesthetic ingredient, Gepazolon contains lidocaine, known for its anesthetic abilities. This substance is especially indispensable if rectal suppositories are prescribed for hemorrhoidal exacerbation. With the help of initial use, you can significantly alleviate the patient’s condition and relieve discomfort in the anal area with severe pain.

Prednisolone is a well-known type of glucocorticosteroids that have an average duration of action.

In fact, it is a synthetic hormone with which you can relieve:

• irritation,
• pain in the area of ​​inflammation,
• burning and itching.

In addition, prednisolone not only removes the symptoms of hemorrhoidal inflammatory processes, but also reduces their severity.

Thanks to such a successful combination of ingredients, the use of Gepazolon suppositories allows you to achieve fairly quick results. Their use during exacerbation of hemorrhoids of the first or second stage alleviates the patient’s condition after 3-4 days of regular use. Complete recovery, depending on the presence of complications, may occur within a week.

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