Ketonof-LF tablet p/o 10 mg No. 20

pharmachologic effect

Non-steroidal anti-inflammatory drug for external use.

It has analgesic, anti-inflammatory and anti-edema effects. Inhibits the activity of COX, which leads to inhibition of prostaglandin synthesis. In addition, ketoprofen inhibits lipoxygenase, bradykinin synthesis, stabilizes lysosomal membranes and prevents the release of enzymes involved in the inflammatory process.

Ketoprofen does not have a negative effect on the condition of articular cartilage.

Possible side effects

Mentions of the frequency of cases of side effects of the drug imply the following indicators:

Very common - more than 1 case per 10 uses of the drug.
Frequent - more than 1 in 100, but less than 1 in 10.
Sometimes - more than 1 case in 1000, but less than 1 in 100.
Rare - more than 1 in 10,000 cases, but less than 1 in 1,000.
Very rare - less than 1 case per 10,000 patients.

Psychosomatic reactions:

Very common - headache (17%).
Sometimes - dizziness, drowsiness, sweating, blurred vision.
Rare - sleep disturbances, anxiety, depression, dry mouth, euphoria and hallucinations, hyperkinesia and difficulty concentrating, myalgia and nervousness.
Very rarely - aseptic meningitis, convulsions, psychotic reactions.

Cardiovascular problems:

Often - arterial hypertension.
Sometimes - pallor, rapid heartbeat.
Rarely - bradycardia, skin flushing, hypotension, chest pain.

Blood and lymph:

Often - thrombocytopenic purpura.
Sometimes - nosebleeds.
Rarely - thrombocytopenia, postoperative bleeding.

Gastrointestinal disorders:

Very often - nausea (12%), dyspepsia (12%), pain and discomfort in the abdomen (13%).
Often - constipation, diarrhea, bloating, stomatitis, vomiting.
Rarely - gastrointestinal ulcers, loss of appetite, esophageal reflux, gastritis, rectal bleeding.
Very rarely - internal bleeding, vomiting with blood, esophagitis, pancreatitis, gastrointestinal perforation, black stool.

Skin reactions:

Sometimes - itching, rash.
Rarely - acne.
Extremely rare - dermatitis, bullous reactions, epidermal necrolysis of a toxic nature, maculopapular exanthema.

Indications for use

Symptomatic treatment of painful and inflammatory processes of various origins, including:

rheumatoid arthritis and periarthritis;
ankylosing spondylitis (ankylosing spondylitis);
psoriatic arthritis;
reactive arthritis (Reiter's syndrome);
osteoarthritis of various localizations;
tendonitis, bursitis;
myalgia;
neuralgia;
radiculitis;
injuries of the musculoskeletal system (including sports), bruises of muscles and ligaments, sprains, ruptures of ligaments and muscle tendons.

Ketoprofen: instructions for use, analogues, price and reviews

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Pharmacological effects

Ketoprofen helps to provide analgesic, antipyretic and anti-inflammatory effects. The anti-inflammatory effect can be achieved after 7 days of oral administration of the drug.

If the drug is used to treat joint syndrome, Ketoprofen will help eliminate pain both at rest and during movement, and will eliminate symptoms such as morning stiffness and joint swelling. With the use of the drug, an increase in mobility is observed.

Ketoprofen gel promotes local anesthetic action. When used topically, the concentration of the active component is maintained for a long period of time at the site of inflammation.

Release form, composition

The drug Ketoprofen is available in the form of forte tablets, retard tablets, capsules, gel, suppositories, injection solution, cream.

• The capsules contain 50 mg of the active ingredient. • Forte tablets contain 100 mg of the active ingredient. • Retard tablets contain 150 mg of active substance. This form of the drug has a prolonged effect, which allows you to take tablets only once a day. • The gel composition (1 gram) contains 25 mg of active substance. • The solution for injection contains 50 mg of the component (in 1 ml of the drug). • The cream (1 gram) contains 50 mg of active substance. • The suppositories contain 100 mg of active substance.

The selection of one or another form of the drug Ketoprofen is carried out by the doctor, depending on the indications for use of the drug and accompanying symptoms.

Indications for use

Indications for the use of the drug Ketoprofen for systemic use (orally, intravenously, rectally, intramuscularly) are the following conditions:

• Complex therapy of inflammatory and degenerative diseases (rheumatoid arthritis, nonspecific spondyloarthritis, gouty arthritis, pseudogout, osteoarthritis, bursitis, tenosynovitis). • Elimination of intense pain of various origins, including postoperative and post-traumatic pain, sciatica, myalgia, therapy for radiculitis, bruises and muscle strains, renal colic. • The drug is used in dentistry and gynecology (including for primary dysmenorrhea). • Intravenous Ketoprofen is used to relieve pain in diseases of the musculoskeletal system.

Ketoprofen for external use is used:

• In the complex treatment of acute and chronic diseases of the musculoskeletal system, including rheumatoid arthritis, arthrosis, osteochondrosis. • For painful traumatic or inflammatory lesions of joints, ligaments, tendons: arthritis, muscle bruises, bursitis, sprains and ruptures of ligaments, dislocations. • For the treatment of phlebitis, thrombophlebitis, inflammatory diseases of the skin.

Contraindications

Ketoprofen is not recommended for use if you are hypersensitive to the active or excipients of the drug.

Contraindications to systemic use are the following conditions: the presence of gastric or duodenal ulcers, “aspirin” asthma, ulcerative colitis in the acute stage, Crohn’s disease, peptic ulcers, bleeding disorders. The drug is not used for renal and liver failure, as well as in children under 18 years of age and in the third trimester of pregnancy.

Suppositories are not recommended for use for hemorrhoids, proctitis, proctorragia.

Ketoprofen gel and cream are not used for weeping dermatoses, eczema, infected abrasions, violations of the integrity of the skin, in children under 6 years of age.

Adverse reactions

Ketoprofen may contribute to the development of such side effects. Central nervous system: possible development of headache, nervousness, dizziness, insomnia, strange dreams, drowsiness, malaise, ringing in the ears, visual disturbances, general malaise.

Cardiovascular system: increased blood pressure, increased heart rate, development of peripheral vascular diseases, anemia, thrombocytopenia.

Gastrointestinal tract: some patients may complain of nausea, constipation, flatulence, pain in the abdominal area. In rare cases, stomatitis, vomiting, increased appetite, dry mouth, rectal bleeding, increased salivation, and hidden bleeding were observed.

Respiratory system: development of nosebleeds, bronchospasm, pharyngitis, rhinitis, laryngeal edema.

Skin: development of allergic reactions in the form of a rash, itching and burning sensation, redness of the skin, alopecia, oncholysis, bullous rash, toxic epidermal necrolysis.

Other adverse reactions are associated with chills, facial swelling, and weight gain.

If Ketoprofen causes the described or any other side effects, use of the drug must be discontinued. A dosage reduction or medication change may be necessary at the discretion of the treating physician.

Overdose

In case of an overdose of the drug, dizziness, lethargy, vomiting, nausea, and abdominal pain may develop. Side effects are reversible. As treatment, it is necessary to rinse the stomach and carry out symptomatic and supportive therapy. Additionally, it is necessary to monitor the condition of the respiratory and cardiovascular systems.

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Mode of application

Ketoprofen is intended for internal, intramuscular, intravenous, rectal, cutaneous and local use. The dosage and method of administration are selected individually, taking into account the severity of the disease and accompanying symptoms.

If necessary, it is possible to combine several dosage forms of the drug at once. Only a doctor should prescribe the drug and select the dosage! Infusions using the drug should be carried out only in hospital settings.

Ketoprofen in the form of tablets, capsules and granules should be taken during or after the main meal. This avoids the development of side effects from the gastrointestinal tract.

Additional recommendations

The use of the drug Ketoprofen is possible with extreme caution and only under medical supervision if the patient has an allergy to aspirin-type drugs, peptic ulcers, diabetes mellitus, anemia, alcoholism, renal and chronic heart failure, high blood pressure.

If the patient's history includes allergic reactions, the use of non-steroidal anti-inflammatory drugs, including Ketoprofen, is possible only in extreme cases.

The use of Ketoprofen can help mask the symptoms of various infectious diseases.

When used externally, do not allow the medicine to come into contact with the eyes, damaged skin or mucous membranes.

When using the drug in patients whose activities require increased attention and concentration, it should be remembered that Ketoprofen may affect the reaction rate.

Cost, analogues

The cost of the drug Ketoprofen for the period January-February 2015 is formed as follows:

• Ketoprofen external gel, 30 grams (Russia) – 45-50 rub. • External gel, 50 grams (Russia) – 60-70 rub.

Analogs of Ketoprofen are the following drugs: Ketonal, Bystrumgel, Artrum, Artrosilen, Fastum gel, Flamax, Flexen.

Patient reviews about the medicine

“I bought Ketoprofen for my grandmother after she hurt her knee joint. The drug is inexpensive and we didn’t have much hope for it. What a surprise it was when, after applying the gel, the pain-relieving effect came literally within 5 minutes. There were no side effects. They say it’s better to combine the gel with tablets, but we don’t risk it because my grandmother has problems with the gastrointestinal tract.”
Marina

“Recently I fell hard on my tailbone and any movement caused severe pain. The pharmacy advised me to use Ketoprofen. I immediately bought the drug, because it is very inexpensive. There was no time to read instructions or go to doctors. I applied a little to the sore spot. I can’t say anything, the pain-relieving effect began almost immediately.

But at the same time there were side effects! I applied the drug twice a day: in the morning and evening, and on the third day a rash in the form of small blisters appeared at the site of application. I immediately stopped treatment with the drug and the rash went away. Now I’m wondering whether I can continue to use the medicine.”

Oksana, 25 years old

“I used Ketoprofen for back pain on the recommendation of a doctor. The pain went away almost immediately. But at the same time, she performed certain physical exercises and took Arthra.
Taken together, all the drugs had the desired effect. In particular, I am very pleased with Ketoprofen; there were no side effects. When I took only Arthra, it did not provide the necessary analgesic effect.”
Olga

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Contraindications

hypersensitivity to the components of the drug;
hypersensitivity to salicylates, tiaprofenic acid or other NSAIDs, fenofibrate, UV blockers, fragrances;
violation of the integrity of the skin (eczema, weeping dermatitis, open or infected wound);
indications in the anamnesis of attacks of bronchial asthma caused by taking NSAIDs and salicylates;
history of photosensitivity reactions;
exposure to sunlight, incl. indirect sunlight and UV irradiation in a solarium throughout the entire treatment period and for another 2 weeks after stopping treatment;
III trimester of pregnancy;
children under 15 years of age.

Directions for use and doses

How to take Ketogenetic and how many tablets to take per day. The optimal course duration is 30 days. This time is enough to reduce the amount of fat without harm to health. You need to drink 1-2 capsules. at a time half an hour before meals. The number of receptions is 2 times a day.

If necessary, the course can be extended. However, first take a break, since the product has a prolonged effect. The course can be resumed only after complete cessation of weight loss.

special instructions

It is necessary to avoid getting the cream in the eyes, on the skin around the eyes, and mucous membranes.

If any side effects occur, you should stop using the drug and consult a doctor.

If the patient forgets to apply the cream, it should be used at the time the next dose is due, but not double it.

Ketonal cream for external use can be used in combination with other dosage forms of the drug Ketonal (capsules, tablets, suppositories). The total daily dose, regardless of the dosage form, should not exceed 200 mg.

If skin reactions occur, including those that developed during combined use with octocrylene-containing drugs, treatment should be stopped immediately.

To reduce the risk of developing photosensitivity, it is recommended to protect the areas of skin treated with the cream with clothing from exposure to UV rays throughout the entire treatment period and for another 2 weeks after stopping use of the gel.

Do not use as occlusive dressings.

You should wash your hands thoroughly after each application of the drug.

Composition and release form Ketogenetic

Ketogenetic capsules contain a number of herbal components. They have a fat burning and cleansing effect. The composition contains the following substances:

Beta-hydroxybutyric acid. It is the main active ingredient. The most powerful fat keto is a complex developed by scientists for the fitness industry. Avocado, coconut, olive, chia seeds, and flax oils do their job. This ingredient is similar to ketone bodies produced by the human body.
Tuckahoe. African mushroom accelerates the process of burning fat and suppresses appetite.
Bitter orange extract. This is a source of synephrine, which accelerates metabolism and the process of destruction of fat cells. Stimulation of adrenergic receptors reduces the need for food. Together with other fat burners, bitter orange extract begins to work 3-4 times more effectively.
Lotus leaf extract. They contain L-carnitine, which promotes the transformation of fats into energy. This substance helps fight visceral fat.
Vitamins and minerals. The product contains vitamins B, C, A, D, magnesium, manganese and zinc. They normalize the functioning of the heart and internal organs.
Caffeine. It provides rapid weight loss by releasing energy from lipids. This substance increases the body's resistance to the negative effects of the environment. Caffeine increases overall vitality.
Guarana extract. The ingredient eliminates fatigue, improves and normalizes appetite.

Thanks to vitamin D, which is present in the preparation, the absorption of phosphorus and calcium improves.

The product is available in capsule form. To achieve the desired result, Keto Genetic must be taken in courses.