Laxatives are a type of medicine that is typically used when a person has difficulty bowel movements. Bisacodyl is one of these drugs. It affects the intestines, improving peristalsis and increasing mucus secretion in the walls of the large intestine.
All this simplifies the passage of feces through the tract and they leave the body without problems. Bisacodyl is available in several forms and has certain indications and contraindications for use.
Dosage form, composition, and packaging
The product is produced in tablet form and in the form of dragees. Round, brown with a pink tint, small in diameter and biconvex tablets contain the active substance - bisacodyl 5 mg.
And the following additional components:
- milk sugar;
- wheat starch;
- microcrystalline cellulose;
- talc;
- anhydrous colloidal silicon dioxide;
- magnesium stearate;
- titanium and iron dioxides.
It is also sold in the form of white, smooth, bullet-shaped rectal suppositories with a grayish tint with a dose of bisacodyl of 10 mg and contains semi-synthetic glycerides as excipients.
Bisacodyl tablets and dragees are contained in cardboard packaging of 10, 20, 30, 40, 50, 60, 80 and 100 pieces. Candles of 6 and 10 pieces.
Manufacturers: suppositories Altfarm LLC (Russia), suppositories and dragees Hemofarm LLC (Russia), tablets Akrikhin OJSC Russia.
Bisacodyl in pill form
Bisacodyl rectal suppositories
Bisacodyl in tablet form
Proctosan candles
They also have an analgesic effect, as they contain the anesthetic lidocaine.
In this regard, these suppositories can be successfully used to relieve acute pain. Sich “Proktosan” also has a pronounced anti-inflammatory effect. They eliminate itching, swelling and burning, normalize the permeability of the capillary walls, so blood microcirculation improves.
Suppositories contain titanium dioxide and bismuth subgallate. Thanks to these compounds, suppositories have an astringent and drying effect, promoting rapid healing of ulcers on the venous wall and rectal mucosa.
During breastfeeding and pregnancy, Proctosan suppositories are contraindicated.
Pharmacological properties
The cleansing effect of Bisacodyl is due to its effect on the mechanoreceptors of the colon, which are located in the mucous layer.
As a result of their mechanical excitation, the impulse is transmitted to the smooth muscle elements of the wall of the large intestine, which leads to increased peristaltic activity.
The strength, amplitude and duration of movements of the intestinal wall increases. Due to contractions of the muscle structure, the intestines are emptied.
By stimulating the production of mucus in the intestinal lumen, Bisacodyl slightly softens the consistency of stool, but bowel cleansing occurs in unchanged, formed stool.
Bisacodyl does not affect the process of digestion and absorption of nutrients from food. You can stop taking the drug at any time without the risk of addiction and without recurrence of constipation.
After taking the Bisacodyl tablet, the effect occurs after 6-10 hours , and the suppository - on average after 1 hour.
It is during this time that Bisacodyl is transported through the digestive tract; in the large intestine, Bisacodyl activates sensitive mechanoreceptors, which ultimately promotes the movement of feces through the intestines until the urge to defecate.
Pharmacokinetics
Bisacodyl is practically not absorbed through the mucous membrane of the digestive tract; its bioavailability is 5%.
When the drug Bisacodyl enters the lumen of the colon, it is hydrolyzed into its active form under the influence of enzymes of beneficial intestinal microflora. The main part of the drug is excreted in the feces and a small amount through the kidneys.
Indications for use
Bisacodyl is a laxative drug that enhances intestinal motility, so indications for its use are atonic stool disorders in the following situations:
- Hypotonic (decreased tone) or atonic (lack of tone) constipation due to insufficient muscle activity of intestinal peristalsis.
- Lack of urge to defecate, feeling of intestinal fullness;
- Intermittent functional constipation due to sedentary work, low activity, stress, climate change, poor nutrition, after childbirth, after operations.
- Regulation of stool for proctitis, hemorrhoids, paraproctitis, anal fissures.
- Excess weight with the aim of reducing it in a short course.
- To cleanse the intestines of feces before ultrasound, X-ray and endoscopic examination of the internal organs of the abdominal cavity.
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Indications for use
Bisacodyl tablets are intended for short-term use. They eliminate the symptom, but do not affect the cause of the violation of physiological bowel movement.
The instructions for use of the tablets provide for their use in the following conditions:
- hypotonic, atonic constipation - impaired muscle contractions, decreased tone of a certain area of the large intestine;
- difficulty defecating in women after the birth of a child, the elderly, patients after surgical treatment;
- regulation and stabilization of stool in people with chronic hemorrhoids, anal fissures, inflammation of the rectum (proctitis).
Contraindications for use
Contraindications to taking Bisacodyl occur in situations in which it is impossible to stimulate intestinal motility.
- History of adverse reactions to Bisacodyl components (to lactose).
- Constipation due to high bowel tone (spastic).
- Intestinal obstruction (blockage, intussusception).
- Acute pain in the abdominal area of unknown etiology (“acute abdomen”).
- Hernial protrusions of the white line of the abdomen, inguinal in the strangulation stage due to increased intra-abdominal pressure as a result of taking Bisacodyl.
- Diseases of the digestive tract of an inflammatory nature (ulcerative colitis, appendicitis, Crohn's disease, acute pancreatitis, acute cholecystitis and others).
- Inflammation of the peritoneum (peritonitis).
- Gastrointestinal bleeding.
- Inflammation of the bladder, ureters.
- Renal colic, gallstone colic.
- Deviations in water and electrolyte balance (hypokalemia) due to the risk of arrhythmias, arterial collapse, renal failure, and dehydration.
- Ulceration of the mucous membrane of the stomach and duodenum, perforation of the ulcer, bleeding from the ulcer.
- Metrorrhagia.
- Malignant formation of the large intestine.
- Children under two years of age.
- Clinical situations that require caution and prior consultation with a doctor when taking Bisacodyl (relative contraindications): in the period after surgery on the abdominal organs and retroperitoneal space;
- period of bearing a child;
- lactation period;
- chronic kidney disease;
- liver pathology and failure.
Instructions for use
Candles
Suppositories: administer only rectally once a day.
The initial dose is 1 suppository (10 mg). If there is no desired effect the next day, you can administer 2 suppositories at once.
Eating food will not affect the effect of the medicine. The action occurs within an hour.
Pills
Tablets and dragees: for adults and adolescents over 12 years old, you need to start drinking Bisacodyl with 1 tablet, preferably before bedtime or, at any time convenient, taking into account the development of the effect, no earlier than 6 hours, 30 minutes before eating, be sure to drink at least 1 /2 cups liquid.
Take daily for three days. If bowel movement does not occur within three days of using Bisacodyl, you should add half a tablet for three days as well.
According to this scheme, in the absence of stool, you can increase the dose of Bisacodyl to three tablets (15 mg) per day at one time, but no more.
If constipation persists after taking the maximum dose, it is recommended to consult a doctor for examination. Taking Bisacodyl for 7 days in a row or more is not recommended due to possible adverse reactions.
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Suppositories and capsules for quick relief of bleeding, pain and itching. Returns elasticity to the veins and prevents the recurrence of hemorrhoids!
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Side effects
Typically, undesirable effects develop only with prolonged use of Bisacodyl in large doses and, as a rule, disappear after discontinuation of the drug without symptomatic treatment:
- Pain in all parts of the abdomen like colic.
- Bloating, nausea, heartburn, vomiting, profuse and frequent loose stools.
- Loss of intestinal tone with long-term use.
- Dehydration, muscle weakness, rhythm disturbances due to decreased sodium and potassium.
- The appearance of protein and blood in the urine, discoloration of urine.
- Muscle twitching, loss of strength, mild disturbances of consciousness.
- A rash may appear on the skin.
- Hypotension is a decrease in blood pressure.
- Deposition of melanin in the intestinal wall.
- Discomfort in the rectal area when using Bisacodyl suppositories.
When can you use suppositories for hemorrhoids Nizhpharm
Suppositories for hemorrhoids from Nizhpharm are presented in several types, which makes it possible to use products from domestic manufacturers for pathologies of various types. Such medications are appropriate for the following problems:
- hemorrhoids of any stage;
- constipation;
- itching, burning, pain in the anus;
- anal fissures;
- inflammation of hemorrhoidal cones;
- inflammation of the rectum;
- bleeding from the rectum;
- complications of hemorrhoids.
When inexpensive and effective suppositories for hemorrhoids are required, Nizhpharm offers several types of medications. A specialist should prescribe the appropriate option after examining the patient and conducting additional studies (if necessary).
Overdose
If you take Bisacodyl more than three tablets per day, you may experience abdominal pain and symptoms of fluid loss in the body (uncontrollable diarrhea, nausea, vomiting, drowsiness, convulsions, drop in blood pressure, rhythm disturbances, loss of strength, fainting).
You should immediately consult a doctor or call an ambulance. Start drinking mineral water yourself. Treatment shows restoration of circulating volume and electrolyte balance.
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Suppositories and capsules for quick relief of bleeding, pain and itching. Returns elasticity to the veins and prevents the recurrence of hemorrhoids!
Read more>>>
Reception during pregnancy and lactation, in children
Due to the spastic contraction of the intestinal wall under the influence of Bisacodyl, its use is not advisable for the movement of feces during pregnancy.
Due to increased pressure in the abdominal cavity and active movements of the intestinal wall, this can lead to miscarriage or premature termination of pregnancy.
If you are still prescribed Bisacodyl, the tablet should be taken with plenty of liquid to soften the stool so that the woman has to push less. In this case, the duration of constipation should not last more than 2 days.
During breastfeeding (lactation), taking Bisacodyl is possible , since it is practically not absorbed into the mother’s bloodstream. And the use of candles is considered a safe form.
It is not recommended for children under 6 years of age.
From the age of six, Bisacodyl is allowed, preference should be given to the form in the form of suppositories.
Dosage table for Bisacodyl for children aged 6 to 18 years:
| Age, years | Tablets (dragées), per day | Candles, per day |
| 2-7 | 1 | 1/2 |
| 8-14 | 1-2 | 1 |
| 15-18 | 1-3 | 1-2 |
Directions for use and dosage
Instructions for use of the drug Bisacodyl Darnitsa in tablets are as follows:
- The manufacturer recommends starting treatment with a minimum dose, namely one tablet before bedtime, in order to get a positive result in the morning.
- In the absence of a therapeutic effect, it is recommended to increase the dose to two tablets per day.
- In order to cleanse the body before surgery, prescribe 2 tablets before bedtime.
Bisacodyl suppositories are taken according to the following scheme:
- Suppositories should be inserted into the rectum once a day.
- Adults can administer up to 2 suppositories per day. If 6 hours after the introduction of the first suppository the desired effect has not occurred, then we introduce the second one.
- Patients under six years of age are prescribed half a suppository.
In order to quickly cleanse the digestive system of toxins, for example, before surgery, it is recommended to take two tablets before bed, and in the morning to administer one suppository rectally.
The manufacturer warns all patients with liver problems. Before taking the drug, you should definitely consult your doctor. In addition, treatment should be started with a minimum dose in order to identify possible adverse reactions in time.
Therefore, if the normal functioning of the liver is disrupted, one tablet or suppository per day is prescribed. If any adverse reactions occur, be sure to stop treatment and consult a doctor.
Serious kidney disease is also a contraindication for Bisacodyl. Only after the doctor's permission can you take the drug no more than one tablet or suppository per day.
Some people use Bisacodyl for weight loss because they believe that cleansing the intestines will lead to weight loss. Actually this is not true.
The drug is intended to restore normal functioning of the stomach when there is weakness of the muscular system. The active component has a gentle effect on the gastric mucosa, speeding up its work, and accumulates water, which dilutes hard stool. However, the product is not capable of burning fat or accelerating metabolic processes in the stomach.
In addition, uncontrolled use of laxatives will lead to an exacerbation of hidden diseases and a deterioration in overall health.
Can Bisacodyl be taken during pregnancy? This question worries every caring expectant mother suffering from constipation. Before taking any laxatives during pregnancy, be sure to consult your doctor.
The active element Bisacodyl practically does not enter the bloodstream and does not affect the tone of the uterus. Its main task is to activate the intestinal muscular system. In addition, the drug does not contain toxic substances. This is why Bisacodyl can be taken during pregnancy, but only after permission from a gynecologist and gastroenterologist.
In order to minimize risks, pregnant women are recommended to use rectal suppositories. They act locally, directly in the intestines, and have virtually no effect on important organs.
During breastfeeding, the active ingredients can enter the baby's body through milk. That is why there should be no contraindications for both mother and child.
Interaction with other drugs and alcohol
If you take drugs that normalize acidity (Omeprazole, Almagel, Gastal, Ranitidine), then the laxative effect of Bisacodyl is reduced.
The effectiveness of Bisacodyl is reduced when taken together with psychotropic drugs, cholestyramine.
When taking Bisacodyl with antiarrhythmic drugs (Verapamil, Digoxin, Strophanthin, Egilok, Concor, Betaloc ZOK, Carvedilol, Anaprilin), monitoring of electrocardiographic parameters is necessary due to a possible decrease in the level of potassium in the blood and, as a result, an increase in the effect of antiarrhythmics.
People taking long-acting medications should be aware of a decrease in this property when taken together with our drug.
Bisacodyl prolongs the effect of thiazide diuretics and glucocorticosteroids, which requires monitoring blood potassium levels and electrocardiographic parameters.
During treatment with Bisacodyl, alcoholic beverages should be avoided due to increased dehydration in case of long-term treatment of constipation.
Admission in old age
In older patients, the primary cause of constipation is often functional disorders due to low physical activity, insufficient fluid and fiber intake.
The tone of the intestinal wall decreases and it becomes atonic.
As a result, to solve this problem, Bisacodyl becomes the drug of choice, as it enhances contractions and restores the tone of the smooth muscle component of the intestine.
Considering that Bisacodyl is practically not absorbed into the blood, dose adjustment is not required in elderly people, except in cases of concomitant pathology of the kidneys and liver.
pharmachologic effect
Bisacodyl is a contact laxative , not absorbed in the stomach, poorly absorbed into the blood, destroyed in the liver, and partially excreted by the kidneys. It is considered a prodrug , since the formation of the active substance is the result of metabolic changes in the alkaline environment of the intestinal tube.
Accelerates and enhances the contraction of the distal parts of the large intestine (sigmoid and rectum). The laxative effect of the drug is due to irritation of the nerve receptors of the mucous membrane, water retention and loosening of the intestinal contents. The mechanism of action of Bisacodyl and the therapeutic effects caused by it are common to all its dosage forms.
special instructions
Due to possible stomach irritation from tablets or dragees, during treatment with Bisacodyl, it is necessary to take up to 1.5 liters of water to prevent this side symptom.
Rules for taking Bisacodyl to cleanse the intestines before diagnostic procedures:
- The day before the examination, take 2 tablets and the night before another 2 tablets.
- The day before the examination, take 2-3 tablets, and in the morning on the day of diagnosis, administer 1 suppository.
Bisacodyl does not reduce the ability to drive vehicles, so it is allowed for drivers and persons whose activities require increased attention, working with moving mechanisms. But possible individual intolerance should be taken into account.
Side effects may be expected when taking Bisacodyl for more than seven days.
If you suspect an inflammatory process of organs in the abdominal cavity (for example, gastritis, pancreatitis, colitis), you should stop taking Bisacodyl until you visit a doctor.
If, as a result of taking the maximum permitted daily dose of Bisacodyl, this applies to both adults and children, the laxative effect does not occur, you must stop taking Bisacodyl and discuss further tactics with your doctor; constipation is likely due to other reasons.
Livarol 400 mg 10 pcs. vaginal suppositories nizhpharm
pharmachologic effect
Antifungal agent.
Composition and release form Livarol 400 mg 10 pcs. vaginal suppositories nizhpharm
Suppositories - 1 soup:
- active ingredient: ketoconazole – 400 mg;
- excipients: butylated hydroxyanisole, macrogol mixture (macrogol 1500, macrogol 400).
Vaginal suppositories 400 mg.
5 suppositories in a blister pack made of polyvinyl chloride film laminated with polyethylene.
1 or 2 blisters along with instructions for medical use of the medicinal product in a cardboard pack.
Description of the dosage form
Suppositories are torpedo-shaped, white or white with a yellowish, or grayish, or creamy tint. Marbling and the presence of an air core and a funnel-shaped depression on the cut are allowed.
Characteristic
Ketoconazole is an imidazoledioxolane derivative.
Directions for use and doses
For intravaginal use.
Remove the suppository from the contour packaging, as shown in the figure (the contour cell packaging of each suppository is equipped with special “wings” that will allow you to easily and quickly remove the suppository without damaging it).
Insert the suppository deep into the vagina while lying on your back.
1 suppository per day for 3-5 days, depending on the course of the disease.
For chronic candidiasis, use 1 suppository per day for 10 days.
Do not interrupt the course of treatment yourself, even if the symptoms that bother you have disappeared, since incomplete treatment can lead to the disease becoming chronic.
If the symptoms of the disease persist or worsen during treatment, you should stop treatment and consult a doctor.
Pharmacodynamics
The active substance is ketoconazole, an imidazoledioxolane derivative. It has a fungicidal and fungistatic effect against dermatophytes (Trichophyton spp., Epidermophyton floccosum, Microsporum spp.) and yeast (Candida spp., Pityrosporum spp.). The mechanism of action is to inhibit the biosynthesis of ergosterol and change the lipid composition of the fungal membrane.
The drug is active against staphylococci and streptococci.
Pharmacokinetics
Systemic absorption after intravaginal use is negligible.
Indications for use Livarol 400 mg 10 pcs. vaginal suppositories nizhpharm
Treatment of acute and chronic recurrent vaginal candidiasis.
Prevention of the occurrence of fungal infections of the vagina with reduced body resistance and during treatment with antibacterial agents and other drugs that disrupt the normal microflora of the vagina.
Contraindications
Hypersensitivity to the components of the drug, pregnancy, breastfeeding, children under 18 years of age.
Application of Livarol 400 mg 10 pcs. vaginal suppositories Nizhpharm during pregnancy and breastfeeding
Clinical data on the use of ketoconazole drugs in women during pregnancy and breastfeeding are limited.
The use of the drug during pregnancy is contraindicated.
If it is necessary to use the drug during lactation, breastfeeding should be discontinued.
Overdose
Due to the low absorption of the drug when used intravaginally in recommended (therapeutic) doses, an overdose is unlikely.
If the drug is accidentally taken orally, symptoms of poisoning may occur. There is no specific antidote. If necessary, you should take activated charcoal and carry out symptomatic treatment.
Side effects Livarol 400 mg 10 pcs. vaginal suppositories nizhpharm
Hyperemia and irritation of the vaginal mucosa, vaginal itching. Allergic reactions: skin rash, urticaria.
If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Drug interactions
Due to low absorption during intravaginal use, interaction with other drugs is unlikely.
Taking Bisacodyl for weight loss
Bisacodyl does not help burn fat deposits, but only cleanses the human body of fecal debris and toxins.
Often, in order to lose weight, people use laxatives, thinking that they help eliminate the food they consumed.
You need to understand that absorption processes occur in another part of the intestine (in the small part).
Laxatives work in the colon, where only water and various toxins remain from the substances obtained from food, and fats, carbohydrates and proteins are absorbed much earlier.
As for Bisacodyl, according to the recommendations of nutritionists, this drug should be taken no more than 1-2 tablets 2 times a week for the purpose of weight loss.
You need to understand that Bisacodyl does not help burn fat deposits, but only cleanses the human body of fecal debris and toxins.
Therefore, with prolonged - more than two days in a row, and frequent use of Bisacodyl, you can get dehydration and disruption of the homeostasis system.
Analogs
On the pharmaceutical market you can find several substitutes for the pharmacological action of the drug Bisacodyl, both Russian and imported:
- Its closest analogue is Dulcolax . Country of origin: Italy. Cost 230 rubles.
- Izafenin is an unnatural drug, the effect occurs later (after 10-12 hours), in the form of a powder with the smell of acetic acid, it is rarely prescribed due to the lack of evidence. Price 20 rubles.
- Phenolphthalein , known under the name Purgen, is not prescribed in medical practice due to the mass of side effects (on the kidneys, pro-carcinogenic effect).
- Guttalax drops are a synthetic drug based on sodium picosulfate. Manufacturer Germany. Cost 200 rubles. Not recommended for daily use. Its analogues are Guttasil, Slabilen, Laxigal, Slabicap.
- Glycerol - suppositories Glycerin, Glycelax. With prolonged use, they cause irritation, itching, and also inhibit the physiological process of emptying. Cost 120 rubles . Manufacturer Russia.
- Angiolax is a drug based on senna and plantain fruits and contains sucrose, which should be taken into account by people with diabetes. Manufacturer Germany. Cost 1500 rubles.
- Phytolax is a dietary supplement based on senna, plantain, dill, and dried apricots. Contraindicated during pregnancy. Price 200-100 rubles. Manufacturer: Evalar.
- Mucofalk powder is a herbal medicine based on plantain seeds. The active substance swells under the influence of fluid in the intestinal lumen and irritates it. Manufacturer Germany, cost 600 rubles.
- Microlax is in the form of microenemas, it is administered rectally. Consists of sorbitol, sodium citrate, sodium lauryl sulfoacetate. Effective in 15 minutes. Belongs to the group of osmotic laxatives. Country of issue: Sweden. The cost is about 400 rubles.
- Senade is a medicinal product with natural ingredients (senna leaves). The price range depends on the number of tablets: 50-500 rubles. Manufacturer India.
- Laxacodyl contains bisacodyl. Manufacturer India. Price 15-30 rubles.
- Laxatin is a homeopathic remedy. Manufacturer Russia. Price 50 rubles.
- Pyrilax. Country of origin: Germany. Price range 250-350 rubles.
Algiolax
Dulcolax
Feonlfthalein
Fitolax
Glycerol
Guttalax
Microlax
Mukofalk
Senade
Before deciding whether to take laxatives or not, both for cleansing the intestines and for losing weight, you should consult your doctor. Read the instructions for the drug, its contraindications and possible side effects.
It is advisable to undergo a minimum list of diagnostic procedures in order to assess the cause of constipation and ensure the absence of diseases for which the use of Bisacodyl, as a laxative drug that increases the tone of the intestinal wall, is contraindicated.
Glycerin suppositories during pregnancy (and lactation)
Carefully.
The official instructions do not describe any restrictions on the use of the drug for constipation during breastfeeding and pregnancy, which is, in principle, confirmed by numerous reviews of women using this remedy during these periods.
However, some gynecologists do not recommend using glycerin suppositories during early pregnancy, since at this time the uterus is quite close to the rectum and the relaxing effect of the drug can also affect its tone. During late pregnancy, the above-described contraindications and the threat of miscarriage may limit the use of this medication.
