Contraindications

According to the instructions for Nolpaza, the drug should not be taken if:

• hypersensitivity to pantoprazole and other substances included in its composition;
• dyspepsia of neurotic origin;
• under 18 years of age.

Since Nolpaza tablets contain sorbitol, they are not prescribed to patients with fructose intolerance.

The drug is prescribed with caution for liver failure, during pregnancy and lactation, and in the presence of risk factors for cyanocobalamin deficiency.

Indications for use

For adults

Nolpaza is prescribed for hyperacid conditions - increased acidity of gastric juice, including erosive and ulcerative lesions of the mucous membrane.

1. Gastroesophageal reflux disease (GERD).
2. Reflux esophagitis.
3. Peptic ulcer localized in the stomach and duodenum.
4. Zollinger-Ellison syndrome.
5. Pathological conditions accompanied by increased secretion of hydrochloric acid and hyperacidity.

Nolpaza is used to treat diseases of the gastrointestinal tract associated with Helicobacter pylori infection during therapy with antimicrobial drugs.

For children

In childhood, the drug is not prescribed.

For pregnant women and during lactation

Nolpaza is not prescribed during pregnancy. The drug penetrates the hematoplacental barrier and has a fetotoxic effect on the fetus. The prescription of the drug is carried out according to vital indications. During lactation, the drug passes into breast milk and can cause intoxication in the child's body. During drug therapy, it is necessary to transfer the child to artificial feeding.

Directions for use and dosage

Nolpaz tablets are taken orally, swallowing them whole.

According to the instructions, Nolpaza is taken before the morning meal. When taking 2 times, the second dose of the drug is taken before dinner.

As maintenance therapy and prevention, Nolpaza is prescribed 20 mg per day, and if necessary, the dose is increased to 40-80 mg per day.

For mild gastroesophageal reflux disease, the dose is 20 mg per day, moderate and severe - 40-80 mg per day for 4-8 weeks.

To prevent erosive lesions after long-term use of NSAIDs, Nolpaza is taken 20 mg.

As a treatment and prophylaxis for peptic ulcer disease, Nolpaza is prescribed 40-80 mg per day for 2-8 weeks.

For eradication of Helicobacter pylori, the dose of the drug is 40 mg twice a day for 7-14 days.

For erosive and ulcerative lesions of the stomach and duodenum, the dose of the drug is 40-80 mg per day for 4-8 weeks.

For Zollinger-Ellison syndrome and other pathologies associated with increased secretion of gastric juice, the initial dose is 80 mg per day, divided into two doses. Then the daily dose is adjusted.

Instructions for use NOLPAZA®

It is necessary to regularly monitor the activity of liver enzymes throughout the entire period of use of pantoprazole (especially during long-term therapy). If the activity of liver enzymes increases, treatment with pantoprazole should be discontinued.

The use of Nolpaza® in a dose of 20 mg as a prophylactic agent for the treatment of erosive and ulcerative lesions of the stomach and duodenum caused by NSAID therapy should be limited only to the group of patients continuing NSAID therapy and at risk of developing gastrointestinal complications. This risk is assessed by the presence of individual risk factors, for example, advanced age (over 65 years), gastric or duodenal ulcers and a history of gastrointestinal bleeding.

When conducting combination therapy for Helicobacter pylori eradication, it is necessary to observe and take into account the characteristics of the relevant drugs. In the presence of alarming symptoms (eg, significant unintentional weight loss, recurrent vomiting, dysphagia, hematemesis, anemia or melena) or in the presence or suspicion of a gastric ulcer, it is necessary to exclude the presence of a malignant neoplasm, because The therapy carried out, masking the symptoms, can delay the correct diagnosis. Re-evaluation should be carried out if symptoms persist despite adequate therapy with pantoprazole.

In patients with Zollinger-Ellison syndrome and other pathological conditions associated with increased gastric secretion that require long-term treatment, pantoprazole may reduce the absorption of vitamin B12 cyanocobalamin against the background of suppressed hydrochloric acid secretion. This should be taken into account in patients with reduced body weight or the presence of risk factors for reduced absorption of vitamin B12 during long-term therapy or in the presence of clinical symptoms.

Long-term therapy, especially lasting more than 1 year, requires regular monitoring of the patient.

When using pantoprazole, like other proton pump inhibitors, it is possible to increase the number of bacteria normally present in the upper gastrointestinal tract. Treatment with Nolpaza® may lead to a slight increase in the risk of developing bacterial gastrointestinal infections caused by bacteria such as Salmonella spp. and Campylobacter spp.

Severe hypomagnesemia has been observed in patients taking proton pump inhibitors, incl. pantoprazole, more than 3 months, and in most cases - within a year. Severe manifestations of hypomagnesemia may include fatigue, tetany, delirium, seizures, dizziness, and ventricular arrhythmia. In most patients, their condition improved after magnesium replacement therapy or cessation of treatment with proton pump inhibitors. If long-term therapy with proton pump inhibitors is planned, as well as during the simultaneous use of digoxin or drugs that cause hypomagnesemia (for example, diuretics), magnesium levels should be monitored before starting therapy and periodically during treatment.

Proton pump inhibitors, when used long-term (more than 1 year) and when used in high doses, may slightly increase the risk of fractures of the femur, wrist and spine, especially in elderly patients or patients with established risk factors. Research suggests that proton pump inhibitors may increase the overall risk of fractures by 10-40%. However, this increase may be due to other risk factors. Patients at risk of developing osteoporosis need to get adequate amounts of vitamin D and calcium; Such patients should be treated in accordance with current clinical guidelines.

Nolpaza® contains sorbitol, so the drug is not recommended for use in patients with rare hereditary conditions associated with fructose intolerance.

Use in pediatrics

Nolpaza® is not recommended for use in children under 12 years of age

due to limited safety data.

Impact on the ability to drive vehicles and machinery

When using the drug, adverse reactions such as dizziness and visual disturbances may occur. In such cases, the patient should not drive vehicles or potentially dangerous machinery.

Side effects of Nolpaza

According to reviews, Nolpaza may cause side effects:

• hematopoietic organs: leukopenia - rarely, thrombocytopenia;
• musculoskeletal system: arthralgia - rare, myalgia - very rare;
• digestive system: abdominal pain, flatulence, diarrhea, nausea, dry mouth, constipation, vomiting, severe liver damage;
• immune system: anaphylactic reactions – rare;
• genitourinary system: interstitial nephritis – rare;
• Central nervous system and peripheral nervous system: dizziness, blurred vision, headache, depression - rarely;
• allergic reactions: rash, itching, Stevens-Johnson syndrome, urticaria, erythema multiforme, angioedema, photosensitivity;
• others: peripheral edema, weakness, increased triglyceride levels, hyperthermia, breast tenderness.

If severe side effects occur, treatment with Nolpaza is stopped.

Interaction with other drugs

Pantoprazole, which is part of the drug, is metabolized in the liver due to the cytochrome P450 enzyme system. Therefore, interactions of pantoprazole with drugs metabolized by the same system cannot be excluded. But clinical studies have not revealed any significant interaction of the drug with diazepam, ethanol, digoxin, diclofenac, glibenclamide, phenytoin, carbamazepine, metoprolol, caffeine, naproxen, piroxicam, nifedipine, theophylline, or oral contraceptives.

Nolpaza reduces the absorption of drugs, the bioavailability of which depends on the acidity of the stomach.

Reviews of Nolpaza contain reports of changes in MHO, although no significant interaction with the simultaneous use of Nolpaza and warfarin was established in clinical studies.

Patients taking coumarin anticoagulants are advised to regularly monitor their prothrombin time or MHO.

Register (radar)

By studying this section, you can learn more about Nolpaza and analogues.

Russian Registers of Medicines (RMS) have information about any medicine, they contain a description of the medicine. All tools in the directory are arranged in alphabetical order, which is convenient for users. There are also instructions and the composition of the substances included in the drug. In addition, along with the basic description of medications, the reference book contains information about drugs that should be used together to treat diseases.

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There are many drugs for the treatment of diseases of the gastrointestinal tract. Therefore, it is possible to take not the drug itself, but replace it with similar means.

Analogs

The medication has analogues, which helps people periodically replace it with another drug during the treatment process.

The most common and best analogues:

• Sanpraz;
• Control;
• Panum;
• Peptazol;
• Ulthera.

In addition to these drugs, there are a number of others that are similar to Nolpaza in their pharmacological actions. These include:

• Omez;
• Ultop;
• Zolopen;
• Rabimak;
• Nexium;
• Akrilanz.

When choosing a medication, you should consult with a specialist, he will help you understand what is best to take in a particular case. All these remedies are effective in treating diseases of the stomach and intestines.

The active substance of the drug Ultop, like Nolpaza, is omeprazole. It is worth remembering that there are contraindications when taking Ultop, so it should be taken only after consultation with a specialist.

Ultop medication is prohibited for children under 12 years of age. The patient will not be able to independently determine which of the drugs, Nolpaza or Ultop, will help him better; only a doctor can make this conclusion based on the individual characteristics of the body.

Omez, the active substance of which is also omeprazole, is good for treating the stomach and has an antiulcer effect. The effect of the drug is to reduce the acidity of gastric juice. If you choose between Omez and Nolpaza, the latter begins to act much faster.

Nolpaza and Omeprazole are used in the treatment of intestinal and stomach diseases; both drugs reduce the level of hydrochloric acid. Despite the fact that the medications are effective, it is impossible to replace Nolpaza or Omeprazole with each other in the treatment of diseases without consulting a specialist.

When choosing between Controloc or Nolpaza medications, you should consult your doctor. But we can say with confidence that Controloc is an analogue of Nolpaza, so if Controloc is prescribed, it can be replaced with Nolpaza in the same dosage.

Another remedy with similar effects as Nolpaza is Sanpraz - a good drug for eliminating many diseases. At an appointment with your doctor, you can consult whether you should take Sanpraz or Nolpaza. The products are analogues, they differ only in price.

Emanera is also an analogue of Nolpaza. The main substances that make up the medication affect the acidity of gastric juice, as a result of which the patient feels better. Emanera begins to act an hour after application. For most patients, taking Emanera helps in the treatment of various diseases of the stomach and intestines.

Not only these drugs can reduce the level of hydrochloric acid in the stomach, there are others. Such as Kvametel, Ranitidine. Doctors do not prescribe these drugs for the treatment of peptic ulcers. They have more side effects than others. The main difference is that to achieve relief from the patient’s condition, the drugs need to be taken several times a day.

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It is worth remembering that the drug Ranitidine is characterized by withdrawal syndrome. Despite this, Ranitidine is prescribed quite often, since some patients may develop an allergic reaction to Nolpaza and its analogues or may not experience improvement. When prescribing a medicine, a doctor always tries to take into account all the characteristics of the patient’s body.

It is because of this that Ranitidine can still be found in pharmacies. Moreover, this drug is quite cheap. It is worth knowing that the doctor will not prescribe drugs from the group of proton pump inhibitors simultaneously with the drug Ranitidine and its analogues.

It is necessary to take into account that the medicine Nolpaza is comparatively cheaper than its analogues, but it treats no worse.

special instructions

Before starting treatment with Nolpaza, the presence of malignant neoplasms should be excluded, since drug therapy can mask symptoms and delay the correct diagnosis of the disease.

If after four weeks of therapy with Nolpaza the desired therapeutic effect is absent, then additional examination is necessary.

Pantoprazole may reduce the absorption of vitamin B12 in achlorine and hypohydria.

Long-term treatment with Nolpaza requires constant monitoring of the patient.