Patient reviews of the treatment of human papillomavirus with Isoprinosine

A weakened immune system can lead to many unpleasant health problems. For example, to the appearance of frequent colds. As a rule, to strengthen it, it is recommended to carry out many preventive measures - taking vitamins, hardening, etc. However, sometimes medication is also prescribed to maintain health. For example, specialists often prescribe Isoprinosine tablets or syrup as an immunostimulating agent. We will consider instructions, reviews and opinions of doctors about this medicine, as well as its analogues, in this article.

Release form and composition

Isoprinosine is available in only one form, which is almost white tablets that have a slight amine odor. They are distinguished by their oblong convex shape and the presence of a mark on one side, along which the drug can be divided into halves. One blister includes 10 tablets, and one pack can contain from 2 to 5 blisters.

• Each tablet contains 500 mg of the active substance inosine pranobex.
• Excipients: wheat starch, mannitol, magnesium stearate, povidone. 10 tablets in a blister, 2, 3, 5 blisters in a cardboard pack.

Isoprinosine does not have dosage forms such as suspension, powder, dragees, syrup, capsules or injections.

Isoprinosine tablet composition

Annotation:

Isoprinosine is a tablet (photos and detailed descriptions can be found on the Internet, and Wikipedia provides detailed information) with antiviral action (immunomodulator). It is popular in many countries (among them Ukraine, Israel).

• International name (INN) - Inosine pranobex.
• Release form: tablets, intended for oral administration (20, 30 or 50 tablets per package).
• The active ingredient is inosine pranobex.
• Pharmacological group – immunostimulant.
• Manufacturer – Portugal.
• The drug is banned in the USA.
• The product is sold (tab) in the Monastyrev online store, in the Zhivika pharmacy chain and in pharmacies without a prescription.
• Such forms of release as injections, syrup, drops, suppositories and ointments are not provided (official information).

Compound:

• inosiplex
• mannitol
• povidone
• wheat starch
• Magnesium stearate.

What helps, when to take?

Isoprinosine is used/treats for:

• human papilloma virus;
• helps with swine flu;
• in the treatment of Epstein-bar;
• with ARVI;
• treatment of viral infections;
• from warts;
• with herpes;
• with sore throat;
• with chickenpox;
• for a cold, if the patient speaks through his nose;
• with cytomegalovirus;
• with adenoids;
• with mononucleosis;
• for human papillomavirus (papilloavirus) and rotavirus infections;
• from condylomas;
• with thrush;
• with genital herpes;
• for pneumonia and bronchitis;
• for immunity;
• when planning pregnancy.

Directions for use: tablets should be taken not BEFORE meals, but after, swallowing whole (as stated in the instructions and advertising).

Isoprinosine an antibiotic or not?

When wondering whether Isoprinosine is an antibiotic or not, we can say with confidence that this drug is not an antibiotic. It is also worth saying that this is not a hormonal drug.

Pharmacological effect

Isoprinosine is a synthetic purine derivative. The active component of the drug, inosine pranobex, stimulates the immune system and has a nonspecific antiviral effect, blocking the proliferation of harmful viruses and alleviating the symptoms of viral diseases. Isoprinosine destroys the genetic apparatus of pathogens and restores the activity of lymphocytes in conditions of reduced immunity.

The drug is active against herpes virus, measles, influenza, cytomegalovirus, poliovirus, and human cellular lymphoma virus. The medication increases the body's resistance to mumps viruses, equine encephalitis, papilloma, and encephalomyocarditis.

Isoprinosine, when taken orally, is absorbed from the gastrointestinal tract and reaches a maximum in the blood plasma after 1-2 hours. In this case, the drug does not accumulate in the body, is metabolized and is completely excreted by the kidneys within 2 days.

Pharmacological properties

The drug has pronounced antiviral and immunostimulating properties. The active ingredient is a synthetic derivative of purine. The substance is considered one of the most effective in the fight against various viruses and other pathogenic microorganisms that provoke a weakening of the human immune system .

When ingested, the active substance leads to rapid activation of the immune system by stimulating the activity of lymphocytes. In addition, the component accelerates the formation of cells, improves intracellular metabolism, and increases their number in the blood to effectively combat pathogenic microorganisms.

An additional property of the drug will be the ability to increase the level of immunoglobulin, which also helps to increase cellular immunity. The antiviral activity of the drug is associated with the destruction of the RNA structure in them. The medicine affects enzymes that take part in the formation of certain viruses, suppresses their activity, and prevents the reproduction of pathogens of many diseases.

By stimulating the formation of interferon, the medication helps the body fight viruses more effectively. In combination with other pharmacological agents that have an antiviral effect, Isoprinosine has a more pronounced therapeutic effect and enhances their activity.

After taking the medication orally, it is quickly absorbed in the organs of the digestive tract, namely in the small intestine. The maximum concentration of the substance in the blood plasma is achieved 1-3 hours after consumption. Experts have found that the active component does not accumulate in the body, but is completely processed, breaking down into uric acid.

The half-life from the blood takes up to 4 hours. The metabolite is released through the urinary system. After completing the course of treatment, complete liberation of the body from decay products takes up to 2 days.

In patients with severe liver and kidney failure, the evacuation time of the processed active substance is slightly prolonged, depending on the individual characteristics of the body.

Indications for use

What does it help with? Isoprinosine is indicated for most viral diseases, the main ones being:

1. Viral hepatitis;
2. Severe measles;
3. Molluscum contagiosum;
4. Stressful situations;
5. Advanced age;
6. Radiation therapy;
7. Treatment of influenza and other acute respiratory viral infections;
8. Sclerosing panencephalitis (subacute);
9. Viral respiratory infections, incl. viral bronchitis;
10. Chronic infectious diseases of the urinary and respiratory systems;
11. Viral infections in patients with normal immune status and in immunodeficiency states;
12. Human papillomavirus infections of the mucous membranes, skin, including human papillomavirus infection of the vagina, vulva, cervix, genital warts.

In autumn and spring, when the body is especially susceptible to viral infections, the doctor may recommend taking isoprinosine for prophylaxis for those patients who often get sick during these periods.

Indications and contraindications for the use of Isoprinosine tablets

Indications

The drug is prescribed for use in the following cases:

• FLU and other respiratory diseases;
• Measles, chicken pox and other viral infections transmitted by airborne droplets;
• Keratitis, herpes, lichen;
• Epstein-Barr virus or herpesvirus type mononucleosis;
• Diseases of the salivary glands caused by cytomegalovirus;

Contraindications

The drug is not prescribed to people with the following symptoms:

• Kidney failure;
• Inflammation in the genitourinary system, stones in the urinary tract or kidneys;
• Gout, arthritis in the acute stage, characterized by salt deposits in the blood concentration of uric acid;
• Allergy to medication components;
• Children under 3 years of age and pregnant women.

Instructions for use

The instructions for use indicate that Isoprinosine tablets are taken after meals with a small amount of water.

• The recommended daily dose for adults and children aged 3 years and older (with body weight from 15-20 kg) is 50 mg/kg body weight in 3-4 doses (for adults - 6-8 tablets / day, for children - 1/2 tablet per 5 kg body weight/day).
• In severe forms of infectious diseases, the dose can be increased individually to 100 mg/kg body weight/day, divided into 4-6 doses. The maximum daily dose for adults is 3-4 g/day, for children - 50 mg/kg/day.

The duration of treatment for acute diseases in adults and children usually ranges from 5 to 14 days. Treatment should be continued until clinical symptoms disappear and for another 2 days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

For chronic recurrent diseases in adults and children, treatment must be continued in several courses of 5-10 days with a break of 8 days.

For maintenance therapy, the dose can be reduced to 500-1000 mg/day (1-2 tablets) for 30 days.

1. For papillomavirus infection in adults, the drug is prescribed 2 tablets. 3 times a day, children - 1/2 tablet. by 5 kg/body weight/day in 3-4 doses for 14-28 days as monotherapy.
2. For herpes infection, adults and children are prescribed the drug for 5-10 days until the symptoms of the disease disappear; during the asymptomatic period - 1 tablet. 2 times a day for 30 days to reduce the number of relapses.
3. For cervical dysplasia associated with human papillomavirus, 2 tablets are prescribed. 3 times a day for 10 days, then 2-3 similar courses are carried out with an interval of 10-14 days.
4. For recurrent genital warts, adults are prescribed the drug 2 tablets. 3 times a day, children - 1/2 tablet. by 5 kg/body weight/day in 3-4 doses, either as monotherapy or in combination with surgical treatment for 14-28 days, then repeating the specified course three times at intervals of 1 month.

Contraindications for use

Despite the relative safety and effectiveness of the drug, its use is not always permitted. The main contraindications for treatment will be the following:

• hypersensitivity to the components of the drug or tendency to allergic manifestations;
• severe arrhythmia or angina;
• children under 3 years of age, child weight less than 20 kg;
• period of bearing a baby and breastfeeding;
• liver failure, acute hepatitis, liver cirrhosis;
• renal failure, the presence of a large number of stones in the kidneys;
• recovery period after surgery on the abdominal organs;
• internal bleeding of unspecified etiology;
• acute and chronic gout.

With extreme caution, the medication is prescribed to elderly patients with a history of myocardial infarction and cerebrovascular accident. Isoprinosine treatment of underweight children is carried out only with the permission of the pediatrician and after a diagnostic examination, since the active component often provokes negative reactions.

Side effects

The instructions for Isoprinosine indicate that the drug can cause side effects from certain body systems, namely:

1. Polyuria (urinary system);
2. Joint pain (musculoskeletal system);
3. Weakness, dizziness, headache, drowsiness or insomnia (central nervous system);
4. Increased uric acid levels in the blood plasma and exacerbation of gout (metabolism);
5. Nausea, pain in the epigastric region, vomiting, temporary increase in the activity of liver transaminases and alkaline phosphatase (digestive system).

The drug can also cause allergic and dermatological reactions.

Overdose

There is no reliable data in the literature on clinical cases of isoprinosine overdose.

The good tolerability of the drug gives reason to believe that a slight overdose will not have a fundamental effect on the patient’s body, but it is better to refuse personal experiments.

If the daily dosage of Isoprinosine is exceeded by more than 1.5 times, especially in a child, it is necessary to consult a doctor as soon as possible and call an ambulance.

special instructions

Before you start using Isoprinosine tablets, you must carefully read the instructions. There are a few special instructions that you should pay attention to, these include:

1. After taking Isoprinosine tablets for 2 weeks, it is advisable to conduct laboratory monitoring of the level of uric acid in the blood.
2. Medicines from the immunosuppressive group may reduce the effectiveness of Isoprinosine tablets when used together.
3. If the drug is used for more than 1 month, laboratory monitoring of indicators of liver functional activity is necessary.
4. It is necessary to carry out additional monitoring of the level of uric acid in the blood when using Isoprinosine tablets together with drugs that increase its level.

The drug does not have a direct effect on the speed of psychomotor reactions and the ability to concentrate.

Contraindications and side effects

Like any product produced by the pharmacological industry, Isoprinosine has a number of contraindications for use, as well as possible side effects. Let's look at each of these points separately.

The drug is not prescribed if:

The main and most commonly diagnosed side effect of taking Isoprinosine is an increase in uric acid levels during clinical tests. However, the indicators return to their original values ​​a few days after the end of treatment.

All side effects from taking the drug can be divided into certain groups depending on the scope of influence:

Drug interactions

During treatment with Isoprinosine, taking xanthine oxidase inhibitors and uricosuric drugs increases the likelihood of an increase in uric acid concentration in the blood.

When the drug is taken in combination with Zidovudine or Acyclovir, there is a noticeable increase in the therapeutic antiviral effect of the above drugs. When taken simultaneously with immunosuppressants, the effectiveness of Isoprinosine is reduced.

Reviews

We have selected some people's reviews about the drug Isoprinosine:

1. Natalia. After cauterization of condylomas, the doctor prescribed Groprinosin 2 tablets. 3 times a day, but at the pharmacy they gave me isoprinosine, saying that it was the same thing, I already took 4 tablets and, oh horror, a headache began and then an allergy, my eyes became swollen and itchy, I’m not an allergy sufferer in life. I will look for a replacement, it’s a shame that it didn’t fit because the money has already been paid! So be careful, and the instructions about side effects do not say anything about an allergic reaction!
2. Victor. Isoprinosine was prescribed for herpes infection in combination with ointment. The disease has gone away, but I cannot guarantee that it was from Isoprinosine. But I can say for sure that these tablets help a lot with ARVI. Within 3 days of treatment, my wife got rid of her symptoms, and the entire treatment took only 5 days.
3. Elena. The HPV virus was discovered. Isoprinosine was prescribed, 2 tablets 3 times a day, plus Genferon suppositories. I read reviews about Isoprinosine and doubt whether I will be throwing money away. Although HPV is generally difficult to cure, I heard there are more effective drugs. Still in thought.
4. Artem. Isoprinosine has a very bad effect on the kidneys. After a couple of weeks of taking it for genital herpes, pain appeared in the kidney area. I went to get tested and it turned out that there was sand in the kidneys and the level of some kind of acid associated with the kidneys had increased, nothing like this had happened before. So my only sin is this remedy or the antibiotics that were prescribed in parallel for another problem. I will no longer take this medicine, no matter how doctors persuade me, I am still too young for such problems.

Most experts note a pronounced antiviral effect of the drug. Reviews from doctors are quite unanimous: Isoprinosine really works, shortening the duration of the disease and mitigating the symptoms of infection. I would like to emphasize that Isoprinosine is a prescription drug. Only a competent specialist can correctly select a treatment regimen that organically combines the dosages of medicinal substances.

Directions for use and dosage

Isoprinosine is recommended for use for various types of warts, including genital warts and papillomatosis. The dosage of the drug is individual in each specific case and depends on the age group of the patient:

• For adolescents over 12 years of age and adult patients, it is recommended to take Isoprinosine three times a day. The dose of the drug depends on the patient's weight. We drink the tablet whole, without crushing it, and wash it down with plenty of clean water;
• For children aged three to eleven years, the selected dose is divided into three to four doses.

Dose calculation

The dosage of the drug for an adult is calculated based on the patient’s weight: 50 mg of Isoprinosine per 1 kg of body weight or one tablet for every ten kilograms of weight.

As a rule, individual dosage is not calculated. The average daily dose for a person with a normal weight of 60–80 kg is six to eight pills. But in childhood (3 – 11 years) the dose must be calculated. One tablet is taken for every ten kilograms of weight. The resulting norm must be divided into several doses (most often, a four-time dose is recommended).

In case of severe HPV, the dosage calculation is performed slightly differently. In this case, per 1 kg of adult weight there should be 100 mg of the drug or two pills for every ten kilograms of body weight. For children, the permissible daily dose of the drug should not exceed 50 mg per 1 kg of weight, regardless of the severity of the papillomavirus infection.

Elderly patients - over 65 years of age - should take Isoprinosine in the standard dosage intended for adults. The duration of treatment depends on the type of disease, i.e. The attending physician decides how long to take Isoprinosine.

Isoprinosine therapy

Identified papillomas of any location, as well as genital warts (genital warts) require a fairly long period of taking the drug - 14-28 days. In this case, warts found on the genitals must be removed.

The dosage of the medication depends on the age of the patient. Children over 12 years of age and adults are most often prescribed 2 tablets three times a day. Children under 11 years of age should receive a dose of the drug calculated based on the child’s weight: take 1 Isoprinosine tablet per 10 kg of body weight.

The received dose must be divided into three to four doses. Duration of treatment is 14 – 28 days. For human papillomavirus, which manifests itself in the formation of only skin warts, one course of taking the drug is sufficient.

But if genital warts are detected, the patient is recommended to undergo two courses. The first - after removal of tumors, the second - a month after the completion of the first. When diagnosing cervical dysplasia, the following therapeutic regimen is used:

• for 10 days, a woman needs to take 2 tablets of the drug three times a day;
• then you need to take a two-week break and repeat the treatment.

In total, you need to complete two to three courses. Isoprinosine produces positive results in approximately 90% of all cases. According to statistics, in precisely this percentage of patients who took the medication in the recommended dosage, histological studies of the epithelium of the cervical canal show a complete absence of viral load. Relapse of the disease during the first six months was recorded in only 3% of patients.

Cheaper analogues

Drugs like:

• Amiksina (628-1019 rubles);
• Viferon (160-970 rubles);
• Indinola (1160-2780 rubles);
• Acyclovir (16-198 rubles);
• Arbidol (300 rubles);
• Lavomax (547-1021 rubles);
• Kagotsela (223-262 rubles)
• Oksolina (42-87 rubles);
• Panavir (150-1790 rubles);
• Amizona (171-389 rubles);
• Cycloferon (128-890 rubles), etc.

Before using analogues, consult your doctor.

Storage conditions and shelf life

The shelf life of Isoprinosine tablets is 5 years from the date of their manufacture. The drug must be stored in a dry place, out of reach of children, at an air temperature no higher than +25° C.

Isoprinosine tablets: instructions for use - tips and recommendations on News4Health.ru

Life in the modern world is replete with many factors that negatively affect human health. The main ones are poor ecology, questionable quality of food, contaminated drinking water, poor quality medical care, as well as stressful situations and bad habits. Therefore, it is so important to pay attention to regular healing of the body using various methods and means. Be sure to consult a specialist so as not to harm your health!

Analogs

Structural analogue of the active substance is Groprinosin.

If necessary, you can replace Isoprinosine with an analogue according to the mechanism of action - these are the following drugs:

1. Lavomax;
2. Kagocel;
3. Amiksin;
4. Tiloron;
5. Isentress;
6. Ergoferon;
7. Nikavir;
8. Viracept;
9. Fuzeon;
10. Oksolin;
11. Panavir.

When choosing analogues, you must remember that the instructions for use of Isoprinosine, price and reviews do not apply to drugs of similar action. Replacing the drug is permissible only after the recommendation of a doctor.