Benzyl benzoate 20 is a drug with acaricidal properties against various types of mites (scabies, demodex, etc.). Included in the Russian list of essential medicines. The main areas of treatment are scabies, demodicosis and pediculosis, but it is also used in the treatment of acne, oily seborrhea and pityriasis versicolor.
Benzyl benzoate 20 is a drug with acaricidal properties against various types of mites (scabies, demodex, etc.).
pharmachologic effect
The anti-scabies drug is used externally only.
Pharmacokinetics
Benzyl benzoate ointment, getting on the surface of the skin, penetrates the upper layer of the epidermis, but is not absorbed into the hematopoietic system.
Benzyl benzoate ointment penetrates the upper layer of the epidermis, but is not absorbed into the hematopoietic system.
Pharmacodynamics
The drug has a toxic effect on scabies mites. It also has a detrimental effect on all types of human lice and demodex mites. Does not affect tick and lice eggs.
Pharmacological authorities
Pharmacodynamics.
Benzyl benzoate has antipediculosis and acaricidal activity on various types of mites, including crustaceans (Acarus scabiei).
Benzyl benzoate passes through the chitinous membrane of ectoparasites, accumulates in the body at toxic concentrations, causing the death of adult individuals and larvae; not suitable for eggs.
The death of lice occurs after 2–5 years, of ticks – after 7–32 years.
Pharmacokinetics.
Benzyl benzoate, when applied to the skin, penetrates the epidermis from the top; the systemic blood flow does not drain.
Method of use of Benzyl benzoate 20
The drug is used by external application to the skin. The course of treatment is 4 days.
Children over three years of age are recommended to use a 10% concentration ointment, adults – 20%.
On the first day of treatment, the ointment is applied to clean hands, body and feet along with fingers. Make sure that there is no untreated area of skin, with the exception of the face. After applying the ointment, you should use clean bedding and clothing. After this, the ointment is not washed off for 2 days. On the 4th day of treatment, after washing, the entire body, arms and legs are treated again and the underwear and things are completely replaced.
After each treatment, do not wash off the ointment from your hands for 3 hours. In the future, after each hand washing, they are treated with Benzyl benzoate ointment. On the fifth day of treatment, the ointment is completely washed off the body. Clothes and bedding must be boiled.
On the first day of treatment, the ointment is applied to clean hands, body and feet along with fingers.
Use of benzene in medicine
The first attempts to use benzene in medicine were made a very long time ago. The first area where it was applied was oncohematology. The main idea behind benzene was to use it to treat a disease such as leukemia. The speed at which this idea spread was enormous. In 1912, doctors around the world used this substance to treat leukemia in patients. At first, the substance was used only for oral administration. However, fairly soon injection attempts were made. By this time, the outbreak of using raw materials for medicinal purposes had already subsided. It turned out that leukemia cannot be cured in this way. In addition, this chemical has many dangerous side effects.
However, while the composition was still being used, doctors highlighted some positive aspects. For example, benzene caused the number of white balls in the blood to decrease significantly by the end of the 2nd and beginning of the 3rd week. Red blood cells initially decreased in number, but then this quickly passed and the number increased again. It was also noted that benzene can improve the leukemic composition of the blood in cases where the X-ray method was not able to cope.
However, as already mentioned, this method was quickly recognized as ineffective and dangerous.
special instructions
If the drug gets into the oral cavity or the mucous membrane of the eyes, it is necessary to rinse with a 1-2% soda solution. In case of accidental ingestion, the stomach should also be rinsed with a weak solution of baking soda.
To avoid secondary infection, treatment must be carried out on everyone in contact with a person with scabies. During treatment, itching is possible, which is the body's reaction to killed mites. To eliminate this discomfort, you can take antihistamines.
Cutlery, things and objects that patients come into contact with are subject to mandatory processing.
Clothes and bedding are treated by boiling in a solution of washing powder for at least 10 minutes.
If it is not possible to boil things, they must be ironed with a hot iron on both sides or taken out into the open air for ventilation for at least 3 days. The apartment should also be disinfected, including furniture, walls and windows.
During pregnancy and lactation
The use of benzyl benzoate ointment during pregnancy and lactation is contraindicated.
For children
The ointment is approved for treatment of children over three years of age at a 10% concentration of the active ingredient.
Alcohol compatibility
Drinking alcohol during treatment with the drug does not affect the quality of therapy.
How much does benzyl benzoate emulsion cost?
Cost of the drug
depends on the packaging volume:
- price for 20% emulsion in 200 ml - from 120 rubles;
- 50 grams of 20% benzyl benzoate emulsion costs from 20 rubles.
Despite the rather low prices, the drug is quite effective. However, to avoid adverse reactions, it should be used based on contraindications, your own condition and strictly according to the instructions.
Average price online*, 29 rub. (ointment 20% 25g)
Directions for use and doses
Treatment with the drug is carried out in a course. For children, a 10% ointment is used, and for adults, a 20% ointment is used. On the first day, treatment is carried out before bedtime, in the evening. Shortly before this, the patient needs to wash thoroughly with warm water and soap in the shower and wipe dry.
The product should be rubbed into a thin layer into the skin on the hands, then gradually applied to the entire surface of the body, including the toes and feet. After the patient's skin has been treated, he needs to put on clean clothes and underwear.
On the second and third days the drug is not used. In this case, the patient should not wash off the remaining ointment all this time.
After treatment, the patient should not wash his hands for 3 hours. If the ointment is washed off your hands, it should be reapplied.
Thus, hand disinfection should be done after each wash.
On the 4th day, the patient must wash thoroughly with soap and rub in the ointment again, just as on the 1st day. Then you should change all linen and clothing.
The patient can completely wash off the product from the entire surface of the skin only on the fifth day, in the morning, after waking up. Water procedures should be carried out using soap.
Contraindications
The product is contraindicated in children under 3 years of age.
Pregnancy and lactation
The drug is contraindicated for women at any stage of pregnancy. It may be prescribed by a doctor when the benefit to the mother outweighs the risk to the fetus.
In addition, the drug is contraindicated for nursing mothers, since a small amount of the drug can enter the baby’s body through breast milk.
Overdose
To date, there have been no reported cases of drug overdose.
In case of overdose, wash the product thoroughly with soap and water and immediately seek help from a medical facility.
Side effects
Local reactions may occur: skin irritation, dry skin, and allergies. Such side effects are especially common in children.
Composition of the drug
The active ingredient is medical benzyl benzoate.
Auxiliary components - sodium hydroxide, nipazole, purified water, arepol, Tween-80, nipagin.
Description: ointment with a specific odor. The color is white-yellowish or white. The formation of air bubbles in the ointment is allowed.
Pharmacology and pharmacokinetics
Anti-scabies product for external use. It has a toxic effect on adult scabies mites.
It can cause death not only of adult scabies mites, but also of their larvae.
The drug penetrates the upper layer of the skin, and at the same time it is not absorbed into the systemic bloodstream.
Other
The shelf life is 4 years from the date of manufacture of the drug. The ointment should not be used after the expiration date. Conditions for dispensing the drug from pharmacies: the drug is dispensed from pharmacies without a prescription.
special instructions
Treatment of infected patients, as well as persons who have been in contact with them, must be carried out simultaneously. This is necessary to prevent a repeat outbreak of infection in the future.
It is not uncommon for the patient’s skin to continue to itch after treatment. In this case, patients should not take any additional actions (for example, again smearing the skin with the drug).
There is also no need to conduct a course of additional specific therapy. The fact is that itchy skin indicates that treatment with the ointment was successful.
Itching is a response of the human body to waste products released by an adult mite, as well as to the dead scabies mite itself and its larvae.
If the itching is unbearable, the patient must take antihistamines or ointments, the main active ingredients of which are glucocorsteroids. After such treatment, the patient should be under the strict supervision of a dermatologist for at least 2 weeks.
Patients undergoing treatment for scabies should pay special attention to objects that have come into contact with skin infected with mites.
All linen, towels and bedding should be boiled in water with added detergent for 5 or 10 minutes. Outerwear should be ironed with a very hot iron on both sides.
As for toys and shoes, as well as other household items that an infected patient has come into contact with, they are placed in a durable plastic bag for a period of 5 days.
Blankets, pillows and mattresses should be disinfected in special disinfection chambers or stopped using for a period of five days.
As for upholstered furniture, its surface is treated with disinfectants. The apartment must be carefully processed (including even the most inaccessible places, especially baseboards and door jambs).
Floors must be washed using special detergents or disinfectants. In this case, you should avoid getting the detergent on your mucous membranes.
Tradename
Benzyl benzoate
International nonproprietary name
Benzyl benzoate
Dosage form
Ointment for external use
Release form
Ointment 10% and 20%, packaged in aluminum tubes of 25 g, 30 g and 50 g. Each tube is placed in a cardboard box along with instructions for use from the manufacturer.
Storage conditions
The product must be stored in a dry, dark place, out of the reach of children. Storage temperature should not be more than 25 degrees.
Precautionary measures
If the drug gets into your eyes or mucous membranes, rinse them immediately with water and seek medical help.
Benzyl benzoate is an external medicine (emulsion, ointment) intended for the treatment of scabies. Causes toxic damage to scabies mites. Has an anti-pediculosis effect. Used in pediatric practice in patients over three years of age. Contraindicated for persons with individual intolerance to the active component, pregnant women and nursing mothers. The duration of treatment, regardless of the dosage form, is 4 days. For adults, 20% ointment (or emulsion) is indicated, for children - 10%. Before use, the emulsion is diluted with boiled water at room temperature, using equal parts of water and the drug. On the first day, apply the emulsion or ointment in the evening before going to bed after taking a warm shower and thoroughly washing with soap. The pharmaceutical substance (whether it is an emulsion or an ointment) is rubbed into the skin of the upper extremities, torso, and then the lower extremities. After the procedure, only clean underwear and wardrobe items are used. For the next two days, benzyl benzoate is not applied, and the remnants of the previously applied substance are washed off with water. The fourth day repeats the first day: the patient takes a shower, performs all hygienic measures, rubs the drug into the skin in a given sequence and changes clothes. After completing the procedure, you should refrain from washing your hands for three hours. In the future, apply the drug to your hands after each wash.
The same is done for other areas of the skin from which the emulsion or ointment was accidentally washed off. The drug is completely removed from the skin of the body on the fifth day. Drug therapy for complications caused by scabies (inflammatory, purulent and/or eczematous skin lesions) is carried out simultaneously with treatment of the underlying disease until the patient is completely cured of all its consequences. Benzyl benzoate is well tolerated by patients. Side effects are relatively rare. In this regard, only allergic and local reactions can be noted, manifested by irritation, hyperemia and local burning. If such reactions of the body to benzyl benzoate develop, its use should be discontinued. There are no cases of drug overdose or pharmacological interaction with other drugs reported in the medical literature. Itchy skin at the end of treatment does not indicate its failure and the need for a second course of medication: this is the body’s reaction to a dead tick. It resolves with the use of antihistamines and external glucocorticosteroids. All items with which the patient has been in contact must be subjected to heat treatment. The apartment must be thoroughly cleaned using detergents and disinfectants.
Release form
25 g - aluminum tubes (1) - cardboard packs.
Dosage
Apply externally. The dosage regimen depends on the indications and dosage form used.
During the Soviet period, liniment was actively used for the treatment of acne and scabies. In modern dermatology, the medicine is practically not used, despite its high effectiveness. Buyers prefer more expensive Western analogues.
Pharmacological group and action
The components of liniment are characterized by targeted activity towards lice, regardless of the type, as well as scabies and mites.
Release form and composition
In pharmacies, the medicine is available in several dosage forms:
- Benzyl benzoate ointment 10% for external use - a homogeneous composition of white color with a pronounced odor, supplied in 25 g aluminum tubes, each of which is placed in a cardboard box;
- liniment Benzyl benzoate 20% for surface treatment;
- emulsion 10% – homogeneous consistency of white color, packaged in 200, 100 and 50 g bottles, glass bottles.
The listed forms of the drug differ little in composition. The emulsion consists not only of the main active ingredient, but also distilled water, medical wax and laundry soap. As for the ointment, the only company with benzyl benzoate is the emulsion-water base.
According to the official instructions, Benzyl benzoate cream is used only externally. To treat pediculosis or get rid of scabies mites in adults, 20% liniment is prescribed. Children are treated with 10% ointment. The average duration of course therapy is 4-5 days.
If we are talking about small lesions, one course of treatment is enough to eliminate pathogenic bloodsuckers. If living individuals (lice or ticks) are detected, the therapeutic course must be repeated.
Indications and contraindications
The ointment in question with benzyl benzoate has been successfully used for several decades to treat a number of diseases and associated complications. I prescribe the drug for the following ailments:
The pharmaceutical product is not suitable for all patients, so it is important to carefully study the contraindications before use.
The drug is not prescribed for:
Despite the relative safety of the drug, it is important to first consult with a dermatologist.
Directions for use and doses
The drug is intended for external use only; doses vary depending on the course of the disease and the age of the patient. To obtain a stable and long-lasting effect, it is recommended to treat all patients simultaneously.
According to the instructions, the composition is recommended to be used as follows:
Side effects and special instructions
In the vast majority of patients, the composition in question does not cause side effects. If the skin is highly sensitive, the possibility of individual allergic reactions may occur:
In 99% of cases, when the ointment is reapplied, the listed symptoms do not appear. In cases where adverse reactions do not go away, you must stop using the drug and consult a doctor to adjust the treatment regimen.
Special instructions:
- the average dosage of liniment for an adult is 10-15 g;
- sensitive areas of the body are treated without rubbing the composition into the epithelial layer;
- if the composition gets into the oral cavity, it is rinsed with a solution of activated carbon and burnt magnesia;
- course therapy involves the use of 60 to 90 g of ointment.
Before treating lice pubis, you should consult a dermatologist. A wide range of highly specialized medications are available for sale to eliminate intimate problems.
Pregnancy and lactation
Pediatricians emphasize that benzyl benzoate is strictly contraindicated during pregnancy or breastfeeding. The active components of the ointment cross the placental barrier and can harm the fetus.
Use in childhood
For children, a 10% composition is prescribed for scabies or a 10% emulsion for the treatment of lice. The method of application is similar to that discussed above. Doctors do not recommend using the medication for patients under 3 years of age.
Drug interactions
The medication does not interact with other drugs. However, dermatologists do not recommend using several external emulsions or ointments at the same time. The use of corticosteroids eliminates the symptoms of the disease, but does not eliminate the invasion as a whole. Part of the bacteriostatic properties of the drug is lost when taking medications that contain cetylpyridinium chloride.
Interaction with other drugs
No cases of negative reactions due to the interaction of the drug Benzyl benzoate have been identified.
The simultaneous use of benzyl benzoate with other external drugs is not recommended.
But, like other antiparasitic agents, simultaneous use with other external drugs is not recommended.
Contraindications
The instructions for use of Benzyl benzoate indicate the following contraindications:
- If the child is under 3 years of age;
- There is a possibility of increased sensitivity to the main components of the product;
- Pregnancy period;
- Breastfeeding period;
- Pustular diseases of the epidermis.
Benzyl benzoate does not affect the ability to react when driving vehicles and when performing everyday work with other mechanisms.
