Goldline is one of the drugs for the treatment of obesity , registered in Russia since 2009. This medicine is manufactured by RANBAXY LABORATORIES Ltd.
(Bulgaria). The active ingredient in Goldline is sibutramine, as in a number of other medications - Reduxin, Lindax, Meridia. The drug is dispensed in pharmacies with a doctor's prescription. Even if you have the opportunity to purchase medicine without a doctor’s prescription (for example, from an online pharmacy), it is strictly not recommended to start treatment with this serious drug without consulting a specialist.
Pharmacokinetics of Goldline
After oral administration, Goldline is well absorbed from the gastrointestinal tract. At least 77% of the active substance enters the blood. Next, Goldline undergoes biotransformation in the liver, where it acquires its active form in the form of metabolites. The maximum concentration of the drug in the blood is achieved after 1.2 hours, and its active metabolites - after 3-4 hours. Simultaneous administration of the drug and food reduces the maximum concentration by 30% and slows down the time of its onset by 3 hours. Goldline is quickly distributed throughout all tissues of the body .
It binds well to plasma proteins (94-97%). After 4 days of regular use of the tablets, the plasma concentration reaches a peak and is twice as high as the same value after a single dose of Goldline. Thus, the maximum effect of the drug occurs only after several days of treatment. The active ingredient in Goldline tablets is excreted mainly by the kidneys. After 14-16 hours from the moment of administration, the concentration of active metabolites in the blood plasma drops by half. Traces of the drug are found in the body within several days after stopping the use of the tablets.
Pharmacological properties
The action of Goldline Plus is determined by its constituent components. Sibutramine is a prodrug that is converted in the body into metabolites - primary and secondary amines, which exert a therapeutic effect - block the reuptake of neurotransmitters - serotonin, norepinephrine, dopamine - in the synaptic cleft. Due to this, the feeling of satiety is prolonged, the feeling of hunger is reduced and heat production is increased.
Clinical studies have shown that reducing the feeling of hunger and prolonging the feeling of fullness leads to a reduction in the volume of food consumed by 20% and caloric intake by 25%. Due to the increase in heat production, about 100 kcal are burned additionally per day.
While taking Goldline Plus, in addition to reducing body weight, there is an increase in the blood level of high-density lipoproteins (HDL), a decrease in low-density lipoproteins (LDL), total cholesterol, triglycerides and uric acid.
Microcrystalline cellulose (MCC) is an enterosorbent, has a nonspecific detoxification and sorbent effect, binds and removes from the body various microorganisms, their metabolic products, allergens, xenobiotics, toxins of endogenous and exogenous nature.
Contraindications to the use of Goldline tablets
This medicine has many contraindications, and therefore should be prescribed by a doctor and only after a thorough examination. So, Goldline for weight loss should not be taken if the patient has organic causes of obesity (hypothyroidism, prolactinoma), bulimia nervosa, mental illness, alcoholism, drug addiction, cerebrovascular accidents, heart and vascular disease, arrhythmia, uncontrolled arterial hypertension, pheochromocytoma, thyrotoxicosis, prostate adenoma, angle-closure glaucoma, severe kidney or liver disease.
Goldline tablets should not be taken by children under 18 years of age and elderly patients over 65 years of age, as well as pregnant women and nursing mothers. You cannot simultaneously take Goldline and other drugs for weight loss with central action, as well as drugs that affect the central nervous system (antidepressants, anticonvulsants), monoamine oxidase inhibitors, tryptophan. If you are allergic to sibutramine or the excipients of the drug, then Goldline is not prescribed.
Popular release forms
- Goldline. The pills consist of sibutramine and microcrystalline cellulose. The drug is also available in a minimum dose - 5 mg, packaged in 10, 30, 60, 90, 120 pieces.
- Goldline Light . Includes L-carnitine and alpha-lipoic acid, which help burn fat deposits, but subject to a balanced diet and moderate physical activity (walking, running, fitness, gymnastics, swimming).
Properties of L-carnitine
- Increases endurance, improves performance and overall well-being.
- Blocks the accumulation of lactic acid in the muscles, thereby reducing discomfort in them after exercise and stress.
- Promotes the release of cellular energy reserves.
- Actively breaks down fat deposits.
- Accelerates muscle growth.
Properties of alpha lipoic acid
- Reduces blood glucose levels.
- Activates metabolism, normalizes carbohydrate and fat metabolism.
- Prevents the formation of “bad” cholesterol.
- Increases the stability of the nervous system, regulates mood.
There is another form of release of the drug - this is Goldline Plus, 15 mg . This drug, unlike the Indian original, can be bought without prescriptions in an online pharmacy.
A special feature of Goldline Plus is that the cellulose contained in it was isolated by the manufacturing company from the group of excipients into a separate component, which also actively affects the weight loss process.
In principle, there are only a few parameters by which you can determine how Goldline differs from Goldline Plus:
- science classifies the first one as a group of pharmacological drugs intended for the treatment of obesity, and the second one as a means of regulating appetite;
- Goldline is an Indian medicine, Goldline Plus is Russian;
- The price for an original imported drug is higher than for a two-component analogue from a domestic manufacturer;
- Goldline Plus is more accessible to consumers who have decided to get rid of extra pounds, as it is freely sold on Internet resources.
The composition and release form of these drugs are identical. But Goldline Light is not a medicine, but is a food supplement that can be purchased without a prescription in Russia. The product is manufactured by Izvarino Pharma.
Side effects of Goldline
During the first month of using Goldline, side effects are most likely to develop. Over time, the severity of these phenomena weakens. From the central nervous system, insomnia, headaches, dizziness, and anxiety are possible. From the cardiovascular system, rapid heartbeat, increased blood pressure, and redness of the skin are sometimes observed. From the gastrointestinal tract, dry mouth, loss of appetite, constipation, nausea, and changes in taste sensations are possible. Sometimes there is increased sweating and itchy skin. Quite rarely, after stopping treatment, a reaction to Goldline withdrawal develops - increased appetite, headache . In isolated cases, other side effects have been recorded.
special instructions
Goldline diet pills are prescribed only in cases where all other measures aimed at weight loss are ineffective. Treatment should be carried out under the supervision of a specialist who has sufficient experience in weight correction for obesity as part of complex treatment (including physical activity, review of diet, habitual lifestyle, diet).
The period of taking Goldline at a dose of 15 mg should be limited in time.
In the first 8 weeks of treatment, heart rate and blood pressure should be monitored every 2 weeks. After this time, monitoring is carried out once a month.
For patients with arterial hypertension (when the pressure is at the level of 145/90 mm Hg), blood pressure and heart rate are recommended to be monitored more often and more carefully. If the pressure rises above the specified values 2 times, treatment with Goldline is stopped.
The appearance of chest pain, swelling of the legs, and progressive dyspnea may indicate the development of pulmonary hypertension (such conditions require consultation with a doctor).
Women of childbearing age should use effective contraception throughout the entire course of use.
Sibutramine has the ability to reduce salivation, cause a feeling of discomfort in the oral cavity, provoke the development of caries and periodontal , thrush .
During the treatment period, you should refrain from performing work that could potentially threaten your health and life, as well as from driving a car.
Reviews about Goldline
Reviews of Goldline from doctors (endocrinologists and therapists) are generally positive . Its high efficiency is noted. Usually the medicine is prescribed to obese patients who are prone to overeating carbohydrates and bulimia. They try to prescribe the drug with caution only to young people without severe chronic diseases. This caution is due to the fact that in many countries sibutramine is banned due to the risk of death in patients from heart attack or stroke, as well as suicide. Similar risks have been identified in fairly long-term controlled studies. In Russia, since 2008, the substance has been included in the officially approved list of potent drugs.
Reviews of Goldline from patients note the high effectiveness of the drug. Patients like the sharp decrease in appetite, increased mood, performance, and vigor, which they associate with taking the drug. Negative reviews talk about side effects: hypertension and insomnia. August 25, 2013
Diet
Many people are concerned about the question of whether it is necessary to rebuild the nutrition system while taking capsules. There are no strict recommendations, however, everyone should understand that the drug in question is just a supplement that does not eliminate extra pounds, but only helps fight appetite and overeating.
It is important to adhere to the basics of proper nutrition so that weight loss is quick and the results are long-lasting. Experts advise avoiding the following products:
- Fried, salted, smoked;
- Sweets;
- Flour products;
- Alcohol.
Try to choose healthier foods; when choosing a diet, consider what benefits a particular product will bring to the body. Dishes should include proteins, calcium, phosphorus, iron, and vitamin complexes.
If the majority of your daily calories are made up of proteins, you will provide yourself with a long-lasting feeling of satiety and increase muscle tone. Iron increases hemoglobin levels, which has a positive effect on the functioning of the immune system.
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An important part is the drinking regime. When taking Goldline, it is imperative to drink as much plain water as possible. Firstly, it will prevent dehydration, and secondly, it will normalize the water balance in the body, speed up the removal of toxins, and get rid of sludge.
The essence of the drug's action
In any case, the use of Goldline should be approached very carefully, since the drug is effective and therefore has a significant effect on the body. The drug is available in 15 mg capsules. The main substance is sibutramine hydrochloride monohydrate. Additional substances include magnesium stearate, cellulose, lactose, and silicon dioxide.
The instructions for use tell us that Goldline is a centrally acting drug that increases the concentration of happiness hormones. They, in turn, reduce appetite and the need for food, and help you feel full faster. Calories are also consumed much faster by the body.
Final recommendations
Unfortunately, the majority of those who want to get rid of the hated kilograms choose the route of taking medications, but are in no hurry to change their attitude towards nutrition and exercise. Otherwise, the results would have been much more impressive.
It is generally accepted that the duration of the full course of treatment is 12 months. During this entire period, you should stick to a specific training plan, and not overeat along with using goldline.
It is necessary to treat the drug as one of the elements of a complex to combat excess weight. But in order not to fall into excessive depression, which can be caused by sibutramine, pharmacists have ensured that Goldline is able to forcibly induce the secretion of serotonin, which is called the hormone of joy. To some extent, this fact can balance out all the possible side effects that the patient encounters while using the drug.
