Normaten: composition, properties, patient reviews

This drug is intended for the control of hypertensive manifestations and management of angina pectoris. It is also used as maintenance therapy for cardiac performance and normalization of blood pressure. Normatens, whose reviews are mostly positive, promotes long-term prevention of myocardial infarction after recovery.

• Country of origin: Russia
• Price: 990 rub.
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Composition and dosage form of the drug

Normatens is available in tablet form, the shell is white, one blister contains 20 pieces. The package contains one or two blisters - 20 or 40 pieces. The abstract indicates that each Normatens tablet contains 5 mg of clopamide, 0.1 mg of reserpine and 0.5 mg of dihydroergocristine methanesulfonate. Additionally, the composition includes magnesium stearate, lactose, zinc, crystalline cellulose and other substances.

Reserpine is a plant alkaloid with sympatholytic properties. Thanks to the action of reserpine, the production of catecholamines in nerve cells is accelerated. In addition to the ability of reserpine to stabilize blood pressure, the substance can normalize sleep and eliminate insomnia. It perfectly helps patients with primary hypertension and prevents the development of possible negative reactions.

Dihydroergocristine is an alkaloid derived from ergot. It blocks alpha receptors in the walls of blood vessels. Thanks to its action, blood pressure is significantly reduced, the pulse rate is reduced, and there is a slight calming effect.

Clopamide is a diuretic drug that acts on certain structures of the nephron. The substance inhibits the reabsorption of sodium and activates the evacuation of ions and water.

Normatens. Pharmacology

Normaten is a combination product. The action of reserpine is aimed at lowering blood pressure for a long time by reducing the amount of neurotransmitter that is released at the endings of the sympathetic nerves. This helps to inhibit the transmission of adrenergic excitation. Its ability to reduce the concentration in neurons of dopamine and other neurotransmitters, including serotonin, has an antipsychotic effect.

The drug reduces the effect of sympathetic innervation on the cardiovascular system, reduces heart rate, as well as total peripheral vascular resistance. At the same time, the activity of the parasympathetic nervous system remains. Under the influence of this remedy, sleep improves significantly. Interoreceptive reflexes (from receptors exclusively in internal organs) slow down.

The drug has a beneficial effect on the gastrointestinal tract, improving its peristalsis and increasing the amount of HCl. Under its influence, all metabolic processes proceed more slowly. Breathing movements become calmer, deeper, less frequent. The consequence of taking the drug is miosis (the pupil is narrowed) and low temperature. Metabolism loses its intensity.

If a person suffers from arterial hypertension, the drug can help normalize protein and lipid metabolism. Blood flow in the kidneys improves, glomerular filtration returns to normal.

Clopamid. Diuretic with moderate effect. It is based on sulfonamide substances. Belongs to the non-thiazide variety. Its action is based on blocking the reabsorption of Na+, reducing the amount of Na+, K+, Cl-, and water.

Dihydroergocristine mesylate. It is essentially a dihydrogenated ergot alkaloid. Its effect is directed at alpha adrenergic receptors, which it blocks. The drug dilates blood vessels and reduces their peripheral resistance.

The hypotensive effect is quite strong. This combination lowers blood pressure more effectively than the individual drugs included in its composition. A combination of two components of this remedy, taken in any order, is also less effective than this combination. The positive effects can be felt after 4 – 7 days. But after a week - 4 weeks, the product will give a lasting effect.

Mode of application

Doctors recommend taking Normatens daily, drinking one tablet daily. In case of urgent need, if patients have a sharp increase in blood pressure, you can take an additional dose, but not more than three tablets.

Important! With prolonged use, the first results from the action of Normatens can be assessed after about two weeks. At first, you should not increase the dosage; you need to wait until the levels stabilize, and then take strictly the daily dose of Normatens per day.

If patients are undergoing surgery for any reason, even not related to cardiac pathologies, then the drug is discontinued one to two weeks before the intervention.

In some cases, patients may experience slower heart rates, changes in blood sugar and uric acid levels. In this case, there is a need to adjust the dosage by contacting a specialist.

special instructions

• During therapy, monitoring of serum potassium levels is necessary;
• long-term treatment requires adherence to a diet with an increased potassium content or the use of additional potassium-containing drugs;
• 2 weeks before the planned surgical intervention, you must stop taking Normatens and replace it with another antihypertensive drug;
• 1 week before electroconvulsive therapy, discontinue the drug;
• do not drink alcohol;
• due to impaired reaction speed and attention, patients should avoid driving, complex mechanisms and activities that require concentration and rapid psychomotor reactions.

During treatment, doctors prescribe the patient a therapeutic diet, which is characterized by a high content of potassium products. The instructions for use also contain other special instructions:

• during drug therapy, potassium levels in the blood are systematically monitored;
• for the period of treatment, patients refuse to drive a vehicle and do not engage in intellectual activity;
• a couple of weeks before surgery, treatment with Normatens is stopped and another antihypertensive drug is selected;
• during treatment, alcohol consumption is completely excluded, otherwise the therapeutic effect is reduced;
• 1 week before electroconvulsive therapy, the medication is discontinued.

Interaction with other substances

Normatens is able to enhance the effect of antihistamines and barbiturate substances. When used together with cardiac glycosides, Normatens promotes bradycardia and a significant decrease in the concentration of potassium ions. A combination of the drug with non-steroidal anti-inflammatory drugs, laxatives and corticosteroids will have the same effect.

Normatens is able to weaken the work of anticoagulants and drugs to lower blood sugar levels. Cannot be combined with Dopamine, Quinidine. If combined with Cordarone, the effect of this drug will decrease. Normatens should not be taken at the same time as drinking alcohol.

Side effects and overdose

Like many drugs, Normatens is not without side effects, a description of which is contained in the information sheet for the drug.

They manifest themselves in various areas of the body’s activity:

• from the digestive system: Normatens can worsen appetite, provoke stool disorders, and cause dry mouth. Rarely, Normatens can cause bleeding and ulceration of the gastric mucosa;
• on the part of the heart and blood vessels, the drug can provoke hypotension, a rare pulse; the nervous system occasionally responds with lethargy, patients experience drowsiness, depression, and twitching is felt in certain muscles;
• on the part of the respiratory system, bronchial obstruction and swelling of the nasal mucosa are sometimes observed;
• Itching and urticaria-type rashes may appear on the skin.

Important! If you take the medication in excess of the recommended dosage, patients may experience vomiting, dizziness, in some cases the blood pressure drops sharply, and there is a risk of coma, although such side effects have been reported in isolated cases. If an overdose is suspected, it is recommended to rinse the stomach and begin therapy to eliminate the symptoms.

Contraindications for use

Normatens is not recommended for use in the following cases:

• if patients have individual sensitivity to the components of the drug; during an exacerbation of gastric and duodenal ulcers, with ulcerative colitis and liver failure;
• with diagnosed angle-closure glaucoma;
• if the patient has elevated urea levels, chronic renal failure or nephritis is diagnosed;
• for epileptic seizures, depression, Parkinson's disease;
• if the patient has a deficiency of potassium, sodium, chlorine;
• with pheochromocytoma;
• when treated with monoamine oxidase inhibitors;
• if the patient suffers from gout;
• with atrioventricular or intraventricular block;
• if the patient suffers from disorders of the hematopoietic process;
• after a recent heart attack, with chronic heart failure, bronchial asthma, bradycardia;
• with arterial hypotension;
• during pregnancy, since the components reserpine and dihydroergocristine are found in breast milk, and clopamide provokes thrombocytopenia in the fetus;
• The drug is also not prescribed for children.

By publishing instructions for use of the drug Normatens, the pharmacy does not recommend using it for self-medication.

Registration number: P N001403/01-191207 Registration number is the number of the registration certificate, which confirms that in the Russian Federation in accordance with the Federal Law of June 22, 1998. No. 86-FZ “On Medicines” the drug is registered and included in the state register of medicines. This is the registration number for the medicine. the drug Videstim® P N001403/01-191107 means that the drug was included in the register under number 001403 in 2001, and the last re-registration of the regulatory document regulating its quality was carried out by Roszdravnadzor on November 19, 2007. Trade name: Normatens Trade name is the name of the medicinal product under which the drug is registered by an authorized state body, entered into the state register and is in circulation of medicinal products. The trade name is protected by a trademark certificate. This means that no drug or other product in the Russian Federation can bear the same name. The trade name is usually created by the drug developer or manufacturer. means and carries a certain meaning: the name Normatens is derived from the words Tens (pressure) and norm and reflects the pharmacological effect of the drug. International nonproprietary name: Normates. International nonproprietary name (INN) is the unique name of the active substance of a drug, recommended by the World Health Organization (WHO). The INN is fundamentally assigned only to single, clearly identifiable substances that can be unambiguously characterized by chemical nomenclature (or formula).

Dosage form: Dosage form is a state given to a medicinal product, or medicinal plant material, that is convenient for use and in which the required therapeutic effect is achieved. Normatens is available in the form of tablets for internal use.

Composition: active substance: reserpine, clopamide, dihydroergocristine Description : dragee. Main characteristics of the finished medicine. forms in accordance with regulatory and technical documentation - appearance, color, if necessary, smell, solubility in water and other solvents. Pharmacotherapeutic group: . Group affiliation of the drug according to the classification of drugs recommended by the World Health Organization Anatomical Therapeutic Chemical Classification (ATC). Due to the fact that Normatens tablets contain Reserpine 0.1 mg Dihydroergocristine methanesulfonate 0.5 mg Clopamide 5 mg. The drug can be classified as a combined drug for lowering blood pressure Code ATX (D10AD02). Anatomical-therapeutic-chemical classification is an international system for classifying medicines. The abbreviations used are Latin - ATC (from Anatomical Therapeutic Chemical) or Russian - ATC (anatomical-therapeutic-chemical). The classification is carried out by WHO according to the methodology of drug statistics. Adopted by the Ministry of Health of the Russian Federation. Pharmacological properties The pharmacological properties of a drug include its effect on sick and healthy organisms. The mechanism of the drug's hypotensive effect includes a moderate diuretic effect and inhibition of the activity of the adrenergic system at the peripheral and central levels. Dilates blood vessels and reduces heart rate. Absorption of individual components of the drug in the digestive tract is: reserpine - about 30–40%, clopamide - almost 60%, dihydroergocristine - <50%. Pharmacokinetics Pharmacokinetics studies the dynamics of drug intake and elimination. substances from the body after its single or repeated application to the skin. The maximum concentration in the blood plasma is achieved: reserpine - after 2 hours, clopamide - after 2 hours, dihydroergocristine - after 1 hour. The components of Normatens distribute well in the tissues of the body. Reserpine and dihydroergocristine are metabolized in the liver to inactive metabolites, which are excreted in urine and feces. Clopamide does not undergo significant hepatic metabolism and is excreted mainly in the urine. . Indications for use A list of pathological conditions for which a particular drug and the method of its use may be recommended. Hypertension with insufficient effectiveness of monotherapy - essential hypertension; symptomatic hypertension - renal (with glomerulonephritis, pyelonephritis, interstitial nephritis), caused by atherosclerosis of peripheral vessels, diseases of the endocrine glands (hyperthyroidism, adrenal hyperfunction, adrenal-genital syndrome, primary hyperaldosteronism, pheochromocytoma). Contraindications A list of restrictions on the use of a particular drug or route of administration (for example, it cannot be prescribed to people with diabetes, liver or kidney pathologies, etc.). Increased individual sensitivity to the components of the drug. Pregnancy and lactation The use of the drug is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus or child. hypersensitivity to sulfonamides, reserpine and ergot alkaloids, depression, epilepsy, Parkinson's disease, peptic ulcers of the stomach and duodenum, ulcerative colitis, hypertension in pheochromocytoma, pregnancy and lactation. Method of administration and dosage A method of using a medicinal product that ensures maximum manifestation of the planned pharmacological effect with minimal side effects. It is recommended to begin treatment by prescribing 1 tablet once a day during or after meals. If the hypotensive effect is insufficient, the dose of the drug is increased to 2 tablets per day (1 tablet every 12 hours), and in exceptional cases, 1 tablet is prescribed 3 times a day (every 8 hours). For long-term treatment, if a satisfactory effect is achieved, it is recommended to switch to maintenance treatment: 1 tablet once a day, and some patients can take 1 tablet every other day.®. The duration of treatment depends on the nature of the disease and can be 4-12 weeks. . Side effects Any unintended effect of a drug (beyond its intended therapeutic effect), due to its pharmacological properties, observed when using the drug in recommended doses. usually well tolerated. In some cases, disturbances in water and electrolyte balance, nausea, vomiting, orthostatic hypotension, and muscle weakness are possible. Overdose Any unintended effect of a drug (beyond the intended therapeutic scope), due to its pharmacological properties, observed when using the drug in high doses. respiratory depression, apathy, severe arterial hypotension, cardiac arrhythmia, impaired consciousness, nausea, vomiting, skin flushing, seizures. Symptomatic therapy is indicated. Interaction with other drugs As a rule, treatment takes place using several drugs. In this case, the doctor must take into account the possible interaction of these drugs in the patient’s body. A distinction is made between pharmaceutical incompatibility and pharmacological incompatibility. when used simultaneously with other antihypertensive drugs, the effect of Normatens may be enhanced. Release form: Tablets/dragés. Storage conditions : dry, protected from light, at room temperature. Storage conditions for the medicinal product that ensure its pharmacological effectiveness throughout the entire shelf life. Shelf life: 5 years. Do not use after expiration date. The shelf life of medicines refers to the time during which they must fully satisfy all the requirements of the regulatory document in accordance with which they were released and stored. The shelf life for medicinal products is established based on the results of many years of work studying the stability of the drug. With proper storage during this period, the manufacturer guarantees that the quality of the drug meets the requirements of approved regulatory documents. In this case, the drug must remain suitable for another six months after the stated expiration date. Conditions for dispensing from pharmacies Without a prescription. There are special lists of medicines that regulate the conditions for its dispensing from pharmacies based on toxicity and pharmacological activity. Normatens does not contain any potent, narcotic or highly toxic substances. Therefore, it is dispensed at the pharmacy without a special prescription.