Pharmacological action and method of use of the antiparasitic drug Medifox

Release form and composition

Available in several types. For external use in the form of a concentrate of 5% and 20%. The liquid is transparent, a clear or light yellow color is acceptable. Sold in ampoules of 2 ml and bottles of 50 ml, 0.5 l and 1 l.

The 20% concentrate has a slightly different composition. Per 100 g of concentrate there are 20 g of permethrin. Excipients added include surfactants, kerosene and fragrance.

Another form of release is gel. Packaged in tubes of 50 g.

Indications

For example, let's look at the indications for use. Here the medicine "Medifox" receives quite good reviews from its customers. After all, the range of diseases and ailments when it is necessary to use the drug is clear to everyone.

As already mentioned, this solution is recommended when any “living creatures” appear on the body and hair. This applies to lice, nits and scabies mites (regular ones too, by the way). So, if you suddenly have scabies or scalp lice, then you can safely buy Medifox. There are no further indications. Everything is extremely simple and clear. Thus, the reviews about this drug are really encouraging. Specifics help buyers accurately decide for themselves whether they need to purchase the product or not.

Instructions for use Medifox (method and dosage)

In any form of release it is intended for external use only.

For scabies

Prepare a solution of 0.4% (8 milliliters of concentrate per 100 milliliters of water). Apply with a swab to the affected areas of the body at night. After 4 days of using the drug, it is necessary to completely change clothes and bed linen, which are subsequently treated.

For scabies, Medifox in the form of a 5% gel is thoroughly rubbed into the skin of adults and children from the head to the soles of the feet. For children, the area of ​​the forehead and temples, as well as the scalp, must be treated. 8-14 hours after applying the gel, rinse it off with water. Repeated treatment is allowed after 67 - 14 days.

For the treatment of head and pubic lice

Prepare a solution of 0.4% (8 milliliters of concentrate per 100 milliliters of water). Apply with a swab to the affected areas of the body at night. After 4 days of using the drug, it is necessary to completely change clothes and bed linen, which are subsequently treated.

An emulsion of 0.1% is prepared from the concentrate (1 ampoule per 200 milliliters of water). It is easy to rub with a swab onto damp hair and pubis. After 20 minutes, the drug should be washed off with water and neutral soap. Dead insects must be carefully combed out with a comb.

The gel should also be rubbed into the hair roots and distributed over clean hair. After 40 minutes, wash off the drug with water and neutral soap. You can process it no more than 2 times a month.

A week after treatment, a test examination is carried out. If live lice are found, the procedure should be repeated. To prevent the risk of re-infection (at school or kindergarten), Medifox solution is applied after shampooing and left on the hair until completely dry. Hair treatment should be performed after each hair washing procedure.

Overdose

According to the instructions, Medifox for lice and scabies is used externally, in the form of a freshly prepared aqueous emulsion.

Recommended dosage regimen:

• Scabies: 0.4% aqueous emulsion (add 100 ml of boiled warm water to 8 ml of concentrate (4 ampoules of 2 ml or 1/3 of the contents of a 24 ml bottle). The prepared emulsion should be thoroughly rubbed into the skin once a day (at night) (the upper limbs are treated first, then the torso and lower limbs). The skin of the neck and face, as well as the scalp, cannot be treated. Course duration is 3 days (24 ml of the drug). On the fourth day after the end of therapy, you need to take a shower and change your underwear and bed linen;
• Head and pubic lice: 0.2% aqueous emulsion (add 200 ml of boiled warm water to 8 ml of concentrate (4 ampoules of 2 ml or 1/3 of the contents of a 24 ml bottle). The prepared emulsion should be applied liberally to the scalp (for phthiriasis) or damp scalp, lightly rubbing into the skin with a cotton swab. Medifox should be washed off after 20 minutes with running warm water and soap (shampoo).

No cases of overdose have been reported at this time.

According to the instructions for Medifox, all dosage forms of the drug are intended for external use.

1. Application for the treatment of scabies

The product is used in the form of a freshly prepared aqueous emulsion with a concentration of 0.4%. To prepare the emulsion, add 8 ml (contents of 4 ampoules or one 8 ml bottle) of Medifox to 100 ml of water at room temperature. The appropriate dilution from the drug packaged in bottles is made in a similar way.

It is recommended to apply the emulsion with a cotton swab, soaking the skin of the body with the liquid. First, the upper limbs are treated, then proceed to the processing of the torso and legs. The use of Medifox in this concentration is contraindicated for treating the skin of the face, neck and scalp.

The treatment is carried out over three days, applying the drug to the skin once a day before bedtime. To carry out one procedure, 40 mg is required, and to complete the full course of treatment - 120 mg of the drug.

2. Application for the treatment of pediculosis

To destroy lice and nits, a 0.1% emulsion is prepared from the Medifox concentrate (for this, the contents of one 2 ml ampoule should be dissolved in 200 ml of water).

The emulsion is applied, lightly rubbing, onto the roots of pre-moistened scalp hair (and covered with a scarf) and/or pubic hair using a tampon. After 20 minutes, wash your hair with water and neutral soap. Dead parasites are combed out with a thick comb.

When using Medifox gel, the drug should be rubbed into the hair roots and distributed onto clean hair, leave for 40 minutes, then wash your hair with water and shampoo or soap. Comb dead insects out of your hair with a thick comb. Treatment should be carried out no more than twice a month.

Learning to use

"Medifox", the instructions, reviews and effectiveness of which many are interested in, should be used strictly according to the specified algorithm. Otherwise, as has already been said, you can create problems for yourself. Moreover, you cannot be cured of lice, ticks and other insect pests.

However, reviews in this regard from consumers and doctors are positive. Medifox does not cause any difficulties or misunderstandings in handling. All you need to do is dilute a special solution. It requires taking 4 ampoules of the product (or 1 cap, depending on the release form), and then mixing them with warm water. The volume of liquid should be 100 milliliters. Next, the resulting concentrate should be rubbed with massaging movements into the affected areas of the skin. Leave on for 20 minutes and then rinse off.

Most buyers advise that if you apply Medifox to your hair, it is advisable to wrap it with a swimming cap for the specified period of time. The course of treatment is 4 days. After this period, progress should be visible. You will have to consult a specialist about continuing treatment. So, as you can see, even a child can cope with using the medication.

pharmachologic effect

Pediculicidal gel eliminates scabies mites, lice, and their eggs. Its pharmacodynamics are associated with the destruction and suppression of the function of sodium channels in the bodies of nits (lice) and their larvae. Permethrin has low toxicity for humans and warm-blooded animals. After application to the surface of the skin, the component does not have an irritating, resorptive or sensitizing effect.

In acceptable dosages, the pharmacokinetics of the drug does not imply absorption of the active substance into the general bloodstream - its absorption does not exceed 2% of the dosage used. Permethrin, which is absorbed, quickly breaks down into metabolites (inactive). It is excreted from the body through the kidneys.

Even a single application of the gel to the problem area gives an effect lasting 2-6 weeks.

Concentrate for external use Medifox

Instructions for medical use of the drug

Description of pharmacological action

The action is due to a violation of the ion permeability of sodium channels and inhibition of the processes of polarization (repolarization) of the membrane of nerve cells of lice, fleas, mites (including scabies) and other ectoparasites of the arthropod family, which leads to a paralyzing effect.

Indications for use

Pediculosis of the scalp, lice pubis, scabies.

Release form

emulsion concentrate for external use 5%; 2 ml ampoule with ampoule knife, cardboard pack 2; emulsion concentrate for external use 5%; bottle (bottle) of 0.5 or 1 l; emulsion concentrate for external use 5%; dark glass dropper bottle 24 ml cardboard pack 1;

Pharmacodynamics

The action is due to a violation of the ion permeability of sodium channels and inhibition of the processes of polarization (repolarization) of the membrane of nerve cells of lice, fleas, mites (including scabies) and other ectoparasites of the arthropod family, which leads to a paralyzing effect.

Use during pregnancy

During pregnancy, it is possible if the expected effect of therapy exceeds the potential risk to the fetus (adequate and strictly controlled studies of the safety of use in pregnant women have not been conducted). FDA category of effect on the fetus is B.

Contraindications for use

Hypersensitivity (including to other synthetic pyrethroids, chrysanthemums and other plants containing pyrethrins), lactation period (for the treatment of scabies), children under 1 year of age (for emulsion), up to 6 months (for cream).

Side effects

Local reactions - burning sensation, tingling or tingling, skin numbness, increased itching, erythema, allergic reactions (skin rashes, swelling).

Directions for use and doses

Externally. For pediculosis - 1% cream or 0.5% lotion using a cotton swab is evenly applied to moistened scalp hair or scalp (for lice pubis), rubbing into the roots of the hair (the head can be covered with a scarf), leave for 10 (1% cream ) or 40 minutes (0.5% lotion), then rinse thoroughly with warm running water and soap or shampoo and dry in the usual way. The hair is combed with a fine comb to remove nits and dead lice; If live lice are found, the treatment is repeated after 7 days. If there is a danger of re-infection in a group, after washing the hair, moisten the scalp with the drug (or thoroughly wipe it) and wait until the hair is dry (do not wash or dry it). The drug applied to the hair retains its activity for approximately 2 weeks (it does not allow lice that have returned to the hair to multiply). For scabies, use a solution in the form of a freshly prepared 0.4% aqueous emulsion, which is thoroughly rubbed once a day (at night) into the skin of the upper extremities, torso, and then lower extremities for 3 days in a row. The skin of the face and neck, as well as the scalp, cannot be treated. On the fourth day, the patient should take a shower and change his underwear and bed linen.

Overdose

In case of ingestion, gastric lavage and symptomatic therapy are necessary.

Precautions for use

It is necessary to avoid contact with the mucous membranes of the eyes, nose, mouth, and external genitalia (if this happens, the mucous membranes are washed generously with running water). Medical personnel are recommended to wear rubber gloves. After the procedure, wash your hands thoroughly with soap. Procedures should be carried out in a well-ventilated area. If you are taking other medications at the same time or have concomitant diseases of the scalp, you must consult a doctor before starting treatment. If itching continues for more than 4 weeks after scabies treatment, a doctor's consultation is required. The occurrence of hypersensitivity reactions requires discontinuation of treatment.

Special instructions for use

To destroy body lice, the contents of the bottle (24 ml) are diluted in 96 ml of water, and underwear and bed linen are soaked in the resulting emulsion for 40 minutes.

Storage conditions

In a dry place, protected from light, at a temperature of −10 - 20 °C.

Best before date

60 months

ATX classification:

P Antiparasitic drugs, insecticides and repellents

P03 Preparations for the destruction of ectoparasites (including scabies mites), insecticides and repellents

P03A Preparations for the destruction of ectoparasites (including scabies mites)

P03AC Pyrethrins (including synthetic compounds)

P03AC04 Permethrin

When to abstain

True, in addition to the indications, this medication also has a number of contraindications. And these are the ones you need to pay close attention to. After all, Medifox, the instructions for use, reviews and recommendations for the use of which are presented to our attention, is not such a safe product. And negligence in taking it leads, as a rule, to huge problems in the body (malaise or deterioration of the general condition) and allergic reactions.

Medifox should not be purchased or used by those who have inflammation of the skin or open wounds in areas that should be treated with the product. In case of hypersensitivity, the drug is also prohibited. If you are allergic, you can use Medifox, but only under the supervision of doctors, and also with strict adherence to all the instructions of a professional. Children under one year of age, pregnant and lactating women should also not use this drug. That's all. In principle, there are no more contraindications. Unless you have too sensitive skin, which “doesn’t accept” almost any components at all and immediately gets irritated. But such cases are extremely rare.

Doctors and patients

Reviews of Medifox from doctors and buyers, as you can see, earn quite good money. Doctors say that this drug is truly safe and practically does not cause allergies. True, you have to follow the instructions for use. Otherwise, allergies, redness, itching and burning may occur. In addition, this is an absolutely safe product for children.

Buyers are pleased with the effectiveness of use, safety and cost of the drug. The solution will relieve you of scabies, lice, mites and nits in just 4 days. And all this without harm to health. According to numerous reviews, such a course of treatment will not have a negative impact on the budget either. The only thing that can put you off buying is the smell of the substance. Buyers claim that it is not particularly pleasant. However, you should not refuse good medicine just because of this. Most analogues smell bad, but work effectively. In principle, if the smell of Medifox causes disgust, you can simply wash your hair with shampoo. And he will disappear.

So we found out what kind of reviews Medifox earns among its customers, as well as medical specialists. Whether you trust them or not is your decision. In any case, if you are faced with lice, nits, scabies and mites, then you should not lose attention to Medifox. Especially if your doctor prescribed this remedy for you.

Precautions when taking Medifox

Reviews of Medifox indicate that it should not come into contact with the mucous membranes of the nose, eyes, mouth and external genitalia. If the drug does get on the mucous membranes, it is necessary to rinse with running water.

The emulsion should be applied in a well-ventilated area. After the procedure, you should wash your hands thoroughly with soap.

If itching continues for more than one month after using the emulsion, you should consult your doctor.

Composition of the drug

Medifox can be purchased in the form of a gel and emulsion. Each mold is intended for external use only. The emulsion contains 5 g of active substance. The gel can be purchased in several concentrations.

In addition to permethrin, Medifox contains:

• butyl acetate;
• Castor oil;
• ethanol

You can purchase the emulsion in half-liter containers, in bottles of 2 and 24 ml.
Small packages contain not just an emulsion, but a concentrate that must be diluted before use. Medifox, which is offered in ampoules, comes with a small ampoule knife. Everything is packed in cardboard boxes. In addition, the drug can be purchased in gel form. For scabies, this form of the drug may be more convenient to use. The volume of the tube is 50 g.

As for how much the product costs, the price depends on the form of the drug and the quantity of the drug. The gel costs on average 150 rubles, and the emulsion can cost from 100 to 2000 rubles.