Tinidazole: instructions for use of the drug

Medicinal properties

The contents of the tablets are absorbed almost immediately after swallowing. The active substance reaches its maximum concentration in the blood 2 hours after taking it. From there it penetrates into all tissues and fluids of the body, overcoming the physiological barrier between the blood and the central nervous system (hemato-encephalic), the barrier between the blood of the pregnant woman and the fetus (placental) and, in particular, enters breast milk.

In the liver, tinidazole undergoes transformation with the formation of substances that enhance its effect. While in the body, tinidazole inhibits the division of pathogens and destroys their DNA, acting as an antibiotic and antiprotozoal agent.

It is excreted in bile (approximately 50%), urine (approximately 25%) and feces (approximately 12%). The half-life from the body of an adult is 10-14 hours.

Comparison of safety of Tinidazole and Ornidazole

The safety of a drug includes many factors.

At the same time, in Tinidazole it is quite similar to Ornidazole. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Tinidazole, as well as Ornidazole, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Tinidazole does not have any risks when used, just like Ornidazole.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of the use of Tinidazole and Ornidazole.

Indications for use

Tinidazole treats diseases caused by various single-celled organisms. Among them are infections with protozoa (single-celled eukaryotes):

Giardiasis
Cutaneous leishmaniasis
Trichomoniasis
Amoebiasis.

Bacteria:

Acute ulcerative gingivitis
Nonspecific vaginitis
Peritonitis
Endometritis
Pyosalpinx
Sepsis
Pneumonia
Empyema
Lung abscess.

To eradicate Helicobacter pylori, it is used together with antibiotics:

Claristromycin + Omeprazole (often, instead of Tinidazole, such combination drugs include Amoxicillin, and instead of Omeprazole, Metronidazole)
Clarithromycin + Lansoprazole
Omeprazole + Tetracycline + De-Nol

There are other combinations including Tinidazole, Amoxicillin, Omeprazole and Clarithromycin, but these are the most common.

Tinidazole is also used to prevent bacterial infections that appear after operations. Also, along with Tinidazole, for giardiasis, liver dubage (washing) is prescribed (which is also a prevention of giardiasis).

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Sometimes the drug is used to treat thrush, but its effectiveness against its pathogens has not been proven.

Which is better ornidazole or tinidazole – All about fungus

1 Composition and release form
2 Indications for use of Tinidazole for thrush
3 How to take?
4 Adverse reactions
5 Contraindications
6 Interaction
7 Drug analogues
8 Conditions of sale and storage

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Composition and release form

Tinidazole is produced in the form of tablets, each of which contains 500 mg of the active substance - tinidazole. They are placed in a blister of 4 pieces. The tablets also contain the following auxiliary components:

MCC;
polysaccharide;
food additive E572;
starch;
sodium salt of lauryl sulfuric acid.

Indications for use of "Tinidazole" for thrush

In the postoperative period, the risk of bacterial infection increases.

Tinidazole is effective for many ailments that are caused by a bacterial infection. But its direct purpose is the treatment of diseases caused by Giardia. The medication is effective in the treatment of amoebic dysentery, trichomoniasis and anaerobic infection.

An antibiotic is prescribed to patients who have undergone surgery to prevent the occurrence of bacterial infections.

“Tinidazole” effectively treats ulcerative lesions of the stomach and duodenum, eliminates the inflammatory process of the vulva and vaginal mucosa, and also restores the vaginal microflora, which is especially important for patients with thrush.

How to use?

Before using an antibiotic for thrush, you need to inform your doctor about any allergic reactions to any medications, as well as a history of blood pathologies. In addition, the doctor will need information about diseases of the nervous system and disorders of the functioning of the brain.

The dosage of Tinidazole is selected individually for each patient. Usually adults are prescribed 1.5-2 g once a day. In childhood, antibiotics are prescribed at 50-75 mg per kilogram of baby’s weight per day.

The duration of the therapeutic course depends on the general condition of the patient and the severity of thrush and can range from 1 to 10 days.

Adverse reactions

Using Tinidazole for thrush, the following negative phenomena may occur:

lack of appetite;
dryness of the oral mucosa;
nausea;
metallic taste in the mouth;
vomiting reflex;
frequent loose stools;
headache;
unreasonable fatigue;
dizziness;
hives;
speech disorder;
skin itching and rash;
convulsive conditions;
angioedema;
nerve neuropathy.

Analogues of the drug

When it is not possible to take Tinidazole, doctors prescribe medications similar in active substance and pharmacological group. Such medicines include:

"Tiniba";
"Fazizhin";
"Geneferon";
"Klion";
"Betadine";
"Flagyl";
"Orvagil";
"Dazolik";
"Gayro";
"Metrogil";
"Miramistin";
"Atrican 250";
"Tiberal"
"Naxojin";
"Iodoxide";
"Trichopolus";
"Ornisid";
"Klion";
"Safocide";
"Terzhinan."

Self-replacement of the medication may worsen the disease.

It is worth understanding that each drug that can replace Tinidazole has its own treatment regimen and application features. Therefore, the selection of an analogue drug should be carried out by a qualified doctor who, based on a diagnostic examination of the patient, will establish a safe dosage and determine the required period of treatment.

Mode of application

Take tablets during or immediately after meals once a day. The dosage and duration of treatment are determined by the doctor depending on the disease and its severity.

Typically, the dose for adults is 1.5-2 g per day, and for children - 50-75 mg per kg of body weight per day.

One dose is one tablet. Treatment does not last more than 6 days.

During pregnancy and breastfeeding

You can take Tinidazole only in the last two trimesters of pregnancy, but only as prescribed by a doctor, since each pregnancy is unique. When breastfeeding, taking the drug is strictly prohibited (since it remains in milk even 3 days after administration), so during treatment they should refuse to feed.

Release form

Tinidazole is available in several forms - tablets and suppositories. The tablet form and suppositories contain 500 mg of the component - tinidazole. Tablets of the drug Tinidazole are contained in blisters of 4 pieces. The blister is packed in cardboard packaging.

The drug Tinidazole is also available in the form of suppositories

The drug contains the following auxiliary components:

alginic acid;
magnesium stearate;
microcrystalline cellulose;
starches;
sodium lauryl sulfate.

Tablets and suppositories have a similar composition, but unlike tablets, suppositories are used by women vaginally.

Interaction with other drugs

Tinidazole enhances the effect of drugs that prevent blood clotting and disulfiram-like reactions, that is, poisoning that occurs as a result of incomplete processing of ethyl alcohol and is accompanied by negative sensations (therefore, taking the drug should not be accompanied by drinking alcohol).

Tinidazole is compatible with most antibiotics, but it is not recommended to be prescribed with ethionamide (an anti-tuberculosis antibiotic).

Phenobarbital (an antiepileptic drug) accelerates the transformation of tinidazole in the liver.

Special Recommendations

When treating a disease such as trichomoniasis, it is necessary to treat both partners simultaneously.

While taking the drug, you should refrain from drinking alcoholic beverages.

If side effects from the central nervous system occur, the medication is discontinued.

When you take tinidazole, your urine may turn dark.

If the patient’s treatment continues for more than 6 days, then it is necessary to constantly monitor the blood picture.

For the prevention of anaerobic infections (postoperative), the dosage of the drug for children under 12 years of age has not been established.

During treatment with the drug in question, you should refrain from engaging in hazardous activities.

Side effects

In addition to a decrease in the number of white blood cells in the blood (namely granulocytes) and weakness, the following side effects may be observed:

Digestion

Decreased appetite
Unpleasant taste and dry mouth
Nausea
Vomit
Diarrhea

Nervous system

Headache
Dizziness
Increased fatigue
Impaired motor coordination
Pronunciation problems
Peripheral nerve disease
Rarely - convulsions

Allergy

Hives
Itchy skin
Skin rash
Quincke's edema

To learn more about how to treat dry mouth, we recommend reading the article: Feeling Dry Mouth - Treatment.

special instructions

During Tinidazole therapy, the patient's urine may acquire a dark tint. This side effect is not a symptom of any pathology and goes away quickly after treatment.

Treatment of helminthic infestation with Tinidazole may cause dizziness and other symptoms that significantly reduce the level of concentration and attention. For this reason, during therapy, doctors recommend avoiding driving and performing other similar tasks.

The simultaneous use of Tinidazole and ethanol has a strong negative effect on the patient’s kidneys and liver. Therefore, it is recommended to exclude alcoholic beverages from the diet for the period of therapy.

Metronidazole: instructions for use

This is a combined agent with strong antibacterial and antimicrobial effects. The drug is active against anaerobic cocci, protozoal infections, gram-negative fusobacteria and other microbes belonging to this group.

After administration, the drug is almost completely absorbed. It quickly reaches the kidneys, lungs and liver. In addition, the active substance penetrates into vaginal secretions, saliva and bile.

It is worth knowing that Metronidazole is excreted in breast milk. Therefore, the drug should not be taken during lactation.

The product has an extensive healing effect. Often, nitroimidazoles are prescribed for giardiasis, trichomoniasis, vaginitis, bacterial vaginosis, chronic gastritis and various aerobic infections. It is less often prescribed for:

diseases of the duodenum;
alcoholism;
stomach ulcer;
difficult-to-heal acne and skin wounds;
ulcers;
seborrheic eczema;
perioral dermatitis.

Treatment with Metronidazole is carried out according to certain regimens. In tablet form, the drug is taken twice a day, 250 mg. The duration of treatment is determined by the doctor depending on the type and severity of the disease.

Vaginal suppositories are used once a day, one piece at a time. The tablet is taken at night. The duration of therapy is about 10 days.

For complex infections occurring in acute and chronic form, a solution is used that is administered intravenously every 8 hours in an amount of 500 mg. Metronidazole is also often prescribed after surgery to prevent the development of infections.

After systemic use of the drug, a number of adverse reactions may develop:

allergic manifestations (itching, rash);
Gastrointestinal tract (diarrhea, unpleasant taste in the mouth, vomiting, nausea, abdominal discomfort);
local reactions (thrombophlebitis and phlebitis after intravenous administration);
hematological reactions (neutropenia, leukopenia);
Central nervous system (convulsions, headache, disturbances of consciousness, dizziness, poor coordination, sometimes epileptic seizures).

When used externally, photodermatitis sometimes appears. In the case of intravaginal use, the genitourinary system may experience itching, frequent urination, burning in the vulva or vagina, and discharge.

Since Metronidazole is a toxic drug, it is contraindicated for any disorders of the central nervous system, liver and blood diseases. The drug is also not prescribed to pregnant women, for diseases of the heart, blood vessels and chronic pathologies of internal organs.

During treatment, the doctor must monitor the patient’s clinical blood parameters, in particular if he has significant disruptions in the functioning of the liver or kidneys.

You should know that Metronidazole cannot be combined with ethanol. Otherwise, with this combination, symptoms of alcohol intoxication will appear (dizziness, vomiting, headache, nausea).

Therefore, it is prohibited to drink alcohol during the treatment period.

Pharmacological action of the drug tinidazole

Antiprotozoal agent with antibacterial action. Active against Trichomonas vaginalis, Entamoeba histolytica, Lamblia intestinalis. The mechanism of action is due to inhibition of synthesis and damage to the DNA structure of pathogens. Tinidazole is an antiprotozoal agent with an antibacterial effect

Has a bactericidal effect against the following anaerobic bacteria: Bacteroides spp. (including Bacteroides fragilis, Bacteroides melaninogenicus), Clostridium spp., Eubacterium spp., Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Veillonella spp.

Instructions for use of the drug tinidazole by men

The drug tinidazole is successfully used to treat men with diseases such as lambiasis and trichomaniasis of the genitourinary system. After taking the tablets, you should not drive a car or engage in other activities that require concentration.

Doses and route of administration of the drug tinidazole in men:

trichomoniasis: if infection is confirmed, simultaneous treatment of both sexual partners is indicated. Take 2 g of tinidazole (4 tablets of 500 mg) once.
lambiasis: take 2 g of Pinidazole (4 tablets of 500 mg each) once.

The drug tinidazole can also be taken by men according to the instructions for use of the drug tinidazole. After taking the pills, you should not drive a car or engage in other activities that require concentration. Tinidazole causes inhibition and decreased reaction.