Proflosin, 0.4 mg, long-acting enteric capsules, 30 pcs.

Composition and dosage forms

The drug can only be purchased in the form of capsules for oral administration. The active substance is tamsulosin hydrochloride. Its concentration in 1 capsule is 0.4 mg. In addition, the composition also includes other components that do not differ in activity:

• microcrystalline cellulose;
• copolymer of methacrylic acid and ethyl acrylate;
• triethyl citrate;
• talc.

The drug can only be purchased in the form of capsules for oral administration.

The pellet shell contains a copolymer of methacrylic acid and ethyl acrylate, talc, triethyl citrate. Composition of the capsule shell:

• iron oxide dye red, black and yellow;
• titanium dioxide;
• gelatin;
• indigo carmine

You can purchase capsules in packages of 30 and 100 pcs.

PROFLOSIN

Drug: PROFLOSIN® (PROFLOSIN)

Active substance: tamsulosin ATC code: G04CA02 CFG: A drug used for urinary disorders associated with benign prostatic hyperplasia. Alpha1-adrenergic blocker Reg. number: LP-000832 Registration date: 10.10.11 Owner reg. cert.: BERLIN-PHARMA (Russia) produced by ROTTENDORF PHARMA (Germany)

DOSAGE FORM, COMPOSITION AND PACKAGING

Modified release gelatin capsules; size No. 2; opaque, with a light orange body and a gray-green cap; one black line is marked on the body and cap, “TSLO.4” is printed on the cap; The contents of the capsules are pellets from white to almost white.

Excipients: microcrystalline cellulose - 276.9 mg, copolymer of methacrylic acid and ethyl acrylate (1:1) - 16.5 mg, triethyl citrate - 1.65 mg, talc - 16.5 mg.

Pellet shell composition: copolymer of methacrylic acid and ethyl acrylate (1:1) - 21.63 mg, talc - 8.65 mg, triethyl citrate - 2.16 mg. Composition of the capsule body: red iron oxide dye - 0.0239 mg, titanium dioxide - 0.53 mg, yellow iron oxide dye - 0.258 mg, gelatin - 38.938 mg. Composition of the capsule cap: indigo carmine - 0.00152 mg, black iron oxide dye - 0.0107 mg, titanium dioxide - 0.356 mg, yellow iron oxide dye - 0.114 mg, gelatin - 23.889 mg.

10 pieces.
- blisters (1) - cardboard packs. 10 pieces. - blisters (3) - cardboard packs. 10 pieces. - blisters (10) - cardboard packs. DESCRIPTION OF THE ACTIVE SUBSTANCE.
The scientific information provided is general and cannot be used to make a decision about the possibility of using a particular drug. PHARMACHOLOGIC EFFECT

α1-adrenergic receptor blocker; a drug for the symptomatic treatment of benign prostatic hyperplasia.

Selectively blocks postsynaptic α1A-adrenergic receptors of smooth muscles of the prostate gland, bladder neck, prostatic urethra. As a result, the tone of the smooth muscles of these formations decreases, and the outflow of urine is facilitated. At the same time, the symptoms of obstruction and irritation associated with benign prostatic hyperplasia are reduced. The therapeutic effect appears approximately 2 weeks from the start of treatment.

Tamsulosin's ability to block α1B-adrenergic receptors of vascular smooth muscles is much less pronounced, so the effect on systemic blood pressure is insignificant.

PHARMACOKINETICS

After oral administration, tamsulosin is quickly and almost completely absorbed from the gastrointestinal tract. After a single oral dose of 400 mcg, the Cmax of the active substance in plasma is achieved after 6 hours.

Plasma protein binding - 99%. Vd is insignificant and amounts to 0.2 l/kg.

Tamsulosin is slowly metabolized in the liver to form pharmacologically active metabolites that retain high selectivity for α1A-adrenergic receptors. Most of the active substance is present in the blood unchanged.

T1/2 of tamsulosin with a single dose is 10 hours, terminal T1/2 is 22 hours. It is excreted by the kidneys, 9% unchanged.

INDICATIONS

Benign prostatic hyperplasia.

DOSING REGIME

Orally - 400 mcg 1 time/day (after breakfast).

SIDE EFFECT

From the cardiovascular system: rarely - dizziness, orthostatic hypotension, palpitations.

From the side of the central nervous system: headache, asthenia are possible.

From the reproductive system: rarely - retrograde ejaculation.

CONTRAINDICATIONS

Hypersensitivity to tamsulosin.

SPECIAL INSTRUCTIONS

Use with caution in patients prone to arterial hypotension and with severe liver dysfunction.

Before starting tamsulosin therapy, the patient should be assessed for the presence of other diseases that may cause the same symptoms as benign prostatic hyperplasia. Before starting treatment and regularly during therapy, a digital rectal examination and, if required, determination of prostate specific antigen should be performed. In patients with impaired renal function, no change in dosage regimen is required.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

DRUG INTERACTIONS

With simultaneous use of tamsulosin with cimetidine, a slight increase in the concentration of tamsulosin in the blood plasma was noted, and with furosemide - a decrease in concentration; with other α1-blockers - a pronounced increase in the hypotensive effect is possible.

Diclofenac and indirect anticoagulants slightly increase the rate of elimination of tamsulosin.

Diazepam, propranolol, trichlormethiazide, chlormadinone, amitriptyline, diclofenac, glibenclamide, simvastatin and warfarin do not change the free fraction of tamsulosin in human plasma in vitro. In turn, tamsulosin also does not change the free fractions of diazepam, propranolol, trichlormethiazide and chlormadinone.

In vitro studies showed no interaction at the level of hepatic metabolism with amitriptyline, salbutamol, glibenclamide and finasteride.

Other α1-blockers, acetylcholinesterase inhibitors, alprostadil, anesthetics, diuretics, levodopa, antidepressants, beta-blockers, slow calcium channel blockers, muscle relaxants, nitrates and ethanol may increase the severity of the hypotensive effect.

Antibiotic or not

The drug is not characterized by antibacterial activity. It represents the pharmacological group of alpha-blockers. The main property of the drug is to maintain metabolism in the prostate. Additionally, the drug corrects the urodynamic process.

The main property of the drug is to maintain metabolism in the prostate.

Proflosin: instructions for use, reviews, analogues, price – Medical office

In the treatment of prostate diseases, an important role is played by drugs that improve urodynamics. Such medications are classified as symptomatic therapy and are prescribed for severe urinary disorders. An effective drug in this group is the drug Proflosin, which is trusted by both urologists and patients.

Release form and composition

Proflosin is a drug used in urology. The drug contains the well-known alpha-blocker tamsulosin. Release form: capsules, 400 mcg of active ingredient each. Auxiliary components:

• cellulose;
• talc;
• ethyl acrylate;
• capsule shell components (gelatin, dyes, titanium dioxide).

Capsules are packaged in blisters, 10 pieces each. The drug is sold in cardboard packs of 3 or 10 blisters. Each package contains detailed instructions for use.

Proflosin is a cheaper analogue of Omnic and contains the same active substance

In fact, the drug Proflosin is a generic version of the drug Omnic. It costs much less than the original drug, but is not inferior in effectiveness.

Do you have prostate problems?

Like all tamsulosin hydrochloride-based medications, Proflosin is available with a doctor's prescription.

Pharmacological properties

Tamsulosin hydrochloride is a selective alpha-adrenergic receptor blocker.

It acts on alpha-1 adrenergic receptors located in the prostate, bladder and urethra.

This leads to a decrease in the tone of the smooth muscles of these organs and sections. The result is a reduction in spasm, normalization of bladder tone and easier urination.

The effect of the active component contained in Proflosin capsules is also manifested in relation to irritation of the bladder and urethra against the background of benign prostatic hyperplasia and prostatitis. After taking the drug, urodynamics improve, pain during urination decreases, and the lumen of the urethra increases.

A special feature of the drug is its rapid absorption by the intestine. This ensures high bioavailability of the drug and a selective effect aimed at alpha-1 adrenergic receptors of the prostate and bladder.

Indications for use

Proflosin capsules, according to the instructions for use, are intended to normalize urodynamics in prostate adenoma. Urologists often prescribe this drug to patients with severe forms of prostatitis, if there is a risk of developing acute urinary stagnation.

The indications for prescribing Proflosin are urodynamic disturbances due to increased bladder tone. It is important to consider that the medicine does not have a diuretic effect and does not increase the amount of urine.

The medicine eliminates problems with urination that occur with prostate pathologies

Dosage regimen and recommended dosages

The drug Proflosin has a prolonged action. This means a slow release of the main active ingredient and providing round-the-clock therapeutic action. Thanks to this property, Proflosin tablets are very easy to take - one capsule daily.

The therapeutic effect of the drug can be reduced in two cases - taking the capsule before meals and chewing the tablet. In this regard, it is recommended to take the medicine immediately after breakfast. To ensure an effective round-the-clock therapeutic effect, Proflosin is recommended to be used daily at the same time.

The capsule must not be chewed. This disrupts the mechanism of gradual release of the active substance, which can lead to short-term peaks of drug action without the effect of smooth regulation of alpha-adrenergic receptors.

Cost and analogues

There are many drugs with the same active ingredient, including domestic ones

When prescribing the drug Proflosin, the price of which depends on the number of capsules in the package, the duration of treatment should be taken into account. In case of adenoma, the drug may be indicated for long-term use.

A package of 30 capsules will cost about 400 rubles, the cost of 100 capsules is about 1000-1100 rubles.

Taking into account the need to take just one capsule daily, we can say that the price of the medicine is quite affordable.

If Proflosin is not on sale, it will not be difficult to find analogues, since different pharmaceutical companies produce drugs based on tamsulosin hydrochloride.

As is known, benign prostatic hyperplasia is often accompanied by dysuric disorders. To improve urodynamics, you can use alpha-1-blockers, for example, Proflosin.

The active component of the drug is tamsulosin hydrochloride. The substance selectively blocks alpha-1 adrenergic receptors, thereby promoting relaxation of the smooth muscles of the genitourinary system.

In Russia and the CIS countries the drug is available in pharmacies. But the medicine is available with a doctor's prescription. How much does the medicine cost? On average, the price of the drug is 1000-1200 rubles. The price is indicated for a package containing 100 capsules.

Does the drug help?

Many men suffering from adenoma wonder whether the drug Proflosin is effective. Reviews from doctors and patients indicate that the medicine is indeed very effective.

As practice shows, treatment with Proflosin gives a positive result in most patients. The medication helps to improve urodynamics and eliminate dysuric disorders in the shortest possible time.

The active component of the drug is tamsulosin hydrochloride. This substance helps block postsynaptic alpha-1 adrenergic receptors. This relaxes the smooth muscles of the prostate gland and urethra.

As a result of using Proflosin capsules, it is possible to:

1. Reduce the amount of residual urine. Due to this, the man’s nocturnal imperative urge to urinate disappears. Moreover, when treated with this drug, the likelihood of progression of acute urinary retention can be significantly reduced.
2. Relieve intermittent flow syndrome. By relaxing the smooth muscles of the prostate gland and urethra, a man can quickly and painlessly empty his bladder.
3. Eliminate pain in the perineum and other unpleasant symptoms of prostate adenoma.
4. Stop low urinary tract patency.
5. Increase urine flow.

The active component of the drug Proflosin is quickly absorbed from the gastrointestinal tract. Moreover, tamsulosin hydrochloride has high bioavailability. The binding rate to plasma proteins reaches 99%. The half-life of the drug is 10-13 hours. Eating slows down the process of absorption of the active substance from the gastrointestinal tract.

The disadvantage of Proflosin and other alpha-1-blockers is the fact that it is completely pointless to use them as monotherapy.

A positive effect can only be achieved if alpha-1 blockers are taken together with 5-alpha reductase inhibitors. The cost of such treatment will be at least 2-3 thousand rubles per month.

Moreover, the duration of the course can even reach several months.

That is why, if you have a limited budget, it is more advisable to use dietary supplements. It is much more profitable to use them, and in some cases, much more effective.

It is advisable to use Proflosin in the treatment of benign prostatic hyperplasia of grade 1-2. The medicine is symptomatic. It does not have a direct effect on the growth of adenoma.

For prostatitis, an alpha-1 blocker is also sometimes used. But such use is justified only if inflammatory processes in the prostate are accompanied by dysuric disorders.

Instructions for use

Before using Proflosin, the instructions for use must be studied, because they indicate how to use the medication correctly. According to the instructions, the daily dose is 1 capsule.

It is advisable to take the medication immediately after breakfast. The capsule must not be chewed. This is due to the fact that when the integrity of the capsule is destroyed, the effect of the active component of the drug is inactivated. The duration of treatment therapy is determined individually. But usually it is 30-90 days.

Proflosin should be taken with caution by men whose work involves driving a vehicle or interacting with dangerous mechanisms.

Principle of action on the body

Alpha-blockers, to which the drug in question belongs, normalize blood pressure, which occurs by eliminating vasospasm of the smallest arteries (arterioles). Additionally, vasodilation is noted, which restores blood flow to the affected area. The advantage of this remedy is the absence of an intense effect on the heart rate.

The drug acts selectively. Thanks to it, the function of alpha1-adrenergic receptors, which are localized in the prostate, the neck of the bladder, and also in the section of the urethra passing through the prostate gland, is blocked. As a result, tension in these tissues decreases, which facilitates a number of processes: normalization of blood flow and urination.

Alpha-blockers, to which the drug in question belongs, normalize blood pressure, which occurs by eliminating vasospasm of the smallest arteries (arterioles).

Absorption of the active substance occurs quickly. It takes no more than 6 hours to reach peak activity. At this rate, the maximum concentration is observed after a single dose. The advantage of the drug is its almost complete binding to proteins (up to 99%), which allows you to quickly reach the peak activity of the drug during therapy.

The process of metabolization of the main substance occurs slowly. This releases weakly active compounds. A significant amount of tamsulosin remains unchanged in the blood. This substance has a weak effect on the liver: it helps to increase the activity of microsomal enzymes. Most of the drug is eliminated through urination. Only a small amount of the active component leaves the body unchanged. The duration of the elimination process varies from 10 to 13 hours, which depends on the duration of the course of treatment.

pharmachologic effect

Proflosin is an adrenergic blocker with prolonged properties.

The medicine acts on the neck of the bladder, reducing tone, relaxing smooth muscles, which helps normalize the outflow of urine.

Alpha-adrenergic blockers reduce peripheral vascular resistance, thereby causing slight downward fluctuations in blood pressure. In patients with normal blood pressure, this property of tamsulosin does not have a negative effect.

What does Proflosin treat?

The drug is characterized by a narrow scope of application. It is prescribed for benign prostatic hyperplasia or BPH for the treatment of dysuric disorders. The drug is effective in the presence of stones in the ureter and in exacerbation of cystitis, and is used as part of complex treatment.

The drug is prescribed for benign prostatic hyperplasia.

Are they prescribed to women?

The medicine is not intended for the treatment of women.

Analogs

Proflosin and Omnik are the most well-known analogues of Fokusin. Proflosin is produced by the German-Italian pharmaceutical association Berlin Chemie/Menarini. Omnik is produced in the Netherlands. The analogues have a slight difference from Fokusin in the set of excipients. All products contain the same amount of tamsulosin, they have the same effect and have the same side effects as Focusin. However, medications vary significantly in cost. The most expensive is Omnik, then Focusin and the cheapest is Proflosin.

It is theoretically possible to replace one drug with another.

The high cost of Omnic is explained by the fact that of all of them, only one is original, and the rest are generics. Omnik has the largest evidence base. For the same reason, it is recommended by many doctors. The technologies for producing the drug from different manufacturers are not completely identical to the original ones; cheaper and less purified substances and substances may be used. Therefore, the effect of generic drugs may differ slightly from Omnic. The different effect may also be due to the large number of counterfeit drugs on the market.

The journal “Medical Council” No. 19 for 2014 published the results of a study of uroselectivity (which determines the effectiveness of the drug for adenoma) of the drug Omnik and generics: Fokusin, Tamsulosin-teva and Proflosin. The assessment was carried out on the basis of regulatory documents for the original Omnic. The release rates of the active substance correspond to the norm only in Omnic. And this parameter determines bioavailability, which has a direct impact on the effectiveness of the product. Based on the content of impurities in Proflosin, two foreign components were detected.

Based on the results of the study, the commission concluded that Omnic has the greatest activity in relation to andrenoreceptors, then in descending order: Tamsulon-F (RF), Hyperprost (RF), Revokarin, Fokusin.

An analogue of the above remedies is also the Russian drug Temsulosin Retard. It costs about the same as Focusin.

The reaction of each patient to the same drug may be different due to the way it is absorbed by the body, as well as due to the presence of concomitant pathologies.

One of the analogues of Prostagun is Prostamol-Uno

Reviews indicate individual perception:

1. Vlad, Vologda: “After the first dose, Omnik causes retrograde ejaculation, after which very unpleasant sensations arise when urinating.”
2. Andrey, St. Petersburg: “After Omnic there is no reaction, only Focusin helps.”
3. Evgeniy, Kirov: “Only Omnik helps my grandfather; other drugs are of no use.”
4. Nadezhda, Serpukhov: “My husband tried everything, but the maximum effect is still from Omnik.”

Judging by thematic forums, most patients, when choosing between Omnic and Focusin, believe that Omnic is better.

How to take Proflosin

This medication is prescribed 1 capsule once a day. The duration of the course is determined individually, which is influenced by the patient’s condition and the presence of other contraindications. Therapy can be long-term, since there are no restrictions on the use of the drug.

Capsules should not be chewed or crushed. This requirement is due to the properties of the drug shell: it promotes the slow release of the active substance, thereby reducing the level of negative effects on the mucous membranes of the stomach and intestines.

The duration of the course is determined individually, which is influenced by the patient’s condition and the presence of other contraindications.

Before or after meals

Food intake affects the absorption of the drug by the walls of the gastrointestinal tract, as well as the level of activity of the main substance. However, it is permissible to take the medicine after breakfast or the first meal.

How long can you drink without a break?

A drug based on tamsulosin is used in a limited dosage and is characterized by a mild effect on the body, which allows it to be taken on an ongoing basis: from 2 weeks to several years. Only a doctor can determine the course of treatment more accurately. During therapy, you cannot stop taking the medicine yourself.

Proflosin side effects

Proflosin is an alpha1-adrenergic receptor blocker used for the symptomatic treatment of benign prostatic hyperplasia.

The drug selectively and competitively blocks postsynaptic alpha1A adrenergic receptors located in the smooth muscles of the prostate gland, bladder neck and prostatic urethra. This leads to a decrease in the tone of the smooth muscles of the prostate gland, bladder neck, prostatic urethra and improved urine outflow.

The effect of alpha-adrenergic receptor blockers helps to reduce peripheral vascular resistance and may cause a slight decrease in blood pressure (BP). This effect of tamsulosin does not affect the clinical parameters of patients with normal baseline blood pressure.

Composition of Proflosin (1 dose of spray):

• Active ingredient: tamsulosin hydrochloride – 0.4 mg;
• Auxiliary components: copolymer of ethyl acrylate and methacrylic acid (1:1), microcrystalline cellulose, talc, triethyl citrate;
• Pellet shell composition: copolymer of ethyl acrylate and methacrylic acid (1:1), talc, triethyl citrate;
• Composition of the capsule cap: gelatin, titanium dioxide, indigo carmine, yellow iron oxide dye, black iron oxide dye;
• Capsule body composition: gelatin, titanium dioxide, red iron oxide dye, yellow iron oxide dye.

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Price in pharmacies

Information about the price of Proflosin in pharmacies in Moscow and Russia is taken from online pharmacies and may differ slightly from the price in your region.

You can buy the drug in Moscow pharmacies at the price: Proflosin capsules 0.4 mg 30 pcs. – from 331 to 438 rubles, cost of packing 100 capsules 0 from 884 to 1100 rubles.

Store at temperatures up to 30 °C. Shelf life – 3 years.

Dispensing conditions from pharmacies are by prescription.

A list of analogues is presented below.

What does Proflosin help with?

The drug Proflosin is prescribed in the following cases:

• Treatment of dysuric disorders associated with benign prostatic hyperplasia.

Instructions for use of Proflosin, doses and rules

The capsule should be swallowed whole, without chewing, with a sufficient amount of water.

The recommended dosage for use of Proflosin is 1 capsule 1 time per day after breakfast or the first meal. The capsule is swallowed whole without damaging it.

The course of use is not limited and is determined by the attending physician.

Before starting to use the drug, the patient should exclude the presence of diseases and conditions accompanied by symptoms similar to those of benign prostatic hyperplasia.

Features of application

Before using the drug, read the sections of the instructions for use about contraindications, possible side effects and other important information.

Side effects of Proflosin

Instructions for use warn of the possibility of side effects of the drug Proflosin:

• Nervous system disorders: often - dizziness; infrequently - headache; rarely - fainting.
• Disorders of the cardiovascular system: infrequently - tachycardia, orthostatic hypotension.
• Gastrointestinal disorders: uncommon - constipation, diarrhea, nausea, vomiting.
• Reproductive system disorders: uncommon - ejaculation disorders; very rarely - priapism.
• Disorders of the skin and subcutaneous tissues: infrequently - rash, itching, urticaria; rarely - angioedema.
• Other: in some cases - development of atonic iris syndrome (narrow pupil syndrome) during cataract surgery, asthenia, rhinitis.

List of analogues of Proflosin

If it is necessary to replace the drug, there are two options - choosing another medication with the same active substance or a drug with a similar effect, but a different active substance.

Analogues of Proflosin, list of drugs:

When choosing a replacement, it is important to understand that the price, instructions for use and reviews of Proflosin do not apply to analogues. Before replacing, you must obtain the approval of your doctor and do not replace the drug yourself.

Reviews from men confirm the effectiveness of the drug. Most reviews of the use of Proflosin note that problems with urination after taking it decreased or completely disappeared. Some men reported low blood pressure, painful erections, and rapid heartbeat. Special information for health care workers

Interactions

Source: //UziMaster.ru/proflosin-pobochnye-jeffekty/

special instructions

Considering that the drug can contribute to the occurrence of arterial hypotension, at the first signs of this pathological condition the patient must take a horizontal position.

The drug does not affect the visual organs or the central nervous system, so it is permissible to drive a vehicle during treatment.

Before starting a course of treatment with Proflosin, an examination is carried out, the purpose of which is to determine the presence of other diseases accompanied by symptoms similar to prostate hyperplasia. If intense side effects develop (angioedema), treatment is stopped. After eliminating the symptoms, the drug is no longer prescribed; analogues should be selected.

The medicine in question can provoke atonic iris syndrome during surgery on the organs of vision (for cataracts). Before starting a course of therapy and during treatment, it is recommended to palpate the prostate gland rectally. If necessary, prostatic antigen levels are monitored.

The drug does not affect the visual organs or the central nervous system, so it is permissible to drive a vehicle during treatment. However, you need to be careful.

For liver dysfunction

The remedy in question is not used for severe pathologies of this organ.

If chronic kidney disease is diagnosed (renal clearance less than 10 ml/min.), the medicine must be taken with caution.

For impaired renal function

If chronic kidney disease is diagnosed (renal clearance less than 10 ml/min.), the medicine must be taken with caution.

Proflosin's analogs

There are a large number of medications similar to Proflosin in composition and pharmacological properties. Analogues of the drug are:

• Tulosin is an alpha-1 adrenergic blocker used to treat urinary disorders caused by benign prostatic hyperplasia. The main active ingredient is tamsulosin hydrochloride. Contraindications include hypersensitivity to the components of the drug. The likelihood of side effects is low. Capsules are taken orally, 1 piece. / day.
• Hyperprost - used to treat benign prostatic hyperplasia. The product is sold in the form of gelatin capsules. Hyperprost has a minimal list of contraindications. The recommended daily dose is 400 mg once. The course of treatment is determined by the doctor.
• Omsulosin is an α-adrenergic receptor blocker used to relieve symptoms of benign prostatic hyperplasia. The drug should not be used by patients intolerant to tamsulosin. It is recommended to take Omsulosin 1 capsule/day after breakfast.
• Revocarin is intended to block postsynaptic α-adrenergic receptors of smooth muscles of the bladder neck, prostatic urethra, and prostate gland. You need to drink 1 capsule/day after your morning meal.
• Taniz-K are long-acting capsules based on tamsulosin. The tablets are prescribed to men for urinary dysfunction associated with benign prostate hyperplasia. Taniz-K should not be used in case of high sensitivity to the components of its composition, severe liver failure, or arterial hypotension. The patient needs to drink 1 capsule daily in the morning after meals.
• Sonizin – has an antidysuric effect. The drug is prohibited for use in patients under 18 years of age, with severe renal and liver failure, or orthostatic hypotension. It is required to take Sonizin 400 mg daily after meals.
• Omnic Okas is an antidysuric, alpha-adrenolytic agent. Available in the form of film-coated tablets. Omnic Okas has a small list of contraindications and side effects. You need to take 400 mg of the drug daily orally. The course of therapy is determined individually.

Side effects of Proflosin

The drug provokes a large number of negative reactions. Among the most frequently encountered are:

• dizziness;
• headache.

The following negative reactions occur less frequently:

• fainting;
• hypotension;
• heart disease: tachycardia, arrhythmia;
• nausea, vomiting;
• liquid/hard stool;
• sexual dysfunction, manifested by impaired ejaculation;
• the occurrence of an erection that is not accompanied by sexual arousal, pain often appears, and sperm may be lost;
• allergies: rash, itching, redness of the skin, angioedema;
• general weakness;
• rhinitis.

A drug

"Proflosin" is a drug intended for use for problems with urination that are associated with benign prostatic hyperplasia. This drug is an alpha-blocker.

The active component is tamsulosin, a substance that, acting on the bladder neck, reduces its tone and has a relaxing effect on smooth muscles.

This effect on the body allows you to remove the symptoms of the disease and irritation, and improves the flow of urine. The composition contains additional components that enhance the effect of using the drug.

Let's look at what the medicine "Proflosin" is. Indications, reviews of its use and effectiveness are presented in the article.

When pain occurs when urinating and it seems that the bladder is never empty, while the stream is weak, you need to urgently visit a urologist. Typically, such conditions require the use of Proflosin. Reviews from patients show that the drug can be used, regardless of the stage at which the disease is.

Release form, composition

The medication is available in the form of capsules, the shell of which dissolves in the intestines. Gelatin capsules have a prolonged effect. In addition to the active substance, the composition contains triethyl citrate, a copolymer of methacrylic acid and ethyl acrylate, cellulose, and talc.

Pharmacokinetics, indications

After entering the body, the active component is almost completely absorbed from the gastrointestinal tract in a short period of time. This process is disrupted after eating food, in such cases it proceeds more slowly.

As a result of taking a product with an active substance in an amount of 0.4 mg, which corresponds to a single dose, the maximum concentration of the main ingredient in the blood is detected after 6 hours.

Reviews of Proflosin show that it has a good connection with blood proteins - 99%. The drug is characterized by insignificant distribution - 0.2 l/kg. Metabolism occurs in the liver, this task is performed slowly, after its implementation metabolites are formed. A considerable part of the drug does not change its form and enters the blood unchanged.

The active ingredient and substances resulting from its processing are excreted mainly in the urine, while a small part of the drug (9%) is excreted unchanged from the body. If the drug was taken after a meal, the half-life occurs in ten hours, if its use is regular - in 13 hours.

Reviews from doctors and patients allow taking the drug “Proflosin” for dysuric disorders that develop against the background of prostatic hyperplasia (benign in nature).

Use of the drug, choice of dosage

"Proflosin" patient reviews, instructions recommend taking it once a day. The product must be used after the first meal. One capsule must be swallowed without violating its integrity.

You need to take the medicine well. Dividing the capsule into parts may interfere with the rate of absorption of the active ingredient.

The course of treatment has not been established, the drug is taken as needed, the treatment period is not limited.

Side effects

Disturbances may occur in the gastrointestinal tract and nervous system. Possible damage to the reproductive system, heart and blood vessels. During treatment with the product, you may notice changes in the skin and tissues located under the skin.

A man may experience problems with ejaculation; in very rare cases, patients develop priapism. A significant deterioration in well-being is possible when there is a headache, dizziness, and sometimes the person is in a pre-fainting state.

After taking Proflosin, patient reviews note that skin manifestations include angioedema, urticaria, skin itching, and a rash. But this happens very rarely. A person may suffer from diarrhea and constipation. It is likely that side effects will include nausea with vomiting, hypotension (orthostatic), and tachycardia.

In a few cases, narrow pupil syndrome develops as a result of cataract removal, rhinitis, and asthenia.

No cases of overdose have been recorded. But theoretically there is such a possibility. In case of an overdose of the drug, blood pressure may decrease and tachycardia may occur. To normalize blood pressure and heart rate, you need to lie down for a while.

It makes no sense to prescribe hemodialysis to a patient, since the active component of the drug binds very well to plasma proteins.

It is necessary to take actions that will stop the absorption of the drug - gastric lavage, use of an osmotic laxative or activated charcoal.

Cost of the drug, analogues

Before using Proflosin, the price, instructions, and reviews in most cases are carefully studied by the patient. The cost of one package of capsules is approximately 400-500 rubles.

Analogues include “Revokarin” and “Tulosin”. Other substitutes for the drug are also known, for example “Fokusin”, “Omnic”.

Reviews

Having read the reviews about the drug, we can talk about its high effectiveness. Proflosin is mainly taken by men after 50 years of age, when prostate disease develops. Many patients are satisfied with the results of the treatment; in most cases, problems with urination disappear or are less painful for the man.

Side effects sometimes include erection problems, tachycardia and decreased blood pressure. Proflosin did not help some patients, so they had to decide to undergo surgery.

Many doctors choose this particular drug for treatment only if they are sure that their prescriptions will be strictly followed by the patient.

Experts say that the need for surgery can be eliminated if the patient uses the drug Proflosin correctly (regularly and at a certain time).

Reviews, instructions, analogues, application, price are now known to you, and after consulting with a doctor, you can begin treatment. The specialist will conduct an examination and prescribe a specific dose of medication that should help in a particular case.

Source: //FB.ru/article/221938/preparat-proflosin-otzyivyi-patsientov-i-vrachey-lekarstvo-proflosin-primenenie-sostav-otzyivyi

Overdose

There have been no recorded cases of side effects with increasing amounts of tamsulosin. However, taking into account the principle of action of this substance and its properties, it is not recommended to exceed the recommended dose of the medicine. As a result, hypotension and tachycardia may develop.

To eliminate negative symptoms, first of all, the patient must be put to bed. Additionally, activated charcoal is taken; gastric lavage is required to eliminate excess amounts of the drug. In order to speed up the elimination of tamsulosin, you should take an osmotic laxative.

In order to speed up the elimination of tamsulosin, you should take an osmotic laxative.

Interaction with drugs and alcohol

When taking Nifedipine, Enalapril, Atenol, tamsulosin indicators do not change. Cimetidine increases plasma levels of the substance.

Under the influence of Diclofenac and Warfarin, tamsulosin is eliminated from the body much faster.

The simultaneous use of Proflosin with drugs of a similar spectrum of action can lower blood pressure. Furosemide reduces the concentration of the active ingredient.

Proflosin and alcohol have negative compatibility. Ethanol almost completely neutralizes the effect of the active components of the drug on the body.

Interoperability and Compatibility

The amount of active substance in the blood increases under the influence of Cimetidine.

If Furosemide is used simultaneously with Proflosin, a slight decrease in tamsulosin concentration is noted. In this case, there is no need to recalculate the dose of the medicine.

Simultaneous use of different types of alpha1-blockers helps reduce blood pressure.

Drugs such as Warfarin, Diclofenac, Enalaprilol, Atenolol, Nifedipine, Theophylline do not affect the effectiveness or concentration of the drug in question.

Simultaneous use of different types of alpha1-blockers helps reduce blood pressure.

With alcohol

It is prohibited to drink alcohol-containing drinks during treatment with Proflosin. In this case, the risk of developing hypotension increases.

Price

The cost of Proflosin depends on the number of capsules in 1 package. The price for 30 pieces will vary from 417 to 460 rubles. Price for 100 capsules - 1120-1280 rubles. Many patients are interested in where they can purchase the drug. Like other medical products, Proflosin is sold in various pharmaceutical chains and is available only with a doctor's prescription. The cost of the medicine directly depends on the pharmacy, its location (district, city), and manufacturer.

You can find out the pricing policy of the drug at the pharmacy by calling, or go online to a specialized website. In addition, you can use online services to order and purchase medicine. In Internet resources you can find a lower cost of Proflosin.

What can be replaced

It is acceptable to consider analogues with the same composition, but products containing other active components are also effective, provided that they act on a similar principle. Capsules can be replaced with tablets if the dosage of the main substance is appropriate. Effective analogues:

• Omnic;
• Tamsolosin;
• Doxozonin;
• Hypersimple;
• Omsulosin;
• Focusin;
• Prostatilen, etc.

Omnic is a direct analogue of the product in question. The drug contains the same active ingredient in the appropriate dosage. This eliminates the need to recalculate the amount of tamsulosin. You can purchase the product in packages of 10, 30 and 100 pcs. If analogues are being considered to replace Proflosin, it is better to first pay attention to such drugs. Another direct analogue is Tamsoluzin.

Doxozonin contains the active substance of the same name. Its concentration in 1 tablet is 2 and 4 mg. The dose differs significantly from the amount of the main component of Proflosin. This means that a recalculation is performed upon assignment. The main properties of this drug: antispasmodic, hypotensive, vasodilator. This drug is prescribed for benign prostatic hyperplasia, and also for arterial hypertension, but in this case the medicine is used as part of complex therapy.

Hyperprost contains tamsulosin in the same dosage as the drug in question. The principle of operation of these drugs is the same. Fokusin has the same composition and pharmacological action.

Prostatilen contains other active components: peptides, which are obtained by extraction from the prostate gland of young bulls. The concentration of the main substances varies depending on the type of drug: suppositories contain 30 and 50 mg, solution for injection - 5 mg.

Prostatilen helps reduce the intensity of swelling of the prostate gland and eliminates the risk of stagnation. At the same time, normalization of the secretory function of prostate epithelial cells is noted. Thanks to this remedy, the risk of developing thrombosis of small vessels is reduced.

Side effects of Proflosin

As is known, benign prostatic hyperplasia is often accompanied by dysuric disorders. To improve urodynamics, you can use alpha-1-blockers, for example, Proflosin.

The active component of the drug is tamsulosin hydrochloride. The substance selectively blocks alpha-1 adrenergic receptors, thereby promoting relaxation of the smooth muscles of the genitourinary system.

In Russia and the CIS countries the drug is available in pharmacies. But the medicine is available with a doctor's prescription. How much does the medicine cost? On average, the price of the drug is 1000-1200 rubles. The price is indicated for a package containing 100 capsules.

Proflosin is mainly prescribed for urinary disorders, which can be manifested by frequent urination in small portions or pain and stinging during urine output. Also, the indication for use may be the opposite - too infrequent urination.

In men, problems with urination usually arise due to diseases of the genitourinary system. Most often, pain during trips to the toilet occurs with prostate adenoma and inflammation of the prostate gland.

Characteristic symptoms of these diseases are pain, pain during urination and frequent urge to go to the toilet. Proflosin is a concomitant drug in the treatment of these diseases and is prescribed for better urine flow.

Like any other drug, Proflosin has some contraindications:

• Firstly, it is forbidden to use Proflosin if you have hypersensitivity to some components of the drug.
• Secondly, this drug should not be used in case of renal failure, since the drug provokes a stronger outflow of urine.
• It is not recommended to use the drug for low blood pressure, since some components of the drug, for example, an adrenergic receptor blocker, can further lower blood pressure.

In general, the drug interacts well with other drugs, however, it should not be used together with drugs that promote the elimination of tamsulosin hydrochloride, since the effectiveness of the drug will be significantly reduced. These drugs include Diclofenac, Warfarin, Atenolol, Enalapril and Theophylline.

Sometimes, due to the use of Proflosin, patients experience some disturbances in the digestive process, nausea and migraines. In addition, you may notice skin rashes and hives. Often, patients experience a significant drop in blood pressure, and men may experience problems with erection.

Due to a sharp decrease in blood pressure, patients' concentration decreases and their attention is dispersed, so it is not recommended to drive a vehicle during the treatment period, or it is necessary to select other means.

Also, the medicine will not be suitable if there is a need to perform work that requires special concentration. If there are contraindications to use or if side effects occur, it is better to replace the medicine with a similar drug.

If the patient decides what to choose, Proflosin or Omnic, then in this case it should be based on the components included in both drugs. It is better to choose those that will be more suitable for a particular patient, since the action and effectiveness of the drugs are the same, and the cost is not much different.

It is important to consider that both drugs are very strong, so they should only be taken under the supervision of a doctor. It is not recommended to purchase the drug yourself without prior consultation and a prescription.

We recommend that you read – Omnik: instructions and reviews.

Fokusin is another analogue of the drug that is as close as possible to Proflosin. When choosing Proflosin or Focusin, you should only take into account the differences in composition. The cost of the drugs is almost the same, while the effect of these drugs is also identical; Fokusin has the same side effects as Proflosin.

The only difference is that Focusin therapy takes a little longer. If Proflosin capsules lead to results within 10 days, then with treatment with Focusin, the first results appear only after two weeks.

Focusin is also available in the form of gelatin-coated capsules; they should also be taken strictly after meals. The action of the active components begins 6 hours after taking the capsule. Thus, the drugs are practically no different, so they can be safely replaced with each other.

Despite the fact that the drug helps normalize urination, with which women also have problems, Proflosin can only be taken by men. The drug will not have any positive effect on women, but it can greatly harm the body.

This is especially true for pregnant women, as well as breastfeeding mothers. During the period of bearing a child and breastfeeding, any medications that have such a strong effect are strictly prohibited.

At the beginning of the course, doctors do not rule out a deterioration in the patient’s well-being. The instructions for use contain a complete list of side effects, which, if they occur, require replacing the medicine or individually adjusting the daily dosage of Proflosin:

• digestive tract: signs of dyspepsia, nausea, vomiting, diarrhea, constipation, gastralgia (abdominal pain);
• cardiovascular system: tachycardia, chest pain of unknown origin, increased heart rate, orthostatic hypotension, fainting;
• nervous system: insomnia, increased drowsiness, dizziness, migraine attacks;
• reproductive system: retrograde ejaculation, decreased libido;
• allergic reactions: swelling, hyperemia of the epidermis, asthenia, urticaria, skin itching and burning.

Reviews about Proflosin are mostly positive, indicating its high clinical effectiveness. Using the drug for prostatitis allows you to get rid of frequent and painful urination within a short time.

Some men, while confirming the therapeutic effect of the drug, are forced to abandon its use because they experience severe side effects during therapy, including disorientation, fainting, and decreased blood pressure.

The price of Proflosin for a package containing 30 capsules can range from 440 rubles, 100 capsules - from 1158 rubles.