Macmiror: instructions for use, analogues and reviews from doctors and users

Macmiror, how to take. Macmiror

Composition and release form

Film-coated tablets	1 table
nifuratel	200 mg
auxiliary ingredients: starch; polyethylene glycol 6000; talc; magnesium stearate; gelatin; gum arabic; sucrose; magnesium carbonate; titanium dioxide; E wax

10 pcs in blister; in a cardboard pack there are 2 blisters (with instructions for use).

Description of the dosage form

Biconvex tablets, coated, white.

Characteristic

Belongs to the group of nitrofurans.

pharmachologic effect

Pharmacological action - antifungal, antiprotozoal, antimicrobial.

Pharmacodynamics

Nifuratel, an antimicrobial agent from the nitrofuran group; has antiprotozoal, antifungal and antibacterial effects.

Nifuratel has high efficiency and low toxicity, which determines a wide range of its clinical use.

Highly effective against Papiliobacter and Helicobacter pylori, gram-positive and gram-negative microorganisms: at a minimum inhibitory concentration (MIC) of 12.5–25 μg/ml, it suppresses from 44.3 to 93.2% of cultures.

Shows high activity against both aerobic and anaerobic pathogens.

The spectrum of action includes: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella flexneri 2a, Shigella flexneri 6, Shigella sonnei, Salmonella typhi, Salmonella typhimurium, Salmonella enteritidis, Klebsiella spp., Enterobacter sph., Serratia spp. , Citrobacter spp., Morganella spp., Rettgerella spp., Pragia fontium, Budvicia aquatica, Rachnella aquatilis and Acinetobacter spp., other atypical enterobacteria, as well as protozoa (amoeba, lamblia); less active against Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa.

It is the drug of choice for the treatment of salmonellosis, shigellosis and other intestinal bacterial infections.

Active against Trichomonas vaginalis, highly active against fungi of the genus Candida.

Particularly effective against Helicobacter pylori strains resistant to metronidazole.

Data have been obtained indicating the high activity of nifuratel (in vitro and in vivo) against Atopobium vaginae, the main marker of bacterial vaginosis.

Pharmacokinetics

When taken orally, it is quickly absorbed from the gastrointestinal tract. Penetrates the blood-brain barrier and the hematoplacental barrier and is excreted in breast milk. Metabolized in the liver and muscle tissue. It is completely excreted from the body by the kidneys (30–50% unchanged), providing a strong antibacterial effect in the urinary tract.

Indications for the drug Macmiror

vulvovaginal infections caused by pathogens sensitive to the drug (pathogenic microorganisms, candida, trichomonas, bacteria, chlamydia);

chronic inflammatory diseases of the upper gastrointestinal tract associated with Helicobacter pylori (chronic gastritis, gastric and duodenal ulcers, gastroesophageal reflux disease);

intestinal amebiasis and giardiasis;

pyelonephritis, urethritis, cystitis, pyelitis and other diseases of the urinary system.

Contraindications

Hypersensitivity to the active substance or any component of the drug.

Use during pregnancy and breastfeeding

Nifuratel penetrates the hematoplacental barrier after an overdose, so the use of the drug is possible only under strict indications, if the expected effect of therapy outweighs the potential risk to the fetus.

Nifuratel is excreted into breast milk, therefore, if it is necessary to prescribe the drug during lactation, the issue of stopping breastfeeding should be decided.

Side effects

In a place protected from light, at a temperature not exceeding 25 °C. 5 years.

Danger of overdose

There are no clinical descriptions that support the diagnosis of overdose cases. But if the drug was taken in high dosage, detoxification procedures are permissible:

gastric lavage;
forced diuresis;
dialysis (extremely rare).

Such therapy may not be required; the patient will simply be advised to skip the next dose of the drug.

Since the medication is excreted from the body by the kidneys, it is permissible to prescribe plenty of fluids and use diuretics.

Such manipulations are considered standard.

Macmiror during pregnancy. About the drug

Macmiror is an antibacterial drug, a modern broad-spectrum antibiotic, widely used in gynecological practice.
Inflammatory processes in the genital organs, which cause discomfort to a woman and have serious consequences, are caused by the presence of viruses and bacteria. By inhibiting pathogenic microflora, the drug has no effect on other microorganisms present on the vaginal mucosa, which certainly prevents the development of dysbacteriosis. This is its undoubted advantage.

Release form: suppositories, tablets and cream

The Italian manufacturing company produces the drug in the following dosage forms:

In the form of tablets for oral administration. Each tablet contains 200 mg of the active substance - nifuratel. The pills are packaged in aluminum blisters of 10 pieces; a cardboard package contains 2 plates.
Intravaginal suppositories contain 500 mg of nifuratel and 200,000 units of nystatin. Suppositories are packaged in plastic packaging of 8 and 12 pieces.
Vaginal cream contains the same components as the two previous medications: nifuratel (100 mg per 1 g of cream) and nystatin (40,000 units per 1 mg). It is usually produced in a tube with a capacity of 30 g, which is sold together with a device that facilitates insertion of the medicine into the vagina.

Compound

The main active ingredient of Macmiror is nifuratel - an antimicrobial and antiprotozoal substance that actively fights pathogenic microorganisms: gram-positive and gram-negative bacteria. Nifuratel also has a depressant effect on chlamydia and trichimonas.

Another active ingredient has been added to the Macmiror Koplex series preparations (suppositories and cream) - the antifungal antibiotic nystatin. This substance suppresses fungi of the genus Candida: by disrupting cell permeability, nystatin promotes their death.

Two active components - nifuratel and nystatin - complement each other favorably, carrying out a targeted strike against all pathogenic microorganisms and fungi. This symbiosis makes it possible to achieve the desired positive dynamics of treatment in the shortest possible time.

Drugs suitable for the treatment of Giardia in children

Among all parasite diseases in children and adults, giardiasis is most often detected. After this, Giardia in children is treated with drugs to avoid undesirable consequences.

As a rule, Giardia infection is quite common. Many people may not be aware of this unless there are obvious clinical symptoms.

Even with today’s development of diagnostic methods and medicine throughout the world, the incidence of giardiasis remains quite high, which is caused by deteriorating environmental conditions, lack of vitamins and other nutrients in the daily diet, decreased immunity due to stress, high loads, and constant tension.

Giardiasis infection: features

Having heard from a doctor a diagnosis of giardiasis, all parents fully understand the seriousness of the disease. Everyone should know how infection occurs and what medicine is prescribed for Giardia to treat children.

Parasites are dangerous for children's bodies

After the onset of infection, the body signals danger. First of all, the baby doesn’t feel well. And this is not surprising, since when they enter the body, microorganisms come to life, emerging from the protective shell. Parasites begin to multiply quite quickly.

It is very important to take all the medications prescribed by the doctor so that the parasites cannot feed on the beneficial substances that reach them through the blood. Therefore, the child may be deprived of vitamins and various useful minerals.

And as a conclusion - vitamin deficiency.

A clear picture of the infection

Infection is possible if more than 10 cysts enter the body. Favorite places of parasites:

Giardia cysts are found in soil and sand;
they live on soft toys and dirty dishes;
pass from mother to child through breast milk;
present on dirty vegetables and fruits;
can contaminate raw water.

Treatment of giardiasis

It is very difficult to get rid of Giardia in children. To achieve a positive result, you will have to spend a lot of time and effort. In addition to traditional medicine, there are many folk recipes. But this does not mean that you can neglect the treatment prescribed by your doctor.

If children are over 10 years old, if desired, you can try folk remedies for Giardia, but do not abandon the main treatment. It's more of an addition to it. If the child is under 10 years old, it is recommended to forget about traditional medicine methods. Otherwise, they will only cause harm to the body. Giardiasis is a disease that requires urgent treatment.

Macmiror analogues. Cheap analogues of Macmiror

In order to treat infectious and inflammatory processes, experts recommend taking the drug Macmiror, which has antibacterial, antiprotozoal, and antifungal effects on the body. If necessary, Macmiror analogues can be used to treat a number of diseases.

Characteristics McMirror

The antibacterial drug belongs to the group of drugs - nitrofurants. Macmiror is an effective and low-toxic medicine with a wide spectrum of action. the product is used for therapeutic purposes to eliminate intestinal infections, fungal infections with Candida fungi and trichomoniasis.

Macmiror is produced by a pharmaceutical company in tablet form. The manufacturer also produces Macmiror Complex in the form of capsules.

The main component of the drug is nifuratel.

The drug Macmiror is a prescription medication and is prescribed by the attending physician when the patient is diagnosed with:

infection with vulvovaginal bacteria and fungi;
intestinal amebiasis;
intestinal giardiasis;
urinary tract infections;
bacterial infection of the gastrointestinal tract.

Contraindications to the prescription of Macmiror tablets include only intolerance to the components of the medication. If there are contraindications or an individual reaction to the drug, a rash or itching may appear on the skin. An adverse reaction can also cause stomach or intestinal upset.

The cost of Macmiror in pharmacies is on average 700 rubles.

Analogs

Replacing Macmiror is not difficult, however, not every drug can have the same effective effect for the treatment of giardiasis and other diseases. An analogue of Macmiror is selected by a specialist observing the patient. Depending on the area of inflammation, not only tablets, but also suppositories or cream can be used for therapy.

If it is necessary to replace Macmiror with an analogue, experts recommend one of the drugs:

Nifuratel;
Furazolidone;
Metronidazole;
Furacilin.

These drugs have a similar pharmaceutical effect, but they are much cheaper. When choosing a cheaper analogue, you need to pay attention not only to the price, but also to the presence of possible contraindications.

Nifuratel

The drug Nifuratel is the closest analogue of Macmiror in tablets. The medicine contains a substance - nifuratel, which is also contained in the original medicine.

The medicine has antifungal and antibacterial effects, and also has a general anti-inflammatory effect. In addition to tablets, Nifuratel is available in the form of suppositories and ointments.

The medication has a therapeutic effect during the development of:

trichomoniasis;
cystitis, pyelitis and other infectious diseases of the genitourinary organs;
vulvovaginitis;
cholecystopancreatitis;
gastroduodenitis;
amoebiasis;
giardiasis;
enterocolitis;
chronic inflammation of the gastrointestinal tract.

The cheap analogue of Macmiror has a number of contraindications:

lactation;
pregnancy;
allergy.

When replacing Macmiror with an analogue, it is necessary to take into account possible adverse reactions:

dysfunction of the intestines or stomach;
gastralgia;
skin allergies;
heartburn.

Reviews of Nifuratel confirm that the drug is quite effective and does not have significant differences from Macmiror in its therapeutic effect.

The price for Nifuratel is from 500 rubles.

Furazolidone

When considering cheap analogues of the original antibiotic, it is recommended to pay attention to the drug Furazolidone, which has a price significantly lower than Macmiror. Reviews of Furazolidone tablets indicate that the drug also has an effective effect against fungi and stomach infections.

The medicine is prescribed:

with giardiasis;
with bacillary dysentery;
for typhus;
with enterocolitis;
for food poisoning;
with urethritis or cystitis;
with infectious trichomonas;

Cheap tablets are also used for external use (preparing a solution by dissolving the tablets in water). The solution is used to treat the skin surface in case of fungal infection, as well as the presence of wounds or burns.

The cheap analogue has certain contraindications:

allergy to the composition;
terminal liver failure;
children up to a month old.

Side effects include:

abdominal pain;
vomiting/nausea;
decreased appetite.

When used externally, in rare cases an allergic reaction is observed.

Furazolidone is a fairly cheap substitute for Macmiror. Its average price is 60 rubles. low cost affects the effectiveness of the drug; the effect of the drug does not occur as quickly as from treatment with the original drug.

Side effects

In practice, side effects rarely occur; there is information that while using the tablets, patients were diagnosed with:

nausea, stomach pain, bitter taste in the mouth;
heartburn, diarrhea;
as well as allergic reactions of various types: rash, itching of the skin.

No other side effects were identified during treatment. But if the above-described phenomena occur, you should consult a doctor to correct the therapy.

What does Macmiror treat? Directions for use and doses

Infectious pathologies of the genital organs.

Adults are recommended to take 1 tablet. Macmiror three times a day after meals for a week. It is advisable to treat the patient and her sexual partner simultaneously. Additionally, you can use intravaginal capsules and/or Macmiror cream.

In some cases, it is possible to prescribe 4 tablets daily. It is better to stop sexual contacts during the therapeutic course.

In children over 10 years of age, Macmiror is prescribed in an amount of 10 mg per kilogram of weight daily, dividing the dosage into two doses. The duration of the course in this case will be about 10 days.

Infectious diseases of the urinary system.

Adults are prescribed three to six Macmiror tablets daily (0.2-0.4 g per day) after meals. Duration of therapy is about 7-14 days.

In children, starting from six years of age, Macmiror can be prescribed in an amount of 10 to 20 mg per kilogram of body weight per day (in two doses). The course of therapy is 7-14 days.

If necessary, treatment can be longer.

Intestinal amebiasis.

Adults are prescribed 2 Macmiror tablets three times a day, after meals, for ten days.

In children, starting from six years of age, it is appropriate to prescribe a daily dosage of 30 mg per kilogram of weight. The total amount of the drug is divided into three doses. The course of therapy is 10 days.

Giardiasis of the intestines.

Adults take 2 Macmiror tablets up to 3 times a day, after meals. Duration of treatment is one week.

Children from the age of six take the medicine at the rate of 30 mg per kilogram of weight, dividing the dosage into two doses. The duration of the course is one week.

Features of application

Use of the drug, especially for a long time, may cause hypersensitivity reactions.

During treatment, it is necessary to refrain from drinking alcohol to prevent the development of fatigue and nausea, which go away on their own after some time.

If signs of an allergic reaction occur, you should stop using the drug.

While using the drug, you should abstain from sexual relations.

It is necessary to simultaneously treat the sexual partner to avoid re-infection.

The drug contains sucrose, which should be taken into account by patients with diabetes.

McMiror for children. McMirror

Film-coated tablets, Doppel Farmaceutici

Release form and composition

Film-coated tablets 1 tablet nifuratel 200 mg auxiliary ingredients: starch; polyethylene glycol 6000; talc; magnesium stearate; gelatin; gum arabic; sucrose; magnesium carbonate; titanium dioxide; E wax

10 pcs in blister; in a cardboard pack there are 2 blisters (with instructions for use).

Characteristic

Belongs to the group of nitrofurans.

Active substance

Nifuratel

Description of the dosage form

Biconvex tablets, coated, white.

Pharmakinetics

Interaction with other drugs and other types of interactions

Film-coated tablets.
Clinically significant interactions of the drug with other drugs have not been established.

Concomitant use of alcohol can lead to disulfiram-like reactions.

Among the structural analogues there is only 1 drug Macmiror complex; it is available both in the form of tablets and in the form of suppositories. The active ingredients are: nifuratel, nystatin.

The drug has no other analogues.

What is better for Giardia: Macmiror or Nemozol

McMiror and Nemozol effectively cope with Giardia. Nemozol has a complex effect when not only giardiasis is detected, but also worms.

The active substances of the drug can provoke a number of side effects and allergic reactions.

Macmiror is a more gentle way to combat Giardia. It does not harm the body, and side effects occur in rare cases. Additionally, it eliminates intestinal infections, helping the body recover from parasitic infection.

The choice between drugs must be made by the doctor, based on the general clinical picture of the disease and the patient’s condition. Changing or prescribing medications and dosages on your own is prohibited.

Timely treatment of giardiasis with Macmiror will be successful and after 7 days the disease will completely recede. To prevent a relapse, you should regularly take tests and undergo preventive examinations. Maintaining good personal hygiene is the best way to protect yourself from infection.