ARGOSULPHAN - instructions for use, price, reviews and analogues

Composition and form of production

Argosulfan ointment has pronounced antimicrobial properties for external application, which is used to treat ulcers, abrasions and various dermatological pathologies.
The drug is approved at any age. Argosulfan is an ointment based on silver sulfathiazole and intended for external use. The medicine is packaged in aluminum tubes of 15 or 40 mg, as well as cardboard packs. Belongs to the pharmacological type of sulfonamides.

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Argosulfan has the following composition:

silver sulfathiazole;
liquid paraffin;
cetostearyl alcohol;
glycerol;
sodium lauryl sulfate;
petrolatum;
methyl parahydroxybenzoate;
propyl parahydroxybenzoate;
potassium dihydrogen phosphate;
sodium hydrogen phosphate.

The medicine is characterized by an antimicrobial effect and is used to accelerate the healing of abrasions and other skin lesions.

pharmachologic effect

The medication belongs to the pharmacological group of sulfonamides, antimicrobial drugs. It is characterized by the presence of pronounced regenerating, wound-healing, and antiseptic properties. Thanks to the presence of silver in the cream, a bactericidal and antimicrobial effect is achieved. The medicine has a powerful analgesic and analgesic effect and prevents wound infection.

The therapeutic effect is achieved due to the ability of Argosulfan components to cause a disruption in the synthesis of dihydrofolic acid, the replacement of para-aminobenzoic acid, which contributes to the destruction of the structure of the pathogen.

Silver ions further enhance the antiseptic and bactericidal effects of the drug. They bind to the DNA of bacterial cells, preventing further proliferation of pathogens and progression of the pathological process.

Silver ions bind to the DNA of bacterial cells, preventing further proliferation of pathogens.

The drug has a wide spectrum of action and is effective against both gram-positive and gram-negative microorganisms. It is characterized by the absence of toxic effects on the body due to minimal resorption rates.

The hydrophilic base allows you to increase the humidity in the area of the treated wound, which helps to activate the processes of healing, restoration and improves the tolerability of the product.

Medicinal properties

The instructions for use say that the product has antimicrobial and bacteriostatic properties. This means that the medicine stops the further proliferation of pathogenic microflora. This effect is due to the ability to inhibit the synthesis of bacteria and pathogens, leading to their death.

Indications for use

Main pharmacological properties:

bacteriostatic,
antibacterial,
painkiller,
anti-inflammatory,
wound healing.

Argosulfan ointment promotes hydration and rapid regeneration of the skin, accelerating the healing of wounds and burns.

The drug affects only the epidermis; a minimal amount of the drug enters the bloodstream. In addition, the ointment effectively protects the area of skin damage from further infection.

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The medicine effectively eliminates the sensation of pain, itching and burning at the site of skin damage.

Due to the fact that it contains silver, the product is highly antibacterial and antimicrobial effective.

Argosulfan cream composition

1 g of cream contains:

Active ingredient: silver sulfathiazole - 20 mg;

Excipients: cetostearyl alcohol (cetyl alcohol 60%, stearyl alcohol 40%) - 84.125 mg, liquid paraffin - 20.0 mg, white petrolatum - 75.9 mg, glycerin - 53.3 mg, sodium lauryl sulfate - 10.0 mg , methyl parahydroxybenzoate - 0.66 mg, propyl parahydroxybenzbate - 0.33 mg, potassium dihydrogen phosphate -1.178 mg, sodium hydrogen phosphate - 13*052 mg, water for injection - up to 1.0 g.

Description

White or white with a shade of pink to light gray, homogeneous soft mass.

Pharmacotherapeutic group: antimicrobial agent, sulfonamide.

ATX code: D06BA02

pharmachologic effect

Argosulfan® is a topical antibacterial drug that promotes the healing of wounds (burn, trophic, purulent, etc.), provides effective protection of wounds from infection, reduces treatment time and the time to prepare a wound for skin grafting, in many cases leads to an improvement in condition, eliminating the need for transplantation.

The sulfanilamide contained in the cream, silver sulfathiazole, is an antimicrobial bacteriostatic agent and has a wide spectrum of antibacterial bacteriostatic action against gram-positive and gram-negative bacteria. The mechanism of the antimicrobial action of sulfathiazole - inhibition of the growth and reproduction of microbes is associated with competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of dihydrofolic acid and, ultimately, its active metabolite - tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines of the microbial cell. The silver ions present in the preparation enhance the antibacterial effect of sulfonamide B; they inhibit the growth and division of bacteria by binding to the deoxyribonucleic acid of the microbial cell. In addition, silver ions weaken the sensitizing properties of sulfonamide. Due to minimal resorption of the drug, it does not have a toxic effect.

Pharmacokinetics

The silver sulfathiazole contained in the drug has low solubility, as a result of which, after local application, the concentration of the active substance in the wound is maintained at the same level for a long time. Only a small amount of silver sulfathiazole ends up in the bloodstream, after which it undergoes acetylation in the liver.

In urine it is found in the form of inactive metabolites and partially unchanged. Absorption of silver sulfathiazole increases after application to large wound surfaces.

Indications for use

The main indications for use are indicated in the instructions for the medication.

Use is recommended in the following cases:

burns and frostbite, regardless of their origin;
non-healing ulcers;
eczema;
purulent wounds;
bedsores;
contact and microbial dermatitis;
cuts, scratches and abrasions.

How to treat burns

Streptoderma and staphyloderma are also considered indications for the use of pharmacological agents. Argosulfan is also used for acne, purulent lesions of the skin and mucous membranes. It not only relieves the inflammatory process, but also accelerates the restoration of epidermal tissue .

Analogs

Medicines with similar properties are:

Levomekol (gel);
Streptocide;
Dermazin;
Sulfargin;
Silvederma;
Sulfatsil-Belmed;
Silvaderm.

Contraindications

Despite its high effectiveness, the drug has several contraindications for use . It is strictly forbidden to use it for the treatment of skin pathologies and injuries in premature babies or newborn infants, since the likelihood of developing jaundice is too high.

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It is not recommended to apply the product in the following cases:

children's age up to 2 months;
intolerance to sulfonamides;
pregnancy period;
individual intolerance to the drug.

The drug is contraindicated during pregnancy

The pharmacological drug is approved for use during the lactation period, but only when only a small area of skin is treated. Treatment during breastfeeding should be carried out under constant medical supervision.

Attention! Argosulfan is not used in the treatment of shock patients with thermal burns that occupy a large area of the skin. This is due to the fact that in such cases it is not possible to establish a tendency to allergic reactions.

Mode of application

Argosulfan instructions for use recommend for external use only.

The damaged area of skin should be pre-treated with an antiseptic, for example, a chlorhexidine solution. The medicine is applied to the wounds in a thin layer at least 3 times throughout the day.

A bandage can be applied on top. It is best to apply not with your fingers, but with a sterile gauze pad. This will prevent the infection from spreading to healthy areas of the skin.

The bandage with the drug must be changed every day. In most cases, the duration of treatment does not exceed 8 weeks.

The product effectively fights acne and purulent rashes, is quickly absorbed by the skin and does not leave a greasy film on it. It should be applied pointwise, exclusively to the area of inflammation. If the product accidentally wears off during the day, it must be reapplied.

Attention! Agrosulfate ointment for burns with silver can also be used to treat corns on the feet . To do this, the damaged area of skin is lubricated and then fixed with a gauze bandage or bactericidal patch.

Argosulfan ointment with silver: instructions for use

› Ointment cream gel ›

Argosulfan ointment is a medicine with antibacterial activity for external use. The drug has disinfecting and restorative properties.

Used to heal wounds of any nature and prevent their infection. The active substance of the drug is effective against most gram-positive and gram-negative bacteria.

Before starting to use the ointment, you should read the instructions and patient reviews of the product.

general description

Argosulfan is a white cream with a pink or light gray tint. The active component is silver sulfathiazole, 20 mg per 1 g of cream. Additionally, the drug contains the following substances:

sodium salt of lauryl sulfuric acid;
preservative E218 (methyl parahydroxybenzoate);
sodium dihydrogen orthophosphate;
propylparaben;
cetyl alcohol;
glycerol;
purified water;
white and liquid Vaseline.

Additional substances of the drug are selected in such a way as to well moisturize problem areas and maintain the pH balance necessary for rapid healing and restoration.

The product is packaged in aluminum tubes, the volume of which can be 15 or 40 g. The original cardboard pack contains one tube and an insert sheet (instructions for use), which presents all the detailed characteristics of the medication.

Argosulfan ointment is produced in Poland: Elfa JSC Farmzavod (Pharmaceutical Works Jelfa, SA) and Russia: Valeant LLC.

Pharmacological characteristics

The therapeutic effect is based on the active component - silver sulfathiazole, which has pronounced antimicrobial activity. The substance is especially active against gram-negative bacteria. Blocks the synthesis of folic acid in the microbial cell.

Silver ion inhibits the growth and doubling of DNA (bactericidal effect), enhances the effect of sulfathiazole, and weakens the allergenic properties inherent in sulfonamides. Accelerates the healing of wounds, bedsores, burns, trophic ulcers. It is practically not absorbed from the application site.

Low solubility and resorption ensure constant concentration in the wound and a virtual absence of systemic manifestations of toxicity.

Thus, Argosulfan:

destroys pathogenic microorganisms in the wound;
prevents infection from penetrating deep into the affected tissues;
removes toxins from the wound that arise due to inflammatory processes;
accelerates the restoration of damaged tissues (rapid healing and scarring occurs);
has a local anesthetic effect;
reduces regeneration time at the cellular level.

Silver sulfathiazole has poor solubility, so after application to the wound, its concentration remains unchanged for a long time. Only a small amount enters the systemic circulation and is then acetylated by the hepatic system. Metabolites are excreted from the body by the kidneys along with urine.

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Indications and contraindications for use

Argosulfan ointment is used in the following cases:

solar, thermal, chemical, radiation burns of any degree;
specific skin damage caused by low temperatures - frostbite;
minor injuries received at home (abrasions, cuts);
necrosis (necrosis) of soft tissues as a result of constant pressure - bedsores;
trophic ulcers of the leg of various origins (including chronic venous insufficiency, obliterating endarteritis, angiopathy in diabetes mellitus, erysipelas).

In addition, the ointment is prescribed for some dermatological problems. For example, contact or infected dermatitis, microbial eczema, impetigo, endarteritis. Argosulfan is also used in skin transplantation, treating it before and after surgery.

The drug is not prescribed for the following conditions:

high sensitivity to the components of the drug;
state of shock with extensive burns;
premature babies;
children up to 2 months;
congenital deficiency of glucose-6-phosphate dehydrogenase.

Argosulfan during pregnancy and breastfeeding is prescribed only after assessing the ratio of expected benefits to possible risks in cases where the burn area does not exceed 20% of the body surface.

Method of application (dosage, method)

Argosulfan cream is for external use only. Treatment is carried out using both the open method and the use of occlusive dressings. Before using the product, the wound is pre-treated with any antiseptic. If purulent fluid is released, it is also removed with an antiseptic, for example, chlorhexidine solution.

Then a thin layer (no more than 2-3 mm) is applied to the ointment. The procedure is carried out 2-3 times a day. Treatment is carried out until the clinical manifestations disappear completely. The maximum daily dosage is 25 g of ointment. The course of therapy should not exceed 2 months.

Side effects, overdose

Allergic manifestations on the skin are the only possible negative consequence of using Argosulfan ointment. Burning and redness at the application site is a rare occurrence. If you use the drug for more than a month, there is a possibility of changes in the blood picture. This is due to prolonged exposure to the active component.

No cases of overdose have been officially registered. If, while using Argosulfan ointment, any nonspecific symptoms occur, you should consult a doctor.

Interaction, special instructions

Argosulfan is not recommended to be combined with other drugs for external use. Folic acid and its structural analogues may weaken the antimicrobial effect of sulfathiazole.

The drug does not affect the central nervous system in any way. Therefore, during therapy with Argosulfan, it is allowed to drive a car and engage in activities that require concentration and precision of action.

Conditions of release and storage

The drug is dispensed from pharmacies without a doctor's prescription. The shelf life is 2 years from the production date, which is indicated on the branded pack and tube.

You cannot use a product that has expired. The ointment should be stored in a dark place away from direct sunlight and limited access to children and pets.

Storage temperature should not exceed 25°C. Freezing the medication is prohibited.

The price of the drug depends on the region where it is sold and the pricing policy of the pharmacy. In Moscow and the Moscow region, the cost of Argosulfan cream for external use is 2%, 40 g tube - from 550 rubles.

Available analogues

The drug Argosulfan has no structural analogues of the active substance. If necessary, you can replace the ointment with the following medications:

Streptocide is an antimicrobial sulfonamide drug from a group of chemotherapeutic drugs with a selective bacteriostatic effect. Prescribed to combat skin pathologies caused by the activity of pathogenic bacterial flora.
Dermazin is an antibacterial drug. Used for the treatment and prevention of infected trophic ulcers and wounds, burn infections. Thanks to the silver sulfadiazine included in its composition, Dermazin has a wide spectrum of antibacterial action, which applies to almost all types of microorganisms that can infect burn wounds.
Sulfargin is an external drug with antibacterial, bactericidal and antifungal effects. The medication is active against gram-negative/gram-positive bacteria (Proteus spp., Escherichia coli, Klebsiella spp., Staphylococcus spp.), as well as dermatophytes and fungi Candida spp.
Advantan is an antibacterial, antiallergic, non-halogenated steroid that is successfully used in the treatment of various dermatoses. Methylprednisolone aceponate is the active substance.
Depanthenol is a regenerating, dermatoprotective drug. Indications for use: dry skin, abrasions, cracks, burns, minor injuries, abscess, boils, bedsores, diaper rash.

All of the listed medications are analogues of Argosultan, which have the same list of indications. A substitute should be selected by the attending dermatologist, who assesses the severity of the disease, the individual characteristics of the human body and other important factors.

Patient reviews of the product

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Good ointment, I have been buying it for a long time. I try to make sure that it is always in my home medicine cabinet. Heals very quickly small wounds, scratches and abrasions.

I even used it under a bandage once, but the bandage didn’t stick to the wound at all. Moreover, I noticed that the ointment relieves the pain a little, which is unexpected. Argosulfan is an effective and safe remedy for the whole family, I recommend it.

It’s not a cheap drug, but it showed excellent results in the treatment of burns. It so happened that my husband managed to get 3 rather large burns in six months. The largest one was the size of a palm.

At first I treated it with lotions based on sea buckthorn oil, but it didn’t help. A friend advised me to buy Argosulfan. Surprisingly, the wound began to heal after 3 days, and after 2 weeks the burn was completely gone.

For subsequent burns, they no longer experimented, but immediately used a proven remedy, which always helped.

Argosulfan helped us a lot with an electrical burn; my husband was injured at work (he did not follow safety precautions). The skin lesions on the arm were quite extensive, and other ointments did not provide a lasting effect.

Usually the pain was relieved only for a while. This drug led to healing in the shortest possible time. And its cost is not high, a tube lasts a long time.

I would especially like to note its texture: moderately greasy, absorbs well, and does not have an unpleasant odor.

The child’s leg wound, which he received after a gymnastics competition, did not go away for a long time. I applied iodine and thought it would help. But the wound did not heal, and suppuration began. We went to the doctor, who prescribed Argosulfan ointment.

Within a week the problem was solved: the wound began to scar. And after 2 weeks there was no trace left of the problem.

It is important that the cream has a very low probability of developing side effects, and it is a pity that the drug is quite expensive, otherwise I am very pleased with the cream.

Argosulfan ointment is an effective remedy with activity against gram-positive and gram-negative bacteria. The medication quickly heals wounds, abrasions, scratches, burns, and bedsores. Side effects during treatment occur extremely rarely, since the remaining ones practically do not penetrate the systemic circulation. Before using Argosulfan, you should consult a specialist.

Argosulfan ointment with silver: instructions for use Link to main publication

Source: https://infofarma.ru/maz-krem-gel/argosulfan

Side effects

The ointment is intended for external use; for this reason, cases of drug overdose have not been recorded in medical practice.

Side effects during the use of the drug occur extremely rarely. These include:

Allergic rashes.
Redness, itching and swelling at the site of application of the ointment.
Leukopenia.
Development of dermatitis.

Allergic reactions to the drug
Leukopenia and dermatitis can develop only during prolonged use of the ointment and never in cases where the course of treatment does not exceed 8 weeks.

A long course of use of the medication requires mandatory medical supervision. Active components can accumulate in the blood plasma and have a negative effect on the condition of the liver and kidneys. with a history of renal or hepatic dysfunction should be closely monitored

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Argosulfan: what is it taken for, dosage, analogues

Argosulfan (cream form) belongs to the group of antimicrobial drugs for the treatment of skin diseases. The instructions for use highlight the following features of the medicine:

During pregnancy: with caution
When breastfeeding: with caution
In childhood: with caution
For liver dysfunction: with caution
If renal function is impaired: with caution

Release form

Argosulfan is produced in the form of a white cream with a pink tint in tubes of 15 and 40 g in cardboard packs.

Pharmacodynamics and pharmacokinetics

The silver salt of sulfathiazole has low solubility, due to which the concentration of the main active component on the surface of the wound is maintained at the optimal, required level.

The drug does not have a toxic effect due to minimal resorption. A small proportion of silver salt enters the systemic circulation and is then acetylated by the hepatic system.

The larger the area of application of the cream, the higher the absorption rate of sulfathiazole.

Side effects

The cream does not change the color of the skin. Long-term therapy can provoke systemic reactions (desquamative dermatitis, changes in the functioning of the hematopoietic organs).

Allergic responses are rarely recorded. The medication is well tolerated if you follow the doctor's recommendations and follow the instructions.

In comparison with drugs of similar action, Argosulfan ointment produces the least adverse reactions.

Instructions for use (Method and dosage)

The medication is not intended for oral administration, only external use is allowed. The cream can be applied to open wounds; the use of a special occlusive dressing is allowed.

The medicine is applied to cleansed skin, observing the rules of asepsis and antiseptics.

In the presence of exudate, it is recommended to pre-treat the skin with a 3% boric acid solution or a 0.1% chlorhexidine solution.

Instructions for Argosulfan: the medication is applied in a thin layer 2-3 mm thick until the wound surface is completely closed or until the skin flap is completely ready for transplantation. It is recommended to carry out 2-3 procedures daily.

No more than 25 g of ointment can be applied daily. The duration of the course of treatment is 2 months. Long-term, continuous therapy requires mandatory monitoring of functional indicators of the liver and renal system.

Interaction

Argosulfan and other medications should not be used simultaneously on the same area of skin. The effectiveness of silver sulfathiazole is reduced when treated with procaine, folic acid preparations and its structural substitutes.

Storage conditions

Away from light and sunlight. The preferred temperature range is 5-15 degrees Celsius. Store in a dry place.

Analogues of Argosulfan

The only structural analogue of the drug is produced - Silver Sulfathiazole. Analogs for pharmacological effect:

Streptocide;
Dermazin;
Sulfargin.

During pregnancy (and lactation)

During pregnancy, Argosulfan can be used only in cases of urgent need, for example, when the skin is damaged over an area of more than 20%. It is recommended to stop breastfeeding due to partial absorption of the medication.

Reviews of Argosulfan

In medical practice, the cream has established itself as an excellent remedy for the treatment of large-area burns.

Thematic forums and medical portals, where ordinary patients share their impressions, contain only positive reviews about Argosulfan.

Young mothers also leave their reviews of the ointment, pointing out its good tolerance by young children and its high effectiveness in treating abrasions, cuts and wounds.

Argosulfan price, where to buy

The medicine is sold in pharmacy kiosks. The price of Argosulfan ointment in Ukraine is 72.50 UAH per 15 g tube. The cream in 40 g tubes costs 103.55 UAH. Argosulfan price in Russia: 15 g tube – 220 rubles, 40 g – 350 rubles.

Nuances

The product can be applied both to open areas of the epidermis and under a sterile bandage. This has no effect on efficiency.

It is strictly forbidden to apply to damaged areas of the skin simultaneously with other medications intended for external use.

The drug does not have any effect on a person’s ability to drive vehicles or operate complex production equipment.

There is no information in medicine regarding the effectiveness of using ointment in old age.

Important! The drug should not be combined with other medications that contain folic acid. Also, it should not be combined with the analgesic drug Procaine. Such drugs affect the pharmacological effectiveness of the ointment.

Side effects and overdose

The medical drug Argosulfan not only destroys pathogenic microorganisms, but also provides temporary pain relief at the source of pathology. Doctors, when prescribing a cream, do not rule out the occurrence of side effects:

local reactions upon direct skin contact with the medicinal composition;
allergic reactions;
desquamatous (with pronounced peeling) dermatitis;
disruption of the hematopoietic organs.

If, after applying the medicinal composition to the surface of the skin, visible redness and swelling appears, the patient complains of the appearance of a small rash and skin itching, doctors recommend choosing an analogue. Otherwise, the healing process of injured tissue will be lengthy, with unpleasant symptoms that will make the patient nervous and irritable.

Cases of overdose of this medicine have not been recorded in medical practice.

There are currently reports of drug overdose

not received.