Urorek - instructions for use, price and reviews

Many older men face pathological growth of prostate tissue or, in medical terms, benign prostatic hyperplasia (BPH). This disease should not be neglected under any circumstances, as this can lead to dangerous complications. Doctors strongly recommend that all men over forty years old undergo regular examinations by a urologist in order to be able to detect the development of pathology in time and begin appropriate treatment. Adenoma of the 1st and 2nd degrees is well treated with medication. The drug Urorek is extremely effective in treating this disease. Below in the article you will find instructions for using Urorek, features of the medicine and its analogues.

Release form, composition and packaging

The drug is available in 1 mg, 2 mg, 4 mg and 8 mg.
Inside the capsules it contains white or light yellow amorphous or finely crystalline powder. The drug contains silodosin as an active substance.

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The drug Urorek is a drug used for urinary disorders that occur against the background of benign prostatic hyperplasia. The active component of the composition, silodosin, is an alpha1-adrenergic blocker. The product is produced by the Irish company Recordati, read the instructions for its use, contraindications, and special recommendations.

Available in the form of capsules of 4 and 8 mg, in one package 25 or 30 capsules. The active substance is the alpha-adrenergic receptor blocker silodosin. The capsule shell protects the contents from the effects of hydrochloric acid in the stomach and dissolves only once it enters the duodenum. You can buy Urorek without a prescription in any pharmacy chain where it is available, or order it online with delivery by courier.

Main indications and contraindications

Due to the positive effect on the functioning of the genitourinary organs, Urorek capsules are most effective in the treatment of prostate adenoma and inflammation of the prostate gland - from prostatitis. The drug is always part of complex therapy. Despite the great potential of the active substance, Urorek is not able to eliminate hyperplasia or acute inflammatory process on its own.

Strict contraindications to the use of the drug Urorek are:

individual intolerance to the main or any of the auxiliary components of the drug,
severe renal or liver failure,
adolescence, children under 18 years of age.

In case of chronic diseases of internal organs, it is necessary to treat prostate pathologies under constant medical supervision. In case of deterioration of health, it is recommended to discontinue the drug followed by symptomatic treatment.

Overdose

There are no particular difficulties in how to take Urorek. The capsule is swallowed and washed down with a moderate amount of water. 8 mg is taken once per day at a time convenient for the patient, without reference to meals. In case of kidney disease, 4 mg per day is used. To achieve a stable positive effect, the medicine should be taken constantly; only if necessary (surgical interventions, severe conditions), breaks should be taken and then continued.

In experimental conditions on volunteers who took up to 48 mg of the drug, the development of orthostatic hypotension - dizziness, darkening in the eyes and a decrease in blood pressure with a sharp change in body position - was described. If in case of an overdose the drug was taken within the last 1.5-2 hours, you should induce vomiting, rinse the stomach and take activated charcoal. In case of a drop in blood pressure, it is necessary to administer hypertensive drugs (caffeine benzoate, adrenaline, prednisolone).

Urorek capsules dosage and method of administration

The recommended dose is 8 mg once, simultaneously with food, preferably at the same time of day. The capsule must be swallowed whole, preferably with a glass of water.

Patients with impaired renal function

In patients with mild renal failure (creatinine clearance >50 - <80 ml/min), no dose adjustment is required. For the treatment of patients with moderate renal failure (creatinine clearance > 30 to < 50 ml/min), it is recommended to take an initial dose of 4 mg per day during the first week; with good individual tolerance, the dose can be increased to 8 mg per day.

The use of the drug for patients with severe renal failure (creatinine clearance <30 ml/min) is not recommended.

Patients with impaired liver function

For patients with mild hepatic insufficiency and moderate hepatic insufficiency, no dose adjustment is required. Due to lack of data, the use of the drug in patients with severe hepatic impairment is not recommended.

Elderly patients

For older people, no dose adjustment is required.

Use in children

There was no corresponding use of the drug Urorek in pediatric practice according to the indications for use.

What Urorek tablets help with: instructions for use

This remedy is most often used to normalize urination, which is difficult due to prostate hyperplasia.

Urorek is presented in the form of yellow (4 mg) or white (8 mg) capsules for oral administration. Urorek contains silodosin, which is its active ingredient, as well as components such as:

Pregelatinized starch.
Magnesium stearate.
Titanium dioxide.
Sodium lauryl sulfate.
Mannitol.

The drug is packaged in cardboard packs in blisters of 5 and 10 capsules. Each pack contains 1, 2, 3, 5, 9 or 10 blisters, as well as instructions for using Urorek.

Effect of the drug

Silodosin is an alpha-adrenergic receptor antagonist with high uroselectivity.
It is able to block these receptors, which are located in the smooth muscles of the prostate, in the neck of the bladder, as well as in the part of the urethra that is inside the prostate.
As a result, the tone of the smooth muscles decreases, the hollow structures of the lower part of the urethra expand, and the outflow of urine, disturbed by the enlarged prostate, occurs more easily.

The drug is highly selective, so it does not have a serious effect on blood pressure.

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The active substance quickly enters the bloodstream and spreads throughout the tissues. The remains of the drug are metabolized by the liver, and breakdown products are excreted by the kidneys.

Indications

The indication for the use of Urorek is the treatment of urinary problems in the presence of benign prostate hyperplasia in men.

Contraindications

Before prescribing the drug Urorek, the doctor must make sure that the patient has no contraindications. These will include the following conditions:

intolerance to certain substances included in the drug;
severe form of renal failure;
presence of liver failure;
age less than 18 years.

In case of disturbances in the functioning of the liver and kidneys, the drug is prescribed with caution and taken under the supervision of a physician.

Urorek capsules are taken orally, during meals, not chewed, and washed down with plenty of water. Capsules are taken once a day, preferably at the same time.

In the first week of the course, it is usually recommended to take 4 mg of the drug, then the dose is increased to 8 mg. Based on the characteristics of the condition of each individual patient, the doctor selects the duration of the course of treatment.

The following side effects are possible when taking Urorek:

On the part of the cardiovascular system, it manifests itself in the form of a decrease in blood pressure with a sudden vertical position.
From the nervous system, it may manifest itself in the form of dizziness and loss of consciousness.
In the form of diarrhea, nausea, dry mouth - from the digestive system.
In the form of nasal congestion, as a reaction of the respiratory system.
From the reproductive system in the form of manifestations of retrograde ejaculation, anejaculation, decreased sexual desire, erectile dysfunction.

If side effects occur after starting therapy with Urorec, the patient should report these conditions to their doctor.

If the recommended dose of the drug is increased, blood pressure may decrease, as well as tachycardia. In such a situation, it is necessary to lavage the stomach and intestines and take sorbents.

We invite you to familiarize yourself with the PSA analysis - the norm in men, decoding the total and free percentage by age and blood, as shown in the table.
Before you start taking Urorek capsules, you need to study the features of its use, which are indicated in the instructions, namely:

Taking the drug may cause a decrease in blood pressure, as well as the development of orthostatic hypotension. If you experience dizziness and darkening in your eyes, you need to sit down or lie down, this will promote blood flow to the brain and will help shorten the duration of such sensations.
If a patient has prostate hyperplasia, it is necessary to ensure that the process is benign.
When using the drug Urorek before surgical manipulation on the eyeball, the symptom of “flabby iris” may appear.
It is not recommended to take this drug together with other drugs from the group of alpha-blockers.
During the course of therapy with Urorek, you should avoid work that requires increased concentration and high speed of reactions.

Urorek is sold in pharmacies and is a prescription drug. This drug is taken only after being prescribed by a specialist.

When undergoing a course of treatment with the drug Urorek, you must avoid drinking alcohol. Both ethanol and silodosin are metabolized by the liver. When taking Urorek and alcohol simultaneously, the incidence of side effects may increase due to excessive stress on liver cells.

Analogues and cost

Analogues of the drug Urorek include drugs that have a similar or different composition and have a similar effect on the body. Such drugs include:

Omnic – alpha-adrenolytic capsules based on tamsulosin;
Tamsulosin - powder, capsules and tablets with the same component in the composition;
Proflosin - capsules with tamsulosin as an active substance;
Omsulosin – capsules based on tamsulosin;
Sonizin - antidysuric capsules containing tamsulosin;
Dalfaz SR - tablets that normalize urination, based on alfuzosin.

The price in Moscow pharmacies for a package of Urorek, depending on the number of capsules in the package and their dosage, is:

4 mg, 25 capsules – 697-716 rubles.
4 mg, 30 capsules – 701-759 rubles.
8 mg, 25 capsules – 678-697 rubles.
8 mg, 30 capsules – 697-729 rubles.

The drug Urorek has a shelf life of no more than 2 years and retains its properties if stored in a dark, dry place inaccessible to children, the temperature should not exceed 30 ° C.

Reviews

The drug Urorek has proven itself in the treatment of difficulty urinating due to prostate hyperplasia.

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Prostate adenoma (hyperplasia) is a common disease diagnosed in men aged 40-45 years. Without proper treatment, it is fraught with urinary disorders, including urinary incontinence, problems with potency, infertility, and is very likely to develop into cancer.

Basically, adenoma is dealt with surgically, but surgery is resorted to when the neoplasm causes severe discomfort and complications have already begun to develop. While the tumor is at an early stage, its growth can be slowed down with medication. This is why Urorek was created.

The drug does not contain dangerous chemical compounds, but to ensure that taking the medication does not cause harm, it is necessary to study the instructions and the possibility of adverse reactions of the body to it.

Urorek is based on one active ingredient – silodosin. Additional components:

Additive E421;
Starch;
Pyrogen-free water;
sodium lauryl sulfate;
Iron oxide yellow;
Titanium dioxide

Available in the form of capsules with an enteric gelatin shell. Dosage of silodosin per 1 piece. – 4 and 8 mg.

Silodosin, a substance with increased selective activity, is an antagonist of α1-adrenergic receptors, which are localized in the prostate gland, the structure of the bladder walls, and the urethral canal.

Stopping the work of alpha1-adrenergic receptors ensures relaxation of smooth muscle tissue in the urinary ducts, which facilitates the outflow of urine several times. At the same time, the drug with silodosin does not have any effect on the functioning of the detrusor (sphincter) of the bladder, and this guarantees the absence of problems with urinary incontinence.

At the same time, Urorek relieves the manifestations of obstruction and irritation of the urinary system associated with prostate hyperplasia.

When taken orally, silodosin penetrates the intestinal wall and reaches the prostate gland in a short time. Its effect is observed after 40-60 minutes. The bioavailability of the substance is more than 30%, but a rich meal can reduce this figure to 27-28%. Therefore, taking medications based on it after eating food is not recommended.

Urorek is prescribed to patients with stages I-II benign prostate hyperplasia in order to slow down the growth of the tumor and get rid of signs of the disease. In the future, the patient is still indicated for surgical intervention, therefore, when taking the drug on a long-term basis, you should not forget about this.

Urorek is also indicated for those who have already undergone surgery. In this case, the medicine will make it possible to speed up the process of restoring the functioning of the pelvic organs and normalize the outflow of urine.

Some information articles indicate that Urorek helps get rid of inflammation of the prostate gland. But in fact, the drug does not cure prostatitis. In rare cases, it is introduced into the complex therapy of bacterial inflammation of the gland as an adjunct to eliminate acute disorders of the urinary system.

Contraindications

Urorek is not prescribed to patients with the following health problems:

Allergy to the main substance or additional components;
Acute renal/liver failure (in the first case, creatine clearance of up to 30 ml per minute is prohibited);
Serious malfunctions of the genitourinary system (in rare cases, the medicine can be taken, but under the supervision of a doctor).

Also, the drug is not suitable for women and children under 18 years of age. Elderly patients should talk to a urologist before taking medication.

Side effects

While taking medications with silodosin, patients often complain of:

Orthostatic hypotension;
Fainting;
Dizziness and pain in the back of the head;
Digestive disorders;
Tachycardia;
Retrograde release of sperm;
Lack of ejaculation;
Loss of sexual desire;

Persons who underwent cataract surgery experienced intraoperative floppy iris syndrome in 10% of cases.
Allergy sufferers during treatment with Urorek experience:

Difficulty breathing due to swelling of the nasopharyngeal mucosa;
Redness of the skin;
Hives;
Body itching;
Headache;
General malaise;
Mild nausea, sometimes vomiting.

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If you have any health problems that arise as a result of taking Urorek, you should stop taking the medicine and visit a doctor. If the patient's condition rapidly worsens, you should call an ambulance.

Urorek is prescribed only to adult patients. Daily dose – 8 mg (1 or 2 capsules) in one or two doses. For certain categories of patients it is halved. The duration of treatment is determined by the doctor based on test results.

Rules of application

The drug Urorek, instructions for use of which are always attached to the capsules, should be taken orally without chewing, with a sufficient amount of water - preferably at least one glass.
The recommended dosage of the drug is 8 mg once a day. To achieve the maximum positive effect, the time of administration should be the same. The drug Urorek has good absorption properties, so it is taken with or after meals, but no later than an hour later.

If you were able to purchase the medicine only in a lower concentration - 4 mg, then the doctor advises taking Urorek twice a day, one capsule or 2 units at a time. However, this form of release is optimal for people suffering from moderate liver and kidney diseases.

For them, the initial daily dosage is no more than 4 mg of silodosin, since the degree of accumulation of the substance in tissues is more than twice that of healthy people - 3.7 mg versus 1.7 mg. Provided there are no disturbances in the functioning of internal organs, the dose is increased to the standard one. Urorek 8 mg capsule is also taken once a day.

How long the course of treatment will be is determined only by the attending physician. Most often, its duration reaches several months, so one month of continuous use of the medicine will not help cure the prostate.

In order to determine the effectiveness of the chosen therapy, the patient must periodically undergo a series of examinations - laboratory and instrumental.

Overdose

In case of an overdose of Urorek, the following symptoms may occur:

compensatory tachycardia is a type of arrhythmia in which the frequency of contractions of the heart muscle reaches 90 or more beats per minute,
a sharp decrease in blood pressure - less than 90 mm Hg. Art. systolic, 60 mm Hg. Art. diastolic.

To eliminate the side effects of an excessive amount of silodosin, it is necessary to thoroughly rinse the stomach, take activated charcoal or a laxative, a vasoconstrictor. Symptomatic treatment is required, aimed at increasing the volume of circulating blood and stabilizing kidney function. Hemodialysis is pointless, given the high binding of the active substance to plasma proteins.

Pharmacological effects

The drug is a highly selective competitive antagonist of alpha1-adrenergic receptors, which blocks postsynaptic alpha1-adrenergic receptors located in the neck of the bladder, smooth muscles of the prostate gland, prostatic part of the urethra, and also reduces the tone of smooth muscles, promoting better urine outflow. Thus, the symptoms of irritation and obstruction caused by benign hyperplasia are reduced.

According to the instructions, Urorek has high selectivity. Silodosin has no effect on blood pressure.

general characteristics

The drug Urorek is one of the leading representatives of the clinical-pharmacological group of alpha-adrenergic receptor antagonist drugs. Their stimulation helps reduce muscle tone in the prostatic urethra, bladder neck and prostate gland.

As a result, the severity of irritation and obstruction caused by hyperplasia decreases, and the outflow of urine is significantly facilitated. The positive effect of taking the drug is provided by the active substance silodosin. Side effects are unlikely, which is why Urorek is in great demand among older people.

The main manufacturer of the drug is an Irish company. It is impossible to find tablets, syrups or injection solutions of the same name in pharmacies. The drug Urorek is available only in the form of hard capsules. The shell has a yellow tint and is made from edible gelatin. Inside there is a white fine crystalline powder. Depending on the concentration of the active substance, Urorek 8 mg or 4 mg is available to choose from. Auxiliary elements:

Magnesium stearate - acts as a stabilizer,
titanium dioxide - provides a perfectly white powder color,
sodium lauryl sulfate - helps maintain the shape of the shell,
starch is responsible for the strength of capsules.

Silodosin has a cumulative effect, which is due to its high affinity for plasma proteins - about 90%, so the substance circulates in the bloodstream for a long time.

Note! The content of silodosin in tissues increases slowly, which means that immediate improvement in well-being is impossible.

But after completing the course, a long-lasting therapeutic effect of the medication is always observed (up to 1 year).

The drug is excreted primarily through the intestines and kidneys. Partial removal takes a lot of time - about 15 hours.

special instructions

When treated with silodosin, a decrease in blood pressure and orthostatic hypotension may be observed. At the first signs of orthostatic hypotension (dizziness, weakness), the patient should sit or lie down and remain in this position until the symptoms disappear.

Patients with suspected benign prostatic hyperplasia need to be examined to exclude prostate tumors before prescribing the drug.

Treatment with the drug leads to a decrease in the amount of seminal fluid released, which can affect male fertility. This effect disappears after stopping its use.

Patients who are taking or have taken alpha1-blockers may experience floppy iris syndrome during cataract surgery, which can lead to complications during surgery. It is necessary to discontinue treatment with alpha1-blockers 1-2 weeks before such surgery. Patients scheduled for cataract surgery are not recommended to begin drug treatment.

There have been no studies of the effect on the ability to drive vehicles and equipment requiring increased attention. However, patients should be informed about the possibility of symptoms associated with orthostatic hypotension (for example, dizziness), and should also refrain from driving vehicles and equipment until individual tolerance to the drug is determined.

The dosage form should not be used before surgical treatment of cataracts due to the risk of developing iris flaccidity syndrome. Dizziness and decreased blood pressure with a sudden change in body position are extremely rare.

The drug Urorek: terms of sale, special instructions and complex therapy

When purchasing a medicine, you should carefully read the expiration date of the medicine and storage conditions.
Under no circumstances should you use expired medications, as this can be harmful to your health. Urorek is a prescription drug, so before purchasing, you must obtain the appropriate medical form from your doctor.

The medicine must be placed in a dry place, protected from light. Children should not have access to the medication. The drug Urorek can be used for 2 years from the date of production. Despite the fact that silodosin is a highly selective drug, it, like other alpha-blockers, can reduce blood pressure, leading to orthostatic hypotension.

If the patient exhibits signs of this pathology, then it is necessary to inform the attending physician. The drug Urorek can negatively affect fertility, as it to some extent reduces the amount of seminal fluid released.

Since the symptoms of prostate adenoma can be similar to a malignant tumor in the gland, before treatment with Urorek it is necessary to exclude oncology by undergoing appropriate tests. Patients undergoing cataract surgery should stop taking Urorec two weeks before the procedure. Considering that side effects from treatment with Urorek can take the form of dizziness, you should be careful when driving.

Urorek in complex therapy

According to urologists, the drug Urorek combines well with Avodart. The last medication is a 5a-reductase inhibitor. Experts say that monotherapy with Urorek or other alpha-blockers does not make sense, since medications in this group only eliminate the acute symptoms of BPH, but do not solve the main problem - an increase in the size of the gland.

In order to effectively treat adenoma, you should take medications from two groups at the same time. 5a-reductase inhibitors reduce the level of dihydrotestosterone in the blood, as a result of which pathological cell division stops and the tumor gradually disappears. Taking medications together will allow a man to quickly and effectively get rid of the symptoms of adenoma, as well as defeat the disease itself. Other 5-alpha reductase inhibitors include Finasteride Teva, Penester, and Proscar.

Side effects

Most often, Urorek, according to reviews, causes retrograde ejaculation and anejaculation (disorders of the reproductive system).

In addition, according to reviews, Urorek can lead to:

Syncope;
Dry mouth;
Erectile dysfunction;
Dizziness;
Nausea;
Nasal congestion;
Orthostatic hypotension;
Decreased libido;
Diarrhea.

If, while taking Urorek, a decrease in blood pressure or the development of orthostatic hypotension in the form of weakness and dizziness is observed, you should sit or lie down.

During operations for cataracts, Urorek, according to reviews, can lead to the development of intraoperative “flabby” iris syndrome. To avoid causing such complications, you should stop taking the medication one to two weeks before the operation.

Side effects

According to many clinical trials, medical products such as Urorek are relatively well tolerated. If the patient is diagnosed with only a diseased prostate that causes discomfort during urination and sexual intercourse, then the likelihood of complications after taking the medicine is minimized. Rare but possible side effects of the drug:

intestinal upset, feeling of nausea, vomiting, dry mouth,
nasal congestion without other signs of a runny nose,
episodic dizziness, up to loss of consciousness,
hypotension when changing body position - from horizontal to vertical,
deterioration of erection, decreased libido, problems with ejaculation - complete absence of ejaculation or reverse request for sperm.

Any of the named side effects of the drug disappears after discontinuation of the drug Urorek, very rarely requires specific treatment

Studies regarding the effect of the drug on the ability to concentrate have not been conducted, therefore Urorek or its direct analogues are not recommended for use before driving vehicles or performing hazardous work

special instructions

Alpha blocker antagonists, such as silodosin, often cause pupillary dilation.
This fact must be taken into account if the patient is preparing for ophthalmic surgery, since the development of flaccid pupil syndrome is inevitable. It is necessary to stop using the drug Urorek several days before the planned surgery.

The compatibility of the active substance with other groups of drugs is quite high. Complex therapy may include antispasmodics, antiseptics, anti-inflammatory, antibacterial agents, as well as representatives of 5-alpha reductase inhibitors, which help reduce tumor tissue.

The simultaneous use of this medication with other types of alpha-blockers is strictly prohibited.

If, after starting treatment with Urorek, the prostate hurts and bothers you more than before, you should immediately stop the prescribed therapy and consult your doctor. After additional diagnostics, the doctor may prescribe other medications with a similar mechanism of action.

Alcohol compatibility

Like any other medications that help lower blood pressure, Urorek and alcohol are absolutely incompatible. Ethanol significantly increases the inhibitory effect on the central nervous system, which is fraught with dangerous consequences. Neglecting this recommendation also increases the risk of side effects.

Urorek: instructions for use, price, reviews and analogues

The following drugs are analogues of Urorek according to their mode of action:

Tablets – Alfuzosin, Tamsulosin retard, Dalfaz retard, Dalfaz SR, Omnic Okas;
Capsules – Hyperprost, Tamsulosin, Omnic, Omsulosin, Proflosin, Tamsulon-FS, Taniz-K, Sonizin, Revokarin, Tamsulosin, Focusin, Tamzelin, Tulosin.

Analogues of Urorek containing the same active substance are not produced.

Analogs are prescribed for treatment:

Avodart;
Adenostop;
Akineton;
Alfinal;
Alfuzosin;
Afala;
Afalase;
Vesilute;
Vitaprost;
Vitaprost forte;
Gentos;
Glansin;
Dalfaz;
Dalfaz retard;
Depostat;
Zerlon;
Indigal;
Ipertrofan 40;
Cornam;
Longidaza;
Methovit;
Nitroxoline;
Omnic;
Omnic Okas;
Omsulosin;
Penester;
Peponen;
Permixon;
Polpressin;
Populus compositum SR;
Proscar;
Prostavern Urtica;
Prostagute;
Prostagut forte;
Prostalamin;
Prostamol Uno;
Prostaplant;
Prosteride;
Prostopin;
Raveron;
Serpens;
Setegis;
Cialis;
Sinestrol;
Sonizin;
Sonirid Duo;
Tadenan;
Tamsulosin;
Tamsulon;
Terazosin;
Trianol;
Tulosin;
Urorek;
Finasteride;
Finast;
Focusin;
Haytrin;
Cernilton;
Cernilton forte.

When choosing between Urorek and Omnic, you should remember that the second of them is based on tamsulosin, which has been proven over the years, no less effective than silodosin. In general, the pharmacodynamics of both drugs are virtually the same, but Urorek more often causes side effects that are characteristic of all adrenergic blockers.

In addition, Omnic involves fewer contraindications and restrictions, so we can conclude that it is a more preferable choice. This statement is all the more true considering the presence on the market of Omnica Ocas, an advanced version with controlled release of tamsulosin.

Drug interactions

The simultaneous use of Urorek and other alpha-blockers is prohibited due to the mutual enhancement of pharmacological action.

It is not recommended to use the medicine during treatment with antihypertensive drugs, including beta-blockers, calcium antagonists and diuretics, as they increase orthostatic hypotension.

Due to the risk of dizziness, Urorek is not prescribed simultaneously with PDE5 inhibitors, in particular tadalafil and sildenafil.

Urorek: instructions for use, price, reviews and analogues

In the pharmacy chain, Urorek capsules are available with a doctor's prescription. The shelf life of the capsules is 2 years. They should be stored in undamaged original packaging, in a dark, dry place, out of reach of children, at an air temperature not exceeding 30° C.

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The average price of a pack of Urorek capsules in Moscow pharmacies depends on their quantity and dosage:

4 mg, 25 capsules – 699 – 717 rubles.
8 mg, 30 capsules – 698 – 730 rubles.

Urorek's analogs

The drug Urorek successfully passed all clinical trials and quickly gained recognition among patients and doctors in the field of urology. It has several important features that qualitatively distinguish it from similar drugs. This drug is well tolerated and suitable for continuous treatment for a long time.

There are no analogues to Urorek in terms of active ingredient. If there are reasons prohibiting the use of this medicine, similar drugs can be found in its pharmacological group. Such means include:

Sonizin;
Hypersimple;
Revocarin;
Omnic;
Dalfaz retrad.

In some cases, Urorek analogs are cheaper, in some their price is higher - it all depends on the specific product and its manufacturer. The urological products listed below have their own characteristics, so their use must be previously agreed with your doctor.

Purpose

The drug is used in the treatment of benign growths in the prostate gland, as a component of complex treatment. Urorek capsules are used for a long time, the duration of the course of treatment is years.

Mechanism of action

Urorek is considered a drug that selectively blocks alpha 1 receptors in the treatment of prostate adenoma. Its action blocks areas located in the smooth muscle fibers of the genitourinary tract and prostate. As a result of using the medicine:

the outflow of urine is normalized;
excessive tension in the urinary system is relieved;
The diameter of the urethra returns to normal.

One of the manifestations of the drug’s action is a reduction in urinary tract obstruction and irritation, which is caused by prostate enlargement.

An additional property of the drug is the lack of influence on blood pressure; the exact mechanism is unknown; it is assumed that this is due to its high selectivity.

The availability of the drug is 30%; taking the drug after meals, on a full stomach, prolongs the period of reaching the peak of silodosin in the blood by a third. The drug is 96% bound in the body and is excreted through the kidneys and intestines in 12-18 hours (depending on metabolism).

Compound

The main active ingredient is silodosin. Also included in the composition of the product to stabilize and enhance the effect:

prepared starch;
sodium lauryl sulfate;
mannitol;
magnesium stearate;

Urorek is a powder in the form of small crystals, packed in hard gelatin capsules with added dyes weighing 4 and 8 grams, sealed in blisters.

The manufacturer is the joint Italian-Irish company Recordati Industry Chimica.

Application

The drug is for men; for therapy, a dosage of 8 mg is used once every 24 hours. The dosage is prescribed exclusively by a doctor and may be reduced. The capsule is not divided - it must be drunk whole with water. For better control over treatment, it is necessary to take the drug at the same time.

The dosage is not adjusted depending on the weight and age of the patients, it is adjusted taking into account the severity of kidney damage.

Urorek is not prescribed if:

the patient is a minor (under 18 years of age);
he has a severe form of liver failure (due to the lack of clinical data on the reactions exhibited by the body in such pathologies);
there are allergies to components;
the patient has renal failure (in case of moderate severity, the doctor may temporarily reduce the dosage, usually a test dose is prescribed - 4 mg per week; if the condition is satisfactory and the effect of treatment is doubled, the indicator for monitoring the condition is creatinine clearance).

Side effects

Urorek, as the instructions for use indicate, has some side effects that are associated with the mechanism of its action on the body. First of all, the symptoms of sexual impotence:

erectile dysfunction;
decreased sex drive;
lack of ejaculation.

For patients with prostate adenoma, these body functions are not vital (the average age of such patients is quite high, over 50 years); after discontinuation of the drug, the functions are restored.

The second group of symptoms develops according to the pattern of an allergic reaction:

there is a feeling of stuffy nose;
dry mouth;
intestinal upset appears;
the patient complains of nausea.

The third group is associated with the drug’s ability to lower blood pressure, causing dizziness, nausea and weakness, and rapid heartbeat.

Any of these symptoms that occur while taking urorek is a reason to consult a doctor. Only the doctor, based on the severity of the symptoms, can cancel or reduce the dosage of the drug. Clinical data on overdose come from studies using a dose of the drug equal to 48 mg.

First aid to the patient is as follows:

the patient is put to bed;
wash the stomach;
provide sorbents.

The patient should remain in bed until he feels better. If the patient is prone to hypertension, then during treatment he should not drive vehicles or engage in work that requires increased attention.

If cataract surgery is necessary, the drug should be discontinued at least 15 days before lens replacement surgery.

Urorek cannot be combined with drugs from the group of adrenergic blockers - when 2 drugs with a similar effect are prescribed simultaneously, their effect is enhanced.

Drugs that speed up the action of Urorek include:

The targeted action of the drugs increases the level of silodosin in the blood.
The simultaneous use of Urorek and Sildenafil provokes dizziness.

It is inappropriate to take Urorek together with diuretics, as well as medications that tend to lower blood pressure.

Side effects

During the period of use of the drug Urorek, patients may experience the following undesirable manifestations:

Allergic reactions: swelling of the mucous membranes; nasal congestion, rhinitis, dermatitis.
From the nervous system, dizziness, a feeling of fatigue, decreased blood pressure, loss of consciousness, fainting, and decreased attention may occur.
Decreased appetite, severe dry mouth, mild nausea, diarrhea, constipation.
On the part of the reproductive system, there may be a sharp decrease in sexual desire and lack of ejaculation.

If dizziness occurs, the patient is recommended to take a horizontal position or sit to improve blood circulation in the brain.

When planning surgical intervention for ophthalmological reasons, in particular cataracts, the use of Urorek is stopped 7-14 days in advance due to the undesirable possible effect of a “flabby” iris during surgery.

While taking silodosin, the patient may experience a slow reaction and inhibition of actions, therefore, during treatment, it is recommended to refrain from performing high-risk work that requires increased concentration.

No studies have been conducted on the effects of silodosin on driving. Due to the risk of a sharp deterioration in well-being, patients are advised not to drive a vehicle while taking Urorek until tolerance to this drug is determined.

Side effects often include a decrease in the volume of seminal fluid, a cessation of its eruption, and a lack of libido.

Taking an increased dose of medication can cause a decrease in blood pressure, tachycardia, dizziness, and nausea. If symptoms of overdose occur, gastric lavage is performed and sorbents are taken to help remove the drug from the body. Treatment aimed at eliminating symptoms is indicated: laxatives and vasoconstrictor medications are prescribed.

Most often, the drug is well tolerated, as evidenced by numerous positive reviews from patients. If any undesirable symptoms appear, the patient should immediately seek medical advice.

Contraindications

for adults

Urorek is used to treat benign prostatic hyperplasia.

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for children

Urorek is not used in pediatrics.

Urorek is not intended for women.

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The drug is contraindicated in patients who have the following pathologies:

severe renal failure, in which the glomerular filtration rate is 30 ml per minute;
severe liver failure;
individual intolerance to the composition of the capsules.

The drug should be used with caution in mild to moderate renal failure, in which the glomerular filtration rate varies from 30 to 50 ml per minute.

Urorek in Moscow and other cities of the Russian Federation is used to reduce the volume of the prostate gland in cases of benign hyperplasia.

This medicine practically does not interact with other medications and has a small number of adverse reactions. The only contraindication for its use is individual intolerance.

Urorek price

Name of the medicine, release form, pack size	Internet price, rubles	Pharmacy cost, rubles
Urorek 8 mg 30 capsules	770	790
Urorek 4 mg capsules 30 pcs.	790	815
Omnic 400 mg 10 tablets	546	575
Profloxin 400 mg 10 capsules	1010	1050

pharmachologic effect

There are α1A adrenergic receptors in the prostate gland. Normally, they change the volume of the prostate depending on physiological needs, for example, during sexual intercourse. With benign hyperplasia (adenoma), the size of the organ increases and makes urination difficult. Silodosin blocks α1A-adrenergic receptors, which causes a decrease in prostate volume and restoration of normal urination.

At the same time, the drug has virtually no effect on α-adrenergic receptors in the vessels, due to which it rarely affects blood pressure numbers. After oral administration, silodosin is absorbed fairly quickly from the gastrointestinal tract. The substance acts throughout the day, which allows you to take it once a day.

Medicine for the treatment of prostate adenoma.

Analogs

You can replace Urorek with the following medications:

Omnic is a substitute for the drug Urorek in the therapeutic group. The medicine is produced in capsules with a slow release of the active substance. Omnic is used to treat dysuric disorders caused by benign prostatic hyperplasia. The drug is contraindicated in cases of hypersensitivity to its composition, severe liver failure, orthostatic hypotension, including a history of it. Omnic is designed specifically for men and is not used in women or children.
Alfirum contains alfuzosin hydrochloride as an active component. The drug is sold in the form of tablets, which are used to eliminate the symptoms of benign prostatic hyperplasia. Alfirum is not used in women and children.
Cornam is an α1-blocker. The drug is available in tablets that contain terazosin as the active ingredient. The drug is used for prostate adenoma and high blood pressure. Kornam is contraindicated for persons under 18 years of age, pregnant women and breastfeeding women.
Focusin contains tamsulosin as an active component. The drug is used to eliminate signs of benign prostatic hyperplasia.
Duodard is a combination drug intended for the treatment of prostate adenoma. The medicine is produced in capsules with a modified release of active substances. Duodard is contraindicated for minors and women.
Artesin is a Russian drug, the therapeutic effect of which is explained by doxazosin. The drug is produced in tablets used for arterial hypertension and benign prostatic hyperplasia. Artesin is contraindicated for persons under 18 years of age. In cases where the benefit to the mother outweighs the risk to the fetus, an α1-blocker can be used to treat pregnant women. It is recommended not to breastfeed while taking Artezin.
Cardura is a medicine manufactured in the USA. It is available in tablets that can be used in patients over 18 years of age with high blood pressure and BPH. Cardura can be prescribed to pregnant and breastfeeding patients if the benefit to them outweighs the potential harm to the baby.
Setegis is a Hungarian medicine containing terazosin as an active substance. Indications for its use are arterial hypertension and prostate adenoma. The drug is commercially available in tablets, which are contraindicated for children and nursing patients. According to strict indications, Setegis can be taken by pregnant women.

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All of the listed drugs are sold strictly on a prescription form, so before replacing Urorek with an analogue, you should consult a specialist.

The following drugs are analogues of Urorek according to their mode of action:

Tablets – Alfuzosin, Tamsulosin retard, Dalfaz retard, Dalfaz SR, Omnic Okas;
Capsules – Hyperprost, Tamsulosin, Omnic, Omsulosin, Proflosin, Tamsulon-FS, Taniz-K, Sonizin, Revokarin, Tamsulosin, Focusin, Tamzelin, Tulosin.

Analogues of Urorek containing the same active substance are not produced.

The drug has substitutes. Analogues of Urorek are represented by the following medications:

Proflosin;
Focusin;
Sonizin;
Omnic.

Proflosin is a medical product prescribed for prostate pathology. Belongs to the group of alpha-blockers. The active component of the drug undergoes metabolism in the liver. Focusin can be purchased in tablet form. The medicine can lower blood pressure. Side effects include weakness and dizziness. Before starting therapy, it is necessary to undergo a complete examination.

Sonizin is a medical drug that can only be purchased with a doctor's prescription. The active component selectively blocks adrenergic receptors and reduces smooth muscle tone. Thanks to the action of the medicine, the functioning of the genitourinary system is restored. Omnic Radar is quite often prescribed in the treatment of prostate adenoma.

The price of Urorek is 700 rubles. The drug has a large number of patient reviews.