Pharmacodynamics and pharmacokinetics
The drug has an antispasmodic effect aimed at the smooth muscles of the gastrointestinal tract, gall bladder, and genitourinary organs. In addition, the secretion of food glands is reduced . In this case, the anticholinergic effect on the nervous system is not manifested.
Thanks to the presence of an additional substance - paracetamol , Buscopan Plus, in addition to its antispasmodic effect, eliminates the cause of pain, providing a muscle-relaxing effect exactly at the site of pain.
The active component, hyoscine butyl bromide, is characterized by insignificant absorption in the gastrointestinal tract. Once inside the body, it is absorbed by 8%, with an average absolute bioavailability of up to 1%. A single use of hyoscine butyl bromide at a dosage of 20-400 mg leads to maximum plasma concentrations after 2 hours.
The active component is predominantly distributed in the muscle cells of the abdominal cavity and pelvis. The interaction of the drug with the movement of choline in the epithelial cells of the human placenta was also noted. The bulk of metabolism is due to hydrolysis of the ester bond. The drug is excreted through urine and feces.
Contraindications
Buscopan is contraindicated in the following diseases and conditions:
- Asthenic bulbar palsy - an autoimmune disease associated with increased fatigue and muscle weakness,
- Congenital enlargement of the human colon,
- Pulmonary edema.
- Atherosclerosis of the brain,
- Hypersensitivity to hyoscine butyl bromide or any other component of the drug,
- In a state of pregnancy,
- During lactation,
- In children under 6 years of age.
Buscopan tablets should not be taken with alcohol.
For chronic constipation, it is not advisable to use Buscopan suppositories, since the active substance of the drug reduces the activity of digestive enzymes and reduces the contractile dynamics of the intestine.
Indications for use of Buscopan
- spasm of the genitourinary and gastrointestinal tract , for example, with renal colic, pyloric spasms, cholecystitis and intestinal colic;
- exacerbation of gastric ulcer and duodenal ulcer;
- dyskinesia of the bile ducts and gallbladder;
- algodismenorrhea and so on.
In addition, indications for the use of Buscopan suppositories for patients before labor were noted.
What is Buscopan
Buscopan contains hyoscine butyl bromide. This active substance has an antispasmodic effect, relieving pain. The release form is varied. There are Buscopan suppositories, Buscopan tablets, and injection ampoules for intramuscular administration. INN – international nonproprietary name – Hyoscine butylbromide. It may be called Buscapina or Buscapina Plus - depending on the country of origin.
Compound
The drug Buscopan, in addition to the main active ingredient, contains auxiliary ones. By themselves, they are harmless and neutral, but occasionally they can cause allergies if there is a specific reaction to one of them. If intolerance to side substances is observed, suppositories with Buscopan or the drug in the form of injections are used. For example, for the tablet form, the “helpers” are calcium hydrogen phosphate plus silicon dioxide. May include:
- corn starch;
- stearic acid;
- wine acid;
- potato starch.
Indications for use
You can take Buscopan for various reasons. It has a pronounced antispasmodic effect, weakens the functioning of smooth muscles in the human body. The drug changes (reduces) the level of secreted digestive compounds and secretions. The medicine is used for pain syndromes of various origins, and in addition, for some other cases and conditions. The indications specified in the instructions include:
- intestinal colic;
- peptic ulcer at the acute stage - stomach, duodenum;
- cholecystitis and spastic pain in other diseases;
- biliary dyskinesia, pain syndrome of the gallbladder and bile ducts;
- painful menstruation – algodismenorrhea;
- pylorospasm;
- cystitis;
- renal colic.
The drug is prescribed as part of complex therapy for such diseases. It must be borne in mind that Buscopan and its analogues are not a replacement for other prescribed drugs - antibiotics, sulfonamides, acidity regulators and enzymes. It only helps fight the disease, and does not completely destroy its manifestations. For acute abdominal pain of unknown origin, use is not recommended, since the symptoms of appendicitis can be eliminated, which can lead to a serious condition, including peritonitis.
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Contraindications
Buscopan is not a prescription drug. This means that a prescription is not required to purchase it. However, you need to read the instructions and follow the rules of administration in order to keep in mind the existing contraindications. The drug is not prescribed to a child under 6 years of age who has an allergic reaction to the components. Conditions under which Buscopan is prohibited include:
- megacolon (colon malformation);
- myasthenia gravis;
- glaucoma;
- pulmonary edema.
Contraindications apply to tablets. Candles with Buscopan have their limitations in use. These include children under 6 years of age, alcohol intake, chronic constipation, since the components of the drug reduce the activity of digestive enzymes. It is prohibited to use the medicine for prostate adenoma, megacolon, intestinal obstruction of the mechanical subtype, and for cerebral atherosclerosis. Use the drug with caution during pregnancy.
Contraindications for use
It is not recommended to take tablets:
- patients under 6 years of age;
- if you have hypersensitivity to Buscopan and its components;
- for myasthenia gravis , megacolony , angle-closure glaucoma and pulmonary edema .
Additional contraindications for suppositories are:
- prostate adenoma;
- abnormalities in cardiac activity and cerebral vessels.
Directions for use and dosage of Buscopan
Buscopan tablets are intended for oral administration.
The dosage of tablets for children over 6 years of age and adults is 10-20 mg 3-5 times a day.
The tablets should be taken with water.
Buscopan suppositories are intended for rectal administration.
Dosage of suppositories for children over 6 years of age and adults – 1-2 suppositories 3 times a day.
The suppositories are removed from the shell and inserted into the rectum with the pointed end.
The duration of treatment and dosage of Buscopan for children under 6 years of age is determined by the doctor.
Side effects
Taking Buscopan may be accompanied by unwanted effects caused by the anticholinergic properties of the drug. Therefore, they are usually mild in severity and pass quickly without additional intervention.
Patients are especially often concerned about:
- skin peeling , urticaria , itching , irritation;
- dry mouth;
- difficulty breathing;
- tachycardia , arrhythmia;
- problems with urination and so on.
Overdose
Cases of overdose with Buscopan have not been established, but the occurrence of the symptoms described in the list of side effects should not be excluded.
In such situations, the following treatment procedures are recommended:
- gastric lavage;
- taking activated carbon or other means of similar action;
- use of cholinomimetics intravenously or intramuscularly.
All other complications require symptomatic therapy.
Interaction
The simultaneous use of Buscopan and tricyclic antidepressants, Hindin, antihistamines, amantadine and disopyramide may enhance the anticholinergic effect.
Combined use with dopamine antagonists , for example, metoclopramide , weakens the effect of each drug on the gastrointestinal tract.
Complex treatment with Buscopan and beta-adrenergic drugs often increases tachycardia .
special instructions
Treatment with Buscopan requires special instructions. For example, you need to stop using the drug gradually, since rapid withdrawal can cause nausea , sweating and dizziness .
It is also recommended to refrain from overheating when performing physical activity, in the heat, in the bath and sauna. If dry mouth does not disappear for more than 2 weeks, then the risk of developing damage to tooth enamel, gums, and fungal infections . When treating with Buscopan, you should be careful when driving vehicles and other activities that require high attention.
Analogues of Buscopan
Level 4 ATX code matches:
In pharmacology there are no analogues of this drug for the active substance.
The list of analogues by pharmacological group includes: Atrovent, Atropine, Gastrocepin, Gastrozem, Driptan, belladonna extract, Midriacil, Novitropan, Spazmex, Trigan and others. Moreover, the price of analogues may vary depending on the manufacturer, the active substance and the number of doses in the package. To change treatment, you must consult a doctor.
Composition and release form
Buscopan is available in the form of tablets and rectal suppositories (suppositories).
The active substance is hyoscine butyl bromide.
According to Buscopan's instructions, 1 tablet contains 10 mg of the active substance and auxiliary components (dibasic calcium phosphate, corn starch, soluble starch, colloidal silicon dioxide, stearic acid, tartaric acid).
1 suppository of Buscopan contains 10 mg of active substance, water, and W45 solid fat.
Reviews of Buscopan
Discussions of this drug are found on various thematic forums dedicated to pregnancy . As reviews of Buscopan show, suppositories are often prescribed before childbirth, which help prepare the cervix for labor. Most patients, leaving reviews of Buscopan suppositories during pregnancy, note that its effectiveness is not always evident. Some users know that suppositories are prescribed during childbirth, and are interested in what the pills help with. There are also reports that the use of medicine in the treatment of pain and colic can quickly eliminate the problem.
Buscopan instructions
It is important for those who plan to take Buscopan to know that the instructions for use include several main points. Application depends on the form and type of disease. There will be no particular problems when using the medicine. Side effects of the medicine will be less pronounced or completely absent if you take tablets, suppositories or injections in strict accordance with the drug manufacturer’s instructions in the instructions.
Pills
Russian pharmacies often offer the drug Buscopan in this form. When taking the medicine, it is necessary to remember that the peculiarity of the substance that has become the basis for pain relief is its localized effect. Only areas of the body subject to spasm are affected, without penetration into the cell membranes of structures not involved in a spastic attack.
The drug in the form of tablets is prescribed in complex therapy or used during the acute pain phase to relieve the syndrome and quickly eliminate the attack. The purpose depends on the age of the patient. Children are prescribed one tablet twice a day. For adults, the dose of Buscopan is increased to one or two tablets three times a day. It is not recommended to take the product on an empty stomach.
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Candles
Buscopan suppositories are white or cream-colored rectal suppositories with a characteristic odor. For some types of pain, a prescription will help cope with the manifestations of the disease more effectively. For example, the effect is more pronounced for renal and gynecological problems. The most noticeable result in complex therapy of the disease is achieved by using one suppository three times a day. For algodismenorrhea and other situational pain, a single use without repetition is possible after the manifestations of the syndrome have gone away.
Buscopan price, where to buy
On average, the price of Buscopan in Moscow pharmacies can vary from 275 to 369 rubles. At the same time, the price of Buscopan candles is higher.
In Ukrainian pharmacies, tablets or suppositories can be purchased for 225-263 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Buscopan rectal suppositories 10 mg 10 pcs. Boehringer/Instituto de Angeli Srl
- Buscopan tablets p.p.o. 10 mg 20 pcs Delpharm Reims
Pharmacy Dialogue
- Buscopan suppositories 10 mg No. 10 Boehringer Ingelheim
- Buscopan tablets 10 mg No. 20Boehringer Ingelheim
Europharm* 4% discount using promo code medside11
- Buscopan suppositories 10 mg 10 pcsInstitut de Angeli S.R.L.
- Buscopan tablets 10 mg n20 Delpharm Reims
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Pharmacy24
- Buscopan 10 mg No. 6 suppositories Istituto de Angeli S.r.l., Italy
- Buscopan 20 mg/ml 1 ml No. 5 solution Boehringer Ingelheim Espana, CA, Spain
- Buscopan 10 mg No. 20 tablets Delpharm Reims, France
PaniPharmacy
- Buscopan ampoule Buscopan solution d/in. 20mg amp. 1ml No. 5 Spain, Boehringer Ingelheim Espana
- Buscopan suppository Supp. buscopan 10 mg No. 10 Italy, Instituto de Angeli
- Buscopan tablets Buscopan etc. 10 mg No. 20 France, Delpharm Reims
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