Trichopolum tablets: instructions for use, composition, indications, dosage

Trichopolum is a very effective medicine that is prescribed for serious infections. This drug is not allowed to be used without a doctor's instructions, as side effects may occur if taken on its own. If the doctor has prescribed Trichopolum, then when using it you must follow the recommendations set out in the instructions.

The duration of treatment with Trichopolum, side effects, and whether the drug is compatible with alcohol are indicated in the instructions for use.

Composition and produced forms

Trichopolum is available in tablet form for oral and vaginal use. The latter is incorrectly called candles. Additionally, it is produced in the form of a solution for intravenous infusion. Detailed composition of the drug:

Tablets for oral administration consist of metronidazole and auxiliary components: magnesium stearate, molasses, starch, gelatin.
Vaginal tablets contain the active substance metronidazole and auxiliary substances: silicon dioxide, cellulose, crospovidone, povidone, stearic acid.
The solution for parenteral administration contains metronidazole and additional substances: sodium chloride, citric acid monohydrate, sodium hydrogen phosphate and water.

pharmachologic effect

The effect of Trichopolum is due to the biochemical reduction of the nitro group. The latter is integrated into the DNA of cells of living beings and inhibits the formation of nucleic acids. This process causes the death of microbes.

The medicine helps in the treatment of diseases caused by:

trichomonas;
fusobacteria;
Giardia;
amoebas;
bacteroids.

The maximum concentration of the drug in the patient's body occurs 1.5-3 hours after oral administration.
The dosage of the drug affects the rate at which metronidazole appears in the systemic circulation.
Trichopolum is not needed for viral diseases, pathologies caused by facultative anaerobes and fungi.
The medicine penetrates the placenta and blood-brain barrier.
The drug is determined in saliva, bile, cerebrospinal fluid and other tissues of the patient.
Metronidazole is characterized by uniform distribution in the body.
Metabolism takes place in the liver.
The half-life of Trichopolum is from 6 to 8 hours. This time may be increased if liver function is impaired.

Drug therapy may lead to changes in the color of urine, which is explained by the excretion of the drug through the kidneys.

For what diseases should metrodinazole be used?

The active substance Trichopolum metrodinazole easily penetrates the hematoplacental barrier and can affect the development of the fetus, so it should not be used in the first trimester. In the second and third trimesters, the possibility and effectiveness of using Trichopolum is assessed by the attending physician. During breastfeeding, metrodinazole is excreted in mother's milk, so lactation will have to be stopped during treatment with this medicine.

Trichopolum is approved as a drug to help cope with:

Regarding thrush, Trichopolum is effective only in the treatment of the chronic form of this disease, due to the fact that this form is accompanied by infections. In cases of acute thrush, the drug is not effective. You should not treat gonorrhea with Tripohol without the supervision and advice of a doctor, otherwise you risk getting a chronic form of this pathology.

Is it an antibiotic

Yes, this is a medicine from the group of antibacterial drugs. Trichopolum has antiparasitic and antimicrobial effects, the active substance is metronidazole. After ingestion by microorganisms, Trichopolum changes its chemical structure and, interacting with the DNA of bacteria or protozoa, disrupts its formation.
Inhibition of DNA duplication leads to cell death. Protozoa, obligate anaerobes, some gram-positive and gram-negative microorganisms (giardia, clostridia, balantidia, gardnerella, trichomonas, fusobacteria, peptococci, bacteroides and others) are sensitive to Trichopolum.

Indications: what does Trichopolum treat?

Indications for use of the tablet form are:

giardiasis, amoebiasis;
infections caused by helicobacter;
stomach ulcer;
cystitis (complex treatment);
leishmaniasis, balantidiasis;
trichomonas colpitis in women and urethritis in men;
bacterial damage to joints and heart;
pulmonary pneumonia;
Endometritis, ovarian abscess.

In gynecology, Trichopolum is widely used for the following conditions:

bacterial vaginosis;
nonspecific vaginitis;
Trichomonas vaginitis;
Together with Nystatin it helps against thrush.

Indications for intravenous administration of Trichopolum are:

giardiasis;
chronic complicated trichomoniasis;
meningitis;
endometritis;
skin infections;
peritonitis, abscess of the brain, abdominal cavity and liver, lung, ovaries and fallopian tubes;
pneumonia, empyema of the pleura of the lungs.

The medicine is used to prevent complications in the postoperative period. Together with bismuth and Amoxicillin, it is prescribed for the treatment of peptic ulcers.

Contraindications

The drug is not prescribed for the following diseases and conditions:

Blood diseases;
Severe central nervous system disorders;
Liver lesions;
Individual drug intolerance;
Pregnancy, since the drug penetrates the placental barrier;
Lactation. Metronidazole can accumulate in breast milk. Therefore, during treatment with Trichopolum, a woman should stop breastfeeding.

The drug is not recommended for children under 3 years of age.

With insufficient liver function, the content of metronidazole in the blood plasma increases significantly. Trichopolum is prescribed with extreme caution in cases of renal dysfunction. Stop taking the medicine if dizziness or gastrointestinal disorders occur.

Contraindications to the use of the drug

The doctor’s choice of the form of release of the drug to prescribe to the patient depends on the disease.

Contraindications for use are:

pregnancy (up to 12 weeks);
lactation;
impaired coordination of movements;
blood diseases;
allergy to the drug and its components;
diseases of the central nervous system caused by organic changes (including tumors and epilepsy);
chronic liver failure;
chronic renal failure;
drinking alcohol.

How to take Trichopolum

Trichopolum tablets are taken orally before meals or after meals, without chewing. The dose determination is influenced by the patient’s age and the disease itself:

Treatment of trichomoniasis involves prescribing children over 10 years of age and adults 1 tablet 3 times a day. Or take 4 tablets per week, divided into 2 doses. If necessary, treatment is repeated after 1 month;
The same dose is used in the treatment of bacterial vaginosis. It is permissible to increase the dosage to 8 tablets during the day;
For amebiasis, Trichopolum is used in the following dosage: 3 tablets 3 times a day for adults and adolescents over 10 years of age. For children under 10 years of age, smaller doses are indicated. Duration of therapy – 5 days;
For amoebic liver damage and other forms of non-intestinal amebiasis, as a rule, a dose reduced by 2 times is used - 1.5 tablets 3 times a day. Treatment is carried out for 5 days. The same amount of Trichopolum is prescribed for cyst carriers in the absence of clinical manifestations. But the duration of treatment can reach 10 days;
For periodontitis and other dental infections, adults and adolescents over 10 years of age take 1 tablet containing 250 mg of metronidazole 3 times a day. The course of treatment is 3-7 days.

Features of the use of Trichopolum

Except for pregnant women (in the early stages) and lactating women, taking Trichopolum is not allowed for leukopenia, epilepsy and individual intolerance to the components of the drug. Metrodinazole is also contraindicated in young children under three years of age. Teenagers are not recommended to use Trichopolum in combination with antibiotics. In case of kidney and liver dysfunction, dose adjustment is required. If the patient has porphyrin disease, the use of the drug Trichopolum can lead to complications and is not recommended.

If you are a car enthusiast, then during Trichopolum therapy you will have to give up driving and activities that require reaction speed. Drug interactions with other drugs have their own characteristics. Trichopolum tends to enhance the effect of anticoagulants (blood thinners) of the coumarin series (for example, warfarin). Combined use with Cimetidine leads to a high concentration of metrodinazole in the blood and provokes side effects. Before starting self-treatment with Trichopolum, consult your doctor.

ask-med.ru

Side effects

If you adhere to the dosage prescribed by the doctor, the medicine is well tolerated by patients. Some people may experience the following side effects:

From the urinary organs - pain when urinating, inflammatory reaction of the bladder, increased urine production. Sometimes the night volume of urine prevails over the daytime volume, its color changes;
Allergies – itching, urticaria, redness of the skin, dermatitis, nasal congestion and discharge, fever;
Myalgia and arthralgia;
From the gastrointestinal tract - loss of appetite, metallic taste in the mouth, nausea, vomiting, flatulence, diarrhea. There may be an increase in the activity of liver transminases, reactive pancreatitis;
From the side of the central nervous system - dizziness, headache, impaired consciousness, excitability, drowsiness, lack of coordination, convulsions. Hallucinations are sometimes possible;
In the hematopoietic system - a decrease in the number of leukocytes, neutrophils, platelets, agranulocytosis.

The development of unpleasant consequences is a reason to contact a specialist. Treatment with Trichopolum should be stopped .

Overdose

There is no information about exceeding the permissible dose of vaginal tablets. Neurological symptoms, convulsive syndrome, peripheral neuropathy are signs of an overdose of Trichopolum solution and oral tablets.

When using more than 15 g of medication at one time, the following were diagnosed:

nausea,
vomit,
The patient's coordination of movements was impaired.

Treatment of overdose with Trichopolum is symptomatic.

Trichopolum release form

The drug Trichopolum is available in tablets and solution form:

According to the instructions, one tablet of Trichopolum contains 250 mg of metronidazole, available in cellular packaging in packs of 10 pieces;
One 20 ml ampoule of a transparent, yellowish-green drug contains metronidazole 500 mg, sodium hydrogen phosphate, citric acid monohydrate, sodium chloride, water for injection, available in 10 ampoules in cardboard packs;
One 100 ml bottle of Trichopolum contains 500 mg of metronidazole, available in 100 ml polyethylene bottles.

special instructions

During treatment with Trichopolum, sexual intercourse should be avoided.
It is recommended to simultaneously treat the sexual partner with the drug, even if he has no clinical manifestations of the disease.
The medicine is capable of immobilizing Treponema pallidum, which causes a false-positive result of the Treponema pallidum immobilization test (TPIRT).
If there is a history of changes in the composition of the blood, as well as when using Trichopolum in large doses or with prolonged therapy, you need to monitor a general blood test.

Pregnancy and lactation

Trichopolum is not prescribed during pregnancy, and especially in the 1st trimester. Later, the drug is used if the expected benefit to the woman is higher than the possible harm to the fetus.
Is it possible to drink Trichopolum while breastfeeding? During lactation, the medicine is contraindicated, since the active substance is passed through breast milk. It is permissible to continue feeding only 2 days after the last dose of Trichopolum.

Trichopolum and alcohol

Any drug that has antibacterial properties negatively affects liver function due to its severe toxicity. For this reason, it is prohibited to use Trichopolum and ethanol at the same time. Many patients ask specialists about the compatibility of the drug with alcohol.

Doctors say that only hepatoprotectors can eliminate extensive liver lesions in this case.

Damage to liver cells is not the only difficulty caused by combining ethanol with Trichopolum.

In what cases is admission prohibited?

Has contraindications for use. Possible contraindications are as follows:

CNS lesions;
renal failure;
leukopenia;
liver problems (dysfunction);
period of pregnancy and lactation (included in the list of relative contraindications; treatment can be prescribed when the risk to the fetus does not exceed the expected benefit to the mother);
private sensitivity to components.

This is an antibiotic and its compatibility with other drugs from drug groups has not been proven.

The use of Trichopolum in the fight against binge drinking

The combination of metronidazole and ethanol leads to unpleasant symptoms for the patient. This is the basis for the use of Trichopolum in the treatment of alcohol dependence. Basically, a person begins to suffer from the following undesirable consequences:

nausea;
uncontrollable vomiting;
stomach ache;
dizziness;
general malaise;
cold sweat;
dyspnea.

In advanced cases, when taking medication and alcohol simultaneously, severe pain appears in the heart area and blood pressure drops. Some patients later said that they felt death was imminent, since their health was very difficult.

As a result, many people who have experienced such stress have stopped drinking alcoholic beverages altogether.

This negative reaction of the body is due to the interaction of metronidazole with acetaldehyde, a product of ethanol metabolism. Due to the use of the drug, the functions of enzymes that normally break down and remove acetaldehyde are disrupted. As a result, the toxic product accumulates and worsens the patient’s well-being.

Experts inform that this method of combating alcohol addiction is effective, but extremely dangerous, so you are not allowed to use it at home on your own. It is not clear whether the body of a particular patient can cope with such a load, because acetaldehyde poisoning can be extremely severe.

It is not recommended to combine Trichopolum and alcohol if the drug is used to treat infections caused by bacteria or protozoa. In this situation, the medicine will only disrupt the function of the liver, which is already damaged due to the disease.

Contraindications and side effects of Trichopolum

Like any other medicine, Trichopolum has side effects:

Digestive system, gastrointestinal tract: loose stools, indigestion, nausea and vomiting, stool retention, loss of appetite, intestinal colic, anorexia, taste disorder, metallic taste and dry mouth, epigastric pain, glossitis, and oral stomatitis. It is much less common to observe deviations from the norms of texts on liver function, cholestatic hepatitis, pancreatitis or jaundice.
Central nervous system, as well as the peripheral nervous system: dizziness and pain in the head due to exceeding the course of therapy, loss of coordination of movements, peripheral neuropathy, ataxia, increased excitability, excessive irritability, insomnia, drowsiness, depression, fatigue. Situations of confused consciousness, convulsive phenomena, and hallucinations occur much less frequently. Isolated cases of encephalopathy.
Urinary system: cystitis, urinary incontinence, dysuria, reddish-brown urine.
Genital organs: formation of excessively excessive vaginal microflora, which in medicine is interpreted as candidiasis, pain in the vagina.
Allergies: skin rash, characteristic itching, nervous urticaria, fever, stuffy nose, erythema multiforme.
Musculoskeletal system: arthralgia or myalgia.
Hematopoietic system: leukopenia, in rare cases, neutropenia, pancytopenia, thrombocytopenia, and agranulocytosis are observed.
Other side effects: flattening of the T wave on the ECG, pustular rashes and ototoskiness appear much less frequently.

To avoid the possibility of such negative consequences from Trichopolum therapy, it is strongly recommended to use the medicine strictly as prescribed by the attending physician, as well as observing the dosage.

There is a certain circle of people who are prohibited from using this drug for therapy:

The initial stage of pregnancy, exactly the first trimester. Due to the fact that the active components of Trichopolum can penetrate the placenta, the drug can harm the fetus.
Breastfeeding period. The drug can concentrate in the milk of a nursing mother, thereby harming the health of the baby during the feeding period. If a woman needs the drug, breastfeeding is suspended during the course of treatment.
Any human blood disease.
Complex pathologies and abnormalities of the central nervous system.
Lesions and pathologies of the liver.
Small children under 3 years of age.
Individual characteristics of a person and allergic reactions to the components of the drug.

The drug Trichopolum is most dangerous for people with liver concentration insufficiency. Also, those people who have problems with kidney function should carefully monitor their health status during the period of therapy. The first signs of quitting Trichopolum are dizziness and gastrointestinal disorders.

Analogues and cost of Trichopolum

If necessary, the medicine can be replaced with the following analogue:

Metronidazole;
Batsimex;
Flagyl;
Metrogil;
Cyptrogyl;
Metran;
Efloran;
Flagyl;
Cleon.

When choosing the right analogue, you should consult with a specialist and do not replace the medicine yourself.

In the pharmacy chain in Russia, the price of Trichopolum is on average 97 rubles.

The drug should be stored in a dry, ventilated and dark place, at a temperature not exceeding 25°C. Keep away from children.

Price and analogues

It would be useful to find out how much the drug Trichopolum costs. The cost of this drug is not high, but it may vary in different pharmacies. On average, the price for a package of Trichopolum tablets, with a quantity of 20 pieces, ranges from 70 to 110 rubles. The drug is dispensed with a prescription from your doctor, but it can often be purchased in pharmacies without presenting a prescription. But it is still better to additionally consult a doctor.

Reviews about the use of the medicine

Irina, 29 years old

. Somewhere a few days after IVF, I began to feel unwell: my head hurt and was dizzy, I felt very nauseous, and my right side suddenly “took”. I came to a gastroenterologist for help. He looked and recommended a gastroendoscopic examination, but I categorically refused because I was afraid of the risks associated with undergoing the procedure. Alternative ultrasound revealed signs of inflammation of the gallbladder. An examination by a doctor confirmed the identified violations. The doctor said that Trichopolum is effective for this inflammation and prescribed complex treatment. I was ordered to take the drug for 10 days. I liked the medicine, I felt better already on the 3rd day. The only thing is that you should try to swallow the drug immediately so that there is no bitter taste in your mouth.

Katya, 17 years old

. The first sex turned into an unpleasant itch. A gynecologist knows how to treat inflammation like a woman. The specialist said that this was a slight irritation and prescribed Trichopolum. Of course, I didn’t like the name, but I started taking the drug. The very next day, all the unpleasant sensations disappeared. The medicine is not expensive, but I was very afraid of the consequences.

Vasily, 40 years old

. The medicine was prescribed to my brother, but he was on a drinking binge. And it so happened that he mixed it with alcohol. I have no idea how much he consumed, but he had, as they say, one foot in the grave. After this situation, my brother doesn’t drink at all and takes Trichopolum. Several years have passed, and he is still afraid to drink.

Vasilisa, 43 years old

. After a simple operation, there was a possibility of developing an infection. Treatment with Trichopolum was prescribed. I started taking it when the doctor told me about my bad tests. I did not observe any side effects during treatment.

Vladimir, 50 years old

. Once you experience the toxic mixture of Trichopolum and alcohol, you will stop drinking for good. I felt it myself and haven’t drank a drop since then.

There are contraindications. Specialist consultation required