What does Analgin help with: instructions for use, composition, price

A popular painkiller and anti-inflammatory medicine is Analgin. Instructions for use indicate how to properly take 500 mg tablets, injections in ampoules, 100 mg suppositories to relieve pain symptoms.

Ampoules and tablets Analgin
Analgin is a pyrazolone derivative. It is characterized by a pronounced analgesic, antipyretic and slight anti-inflammatory effect.

The analgesic effect is ensured by the ability of the active substance to inhibit cyclooxygenase and the synthesis of prostaglandins (participate in the development of inflammatory and pain reactions). In addition, metamizole blocks the transmission of pain impulses and increases the sensitivity threshold of pain centers, reduces the response of brain structures to pain caused by a particular irritant.
The anti-inflammatory effect of metamizole is also due to inhibition of prostaglandin production.
The antipyretic effect of Analgin is achieved due to the ability to reduce the production and release of chemical substances that affect heat production.

The medication also has an antispasmodic effect on the smooth muscles of the biliary and urinary tract. What does Analgin help with?

Composition and release form

A popular form of release of Analgin is tablets, dragees or capsules. However, no less common is a medicinal drug in ampoules or as a component of an injection solution. It is worth knowing that suppositories for rectal use called Spazdolzin are also a derivative of Analgin. All medicinal varieties of the drug differ from each other only in the content of metamizole. Eg:

The standard dosage of the active components of the tablets is 500 mg per 1 piece.

Analgin in ampoules contains 250/500 mg of the substance per 1 or 2 ml.

There is also a special preparation for children. The concentration of metamizole is 50/100/150 mg.

Spazdolzin suppositories for adults contain 650 mg of the substance, and the children's version contains 200 mg.

Why is Analgin prescribed?

According to the instructions, the drug is prescribed for pain syndrome:

headache;
migraine pain;
toothache;
neuralgia;
myalgia;
algodismenorrhea;
postoperative pain;
renal and biliary colic (in combination with antispasmodics);
febrile conditions in infectious and inflammatory diseases.

The drug is also used as a nonspecific remedy for feverish conditions, rheumatism, and acute respiratory infections.

It has no therapeutic effect, only relieves pain.

Medical instructions for use

The use and dosage of analgin directly depend on the nature, severity of pain, adverse reactions, the cause of the pain syndrome, and the body’s response to treatment. The optimal dose is considered to be the one that controls fever and pain in minimal amounts. Most often the medication is taken orally.

With parenteral use, allergic reactions are more likely to develop. In case of an overdose of the drug, gastric lavage with a tube, forced diuresis, saline laxatives, and enterosorbents are prescribed.

How to take the Tablets?

When using Analgin in tablets, the dosage is selected depending on the intensity of pain and the body's individual response to treatment. It is considered optimal to use the minimum dose that controls fever and pain.

The tablets are swallowed whole and washed down with a large (about 200 ml) volume of liquid.

For an adult weighing more than 53 kg, a single dose of Analgin is 0.5-2 tablets. If one dose is not enough, the maximum single dose (two tablets) can be taken three more times during the day. The safe upper limit for daily dosage is 4 grams (eight tablets).

How to take Analgin tablets for toothache?

For toothache, start taking Analgin with half a tablet. If this does not help relieve the pain, you can drink the remaining half.

Before taking the tablet, it is recommended to brush your teeth and rinse your mouth with warm water and baking soda.

Instructions for Analgin in ampoules

Subcutaneous injections of Analgin are unacceptable, as they can lead to severe allergic reactions and inflammation. Injections of any dosage are given only intravenously or intramuscularly. It is advisable to do injections only when other drugs do not help or the person is in critical condition and cannot take the pill.

According to the instructions for Analgin in ampoules, the dosage of the drug is calculated according to the patient’s age, for example:

Adolescents over 14 years of age and adults are administered up to 2500 mg of metamizole sodium per injection, and the maximum daily volume is 5000 mg. Analgin injections are given up to 3 times a day, keeping a 4-hour interval between them.
Analgin is administered to children with fever in the minimum dosage, calculated from the ratio of 4-10 mg per 1 kg of weight. The result obtained must be divided by 2, and the drug should be administered 2-3 times per day.

The injected solution for injection must be within body temperature, so after drawing the liquid into the syringe, it must be warmed in the palms for some time. The injection is usually administered intramuscularly, but in critical conditions it is permissible to inject intravenously.

Storing opened ampoules on the table, in the refrigerator or other places is strictly prohibited. If the drug has been left open for more than 15 minutes, it is considered unsuitable for use.

Instructions for use of Analgin rectal suppositories

Suppositories are inserted into the anus in the required dosage. Since Analgin can cause a sharp decrease in blood pressure some time after administration, the suppositories should be administered while lying down in bed. After inserting the suppository, you need to lie down for 30–40 minutes, after which you can carefully get up and perform light necessary actions.

Suppositories are recommended to be used as a means for single use during the day, when it is necessary to quickly relieve pain or reduce body temperature. That is, you can administer suppositories containing the daily dosage of Analgin to a child or adult at one time.

But after this, the drug cannot be used during the day in any form, so there must be good reasons for using suppositories, such as severe sharp pain or body temperature of 40 C or higher, which does not decrease under the influence of other drugs.

Dosages of Analgin suppositories are determined by a person’s age and are as follows:

Adults and adolescents over 14 years of age - administer suppositories in a total dosage of 300 mg, 650 mg or 1000 mg per day;
Children 8 – 14 years old – administer suppositories 200 – 600 mg per day;
Children 3 – 7 years old – administer suppositories 200 – 400 mg per day;
Children 1 – 3 years old – administer 200 mg suppositories per day;
Children 6 – 12 months – administer 100 mg per day.

Read also: Why is Betahistine prescribed?
Instructions for medical use For children, it is recommended to use suppositories with a dosage of 100 mg, and for adults - 250 mg. The indicated daily dosages can be used at a time or divided into 2 to 3 administrations, depending on the prognosis of the child or adult’s condition.

For example, the daily dosage for children 1 to 3 years old of 200 mg can be divided into two administrations and the child can be given one 100 mg suppository in the morning and in the evening. If you need to reduce the high temperature and within 24 hours it is not expected to rise as strongly again, then you can introduce suppositories in a daily dosage at a time.

How to use Analgin

Analgin can be taken orally, and also administered intramuscularly or intravenously.

When administered orally, the instructions for Analgin recommend the following dosage regimen:

Adults should take 250-500 mg 2 or 3 times a day, but the maximum daily dose should not exceed 3 g, no more than 1 g of the drug should be consumed at a time;
When prescribing Analgin to children, the following single doses are recommended: 2-3 years - 50-100 mg, 4-5 years - 100-200 mg of the drug, 6-7 years - 200 mg, 8-14 years - 250-300 mg. It is also recommended to use Analgin for children 2-3 times a day .

When administering the drug intravenously or intramuscularly, a single dose for adults is 250-500 mg, and Analgin for children is prescribed in a volume of 5-10 mg. It is recommended to use the drug 2-3 times a day.

If Analgin is used for intravenous or intramuscular administration, several recommendations should be followed:

For children under 1 year of age, the drug can only be administered intramuscularly;
The injection solution of the medicine must be at body temperature;
When using Analgin, you should be prepared for anti-shock therapy and have everything you need on hand;
Intravenous administration should occur slowly, since a high injection rate can provoke a sharp decrease in blood pressure.

Contraindications for use

Contraindications to taking Analgin are:

individual intolerance to pyrazolone/pyrazolidine derivatives, allergic reactions to auxiliary components of the drug;
renal failure;
liver failure;
inhibition of hematopoiesis and dysfunction of the bone marrow (including after taking cytostatics);
leukopenia, hereditary hemolytic anemia and other types of anemia;
rheumatic attack;
dysmenorrhea;
“aspirin” asthma or intolerance syndrome to non-steroidal anti-inflammatory drugs and analgesics;
children under 10 years of age;
first and third trimesters of pregnancy.

Contraindications:

Analgin should not be used:

In case of hypersensitivity to metamizole and other pyrazolone derivatives or pyrazolidines (including patients who were diagnosed after using these substances) or any other ingredients of analgin;

In patients with a history of aspirin asthma or analgesic intolerance syndrome (urticaria, angioedema), in patients with bronchospasm or other forms of anaphylactoid reactions to salicylates, paracetamol or other non-narcotic analgesics such as diclofenac, ibuprofen, indomethacin or naproxen;

Forced diuresis, alkalization of the blood, symptomatic therapy aimed at maintaining vital functions. When a convulsive syndrome develops, intravenous diazepam and fast-acting barbiturates are administered.

Side effects

Analgin can cause the following side effects:

Renal dysfunction;
Oliguria;
Anuria;
Interstitial nephritis;
Proteinuria;
Red coloration of urine;
Urticaria (including on the mucous membranes of the nasopharynx and conjunctiva);
Angioedema;
Toxic epidermal necrolysis;
Malignant exudative erythema;
Bronchospastic syndrome;
Anaphylactic shock;
Agranulocytosis;
Leukopenia;
Thrombocytopenia;
Reduced blood pressure;
Infiltrates at the site of intramuscular injection.

Side effects:

The frequency of possible side effects listed below is determined as follows: very common (> 1/10), common (> 1/100 to 1/1000 to 1/10000

Skin allergic reactions. Sometimes: rash. Rare: maculopapular. Anaphylactic or anaphylactoid reactions, especially after parenteral use. Such reactions may develop later, during injection or immediately after administration, as well as after 10-12 hours. But they occur mainly within the first hour after administration. Reactions usually manifest themselves in the gastrointestinal mucosa and in the form of skin reactions (such as itching, burning, redness, rash, swelling), rarely. These reactions can occur with more severe forms such as: severe angioedema (including the larynx), severe heart rhythm disturbances (sometimes preceded by an increase in blood pressure).

If skin reactions occur, taking analgin should be stopped immediately.

In patients with aspirin-induced asthma, reactions usually manifest as asthma attacks. Very rare: analgesic-induced, Stevens-Johnson syndrome or Lyell's syndrome, shock.

Blood and lymphatic system. Rarely: . Very rarely: or. These reactions are probably immunological. They can occur even if metamizole has been given on previous occasions without complications. The risk of development may be increased if analgin is taken for more than 1 week. manifested by high fever, chills, sore throat, difficulty swallowing, stomatitis, inflammation of the mucous membranes of the nose, throat and genitals, or anal itching. In patients receiving antibiotics, these symptoms may be minimal.

The ESR accelerates significantly, granulocytes are significantly reduced or completely absent. Typically, but not always, laboratory values for hemoglobin, red blood cells, and platelets remain within normal limits.

Taking analgin should be stopped immediately if there is an unexpected deterioration in the general condition that is not associated with a decrease in temperature and the manifestation of colds or inflammatory diseases.

The cardiovascular system. Uncommon: hypotensive reactions during or after use, which may be pharmacologically dependent and not concomitant with anaphylactoid reactions. Such reactions can lead to a serious drop in blood pressure. Rapid intravenous administration increases the risk of developing hypotensive reactions. Even with hyperthermia, a critical dose-dependent decrease in blood pressure can occur without any evidence of a hypersensitivity reaction.

Diseases of the kidneys and urinary tract. Very rare: acute deterioration of renal function - deterioration, after which it can very rarely develop, oligo-or and, acute. Discoloration of urine red.

How to take it for children?

Analgin in tablets or injections can be given to a child from the age of 10, otherwise the body’s reaction may be unpredictable - as indicated in the instructions for use. For children of the younger age group, it is customary to treat with rectal suppositories, since they have the proper therapeutic effect without a detrimental effect on the stomach and the baby’s body as a whole.

Instructions for use of Analgin for children indicate the need to comply with the correct dosages. If these are suppositories, then children under one year old are usually given 1 capsule per day. Children over 2 years old can use two candles per day. As for tablets and solutions, the dosages remain the same and are calculated strictly according to the child’s weight. Parents should understand that regular use of Analgin does not guarantee recovery and can cause a lot of negative reactions.

Side effect

The disadvantage of treatment using the drug "Analgin" is the possibility of negative reactions of the body. The greatest danger lies in the likelihood of agranulocytosis. Because of this, many countries have banned the use of the drug. In addition, the following side effects are observed:

kidney dysfunction;
oliguria;
proteinuria;
thrombocytopenia;
anuria;
hives;
interstitial nephritis;
decrease in pressure;
angioedema;
leukopenia;
anaphylactic shock (rare);
bronchospastic syndrome (rare).

Contraindications

"Analgin" instructions for use prohibit use for:

individual intolerance;
blood diseases;
rheumatic attack;
aspirin triad, asthma;
liver failure;
anemia;
dysmenorrhea;
1st trimester of pregnancy;
leukopenia;
kidney dysfunction;
during breastfeeding.

Caution must be exercised when prescribing the medicine to babies under 3 months, with long-term use of alcohol, and with renal pathologies. The patient's condition should be monitored in case of low blood pressure and unstable blood circulation.

Analogs

Analgin Bufus; -Rusfar; quinine; -UBF; -Ultra;
Baralgin M;
Metamizole sodium;
Optalgin;
Spazdolzin for children.

When choosing analogues, you must remember that the instructions for use of Analgin, the price and reviews of drugs with similar effects do not apply. Replacing the drug is permissible only after the recommendation of a doctor.

Analgin injections with Diphenhydramine

A very effective pain reliever that works within 10 minutes. Analgin injection with Diphenhydramine can be used for injuries in adults and children and if renal colic is suspected.

Analgin and Diphenhydramine are very compatible, they complement each other and are used for toothache, migraine, neuralgia, myalgia, and postoperative pain. For children, this combination of drugs is best given in tablets. Before giving the injection, first fill the syringe with analgin, and then diphenhydramine and slowly inject the medicine.

At high temperatures, this injection gives a good result, only after it you need to drink half a liter of water. There are Analdim suppositories on sale, which must be administered 1-3 times a day into the rectum; they are usually prescribed to children.

These drugs should not be combined in case of kidney and liver pathologies, diabetes mellitus, blood disease, bronchial asthma and during pregnancy.

special instructions

Attention! It is unacceptable to use Analgin in the event of acute pain of an unknown nature before examining the patient by a doctor!

Long-term use of the drug requires periodic monitoring of the leukocyte blood count.
In some cases, the administration of Analgin may turn the urine red, which is not a sign of negative phenomena, is associated with the release of the intermediate metabolic product metamizole sodium and does not require discontinuation of the drug.
This product is incompatible with alcohol consumption.
It is unacceptable to mix Analgin with other drugs in one syringe.

It interacts with other medicinal substances, changing them and its therapeutic activity, therefore, when taking other medications, it is necessary to inform the attending physician about the use of Analgin.

Drug interactions

During treatment with Analgin, penicillin-based drugs, colloidal blood substitutes and radiocontrast agents should not be used. It is also not recommended to use simultaneously with other non-narcotic analgesics, allopurinol, contraceptive hormonal drugs and tricyclic antidepressants, since the combination of these drugs with the drug leads to increased toxicity.

The use of barbiturates, phenylbutazone and other hepatoinducers reduces the effectiveness of the analgesic, while tranquilizers and sedative drugs enhance its analgesic effect. Myelotoxic drugs can increase side effects affecting the hematopoietic system, and cytostatics and thiamazole can increase the risk of leukopenia.

Analgin has the ability to increase the activity of oral hypoglycemic agents, indomethacin, indirect coagulants and corticosteroids. To avoid various undesirable interactions with other drugs, this analgesic should be taken only as prescribed by a doctor.

Interaction with other drugs

It is worth considering the compatibility of Analgin with other drugs and chemical compounds. First of all, many are interested in the combination of medicine and alcohol. Doctors immediately say that such a combination is extremely harmful. After all, this is direct toxic damage to the liver. Analgin can enhance the effect of ethyl alcohol, which means that it does not combine well with various alcohol tinctures.

When Analgin is combined with Chlorpromazine, a person may experience a slight decrease in body temperature. You should not use penicillin-based antibiotics in parallel with such a drug. Barbiturates reduce the effectiveness of the drug, tranquilizers, on the contrary, increase it. But the combination of Analgin with oral contraceptives becomes harmful to the body, because emphasizes and increases the toxicity of the active substance.

What do the reviews say?

Analgin is a time-tested universal, potent and very affordable pain reliever that is good for headaches, pain that occurs during menstruation, rheumatism, neuralgia and arthralgia.

Reviews about the drug are quite contradictory: on the one hand, metamizole sodium works reliably and is effective even with severe pain, on the other hand, it has a large number of contraindications and side effects (which is why it is prohibited for use in most developed countries).

Most people agree that adults can take Analgin, but without abusing it; for children (especially small ones), it is better to choose a safer analogue.

750