An effective remedy for hypoxia - Mexiprim

Mexidol in the treatment of alcoholism

When treating patients with a history of ethanol addiction, Mexidol is rightfully considered one of the best drugs. The medicine gently relieves the neurological consequences caused by taking large doses of ethanol, helps restore the emotional background, improves the learning process, memory and cognitive functions.

Indications

Patients with alcoholism can take Mexidol with the following symptoms:

• Severe form of alcohol withdrawal.
• Alcoholic encephalopathy.
• Epilepsy due to alcohol abuse.
• Polyneuropathy caused by constant alcohol intoxication.
• Brain diseases, including traumatic brain injuries.
• Severe poisoning with ethanol and antipsychotics.
• Increased level of anxiety in neuroses and similar conditions.

The inclusion of Mexidol in standard therapy allows for a short period of time to achieve lasting improvement in the condition of patients with alcoholic delirium, convulsive conditions and severe withdrawal syndrome. In such cases, the drug is prescribed intravenously.

Mechanism of action

The anti-withdrawal effect of Mexidol is aimed at relieving urgent severe conditions associated with the withdrawal of alcohol previously taken for a long time. In extremely severe cases of alcohol withdrawal, severe hypoxia occurs, which can result in death.

Mexidol, as an antihypoxic and antioxidant agent, helps increase cell resistance to oxygen deficiency and, thus, has a quick but rather mild effect.

In addition, Mexidol has a potentiating effect on other drugs used in the treatment of alcoholism, which leads to a reduction in dosage and a decrease in side effects from the therapy used.

The drug also helps in the functioning of the liver, breaking down damaged cells and thereby helping to accelerate the regeneration of the organ.

Complex therapy using Mexidol always gives faster and more effective results than traditional treatment. This has been proven by numerous studies in the treatment of patients with severe alcoholic pathologies.

Contraindications and side effects

The drug is a low-toxicity drug, so it is always well tolerated by patients with alcohol dependence. The exceptions are patients with severely impaired liver and kidney function, as well as people with personal intolerance to the components of the drug.

Pregnant women should not use Mexidol due to unproven effects on the fetus.

Some patients report dry mouth and slight nausea. There were no other negative effects when taking any forms, including Mexidol injections.

The drug combines well with absolutely all other medications used by narcologists to treat addictions.

Mexiprim - help for neurological patients

Mexiprim is a drug from the group of antioxidants. Its main task is to increase the body’s resistance to stressful situations and help cope with high loads. Mexiprim tablets are often used to correct memory and learning disorders.

The use of Mexiprim is widespread in neurology and psychiatry. Tablets and injection solution are used to correct cerebral circulatory disorders, for various forms of encephalopathy and in a number of other cases.

Composition of the drug

The drug Mexiprim contains the only active ingredient - ethylmethylhydroxypyridine succinate. In addition to the active substance, tablets contain auxiliary agents such as kaolin, talc, magnesium stearate, etc. Thanks to these substances, the tablets retain their shape and their shelf life increases.

In addition to the main active ingredient, the injection drug Mexiprim contains about 1 ml of water for injection.

Dosage, release forms and manufacturers

There are two forms of release of the drug Mexiprim: tablets and solution for injection. Tablets of the drug contain 0.125 grams of active substance. One milliliter of injection solution contains 50 grams of active substance.

Important! In order for the injection solution to be taken correctly, it is necessary to calculate the dosage. This can be done by the attending physician!

Two companies are engaged in the production of solution for injection: Moscow Endocrine Plant and POLYSAN. The Obninsk Chemical and Pharmaceutical Company and NIZHFARM specialize in the production of tablets.

Therapeutic effect

Taking Mexiprim is justified if a good antioxidant effect is needed. The medication helps cope with stress, fatigue of the body, exhibits a pronounced anxiolytic effect, but does not cause drowsiness and absent-mindedness, which is what other anxiolytics are famous for.

It has been proven that the drug Mexiprim has a nootropic, vasodilating effect. Taking it helps facilitate learning and reduces symptoms of age-related memory problems. The tablets are also known for their ability to have a positive effect on brain tissue by increasing blood flow in them.

Another property of the drug Mexiprim is hypolipidemic. Taking it helps reduce the level of platelets in the bloodstream.

Indications, contraindications and side effects

The drug Mexiprim, like any other medicine, has its indications, contraindications and side effects. They must be taken into account before you start using the medication.

Tablets and solution for injection have the same indications and contraindications. Possible side effects for the two dosage forms are also similar.

Instructions for use

The instructions for use of Mexiprim state that the dose of the drug should be calculated individually by the attending physician. It is worth reading the instructions to understand what unwanted reactions you can expect and know how they will manifest themselves.

Open instructions (.pdf)

General recommendations

• Mexiprim tablets are taken orally 2-3 times a day. The amount of the drug is calculated individually, based on the characteristics of the patient and the disease for which the medicine is used. It is recommended to titrate the medication from a minimum dose of 0.25 grams with a gradual increase to 0.8 grams. Tablets are also gradually being phased out; you should not immediately remove them from circulation.
• The injection solution can be administered intramuscularly or intravenously 1 to 3 times a day.
• It is important to remember that Mexiprim and alcohol are incompatible with each other. The drug has the opposite effect of alcohol on the body, which can lead to a decrease in its therapeutic effectiveness.

Recommended dosage and regimen

If you need to take Mexiprim, it is prescribed in individual dosages. It is recommended to adhere to the following rules:

• in case of cerebrovascular accidents, 200-300 mg of the drug is administered intravenously, then switch to intramuscular administration of 100 mg three times a day for 10-14 days;
• in case of withdrawal syndrome, administration is carried out intramuscularly at 100-200 mg twice or thrice a day;
• mild disorders of brain activity require intramuscular administration of the drug 100-300 mg for two to four weeks;
• for encephalopathy, the drug dosage regimen is complex and is often adjusted by the doctor depending on the patient’s characteristics.

If you decide to use tablets, then start taking it with 0.25 g, gradually increasing the dose to 0.8 g. For anxiety disorders and memory disorders, the course is 2-6 weeks; to correct withdrawal syndrome, 7 days of use is enough.

Medicine for children: instructions and dosage

According to official instructions, Mexiprim is not recommended for the treatment of children. This is due to the fact that doctors do not have enough data regarding the safety of the drug in childhood.

However, a doctor may recommend Mexiprim to patients under 18 years of age. In this case, the dose is selected individually, and the child must be under the supervision of a physician during therapy.

Drug analogues

There are analogues of Mexiprim in terms of active substance and effect. The latter may differ from the main drug in composition, but have a similar effect on the patient’s body.

Analogs for the active substance

Mexiprim tablets have the following analogs for the active substance:

1. Medomexi, available in two forms and having similar indications, contraindications and scope of application;
2. Cerecard is a drug presented only in the form of an injection solution;
3. Neurox is another product that is completely identical to Mexiprim, but is available only in the form of injections, etc.

Today on the pharmaceutical market there are many analogues of Mexiprim in action. One of the most famous is Mexidol, used in many hospitals to treat patients with neurological diseases.

Similar in effect

Mexiprim tablets also have analogs in effect, mainly belonging to the group of antioxidants. Among them:

1. Actovegin is a drug that differs in its active substance, but stimulates blood circulation in the brain, positively affecting its functioning;
2. Preductal is a drug used mainly in cardiological practice due to its anti-ischemic and anti-anginal effects, but it can also be used as an antioxidant;
3. Antisten is another analogue in effect, more often used in cardiological practice than in neurology.

Patients should be careful when choosing an analogue. The question of whether it is possible to take Mexiprim instead of the drug chosen by the doctor or replace the main medicine with another drug should be decided only by the attending physician.

Opinions of doctors and patients about the medicine

Reviews of Mexiprim are mostly positive. Doctors note the pronounced effects of Mexiprim when the dosage is calculated correctly and used in accordance with the indications. According to their reviews and observations, taking the drug improves the general condition of patients, has a positive effect on cognitive skills when they are impaired, and allows them to more quickly cope with withdrawal symptoms.

Reviews from patients say that thanks to taking Mexiprim, their memory has improved and they can concentrate better. Those people who have used the drug on the recommendation of a doctor to treat sick elderly relatives also note a positive effect: patients become calmer, their brain activity improves, and sometimes skills lost due to brain disorders return.

Among the disadvantages of the drug, as some reviews note, are primarily the difficulty in calculating dosages, as well as the inability to use in the treatment of children.

Prices and terms of sale in pharmacies

The price of the drug Mexiprim varies in different regions, as well as depending on the pharmacy chain and the pharmaceutical company of the manufacturer. On average, the cost of a package of 30 tablets ranges from 150-200 rubles. An injection solution can cost more than 300 rubles due to the number of ampoules and dosage in them.

Mexiprim is dispensed from pharmacies with a prescription, as stated in the instructions for use.

However, practice shows that you can purchase the medicine without a prescription from a doctor. However, it is not recommended to do this so as not to self-medicate.

about taking the drug

There are several videos that will help you better understand the features of using Mexiprim.

conclusions

Mexiprim tablets are a drug that has proven itself in the treatment of patients with various neurological disorders. When used correctly and strictly following the instructions, the drug gives a pronounced effect. If necessary, courses can be repeated to consolidate the achieved results.

Source: https://tabletki-glicin.ru/analogi/meksiprim.html

How to use the medicine

It is best to start taking Mexidol the next day after you stop drinking alcohol. The drug will promote the rapid removal of all toxic ethanol toxins and relieve the unpleasant phenomena that a hangover brings with it.

The drug is intended for course use. On average, it must be taken for at least two weeks.

Doctors do not recommend using alcohol when treating with this drug. But, even if a person violates the ban, there will be no particularly dangerous or life-critical consequences. All thanks to the low toxicity of the product. But there will be no benefit from such an alliance, especially in the treatment of alcohol addiction.

The medicine is eliminated from the body within 4-5 hours. It should be remembered that only a narcologist can prescribe this medication and develop a course and dosage. The doctor will take into account the general picture of the disease, the condition of the internal organs and the degree of their damage. Self-treatment with Mexidol is not recommended.

Indications for use

The tablet form is prescribed for:

1. Intellectual disability in gerontology;
2. Stressful influences;
3. Anxious states against the background of neuroses, neurosis-like states;
4. Vegetative-vascular dystonia;
5. Cognitive disorders;
6. Alcohol withdrawal with vegetative-vascular manifestations.

The injection form is prescribed for:

1. Alcohol withdrawal syndrome;
2. Discirculatory encephalopathy;
3. Intoxication with antipsychotic drugs;
4. Acute cerebral circulation disorders;
5. Neurocirculatory dystonia;
6. Cognitive disorders due to atherosclerosis;
7. Anxiety states of moderate severity against the background of neurological disorders;
8. Acute purulent-inflammatory pathologies of the abdominal cavity.

Drug interactions

The medicine is combined with psychotropic drugs.

When taken simultaneously, the effect of benzodiazepine anxiolytics, drugs against Parkinson's disease, and carbamazepine is enhanced.

The medicine reduces the toxic effects of ethyl alcohol.

If it is necessary to simultaneously take several medications together with Mexiprim (Clotrimazole, Zinnat or other antibiotics and antifungals), caution must be exercised, as the load on the liver increases.

Therapy with Mexiprim can be combined with the use of psychotropic drugs.

Ethylmethylhydroxypyridine succinate enhances the effect of antiparkinsonian drugs, benzodiazepine anxiolytics and carbamazepine.

According to the instructions, Mexiprim reduces the toxic effect of ethyl alcohol on the body.

Complete analogues for the active element:

1. Medomexy.
2. Mexipridol.
3. Metostabil.
4. Mexican.
5. Ethylmethylhydroxypyridine succinate.
6. 3-hydroxy-6-methyl-2-ethylpyridine succinate.
7. Mexidol injection solution 5%.
8. Mexicofin.
9. Mexidol.
10. Neurox.
11. Mexidant.
12. 2-ethyl-6-methyl-3-hydroxypyridine succinate.
13. Cerecard.

The category of antihypoxants and antioxidants includes analogues:

1. Preducted.
2. Thiotriazolin.
3. Kudevita.
4. Sodium hydroxybutyrate.
5. Trimectal.
6. Glation.
7. Limontar.
8. Mitomin.
9. Triducard.
10. Yantavit.
11. Oxylic.
12. Metaguard.
13. Cardioxipin.
14. Dimephosphone.
15. Enerlit.
16. Rimekor.
17. Deprenorm MV.
18. Thiogamma.
19. Kudesan for children.
20. Laprote.
21. Antisthene.
22. Ethoxydol.
23. Angiosil retard.
24. Preductal MV.
25. Ethylthiobenzimidazole hydrobromide.
26. Solcoseryl.
27. Cytochrome C.
28. Trimetazidine.
29. Trekrezan.
30. Mexidol.
31. Histochrome.
32. Emoxipin.
33. Vitanam.
34. Valeocor Q10.
35. Proxipin.
36. Precard.
37. Actovegin.
38. Carnifit.
39. Phenosanic acid.
40. Levocarnitine.
41. Predisin.
42. Carnitine.
43. Olifen.
44. Kudesan.
45. Kudesan Forte.
46. Methylethylpyridinol.
47. Hypoxene.
48. Confumin.

Mexiprim tablets can be prescribed simultaneously with psychotropic drugs.

Under the influence of this drug, the therapeutic effect of sedatives, carbamazepine, and anticonvulsants is enhanced. In view of these data, the patient's condition should be monitored and, if necessary, the dosage of medications should be adjusted.

Under the influence of the drug Mexiprim, the risk of toxic damage to the patient’s body from ethanol is reduced.

Composition of the drug

Mexiprim tablets

Contents of components in 1 table:

• Active: 125 mg ethylmethylhydroxypyridine succinate
• Auxiliary: kaolin, sodium KMC, CME, povidone, talc, E 572
• Coating: hypromellose, macrogol, E 171, talc.

Round pills with convex sides, enclosed under a white/beige film coating. The kernel is white or with a tint (grayish, beige or yellowish). There are 10 tablets in a blister pack made of PVC/aluminum film. A cardboard pack contains 1, 2, 3, 4 or 6 plates, description and instructions.

Mexiprim injections

Components content in 1 ml:

• Active: 50 mg ethylmethylhydroxypyridine succinate
• Auxiliary: water.

Medicine in the form of an uncolored or creamy liquid without impurities. Packaged in ampoules of 2 or 5 ml, enclosed in contour packaging. A cardboard pack contains 5 records and an annotation.

Instructions for use

• mild cognitive disorders of various nature (against the background of asthenic disorders and psychoorganic syndrome caused by traumatic brain injuries, acute/chronic cerebrovascular accidents, intoxications, neuroinfections, atrophic and senile processes);
• vegetative-vascular dystonia;
• anxiety disorders accompanying neurotic and neurosis-like conditions;
• memory disorders and intellectual disability in elderly patients;
• withdrawal syndrome in alcoholism with dominance of neurosis-like and vegetative-vascular disorders;
• influence of extreme (stress) factors.

Additionally for the solution:

• encephalopathy;
• acute cerebrovascular accidents (as part of combination therapy);
• acute intoxication caused by antipsychotic drugs (neuroleptics).

Solution

Mexiprim solution should be administered intravenously (stream/drip) or intramuscularly. Before infusion of the drug, it must be diluted with isotonic sodium chloride solution.

Doses are set individually, taking into account the indications and severity of the patient’s condition. At the beginning of the course, it is recommended to use the drug 1–3 times a day at a dose of 50–100 mg, gradually increasing it until the desired effect is obtained. The maximum dose per day is no more than 800 mg.

Mexiprim should be administered dropwise at a rate of 40-60 drops per minute, in a stream - slowly, over 5-7 minutes.

Recommended dosage regimen:

• acute cerebrovascular accidents (as part of combination treatment): 1 time per day at a dose of 200–300 mg intravenously during the first 2–4 days, then 3 times per day at a dose of 100 mg intramuscularly; course – 10–14 days;
• dyscirculatory encephalopathy in the decompensation phase: 2–3 times a day at a dose of 100 mg IV drip or stream for 14 days, then a two-week course of 100 mg 2–3 times a day IM; course prophylaxis of discirculatory encephalopathy – 2 times a day at a dose of 100 mg for 10–14 days intramuscularly;
• mild cognitive impairment in elderly patients, anxiety disorders: in a daily dose of 100–300 mg IM, duration of treatment – ​​14–30 days;
• acute intoxication with antipsychotic drugs: at a dose of 50–300 mg per day intravenously, course – 7–14 days;
• alcohol withdrawal syndrome: at a dose of 100–200 mg 2–3 times a day intramuscularly or 1–2 times a day intravenously, duration of therapy is 5–7 days.

Pills

Mexiprim tablets are taken orally. The dose and duration of treatment are determined depending on the sensitivity of the patient. The initial and average daily dose can vary from 250 to 500 mg (2-4 tablets), the maximum dose per day should not exceed 800 mg. Recommended daily doses should be divided into 2-3 doses.

The course of therapy for vegetative-vascular dystonia, anxiety disorders and cognitive impairment is 2–6 weeks. In order to relieve alcohol withdrawal syndrome, it is recommended to take the drug for 5–7 days.

To complete long-term therapy, do not abruptly interrupt the dose; the dose should be reduced gradually over 2-3 days.

Mexiprim tablets

Prescribed internally. The therapeutic dose and duration of treatment are determined by the patient's sensitivity to the drug.

At the beginning of treatment, the drug is prescribed in a dose of 250-500 mg, the average daily dose is 250-500 mg, the maximum daily dose is 800 mg. The daily dose is distributed into 2-3 doses during the day.

When relieving alcohol withdrawal syndrome, the duration of use is 5-7 days. For the treatment of anxiety disorders, vegetative-vascular dystonia and cognitive impairment, the drug is used for 2-6 weeks.

The course of therapy with Mexiprim is completed gradually, reducing the dose over 2-3 days.

"Mexiprim" in ampoules is administered intramuscularly or intravenously (stream or drip (in the form of a dropper)). To prepare a solution for infusion, the drug should be diluted with isotonic sodium chloride solution.

Doses are selected individually depending on the pathology and severity of the patient's condition. The initial dose is 50-100 mg 1-3 times a day. In the future, it is possible to increase the dose until a therapeutic effect is obtained. The maximum daily dose is 800 mg.

Mexiprim is administered in a stream slowly over 5-7 minutes, and dropwise at a rate of 40-60 drops/min.

In the treatment of acute cerebrovascular accidents, the drug is used in complex therapy in the first 2-4 days intravenously at a dose of 200-300 mg once a day, then intramuscularly at a dose of 100 mg 3 times a day. The duration of treatment is 10-14 days.

For dyscirculatory encephalopathy in the decompensation phase, Mexiprim should be prescribed intravenously in a stream or drip at a dose of 100 mg 2-3 times a day for 14 days. Then the drug is administered intramuscularly at 100 mg per day over the next 2 weeks.

For a course of prophylaxis of dyscirculatory encephalopathy, the drug is administered intramuscularly at a dose of 100 mg 2 times a day for 10-14 days.

For alcohol withdrawal syndrome, Mexiprim is administered in a dose of 100-200 mg IM 2-3 times a day or IV drip 1-2 times a day for 5-7 days.

In case of acute intoxication with antipsychotic drugs, the drug is administered intravenously at a dose of 50-300 mg per day for 7-14 days.

For mild cognitive impairment in elderly patients and anxiety disorders, the drug is used intramuscularly in a daily dose of 100-300 mg for 14-30 days.

Mexiprim is an antioxidant medicine. What is this remedy prescribed for? The drug has anxiolytic properties. Instructions for use recommend taking Mexiprim injections and tablets for neuroses, neurasthenia and other mental disorders.

Release forms and composition

"Mexiprim" is produced in the form of:

1. Solution for intravenous and intramuscular administration (injections in injection ampoules).
2. Film-coated tablets 125 mg.

One milliliter of Mexiprim solution contains 50 grams of the active drug compound, as well as about 1 milliliter of an excipient - water for injection.

One film-coated tablet contains 0.125 grams of ethylmethylhydroxypyridine succinate, as well as excipients such as talc, kaolin, povidone, sodium carboxymethyl starch, calcium stearate and MCC.

Pharmacological properties

Since the instructions for use classify the drug “Mexiprim” as an antioxidant of the heteroaromatic series, it has a wide range of applications. The medicine increases the body's resistance to stressful situations. When using the drug, its anxiolytic properties appear, without muscle relaxant effects or drowsiness.

Mexiprim tablets are intended for oral administration. If necessary, the drug can be crushed with a small amount of water or other liquid. The dose of the drug is determined by the attending physician, which depends on the severity of the pathological process, the individual characteristics of the body and other factors.

The initial daily dose of the drug is 2 tablets, which are divided into 2 doses. If the effect is not sufficiently pronounced, the dose of the drug is increased under the supervision of a doctor. The maximum daily dose of the drug should not exceed 800 mg, which is divided into 3-4 doses.

The duration of the course of therapy depends on the indications, for example, for alcohol withdrawal syndrome it is 7 days, while for neurocirculatory dysfunction with frequent attacks of panic attacks, the duration of the course of therapy is at least 1.5 months.

If it is necessary to cancel treatment, the daily dose of the drug is reduced gradually over 5-7 days, otherwise the clinical signs of the pathology may worsen. .

Price for Mexiprim in pharmacies

The price for a package of the drug in tablets ranges from 150 to 350 rubles.

The price of Mexiprim in solution form ranges from 200 to 350 rubles.

Mexiprim is an antioxidant agent. Mexiprim is a heteroaromatic antioxidant. It has a wide range of pharmacological activity: it increases the body’s resistance to stress, exhibits an anxiolytic effect that is not accompanied by a muscle relaxant effect; has nootropic properties, prevents and reduces learning and memory disorders that occur with aging and exposure to various pathogenic factors; has an anticonvulsant effect; exhibits antioxidant and antihypoxic properties; increases concentration and performance; weakens the toxic effect of alcohol. The drug improves the metabolism of brain tissue and their blood supply, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets). It has a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins. The mechanism of action of Mexiprim is due to its antioxidant and membrane protective effect. It inhibits lipid peroxidation, increases superoxide oxidase activity, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission. Mexiprim increases dopamine levels in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes. Pharmacokinetics Mexiprim is rapidly absorbed from the gastrointestinal tract with a half-absorption period of 0.08-0.1 hours. The time to reach maximum concentration in blood plasma is 0.46-0.5 hours. The maximum concentration of Mexiprim in blood plasma ranges from 50 to 100 ng/ml. The half-life of Mexiprim and the average retention time of the drug in the body are 4.7-5.0 hours and 4.9-5.2 hours, respectively. Mexiprim is intensively metabolized in the human body with the formation of its glucuron-conjugated product. On average, over 12 hours, 0.3% of the unchanged drug and 50% of the administered dose are excreted in the urine in the form of glucuronoconjugate. Mexiprim and its glucuronoconjugate are excreted most intensively during the first 4 hours after taking the drug. The urinary excretion rates of Mexiprim and its conjugated metabolite have significant individual variability. Indications for use: Indications for the use of Mexiprim tablets are: - anxiety disorders in neurotic and neurosis-like conditions; — vegetative-vascular dystonia; - mild cognitive disorders of various origins (with psychoorganic syndrome and asthenic disorders caused by acute and chronic cerebrovascular accidents, traumatic brain injuries, neuroinfections and intoxications, senile and atrophic processes); - memory disorders and intellectual disability in the elderly; — exposure to extreme (stress) factors; - alcohol withdrawal syndrome with a predominance of neurosis-like and vegetative-vascular disorders. Method of administration: Mexiprim is prescribed orally. The therapeutic doses used and the duration of treatment are determined by the sensitivity of patients to the drug. Treatment begins with a dose of 0.25-0.5 g; the average daily dose is 0.25-0.5 g, the maximum daily dose is 0.8 g. The daily dose of the drug is distributed into 2-3 doses during the day. For the treatment of patients with anxiety disorders, vegetative-vascular dysfunctions and cognitive impairment, Mexiprim is used for 2-6 weeks. When relieving alcohol withdrawal syndrome, Mexiprim is used for 5-7 days. Course therapy with Mexiprim is completed gradually, reducing the dose of the drug over 2-3 days. Side effects: Rarely - nausea, dry oral mucosa, drowsiness, allergic reactions. Contraindications: Contraindications to the use of the drug Mexiprim are: liver and/or renal failure, increased individual sensitivity to the drug, childhood, pregnancy, breastfeeding. Pregnancy: Taking Mexiprim tablets during pregnancy is contraindicated. Interaction with other drugs: Mexiprim is compatible with psychotropic drugs; enhances the effect of benzodiazepine anxiolytics, antiparkinsonian drugs and carbamazepine. Reduces the toxic effect of ethyl alcohol. Overdose: Symptoms of Mexiprim overdose: sleep disturbance (insomnia, in some cases drowsiness). Treatment: as a rule, not required - symptoms disappear on their own within 24 hours. In severe cases of insomnia, it is recommended to take nitrazepam 10 mg, oxazepam 10 mg or diazepam 5 mg. Storage conditions: In a dry place, protected from light and out of reach of children, at a temperature not exceeding 30° C. Release form: Mexiprim - film-coated tablets of 125 mg. 10 tablets per package. 1, 2, 3, 4 or 6 packs per pack. Composition: 1 Mexiprim tablet contains the active substance - ethylmethylhydroxypyridine succinate in terms of 100% substance - 0.125 g. Excipients (tablet core): kaolin - 0.00247 g, sodium carboxymethyl starch - 0.01258 g, microcrystalline cellulose - 0.1135 g , povidone - 0.0134 g, talc - 0.0053 g, calcium stearate - 0.00275 g. Excipients (shell): hypromellose - 0.00495 g, macrogol - 0.00128 g, titanium dioxide - 0.00165 g , talc - 0.00037 g. Additionally: During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Contraindications

The drug is not prescribed to children, pregnant and lactating women, patients with liver and kidney failure.

Do not take if you have an individual negative reaction to the drug.

During abstinence

In patients undergoing withdrawal, medication is not prescribed if there are concomitant contraindications.

During the post-abstinence period

It is prohibited to combine with alcohol. If there are additional contraindications, treatment with Mexiprim is not prescribed.

It is not recommended to use this drug for treatment if you have impaired liver or kidney function. A contraindication for the use of the medication is a tendency to be allergic to the active component of the drug. In addition, the drug is not prescribed for impaired renal function.

• renal/liver failure (for tablets);
• acute renal/liver dysfunction (for solution);
• pregnancy and lactation;
• age under 18 years;
• hypersensitivity to any of the components of the drug.

General contraindications for Mexiprim injections and tablets are:

• pregnancy;
• disorders of the liver or kidneys (acute stages of the disease);
• lactation period;
• hypersensitivity;
• childhood.

The tablet form of the drug is not recommended for use in case of renal or liver failure.

Mexiprim tablets are prescribed to patients for the treatment of the following conditions:

• Vegetative-vascular dystonia with frequent attacks of panic attacks;
• Coronary heart disease as part of complex treatment;
• Prevention and treatment of ischemic stroke and its consequences;
• Encephalopathies of various origins;
• Anxiety, disturbance of psycho-emotional state, unreasonable feeling of fear;
• Suffered traumatic brain injuries, accompanied by mild disturbances in the functioning of the brain and cerebral vessels;
• Neuroses of various origins;
• Disorders of memory, attention and perception of information in elderly people;
• Withdrawal syndrome in alcoholism;
• Constant stress.

Before starting drug therapy, you should definitely consult your doctor. The instructions indicate the following contraindications for use:

• Severe liver dysfunction, acute and chronic liver failure;
• Impaired kidney function, acute and chronic renal failure;
• Pregnancy and lactation period;
• Individual hypersensitivity to the constituent components of the drug;
• Age under 18 years (due to the lack of clinical experience in use and data on the safety of the drug on the child’s body).

Indications for prescribing Mexiprim

The medicine has anxiolytic, antihypoxic, antiplatelet, antidepressant, nootropic, and membrane-stabilizing effects.

Indications for use of Mexiprim tablets:

1. Coronary heart disease, pre-infarction and post-infarction condition.
2. Traumatic brain injuries of varying severity.
3. Neuroses and neurosis-like conditions.
4. Cardiopsychoneurosis.
5. Depression.
6. Senile dementia and its prevention.
7. Chronic stress.
8. Neuroinfections: encephalitis, meningitis.
9. Anxiety disorders.
10. Alcohol intoxication, hangover syndrome.
11. Hypertension, hypotension, atherosclerosis.

Possible consequences

To begin with, you should understand that it is unlikely that a doctor will prescribe Mexidol without special indications. And if we take into account the indications for which the medication is most often prescribed, it becomes clear that drinking alcohol for diseases of the brain and central nervous system, even without treatment with Mexidol, is very dangerous for the patient’s life.

Drinking alcohol against the background of a traumatic brain injury or acute cerebrovascular accident can easily lead to death for the patient, and for patients with severe alcohol withdrawal, additional ethanol poisoning is completely unnecessary.

Pharmacologists claim that no serious research has been carried out on the interaction of Mexidol with alcohol, and no one can say whether these substances can be combined. Therefore, a patient who wants to try this combination will have to experiment on himself personally and, quite possibly, pay for it with his own health.

Action of Mexiprim

Mexiprim is a metabolic agent, an antioxidant. The active substance succinate salt (succinate) determines the drug’s ability to have an antihypoxic effect when there is not enough oxygen in the tissues for their normal functioning. Succinate, when entering the body, improves the metabolism of brain, heart, and muscle cells.

Mexiprim is used as a nootropic drug for the prevention of memory loss after traumatic brain injury, hemorrhagic or ischemic stroke.

The drug improves the rheological properties of blood, preventing new attacks of acute disorders of cerebral and cardiac circulation. Reduces platelet aggregation (sticking together), preventing repeated attacks of coronary heart disease.

The drug stabilizes cell membranes, preventing their death in conditions of insufficient blood circulation. Helps reduce low-density cholesterol in the blood, stopping the atherosclerotic process. Increases the sensitivity of cell membranes to hormonal stimuli (when some endocrine organs produce their hormones under the influence of other hormones), reduces their viscosity.

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Increases the efficiency of transmission of nerve impulses to the benzodiazepine, cholinergic, and GABAergic systems. Improves the condition after alcohol intoxication - hangover syndrome, as it contains a residue of succinic acid, which is included in energy metabolism. Calms the nervous system.

Acts as a mild antidepressant, supporting the synthesis of dopamine in the brain. This is important when mood declines in older people, people after a stroke and those who have had serious illnesses. Promotes the processes of aerobic glycolysis even in conditions of lack of oxygen.

Price and holiday conditions

The price of Mexiprim varies in the range:

• tablets 125 mg: 30 pcs. in packaging - from 135 to 175 rubles; 60 pcs. – from 310 to 350 rubles;
• solution 50 mg/ml: 2 ml ampoules – 10 pcs. per package from 220 to 340 rubles; 5 ml ampoules – 5 pcs. per package from 350 to 380 rubles, 15 pcs. – from 960 to 1040 rubles.

The average price of Mexiprim in pharmacies (Moscow) is 166 rubles for 30 tablets of 125 mg. Injections cost 380 rubles for 10 ampoules of 2 ml. In Minsk and Kazakhstan, the medicine can be purchased to order. In Kyiv, the drug is sold for 126 hryvnia. Can be purchased with a prescription.

In Moscow pharmacies, the average cost of Mexiprim in tablet form is 180 rubles.

Release form

Available in the form of tablets with a dose of 0.125 g, in a package of 10 pieces, as well as ampoules for intramuscular and intravenous administration of the solution.

Store in a dark, dry place at a temperature not exceeding 30 degrees.

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