Analgin in ampoules instructions for use for adults

Description of the composition of the drug

A liquid analgesic intended for injection is available in ampoules. The active substance of the medicinal solution is the synthetic substance metamizole sodium, which gives the injection solution analgesic, antipyretic, and weak anti-inflammatory properties.

The transparent liquid of a yellowish tint is packaged in glass ampoules, which are placed in the cells of cardboard boxes. One ampoule with a volume of 1 ml or 2 ml contains, respectively, 500 or 1000 mg of the active substance plus 1 ml of water for injection. The packaging is designed for 10 ampoules and includes instructions for using the drug.

"Analgin" in ampoules: instructions for use, composition, description and reviews

The drugs are in the form of a liquid injection and are often prescribed to patients. Many consumers do not want to undergo procedures on an outpatient basis. More often, self-taught relatives give them injections. People with medical education are less likely to turn to people for help. There are now a huge variety of drugs available in the form of liquid for injection.

These include drugs for treating the digestive system and medications for eliminating neurological problems. However, the first place in popularity is occupied by painkillers and antipyretic drugs. This is “Analgin” in ampoules. Instructions for use, price, reviews about this product will be presented to your attention in the article.

Please remember that the information provided does not encourage self-treatment.

Description of the medication

The medicine "Analgin" is available in different forms. Tablets are very popular. They are easy to take and store in your home medicine cabinet. The drug is also often prescribed to patients in the form of a solution. It is administered intravenously or intramuscularly.

The medicine has a transparent color. It is sealed in ampoules made of fragile glass. After this, the product is placed in a cardboard box with separated cells.

In one package you can find 10 such ampoules. On each of them, as well as on the front side of the pack, there is a trade name - “Analgin” (in ampoules).

Instructions for use and administration of the medication are included with the package.

Composition of the drug

What is the first thing the instructions say about the drug “Analgin” (in ampoules)? The annotation is one of the first to indicate the composition of the drug. The main active ingredient is metamizole sodium. Water for injection is also present as an additional component.

The medication can be produced in the form of a 25 or 50 percent solution. One ampoule will contain 1 or 2 milliliters of the drug.

Action of the medicine

How does the medicine "Analgin" work in ampoules? The instructions for use indicate that it belongs to the category of non-steroidal anti-inflammatory drugs. The product has a pronounced analgesic effect. It also relieves fever and eliminates fever. There is still controversy about the anti-inflammatory effect of the drug. If there is such an effect, it is very insignificant.

The medicine, among other things, can have an antispasmodic effect on the lining of the stomach and intestines. The drug begins to work almost immediately after use. When using tablets, the effect is noticeable within 20-30 minutes. If injections are used, the effect of the medicine begins much faster.

What does Analgin in ampoules help with?

Instructions for use of the drug contain information about indications for use. These include the following situations:

• pain of various origins (dental, headache, joint);
• neurological diseases (myalgia);
• fever (often with colds and inflammatory processes);
• inflammation (in complex therapy);
• female periodic ailments accompanied by severe pain;
• white fever (in combination with additional medications);
• condition after surgery, when it is impossible to use other NSAIDs;
• premedication and so on.

The medicine is used only as needed. It is not used for prophylactic purposes. The drug must be prescribed by a specialist in dosage according to an individual regimen. In this case, injections are prescribed in exceptional cases.

Read the restrictions

The instructions for use of the medicine "Analgin" (in ampoules) inform that it has its contraindications. They need to be studied before starting therapy. Even if the medication is prescribed to you by a specialist, do not be lazy and read the annotation. If one of the contraindications is detected, you must stop using it and consult a doctor for advice.

The medicine is not prescribed to persons with hypersensitivity to metamizole sodium. Also, it should not be administered to patients who have previously experienced an allergic reaction to other non-steroidal anti-inflammatory compounds or Aspirin.

It is prohibited to use injections for persons with exacerbation of diseases of the kidneys, liver and hematopoietic system. Anemia of various origins is a contraindication to the use of the drug.

The drug is not recommended for lactating women, pregnant women and children under three months of age (with body weight below 5 kilograms).

Particular care should be taken when administering the medicine for bronchitis, urticaria, rhinitis and some diseases of the organs of vision. If you are prone to developing bronchospasm, then you need to have appropriate medications for inhalation with you during therapy.

"Analgin" (ampoules): instructions for use

The price of the medicine will be presented later in the article. You can also read the reviews that the medicine receives. Before this, you need to learn about the method of its use and dosage.

For adult patients and children over 15 years of age, the drug is prescribed 500 milligrams of metamizole sodium once. This amount is in one ampoule (50%) or two (25%). The maximum single dose is 1 gram. The daily volume of medication should not be more than 2 grams.

What else does the instructions for use say about the use of the drug “Analgin” (in ampoules)? For children weighing from 5 to 9 kilograms, the medicine is administered exclusively intramuscularly, while intravenous administration is also acceptable for older patients. The dosage depends on body weight.

For every kilogram there should be 5 to 10 milligrams of metamizole sodium. This means that if your child weighs 10 kilograms, he is recommended to take 50-100 mg of the active substance. If you use a 50 percent solution (which happens more often), then you need to take 0.1-0.2 milliliters.

The frequency of application should be 2-3 times a day.

How to give an injection?

Despite the fact that instructions for use are included with the drug "Analgin" in ampoules, patients often have questions about the algorithm of actions. First, the consumer must decide on the dosage. After this, you need to prepare everything you need for the injection. At home, the drug is most often administered intramuscularly.

Wash your hands with soap and wipe them with disinfectant gel or an alcohol wipe. Open the ampoule in the marked area. Some containers must first be filed with the supplied sandpaper. Be very careful not to get hurt.

After this, unseal the syringe and carefully remove the cap from the needle. Dial the volume of the drug you need. Always remember that the dosage of the solution may vary. Release any excess air from the syringe and proceed to the next step.

Wipe the injection area with an alcohol wipe. This could be the gluteal or femoral muscle. Insert the needle with a sharp movement and gradually empty the syringe.

Remember that the instructions (for children and adults) advise administering the medicine “Analgin” (in ampoules) very slowly. If you give a full injection (500 mg), then the syringe should not empty faster than in one minute.

Otherwise, there is a high probability of side effects.

The instructions for the drug "Analgin" for injections (in ampoules) indicate that it can cause adverse reactions. With very rapid administration, a sharp change in blood pressure and shock are observed, and breathing is impaired. This condition is especially dangerous in children. Therefore, it is important to calculate the correct dose for each child, based on individual characteristics.

Side effects also include allergic reactions. They can take completely different forms: urticaria, rash, itching, bronchospasm, swelling.

During treatment with this drug, diseases of the liver, kidneys, and hematopoietic organs may worsen.

If an overdose occurs, then there is a high probability of disruption of the digestive process, in which nausea, constipation, and flatulence are observed. Convulsions, fainting and other conditions may develop.

Special situations

What other information does the instructions for use tell the consumer about injections of Analgin (in ampoules)? For adult women during pregnancy, the drug is not prescribed in the first and last trimesters. At this time, the medicine can be dangerous both for the patient herself and for her baby. Injections can be administered under the strict supervision of a doctor only during the period from the 4th to the 6th months of pregnancy.

The medicine "Analgin" is often used to prepare a lytic mixture. At the same time, it is mixed with an antihistamine (usually Diphenhydramine or Tavegil) and an antispasmodic (No-shpa, Papaverine).

All ingredients should be selected according to the age and/or body weight of the patient. The medicine is administered intramuscularly and produces a pronounced antispasmodic, antipyretic and anti-allergic effect.

Opinions about the drug

You already know what the instructions say about the medicine “Analgin” in ampoules. The price of the drug is very attractive and affordable. Most consumers report this. One package of medication will cost you on average about 130 rubles. In this case, do not forget to purchase syringes of the appropriate volume.

Consumers say that the administered product begins to act instantly. The instructions for use promise a noticeable effect only 20 minutes after use. Most consumers say that the effect is detected after 5-10 minutes. The duration of the drug is determined individually and ranges from 4 to 8 hours.

Many users report that after intramuscular injections they are left with lumps at the injection site. Doctors say that such consequences usually go away on their own and do not require additional therapy. The medicine is often prescribed in combination with other drugs.

Before such use, be sure to read the composition and study the interaction. If you are taking other medications, but at the same time you were prescribed the drug "Analgin" by injection, then you should definitely inform your doctor. Your doctor may need to adjust your medication regimen so that it does not react in your body.

After all, some medications can often reduce or increase the effectiveness of others.

A short summary...

The medicine "Analgin" in ampoules has been used for quite some time. This is a well-known and affordable drug. It is available from pharmacies without a prescription. Despite this fact and all the positive reviews, you should not use the product yourself.

This is especially true for intravenous and intramuscular administration. After all, you cannot predict the reaction to a particular medicine. Be sure to consult a doctor if necessary. The doctor will select the most suitable regimen and dose of the drug for you.

Good health to you, don’t get sick!

Source: https://FB.ru/article/245869/analgin-v-ampulah-instruktsiya-po-primeneniyu-sostav-opisanie-i-otzyivyi

Therapeutic effect

• Features of pharmacodynamics

The mechanism of action of analgin in solution for injection, which is a pyrazolone derivative, is similar to the effect of a number of nonsteroidal anti-inflammatory drugs (NSAIDs). The result is a non-selective blocking of cyclooxygenase, as well as a decrease in the synthesis of prostaglandins and arachidonic acid. The process prevents the spread of pain bursts along the nerve endings with an increase in the threshold of pain perception and an increase in heat transfer. Very low anti-inflammatory activity contributes to sodium and water retention and has little effect on the condition of the gastrointestinal mucosa. Due to its antispasmodic effect, it relieves spasms of the smooth muscles of the biliary and urinary tract against the background of an analgesic as well as antipyretic effect.

• Pharmacokinetic aspects

The solution of the active substance, after rapid absorption, ends up in the liver, where, during the hydrolysis process, it decomposes into active and inactive metabolites. A small amount of the unchanged form of analgin is registered in the blood, where a reversible interaction with plasma proteins of the intramuscularly administered substance occurs. For effective action, the total concentration of analgin metabolites should not exceed 10 mcg/ml. If the concentration exceeds 20 mcg/ml, there is a risk of intoxication; repeated administration of the drug does not change its pharmacokinetics.

Important: since the excretion of metabolites occurs in the urine, in case of impaired functioning of the kidneys and liver, the recommended dosage should be followed to avoid the fact of drug accumulation. Injection of the drug provides a faster onset of effect than treatment with tablets.

Contraindications

Increased individual sensitivity to metamizole sodium and other pyrazolone derivatives. History of attacks of bronchial asthma, rhinitis, conjunctivitis caused by acetylsalicylic acid or other non-steroidal anti-inflammatory drugs. Hematopoietic disorders (agranulocytosis, cytostatic or infectious neutropenia). Liver and/or kidney failure. Hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase. Abdominal pain of unknown origin. Anemia, leukopenia. Kidney diseases: pyelonephritis, glomerulonephritis, including a history. It should not be administered intravenously to patients with systolic blood pressure below 100 mm Hg. Art. Polytrauma. Shock. Porphyria.

Interaction with other drugs and other types of interactions.

The toxic effect of the drug is enhanced when used simultaneously with other non-narcotic analgesics, tricyclic antidepressants (amizole, doxepin), hormonal contraceptives and allopurinol. Sarcolysin and Mercazolil (thiamazole) increase the likelihood of developing leukopenia. The effect of the drug is enhanced by histamine H2-blockers, propranolol (anaprilin), and weakened by phenylbutazone, barbiturates and other inducers of microsomal liver enzymes. The analgesic effect of the drug is enhanced by sedatives and tranquilizers (sibazon, trioxazine, valocardine, codeine, etc.). The drug increases the activity of oral hypoglycemic agents, indirect coagulants, phenytoin, ibuprofen, glucocorticosteroids and indomethacin (released from binding to blood proteins), the sedative activity of alcohol, and reduces the concentration of cyclosporine in plasma. Simultaneous use with phenothiazine derivatives (chlopromazine, etc.) can lead to the development of severe hyperthermia.

When used simultaneously with other non-steroidal anti-inflammatory drugs, their analgesic and antipyretic effects are potentiated and the likelihood of additive unwanted side effects increases.

Metamizole in high doses can lead to an increase in the concentration of methotrexate in the blood plasma and an increase in its toxic effects (on the digestive system and hematopoietic system).

When used simultaneously with sarcolysine, mercazolyl (thiamazole), drugs that inhibit bone marrow activity, including gold drugs, the likelihood of hematotoxicity increases, including the development of leukopenia.

Caution is required when using the drug simultaneously with diuretics (furosemide).

The drug should not be used simultaneously with radiopaque agents, colloidal blood substitutes and penicillin.

When used simultaneously with ethanol, the effect of ethanol is enhanced.

When is the drug prescribed?

The analgesic is used strictly after a doctor’s prescription, and also under his supervision, guided by the information from the instructions. The main goal of treatment is to relieve pain and provide an antipyretic effect. Injections are prescribed to relieve the following painful symptoms:

• mild or moderate pain associated with headache, toothache, neuralgia, colic (renal, intestinal, biliary);
• intramuscular injections are necessary for injuries, burns, decompression sickness, and postoperative pain syndrome;
• injections are effective in relieving fever syndrome caused by insect bites;
• the drug alleviates the condition and lowers body temperature accompanying infections, inflammatory diseases, and colds;
• injections are necessary for radiculitis, arthrosis, rheumatoid arthritis, and manifestations of osteochondrosis.

Note: tablets or injections of analgin, which belongs to the line of nonspecific anti-inflammatory drugs, relieve pain only for a short time. The daily dose should be carefully calculated so as not to exceed the maximum limit, since the medicine has a considerable number of negative effects.

General recommendations for metamizole sodium injection

When choosing an effective dose for injection, the instructions indicate that the intensity of pain, the level of fever symptoms, and the fact of individual sensitivity to the drug should be taken into account. Preference is given to minimal doses that provide relief from pain and signs of fever. According to the instructions, the dosage of a solution that can reduce fever in children is calculated taking into account the child’s weight and age.

Analgin solution in ampoules

Last update of the manufacturer's description 07/31/1998
Metamizole sodium* (Metamizole sodium*) N02BB02 Metamizole sodium

1 ml of solution for injection contains metamizole sodium 250 or 500 mg; ampoules of 1 or 2 ml, 10 pcs in a cardboard box.

1 tablet - 0.5 g; in contour cell (blisters) or cellless packaging of 10 pcs.

Pharmacological action - analgesic, anti-inflammatory.

Inhibits the activity of cyclooxygenase and reduces the formation of endoperoxides, PGs, free radicals, and inhibits lipid peroxidation.

Pain (headache, neuralgia, sciatica, myalgia) and fever syndromes.

Hypersensitivity, agranulocytosis.

Granulocytopenia, agranulocytosis, allergic reactions.

IM or IV (for severe pain) - 1-2 ml of a 50% solution 2-3 times a day, maximum dose - 2 g/day. Orally, after meals, 0.25–0.5 g 2–3 times a day.

In a dry place, protected from light.

Keep out of the reach of children.

tablets 500 mg - 5 years.

injection solution 25% - 3 years.

injection solution 50% - 3 years.

Do not use after the expiration date stated on the package.

Category ICD-10 Synonyms of diseases according to ICD-10

Source: https://www.rlsnet.ru/tn_index_id_10732.htm

Dose recommendations for children

Clarification: children over 15 years of age, as well as adults with a body weight of more than 53 kg, are prescribed an injection method of treatment of 1-2 ml with a possible increase in a single dose to 5 ml, and a daily dose to a maximum of 10 ml. For elderly people, the dose of metamizole is reduced due to the slow elimination of metabolites, especially with long-term treatment.

TRINALGIN

– metamizole sodium – pitofenone hydrochloride
– fenpiverinium bromide

Composition and release form of the drug

Solution for intravenous and intramuscular administration

white, round, flat, with cut edges and a dividing groove.

Excipients: sodium disulfite - 1 mg, sodium hydroxide solution 2M - sufficient to bring the pH to 6.0-7.5, water for injection - up to 1 ml.

2 ml – light-protective glass ampoules (10) – cardboard boxes. 2 ml – light-protective glass ampoules (5) – cellular contour packaging made of polyvinyl chloride film (1) – cardboard packs.

2 ml - ampoules of light-protective glass (5) - cellular contour packages made of polyvinyl chloride film (2) - cardboard packs. 5 ml - ampoules of light-protective glass (5) - cellular contour packages of polyvinyl chloride film (1) - cardboard packs.

5 ml – light-protective glass ampoules (5) – cellular contour packaging made of polyvinyl chloride film (2) – cardboard packs.

pharmachologic effect

Combined analgesic and antispasmodic agent. The combination of the components of the drug leads to a mutual enhancement of their pharmacological action.

Metamizole sodium

– a pyrazolone derivative, has an analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with inhibition of prostaglandin synthesis.

Pitophenone hydrochloride

has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation (papaverine-like effect).

Phenpiverinium bromide

has an m-anticholinergic effect and has an additional myotropic effect on smooth muscles.

Pharmacokinetics

Metamizole sodium

After oral administration, metamizole sodium is rapidly absorbed from the gastrointestinal tract. In the intestinal wall it is hydrolyzed to form an active metabolite.

Unchanged metamizole sodium is not detectable in the blood (only after intravenous administration it is found in the blood plasma in a small concentration and quickly becomes inaccessible for determination).

After intramuscular administration, the active substances of the drug are quickly and largely absorbed from the injection site.

Binding to blood plasma proteins is 50-60%. When taken in therapeutic doses, it is excreted in breast milk.

Metamizole sodium undergoes intensive biotransformation in the liver. The main metabolites are 4-methylaminoantipyrine, 4-formylaminoantipyrine, 4-aminoantipyrine and 4-acetylaminoantipyrine. About 20 additional metabolites have been identified, including glucuronic acid derivatives. The main four metabolites are found in the cerebrospinal fluid. It is excreted mainly by the kidneys.

Pitophenone

Rapidly absorbed from the gastrointestinal tract when taken orally. Cmax in blood plasma is achieved after 30-60 minutes. It is quickly distributed in organs and tissues and does not penetrate the BBB.

Metabolized in the liver by oxidative reactions. Excreted in urine. T1/2 is 1.8 hours.

Phenpiverinium bromide

When taken orally, it is quickly absorbed from the gastrointestinal tract. Cmax in blood plasma is achieved within 1 hour. Does not penetrate the BBB. Excreted unchanged in urine 32.4-40.4%, in bile – 2.3-5.3%.

Indications

Pain syndrome (mild or moderate) with spasms of smooth muscles of internal organs: renal colic, spasm of the ureter and bladder; biliary colic; biliary dyskinesia; postcholecystectomy syndrome; intestinal colic; chronic colitis; algodismenorrhea; diseases of the pelvic organs. For short-term treatment of arthralgia; myalgia; neuralgia, sciatica.

As an auxiliary drug for pain after surgical interventions and diagnostic procedures.

Contraindications

Severe liver and/or renal failure; inhibition of bone marrow hematopoiesis; deficiency of glucose-6-phosphate dehydrogenase; tachyarrhythmia; severe angina; decompensated chronic heart failure; collapse; angle-closure glaucoma; prostatic hyperplasia (with clinical manifestations); intestinal obstruction; megacolon; pregnancy (especially the first trimester and the last 6 weeks); lactation period; children under 3 months of age or body weight less than 5 kg (for intravenous administration); children under 5 years of age (for tablets); hypersensitivity (including to pyrazolone derivatives).

Carefully :

renal/liver failure; bronchial asthma; tendency to arterial hypotension; hypersensitivity to NSAIDs; urticaria or acute rhinitis caused by taking acetylsalicylic acid or other NSAIDs.

Dosage

Inside

Adults and adolescents over 15 years old: 1-2 tablets. 2-3 times a day, without chewing, with a small amount of liquid. Children aged 12-14 years: single dose – 1 tablet, maximum daily dose – 6 tablets. (1.5 tab.

4 times/day), children aged 8-11 years – 0.5 tablets, maximum daily dose – 4 tablets. (1 tablet 4 times/day), children aged 5-7 years – 0.5 tablet, maximum daily dose – 2 tablets. (0.5 tablet 4 times/day).

Parenteral (i.v., i.m.)

For adults and adolescents over 15 years of age with acute severe colic, 2 ml are administered intravenously slowly (1 ml over 1 minute); if necessary, re-inject after 6-8 hours. IM - 2-5 ml of solution 2-3 times a day. The maximum daily dose should not exceed 10 ml (corresponding to 5 g of metamizole sodium).

The duration of the course of treatment is determined depending on the clinical symptoms and etiopathogenesis of the disease, but should not exceed 5 days. Calculation of the dose for children with IV and IM administration: 3-11 months (5-8 kg) – only IM – 0.1-0.2 ml; 1-2 years (9-15 kg) – IV – 0.1-0.

2 ml, IM – 0.2-0.3 ml; 3-4 years (16-23 kg) – IV – 0.2-0.3, IM – 0.3-0.4 ml; 5-7 years (24-30 kg) – IV – 0.3-0.4 ml, IM – 0.4-0.5 ml; 8-12 years (31-45 kg) – IV – 0.5-0.6 ml, IM – 0.6-0.7 ml; 12-15 years – IV and IM – 0.8-1 ml.

Before administering the injection solution, it should be warmed in your hand.

Allergic reactions:

urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospasm, anaphylactic shock.

From the hematopoietic system:

thrombocytopenia, leukopenia, agranulocytosis (may be manifested by the following symptoms: unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of vaginitis or proctitis).

From the cardiovascular system:

decrease in blood pressure.

From the urinary system:

impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, red staining of urine.

Anticholinergic effects:

dry mouth, decreased sweating, accommodation paresis, tachycardia, difficulty urinating.

Local reactions:

with intramuscular administration, infiltrates are possible at the injection site.

Drug interactions

Histamine H1 receptor blockers, butyrophenones, phenothiazines, tricyclic antidepressants, amantadine and quinidine

– it is possible to enhance the m-anticholinergic effect.

Chlorpromazine or other phenothiazine derivatives

– development of severe hyperthermia is possible.

Non-narcotic analgesics, tricyclic antidepressants, oral hormonal contraceptives and allopurinol

– increase the toxicity of the drug.

Phenylbutazone, barbiturates and other microsomal enzyme inducers

– decrease in the effectiveness of metamizole sodium.

Sedatives and anxiolytics (tranquilizers)

– enhancing the analgesic effect of metamizole sodium.

Radiocontrast drugs, colloidal blood substitutes and penicillin

– combinations with drugs containing metamizole sodium should not be used.

Cyclosporine

– a decrease in the concentration of cyclosporine in the blood is possible.

Oral hypoglycemic agents, indirect anticoagulants, corticosteroids and indomethacin

– metamizole sodium displaces these drugs from their connection with proteins, as a result of which the severity of their action may increase.

Thiamazole and cytostatics

– increased risk of developing leukopenia.

Medicines with myelotoxic effects:

enhancing the hematotoxic effect of the drug.

Codeine, histamine H2 receptor blockers, propranolol

– enhanced effect of the drug due to slower inactivation of metamizole sodium.

Ethanol

– enhanced effects of ethanol.

The solution for injection is pharmaceutically incompatible with other drugs.

special instructions

With long-term (more than a week) treatment, monitoring of the peripheral blood picture and the functional state of the liver is necessary.

If agranulocytosis is suspected or thrombocytopenia is present, the drug should be discontinued.

The use of the drug to relieve acute abdominal pain is unacceptable until the cause of the disease is determined.

Intolerance is very rare, but the risk of developing anaphylactic shock after intravenous administration of the drug is relatively higher than after taking the drug orally.

In patients with atopic bronchial asthma and hay fever, the risk of developing allergic reactions increases.

Parenteral administration of the drug should be used only in cases where oral administration is impossible or absorption from the gastrointestinal tract is impaired.

The IV injection should be carried out slowly, with the patient lying down and under the control of blood pressure, heart rate and respiratory rate.

Particular care must be taken when administering more than 2 ml of solution (there is a risk of a sharp decrease in blood pressure).

For intramuscular administration it is necessary to use a long needle.

When treating children under 5 years of age and patients receiving cytostatics, the use of metamizole sodium should only be carried out under medical supervision.

It is possible that the urine may turn red due to the release of a metabolite (it has no clinical significance).

During treatment with the drug, it is not recommended to take ethanol.

Impact on the ability to drive vehicles and operate machinery

During treatment, drivers of vehicles and persons engaged in potentially hazardous activities that require rapid psychomotor reactions should be careful.

Pregnancy and lactation

The use of the drug is contraindicated during pregnancy (especially in the first trimester and in the last 6 weeks).

If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Use in childhood

IV administration of the drug is contraindicated in children under 3 months of age or with a body weight of less than 5 kg.

The use of the drug in tablet form is contraindicated in children under 5 years of age.

For impaired renal function

The use of the drug is contraindicated in cases of severe renal failure.

The drug should be prescribed with caution in case of renal failure.

For liver dysfunction

The use of the drug is contraindicated in cases of severe liver failure.

The drug should be prescribed with caution in case of liver failure.

The description of the drug TRINALGIN is based on officially approved instructions for use and approved by the manufacturer.

Found an error? Select it and press Ctrl+Enter.

Source: https://health.mail.ru/drug/trinalgin/

Features of introduction and safety measures

• Usually, to relieve symptoms of pain and inflammation, taking the drug in tablets is enough. With intramuscular or intravenous injections, it is possible to accelerate the effect of relief, but the increased risk of anaphylactic reaction should be taken into account.
• Before administering the treatment solution, it should be heated so that its temperature matches body temperature. The choice of intravenous injections should be carefully considered; after them, the likelihood of a sharp drop in blood pressure increases.
• To dilute the injection solution, you can use glucose (5% solution), physiological and Ringer's lactate solutions, taking into account immediate use due to their limited stability. Analgin solution is incompatible with other drugs, especially in the same container.
• When choosing the option of long-term therapy with injections or administration of the maximum permissible dose, regular monitoring of blood composition indicators is required. Injections are given while lying down under close medical supervision.
• To minimize a sharp drop in blood pressure, as well as to promptly stop the treatment process, intravenous injection of analgin is performed at a very slow pace (speed 1 ml/min). Heart function and breathing rate should be monitored.

Application and dosage

The solution is intended for intramuscular and intravenous (for severe pain) administration.
For adults, a single dose of 250–500 mg is prescribed up to three times a day.

For children, the dosage is calculated according to the formula: 5–10 mg of active substance per kilogram of the child’s weight. For children from 3 months to 1 year with a body weight of 5 kg, the drug can be administered intramuscularly, but the course of treatment in this category of patients should not exceed 3 days.

Before injection, it is recommended to warm the solution in the ampoule somewhat, for example, in the palm of your hand. When administered, it must be at body temperature.

If it is necessary to administer a dose of more than 1 g, the solution is administered intravenously. Such injections must be carried out in a hospital setting, and a prerequisite is the availability of anti-shock therapy. Administration should be slow to avoid a drop in blood pressure. In addition, when administering an Analgin solution intravenously, a prerequisite is that the patient is lying down, monitoring blood pressure and heart rate.

For whom the medicine is contraindicated

Intramuscular injections of metamizole are not prescribed to children under 3 months of age with a body weight of up to 5 kg; from 3 to 11 months, intravenous injections are prohibited. In case of severe renal pathologies, as well as problems with the liver, increased reaction to the active substance or pyrazolone derivatives, the administration of analgin solution is contraindicated. The instructions for using analgin in injections inform that blood diseases, not excluding hereditary hemolytic anemia, problems with hematopoiesis after therapy with cytostatics, as well as myasthenia gravis, optic neuritis are considered a good reason for refusing to prescribe the drug.

It is important to note that during pregnancy, especially at the beginning (1st trimester) and before childbirth (6 weeks), taking any form of medication is not recommended. Even a minimal dose of medication threatens the fetus or an infant during breastfeeding with various genetic abnormalities. Traces of active metabolites of analgin are found in breast milk, so if even minimal doses are necessary, you will have to stop breastfeeding for the duration of treatment with the drug.

Threat of side effects

Despite the fact that analgin tablets are inexpensive, and the drug administered intramuscularly helps quite quickly, the fact of undesirable side effects from treatment should be taken into account. As the instructions warn, in case of an overdose of the drug, tinnitus, drowsiness and confusion, breathing problems, even stopping it, may occur. The human body may react with the following adverse reactions:

• diseases of the blood and lymphatic system, the development of aplastic anemia with the threat of death;
• significant disturbances in the functioning of the excretory organs with a change in the color of urine to red;
• a decrease in blood pressure to critical levels;
• the development of allergic reactions, bronchospasm, even anaphylactic shock;
• the appearance of infiltration at the injection site, problems with the skin and subcutaneous tissue.

It is important to know that in case of an overdose of the drug, you should induce vomiting, drink a laxative (saline), rinse the stomach, and take sorbents. In particularly severe cases, convulsive syndrome, treatment is performed with intravenous injections of diazepam, as well as fast-acting barbiturates.

Interaction with medications

The instructions warn that the analgin prescribed in injections demonstrates high pharmaceutical incompatibility with many dosage forms. Metamizole sodium is dangerous to combine with the following drugs:

• other non-narcotic analgesics – mutual enhancement of toxicity;
• antidepressants (tricyclic), allopurinol, contraceptives;
• when combined with alcoholic drinks, the medicine enhances its effect;
• taking barbiturates and phenylbutazone harms the action of analgin;
• metamizole, simultaneously prescribed with cyclosporine, reduces its concentration in the blood;
• combination with hypoglycemic drugs, anticoagulants, corticosteroids enhances their effect;
• simultaneous use with tranquilizers and sedatives, the analgesic response of analgin is enhanced.

If you have pain of any intensity, you should not immediately look for tablets or ampoules of analgin in the medicine cabinet. You should see a specialist to determine the cause of the pain and receive adequate treatment. Despite the wide availability of any form of the drug and its rapid effect, the list of restrictions on therapy with metamizole sodium should be taken into account. In addition, the cause of a headache can be an increase in blood pressure, but in this case analgin is powerless, and a worsening of the situation is inevitable.

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Side effects

From the liver and biliary tract:

hepatitis.

From the cardiovascular system:

tachycardia.

From the urinary system:

oliguria, anuria, proteinuria, interstitial nephritis, red staining of urine.

From the hematopoietic system:

agranulocytosis, leukopenia, thrombocytopenia, anemia, granulocytopenia.

Allergic reactions:

hypersensitivity reactions, skin rashes, itching, urticaria, conjunctivitis, Quincke's edema; rarely - Stevens-Johnson syndrome, Lyell's syndrome, bronchospastic syndrome, anaphylactoid reactions, anaphylactic shock, skin hyperemia, angioedema.

Other:

decreased blood pressure, infiltrates at the injection site (with intramuscular injection), hyperemia, swelling, local rashes and itching of the skin at the injection site.

Incompatibility.

Due to the high probability of pharmaceutical incompatibility, the drug should not be mixed with other drugs in the same syringe.